Photo of Dianne M. Finkelstein,  PhD

Dianne M. Finkelstein, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-5970
Fax: (617) 724-9878


dfinkelstein@partners.org

Dianne M. Finkelstein, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Biostatistics, Harvard T.H. Chan School Of Public Health
  • Professor, Medicine, Harvard Medical School
  • Director, Cancer Center Biostatistics, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Dr. Finkelstein's research is focused on the development of semi-parametric methodology for analyzing the effect of covariates on failure time distributions that arise in Acquired Immune Deficiency Syndrome (AIDS) and cancer epidemiological studies and clinical trials. She has developed methods for analyzing the failure time distributions from interval censored data. Such interval censored data arise in screening studies, where the infection time is not known exactly, but rather is only known to lie in an interval which is of different length for each individual. Dr. Finkelstein's research has also focused on the development of methods for analyzing animal carcinogenicity experiments. Dr. Finkelstein is the director of Biostatistics at the MGH Cancer Center. In addition, she is the Principal Investigator for the Statistical Coordinating Center for the NCI sponsored Cancer Genetics Network.

Publications

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  • Isakoff SJ, Mayer EL, He L, Traina TA, Carey LA, Krag KJ, Rugo HS, Liu MC, Stearns V, Come SE, Timms KM, Hartman AR, Borger DR, Finkelstein DM, Garber JE, Ryan PD, Winer EP, Goss PE, Ellisen LW. TBCRC009: A Multicenter Phase II Clinical Trial of Platinum Monotherapy With Biomarker Assessment in Metastatic Triple-Negative Breast Cancer. J Clin Oncol 2015. PubMed
  • Ramchandani R, Finkelstein DM, Schoenfeld DA. A model-informed rank test for right-censored data with intermediate states. Stat Med 2015; 34:1454-66. PubMed
  • Boyle FM, Smith IE, O'Shaughnessy J, Ejlertsen B, Buzdar AU, Fumoleau P, Gradishar W, Martin M, Moy B, Piccart-Gebhart M, Pritchard KI, Lindquist D, Amonkar M, Huang Y, Rappold E, Williams LS, Wang-Silvanto J, Kaneko T, Finkelstein DM, Goss PE, . Health related quality of life of women in TEACH, a randomised placebo controlled adjuvant trial of lapatinib in early stage Human Epidermal Growth Factor Receptor (HER2) overexpressing breast cancer. Eur J Cancer 2015; 51:685-96. PubMed
  • Ager EI, Kozin SV, Kirkpatrick ND, Seano G, Kodack DP, Askoxylakis V, Huang Y, Goel S, Snuderl M, Muzikansky A, Finkelstein DM, Dransfield DT, Devy L, Boucher Y, Fukumura D, Jain RK. Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy. Journal of the National Cancer Institute 2015. PubMed
  • O'Donnell E, Mahindra A, Yee AJ, Nardi V, Birrer N, Horick N, Borger D, Finkelstein D, Iafrate JA, Raje N. Clinical Grade "SNaPshot" Genetic Mutation Profiling in Multiple Myeloma. EBioMedicine 2015; 2:71-3. PubMed
  • Strasser-Weippl K, Horick N, Smith IE, O'Shaughnessy J, Ejlertsen B, Boyle F, Buzdar AU, Fumoleau P, Gradishar W, Martin M, Moy B, Piccart-Gebhart M, Pritchard KI, Lindquist D, Rappold E, Finkelstein DM, Goss PE. Long-term hazard of recurrence in HER2+ breast cancer patients untreated with anti-HER2 therapy. Breast Cancer Res 2015; 17:56. PubMed
  • Schaid DJ, Spraggs CF, McDonnell SK, Parham LR, Cox CJ, Ejlertsen B, Finkelstein DM, Rappold E, Curran J, Cardon LR, Goss PE. Prospective validation of HLA-DRB1*07:01 allele carriage as a predictive risk factor for lapatinib-induced liver injury. J Clin Oncol 2014. PubMed
