Deborah Burstein, PhD

Beth Israel Deaconess Medical Center

Beth Israel Deaconess Medical Center
Phone: (617) 667-3349
Fax: (617) 667-7021


dburstei@bidmc.harvard.edu

Deborah Burstein, PhD

Beth Israel Deaconess Medical Center

EDUCATIONAL TITLES

  • Associate Professor, Radiology, Harvard Medical School
  • Associate Professor, Radiology, Beth Israel Deaconess Medical Center

Research Abstract

Our research focus is on Magnetic Resonance Imaging (MRI) of animal models of cancer. Our facilities include an 8.5T vertical 9 cm bore MRI unit, and a 4.7T horizontal 40 cm bore unit. Animal models from mice to rabbits can be studies within these systems. Pulse sequences include standard T1 and T2 weighted sequences, diffusion imaging, magnetization transfer, perfusion, and contrast enhanced studies. Personnel are available to assist in the planning and MRI scanning.

Publications

Powered by Harvard Catalyst
  • Li W, Scheidegger R, Wu Y, Edelman RR, Farley M, Krishnan N, Burstein D, Prasad PV. Delayed contrast-enhanced MRI of cartilage: Comparison of nonionic and ionic contrast agents. Magn Reson Med 2010; 64:1267-73. PubMed
  • Hunter DJ, Losina E, Guermazi A, Burstein D, Lassere MN, Kraus V. A Pathway and Approach to Biomarker Validation and Qualification for Osteoarthritis Clinical Trials. Curr Drug Targets 2010; 11:536-45. PubMed
  • Wu M, Orta L, Gil J, Li G, Hu A, Burstein DE. Immunohistochemical detection of XIAP and p63 in adenomatous hyperplasia, atypical adenomatous hyperplasia, bronchioloalveolar carcinoma and well-differentiated adenocarcinoma. Mod Pathol 2008; 21:553-8. PubMed
  • Burstein DE, Idrees MT, Li G, Wu M, Kalir T. Immunohistochemical detection of the X-linked inhibitor of apoptosis protein (XIAP) in cervical squamous intraepithelial neoplasia and squamous carcinoma. Ann Diagn Pathol 2008; 12:85-9. PubMed
  • Williams A, Shetty SK, Burstein D, Day CS, McKenzie C. Delayed gadolinium enhanced MRI of cartilage (dGEMRIC) of the first carpometacarpal (1CMC) joint: a feasibility study. Osteoarthritis Cartilage 2008; 16:530-2. PubMed
  • Shtilbans V, Wu M, Burstein DE. Current overview of the role of Akt in cancer studies via applied immunohistochemistry. Ann Diagn Pathol 2008; 12:153-60. PubMed
  • Gray ML, Burstein D, Kim YJ, Maroudas A. 2007 Elizabeth Winston Lanier Award Winner. Magnetic resonance imaging of cartilage glycosaminoglycan: basic principles, imaging technique, and clinical applications. J Orthop Res 2007; 26:281-91. PubMed
  • Emanuel PO, Phelps RG, Mudgil A, Shafir M, Burstein DE. Immunohistochemical detection of XIAP in melanoma. J Cutan Pathol 2008; 35:292-7. PubMed
  • Wu M, Orta L, Gil J, Li G, Hu A, Burstein DE. Immunohistochemical detection of XIAP and p63 in adenomatous hyperplasia, atypical adenomatous hyperplasia, bronchioloalveolar carcinoma and well-differentiated adenocarcinoma. Mod Pathol 2008. PubMed
  • Xiao GQ, Burstein DE. Cytologic findings of rhabdoid meningioma in cerebrospinal fluid. Acta Cytol 2008; 52:118-9. PubMed
  • Nagi C, Xiao GQ, Li G, Genden E, Burstein DE. Immunohistochemical detection of X-linked inhibitor of apoptosis in head and neck squamous cell carcinoma. Ann Diagn Pathol 2007; 11:402-6. PubMed
  • Williams A, Mikulis B, Krishnan N, Gray M, McKenzie C, Burstein D. Suitability of T(1Gd) as the dGEMRIC index at 1.5T and 3.0T. Magn Reson Med 2007; 58:830-4. PubMed
