David S. Milstone, M.D. Ph.D.

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 525-4308
Fax: (617) 525-4331


milstone@rics.bwh.harvard.edu

David S. Milstone, M.D. Ph.D.

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Pathology, Harvard Medical School
  • Associate Pathologist, Pathology, Brigham And Women's Hospital

Publications

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  • Tache V, Ciric A, Moretto-Zita M, Li Y, Peng J, Maltepe E, Milstone DS, Parast MM. Hypoxia and trophoblast differentiation: a key role for PPARç²’. Stem Cells Dev 2013; 22:2815-24. PubMed
  • Rose JA, Rabenold JJ, Parast MM, Milstone DS, Abrahams VM, Riley JK. Peptidoglycan Induces Necrosis and Regulates Cytokine Production in Murine Trophoblast Stem Cells. Am J Reprod Immunol 2011. PubMed
  • Parast MM, Yu H, Ciric A, Salata MW, Davis V, Milstone DS. PPARgamma regulates trophoblast proliferation and promotes labyrinthine trilineage differentiation. PLoS ONE 2009; 4:e8055. PubMed
  • Ye CP, Duan SZ, Milstone DS, Mortensen RM. G(o) controls the hyperpolarization-activated current in embryonic stem cell-derived cardiocytes. Am J Physiol Heart Circ Physiol 2007; 294:H979-85. PubMed
  • Duan SZ, Christe M, Milstone DS, Mortensen RM. Go but not Gi2 or Gi3 is required for muscarinic regulation of heart rate and heart rate variability in mice. Biochem Biophys Res Commun 2007; 357:139-43. PubMed
  • Duan SZ, Ivashchenko CY, Whitesall SE, D'Alecy LG, Duquaine DC, Brosius FC, Gonzalez FJ, Vinson C, Pierre MA, Milstone DS, Mortensen RM. Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality. J Clin Invest 2007; 117:812-22. PubMed
  • Duan SZ, Ivashchenko CY, Russell MW, Milstone DS, Mortensen RM. Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice. Circ Res 2005; 97:372-9. PubMed
  • Friedrich EB, Liu E, Sinha S, Cook S, Milstone DS, MacRae CA, Mariotti M, Kuhlencordt PJ, Force T, Rosenzweig A, St-Arnaud R, Dedhar S, Gerszten RE. Integrin-linked kinase regulates endothelial cell survival and vascular development. Mol Cell Biol 2004; 24:8134-44. PubMed
  • Yu Y, Moulton KS, Khan MK, Vineberg S, Boye E, Davis VM, O. E-Selectin Is Required For The Anti-angiogenic Activity of Endostatin Proc Natl Acad Sci U S A 2004; 1:1.
  • Yu Y, Moulton KS, Khan MK, Vineberg S, Boye E, Davis VM, O'Donnell PE, Bischoff J, Milstone DS. E-selectin is required for the antiangiogenic activity of endostatin. Proc Natl Acad Sci U S A 2004; 101:8005-10. PubMed
  • Moore KJ, Rosen ED, Fitzgerald ML, Randow F, Andersson LP, Altshuler D, Milstone DS, Mortensen RM, Spiegelman BM, Freeman MW. The role of PPAR-gamma in macrophage differentiation and cholesterol uptake. Nat Med 2001; 7:41-7. PubMed
  • Rosen ED, Sarraf P, Troy AE, Bradwin G, Moore K, Milstone DS, Spiegelman BM, Mortensen RM. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell 1999; 4:611-7. PubMed
  • Ye C, Sowell MO, Vassilev PM, Milstone DS, Mortensen RM. Galpha(i2), Galpha(i3)and Galpha(o) are all required for normal muscarinic inhibition of the cardiac calcium channels in nodal/atrial-like cultured cardiocytes. J Mol Cell Cardiol 1999; 31:1771-81. PubMed
  • Milstone DS, Fukumura D, Padgett RC, O'Donnell PE, Davis VM, Benavidez OJ, Monsky WL, Melder RJ, Jain RK, Gimbrone MA. Mice lacking E-selectin show normal numbers of rolling leukocytes but reduced leukocyte stable arrest on cytokine-activated microvascular endothelium. Microcirculation 1998; 5:153-71. PubMed
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