  • Fan L, Strasser-Weippl K, Li JJ, St Louis J, Finkelstein DM, Yu KD, Chen WQ, Shao ZM, Goss PE. Breast cancer in China. Lancet Oncol 2014; 15:e279-89. PubMed
  • Finkelstein DM, Schoenfeld DA. A joint test for progression and survival with interval-censored data from a cancer clinical trial. Stat Med 2014. PubMed
  • Hill DA, Horick NK, Isaacs C, Domchek SM, Tomlinson GE, Lowery JT, Kinney AY, Berg JS, Edwards KL, Moorman PG, Plon SE, Strong LC, Ziogas A, Griffin CA, Kasten CH, Finkelstein DM. Long-term risk of medical conditions associated with breast cancer treatment. Breast Cancer Res Treat 2014; 145:233-43. PubMed
  • Dwojak SM, Finkelstein DM, Emerick KS, Lee JH, Petereit DG, Deschler DG. Poor Survival for American Indians with Head and Neck Squamous Cell Carcinoma. 2014. PubMed
  • Lowery JT, Horick N, Kinney AY, Finkelstein DM, Garrett K, Haile RW, Lindor NM, Newcomb PA, Sandler RS, Burke C, Hill DA, Ahnen DJ. A randomized trial to increase colonoscopy screening in members of high-risk families in the colorectal cancer family registry and cancer genetics network. Cancer Epidemiol Biomarkers Prev 2014; 23:601-10. PubMed
  • Liedke PE, Finkelstein DM, Szymonifka J, Barrios CH, Chavarri-Guerra Y, Bines J, Vasconcelos C, Simon SD, Goss PE. Outcomes of breast cancer in Brazil related to health care coverage: a retrospective cohort study. Cancer Epidemiol Biomarkers Prev 2014; 23:126-33. PubMed
  • Chavarri-Guerra Y, St Louis J, Liedke PE, Symecko H, Villarreal-Garza C, Mohar A, Finkelstein DM, Goss PE. Access to care issues adversely affect breast cancer patients in Mexico: oncologists' perspective. BMC Cancer 2014; 14:658. PubMed
  • Specht MC, Miller CL, Russell TA, Horick N, Skolny MN, O'Toole JA, Jammallo LS, Niemierko A, Sadek BT, Shenouda MN, Finkelstein DM, Smith BL, Taghian AG. Defining a threshold for intervention in breast cancer-related lymphedema: what level of arm volume increase predicts progression? Breast Cancer Res Treat 2013; 140:485-94. PubMed
  • Sgroi DC, Carney E, Zarrella E, Steffel L, Binns SN, Finkelstein DM, Szymonifka J, Bhan AK, Shepherd LE, Zhang Y, Schnabel CA, Erlander MG, Ingle JN, Porter P, Muss HB, Pritchard KI, Tu D, Rimm DL, Goss PE. Prediction of late disease recurrence and extended adjuvant letrozole benefit by the HOXB13/IL17BR biomarker. Journal of the National Cancer Institute 2013; 105:1036-42. PubMed
  • Goss PE, Smith IE, O'Shaughnessy J, Ejlertsen B, Kaufmann M, Boyle F, Buzdar AU, Fumoleau P, Gradishar W, Martin M, Moy B, Piccart-Gebhart M, Pritchard KI, Lindquist D, Chavarri-Guerra Y, Aktan G, Rappold E, Williams LS, Finkelstein DM, . Adjuvant lapatinib for women with early-stage HER2-positive breast cancer: a randomised, controlled, phase 3 trial. Lancet Oncol 2013; 14:88-96. PubMed
  • Schoenfeld DA, Rajicic N, Ficociello LH, Finkelstein DM. A test for the relationship between a time-varying marker and both recovery and progression with missing data. Stat Med 2011; 30:718-24. PubMed
  • Finkelstein DM, Schoenfeld DA. Correcting for discretionary treatment crossover in an analysis of survival in the Breast International Group BIG 1-98 trial by using the inverse probability of censoring weighted method. J Clin Oncol 2011; 29:1093-5. PubMed
  • Schoenfeld DA, Rajicic N, Ficociello LH, Finkelstein DM. A test for the relationship between a time-varying marker and both recovery and progression with missing data. Stat Med 2011. PubMed