  • Baldassarri M, Goodwin JS, Farley ML, Bierbaum BE, Goldring SR, Goldring MB, Burstein D, Gray ML. Relationship between cartilage stiffness and dGEMRIC index: correlation and prediction. J Orthop Res 2007; 25:904-12. PubMed
  • Nieminen MT, Menezes NM, Williams A, Burstein D. T2 of articular cartilage in the presence of Gd-DTPA2-. Magn Reson Med 2004; 51:1147-52. PubMed
  • Sun Y, Schmidt NO, Schmidt K, Doshi S, Rubin JB, Mulkern RV, Carroll R, Ziu M, Erkmen K, Poussaint TY, Black P, Albert M, Burstein D, Kieran MW. Perfusion MRI of U87 brain tumors in a mouse model. Magn Reson Med 2004; 51:893-9. PubMed
  • Menezes NM, Gray ML, Hartke JR, Burstein D. T2 and T1rho MRI in articular cartilage systems. Magn Reson Med 2004; 51:503-9. PubMed
  • Weis S, Shintani S, Weber A, Kirchmair R, Wood M, Cravens A, McSharry H, Iwakura A, Yoon YS, Himes N, Burstein D, Doukas J, Soll R, Losordo D, Cheresh D. Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction. J Clin Invest 2004; 113:885-94. PubMed
  • Williams A, Gillis A, McKenzie C, Po B, Sharma L, Micheli L, McKeon B, Burstein D. Glycosaminoglycan distribution in cartilage as determined by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC): potential clinical applications. Am J Roentgenol 2003; 182:167-72. PubMed
  • Kim YJ, Jaramillo D, Millis MB, Gray ML, Burstein D. Assessment of early osteoarthritis in hip dysplasia with delayed gadolinium-enhanced magnetic resonance imaging of cartilage. J Bone Joint Surg Am 2003; 85-A:1987-92. PubMed
  • Nelson AL, Algon SA, Munasinghe J, Graves O, Goumnerova L, Burstein D, Pomeroy SL, Kim JY. Magnetic resonance imaging of patched heterozygous and xenografted mouse brain tumors. J Neurooncol 2003; 62:259-67. PubMed
  • Burstein D, Gray M. New MRI techniques for imaging cartilage. J Bone Joint Surg Am 2003; 85-A Suppl 2:70-7. PubMed
  • Williams A, Oppenheimer RA, Gray ML, Burstein D. Differential recovery of glycosaminoglycan after IL-1-induced degradation of bovine articular cartilage depends on degree of degradation. Arthritis Res Ther 2003; 5:R97-105. PubMed
  • Gillis A, Gray M, Burstein D. Relaxivity and diffusion of gadolinium agents in cartilage. Magn Reson Med 2002; 48:1068-71. PubMed
  • Henkelman RM, Stanisz GJ, Menezes N, Burstein D. Can MTR be used to assess cartilage in the presence of Gd-DTPA2-? Magn Reson Med 2002; 48:1081-4. PubMed
  • Gray ML, Burstein D, Xia Y. Biochemical (and functional) imaging of articular cartilage. Semin Musculoskelet Radiol 2001; 5:329-43. PubMed
  • Gillis A, Bashir A, McKeon B, Scheller A, Gray ML, Burstein D. Magnetic resonance imaging of relative glycosaminoglycan distribution in patients with autologous chondrocyte transplants. Invest Radiol 2001; 36:743-8. PubMed
  • Recht M, Bobic V, Burstein D, Disler D, Gold G, Gray M, Kramer J, Lang P, McCauley T, Winalski C. Magnetic resonance imaging of articular cartilage. Clin Orthop Relat Res 2001. PubMed
  • Burstein D, Velyvis J, Scott KT, Stock KW, Kim YJ, Jaramillo D, Boutin RD, Gray ML. Protocol issues for delayed Gd(DTPA)(2-)-enhanced MRI (dGEMRIC) for clinical evaluation of articular cartilage. Magn Reson Med 2001; 45:36-41. PubMed
  • Burstein D, Bashir A, Gray ML. MRI techniques in early stages of cartilage disease. Invest Radiol 2000; 35:622-38. PubMed
  • Rosen GD, Burstein D, Galaburda AM. Changes in efferent and afferent connectivity in rats with induced cerebrocortical microgyria. J Comp Neurol 2000; 418:423-40. PubMed
