Photo of Dhvanit I. Shah,  PhD

Dhvanit I. Shah, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 355-9042


dshah@research.bwh.harvard.edu

Dhvanit I. Shah, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Instructor, Medicine, Harvard Medical School
  • Associate Scientist, Medicine, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Our laboratory investigates the origin, development, and differentiation of hematopoietic stem cells (HSCs) to treat patients with leukemia, lymphoma, genetic blood disorders, and bone-marrow failure syndromes. We have expertise in utilizing zebrafish, mice, and human induced pluripotent stem (iPS) cells to clone and analyze novel genes and mechanisms important for blood formation. Our goal is to utilize our knowledge in developing generating functional HSCs from patient-derived tissues for the treatment of hematological diseases using state-of-the-art gene-editing, 3D organoid development, cell-engineering, machine learning, and computational approaches.

Publications

Powered by Harvard Catalyst
  • Hagedorn EJ, Cillis JL, Curley CR, Patch TC, Li B, Blaser BW, Riquelme R, Zon LI, Shah DI. Generation of Parabiotic Zebrafish Embryos by Surgical Fusion of Developing Blastulae. 2016. PubMed
  • Anderson H, Patch TC, Reddy PN, Hagedorn EJ, Kim PG, Soltis KA, Chen MJ, Tamplin OJ, Frye M, MacLean GA, Hübner K, Bauer DE, Kanki JP, Vogin G, Huston NC, Nguyen M, Fujiwara Y, Paw BH, Vestweber D, Zon LI, Orkin SH, Daley GQ, Shah DI. Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression. Blood 2015. PubMed
  • Shah DI, Takahashi-Makise N, Cooney JD, Li L, Schultz IJ, Pierce EL, Narla A, Seguin A, Hattangadi SM, Medlock AE, Langer NB, Dailey TA, Hurst SN, Faccenda D, Wiwczar JM, Heggers SK, Vogin G, Chen W, Chen C, Campagna DR, Brugnara C, Zhou Y, Ebert BL, Danial NN, Fleming MD, Ward DM, Campanella M, Dailey HA, Kaplan J, Paw BH. Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts. Nature 2012; 491:608-12. PubMed