  • Rizvi I, Celli JP, Evans CL, Abu-Yousif AO, Muzikansky A, Pogue BW, Finkelstein D, Hasan T. Synergistic enhancement of carboplatin efficacy with photodynamic therapy in a three-dimensional model for micrometastatic ovarian cancer. Cancer Res 2010; 70:9319-28. PubMed
  • Moorman PG, Iversen ES, Marcom PK, Marks JR, Wang F, , Lee E, Ursin G, Rebbeck TR, Domchek SM, Arun B, Susswein L, Isaacs C, Garber JE, Visvanathan K, Griffin CA, Sutphen R, Brzosowicz J, Gruber S, Finkelstein DM, Schildkraut JM. Evaluation of established breast cancer risk factors as modifiers of BRCA1 or BRCA2: a multi-center case-only analysis. Breast Cancer Res Treat 2010; 124:441-51. PubMed
  • Finkelstein DM, Wang R, Ficociello LH, Schoenfeld DA. A Score Test for Association of a Longitudinal Marker and an Event with Missing Data. Biometrics 2010; 66:726-32. PubMed
  • Nichols AC, Finkelstein DM, Faquin WC, Westra WH, Mroz EA, Kneuertz P, Begum S, Michaud WA, Busse PM, Clark JR, Rocco JW. Bcl2 and Human Papilloma Virus 16 as Predictors of Outcome following Concurrent Chemoradiation for Advanced Oropharyngeal Cancer. Clin Cancer Res 2010; 16:2138-46. PubMed
  • Crippa S, Fernández-Del Castillo C, Salvia R, Finkelstein D, Bassi C, Domínguez I, Muzikansky A, Thayer SP, Falconi M, Mino-Kenudson M, Capelli P, Lauwers GY, Partelli S, Pederzoli P, Warshaw AL. Mucin-producing neoplasms of the pancreas: an analysis of distinguishing clinical and epidemiologic characteristics. Clin Gastroenterol Hepatol 2010; 8:213-9. PubMed
  • Rajicic N, Cuschieri J, Finkelstein DM, Miller-Graziano CL, Hayden D, Moldawer LL, Moore E, O'Keefe G, Pelik K, Warren HS, Schoenfeld DA, . Identification and interpretation of longitudinal gene expression changes in trauma. PLoS ONE 2010; 5:e14380. PubMed
  • Rajicic N, Finkelstein DM, Schoenfeld DA, . Analysis of the relationship between longitudinal gene expressions and ordered categorical event data. Stat Med 2009; 28:2817-32. PubMed
  • Souglakos J, Philips J, Wang R, Marwah S, Silver M, Tzardi M, Silver J, Ogino S, Hooshmand S, Kwak E, Freed E, Meyerhardt JA, Saridaki Z, Georgoulias V, Finkelstein D, Fuchs CS, Kulke MH, Shivdasani RA. Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. Br J Cancer 2009; 101:465-72. PubMed
  • Schoenfeld DA, Hui Zheng , Finkelstein DM. Bayesian design using adult data to augment pediatric trials. Clin Trials 2009; 6:297-304. PubMed
  • Nisbet DR, Moses D, Gengenbach TR, Forsythe JS, Finkelstein DI, Horne MK. Enhancing neurite outgrowth from primary neurones and neural stem cells using thermoresponsive hydrogel scaffolds for the repair of spinal cord injury. J Biomed Mater Res A 2009; 89:24-35. PubMed
  • Alm El-Din MA,Hughes KS,Finkelstein DM,Betts KA,Yock TI,Tarbell NJ,Aisenberg AC,Taghian AG. Breast cancer after treatment of Hodgkin's lymphoma: risk factors that really matter. Int J Radiat Oncol Biol Phys 2008; 73:69-74. PubMed
  • Neklason DW,Kerber RA,Nilson DB,Anton-Culver H,Schwartz AG,Griffin CA,Lowery JT,Schildkraut JM,Evans JP,Tomlinson GE,Strong LC,Miller AR,Stopfer JE,Finkelstein DM,Nadkarni PM,Kasten CH,Mineau GP,Burt RW. Common familial colorectal cancer linked to chromosome 7q31: a genome-wide analysis. Cancer Res 2008; 68:8993-7. PubMed
  • Matthews AG,Finkelstein DM,Betensky RA. Analysis of familial aggregation studies with complex ascertainment schemes. Stat Med 2008; 27:5076-92. PubMed
  • Bell DW,Brannigan BW,Matsuo K,Finkelstein DM,Sordella R,Settleman J,Mitsudomi T,Haber DA. Increased prevalence of EGFR-mutant lung cancer in women and in East Asian populations: analysis of estrogen-related polymorphisms. Clin Cancer Res 2008; 14:4079-84. PubMed