  • Bashir A, Gray ML, Hartke J, Burstein D. Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRI. Magn Reson Med 1999; 41:857-65. PubMed
  • Allen RG, Burstein D, Gray ML. Monitoring glycosaminoglycan replenishment in cartilage explants with gadolinium-enhanced magnetic resonance imaging. J Orthop Res 1999; 17:430-6. PubMed
  • Fung SH, Burstein D, Born RT. In vivo microelectrode track reconstruction using magnetic resonance imaging. J Neurosci Methods 1998; 80:215-24. PubMed
  • Rosen GD, Burstein D. MRI visualization of focal induced neocortical malformations of the rat. Neuroreport 1998; 8:3883-7. PubMed
  • Bashir A, Gray ML, Boutin RD, Burstein D. Glycosaminoglycan in articular cartilage: in vivo assessment with delayed Gd(DTPA)(2-)-enhanced MR imaging. Radiology 1997; 205:551-8. PubMed
  • Chao H, Burstein D. Multibolus stimulated echo imaging of coronary artery flow. J Magn Reson Imaging 1997; 7:603-5. PubMed
  • Donahue KM, Weisskoff RM, Burstein D. Water diffusion and exchange as they influence contrast enhancement. J Magn Reson Imaging 1997; 7:102-10. PubMed
  • Bashir A, Gray ML, Burstein D. Gd-DTPA2- as a measure of cartilage degradation. Magn Reson Med 1996; 36:665-73. PubMed
  • Gray ML, Burstein D, Lesperance LM, Gehrke L. Magnetization transfer in cartilage and its constituent macromolecules. Magn Reson Med 1995; 34:319-25. PubMed
  • Donahue KM, Burstein D, Manning WJ, Gray ML. Studies of Gd-DTPA relaxivity and proton exchange rates in tissue. Magn Reson Med 1994; 32:66-76. PubMed
  • Prasad PV, Burstein D, Edelman RR. MRI evaluation of myocardial perfusion without a contrast agent using magnetization transfer. Magn Reson Med 1993; 30:267-70. PubMed
  • Burstein D, Gray ML, Hartman AL, Gipe R, Foy BD. Diffusion of small solutes in cartilage as measured by nuclear magnetic resonance (NMR) spectroscopy and imaging. J Orthop Res 1993; 11:465-78. PubMed
  • Foy BD, Burstein D. Characteristics of extracellular sodium relaxation in perfused hearts with pathologic interventions. Magn Reson Med 1992; 27:270-83. PubMed
  • Lesperance LM, Gray ML, Burstein D. Determination of fixed charge density in cartilage using nuclear magnetic resonance. J Orthop Res 1992; 10:1-13. PubMed
  • Edelman RR, Manning WJ, Burstein D, Paulin S. Coronary arteries: breath-hold MR angiography. Radiology 1991; 181:641-3. PubMed
  • Burstein D, Taratuta E, Manning WJ. Factors in myocardial "perfusion" imaging with ultrafast MRI and Gd-DTPA administration. Magn Reson Med 1991; 20:299-305. PubMed
  • Burstein D. MR imaging of coronary artery flow in isolated and in vivo hearts. J Magn Reson Imaging 1991; 1:337-46. PubMed
  • Powell D, Burstein D, Fossel ET. Nuclear magnetic resonance studies of sodium/calcium exchange in frog perfused, beating hearts. Eur J Biochem 1990; 193:887-9. PubMed
  • Foy BD, Burstein D. Interstitial sodium nuclear magnetic resonance relaxation times in perfused hearts. Biophys J 1990; 58:127-34. PubMed
  • Manning WJ, Wei JY, Fossel ET, Burstein D. Measurement of left ventricular mass in rats using electrocardiogram-gated magnetic resonance imaging. Am J Physiol 1990; 258:H1181-6. PubMed
  • Atkinson DJ, Burstein D, Edelman RR. First-pass cardiac perfusion: evaluation with ultrafast MR imaging. Radiology 1990; 174:757-62. PubMed
  • Burstein D, Litt HI, Fossel ET. NMR characteristics of "visible" intracellular myocardial potassium in perfused rat hearts. Magn Reson Med 1988; 9:66-78. PubMed
Hide