  • Tanabe KK, Lemoine A, Finkelstein DM, Kawasaki H, Fujii T, Chung RT, Lauwers GY, Kulu Y, Muzikansky A, Kuruppu D, Lanuti M, Goodwin JM, Azoulay D, Fuchs BC. Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis. JAMA 2008; 299:53-60. PubMed
  • Kerber RA,Amos CI,Yeap BY,Finkelstein DM,Thomas DC. Design considerations in a sib-pair study of linkage for susceptibility loci in cancer. BMC Med Genet 2008; 9:64. PubMed
  • Parmigiani G, Chen S, Iversen ES Jr, Friebel TM, Finkelstein DM, Anton-Culver H, Ziogas A, Weber BL, Eisen A, Malone KE, Daling JR, Hsu L, Ostrander EA, Peterson LE, Schildkraut JM, Isaacs C, Corio C, Leondaridis L, Tomlinson G, Amos CI, Strong LC, Berry DA, Weitzel JN, Sand S, Dutson D, Kerber R, Peshkin BN, Euhus DM. Validity of models for predicting BRCA1 and BRCA2 mutations. Ann Intern Med 2007; 147:441-50. PubMed
  • Tripanichkul W, Sripanichkulchai K, Duce JA, Finkelstein DI. 17Beta-estradiol reduces nitrotyrosine immunoreactivity and increases SOD1 and SOD2 immunoreactivity in nigral neurons in male mice following MPTP insult. Brain Res 2007; 1164:24-31. PubMed
  • Matthews AG, Finkelstein DM, Betensky RA. Multivariate logistic regression for familial aggregation in age at disease onset. Lifetime Data Analysis 2007; 13:191-209. PubMed
  • Taveras EM, Sobol AM, Hannon C, Finkelstein D, Wiecha J, Gortmaker SL. Youths' perceptions of overweight-related prevention counseling at a primary care visit. Obesity (Silver Spring) 2007; 15:831-6. PubMed
  • Stephen AE, Roth SI, Fardo DW, Finkelstein DM, Randolph GW, Gaz RD, Hodin RA. Predictors of an accurate preoperative sestamibi scan for single-gland parathyroid adenomas. Arch Surg 2007; 142:381-6. PubMed
  • Troped PJ, Wiecha JL, Fragala MS, Matthews CE, Finkelstein DM, Kim J, Peterson KE. Reliability and validity of YRBS physical activity items among middle school students. Med Sci Sports Exerc 2007; 39:416-25. PubMed
  • Shepard JL, Amatruda JF, Finkelstein D, Ziai J, Finley KR, Stern HM, Chiang K, Hersey C, Barut B, Freeman JL, Lee C, Glickman JN, Kutok JL, Aster JC, Zon LI. A mutation in separase causes genome instability and increased susceptibility to epithelial cancer. Genes Dev 2007; 21:55-9. PubMed
  • Finkelstein DM, Kubzansky LD, Goodman E. Social status, stress, and adolescent smoking. J Adolesc Health 2006; 39:678-85. PubMed
  • Rajicic N, Finkelstein DM, Schoenfeld DA,. Survival analysis of longitudinal microarrays. Bioinformatics 2006; 22:2643-9. PubMed
  • Wiecha JL, Finkelstein D, Troped PJ, Fragala M, Peterson KE.. School vending machine use and fast-food restaurant use are associated with sugar-sweetened beverage intake in youth J Am Diet Assoc 2006; 106:1624-30.
  • Ferrone CR, Finkelstein DM, Thayer SP, Muzikansky A, Fernandez-delCastillo C, Warshaw AL. Perioperative CA19-9 levels can predict stage and survival in patients with resectable pancreatic adenocarcinoma. J Clin Oncol 2006; 24:2897-902. PubMed
  • Matthews AG, Betensky RA, Anton-Culver H, Bowen D, Griffin C, Isaacs C, Kasten C, Mineau G, Nayfield S, Schildkraut J, Strong L, Weber B, Finkelstein DM. Analysis of co-aggregation of cancer based on registry data. Community Genet 2006; 9:87-92. PubMed
  • Amrein PC, Clark JR, Supko JG, Fabian RL, Wang CC, Colevas AD, Posner MR, Deschler DG, Rocco JW, Finkelstein DM, McIntyre JF. Phase I trial and pharmacokinetics of escalating doses of paclitaxel and concurrent hyperfractionated radiotherapy with or without amifostine in patients with advanced head and neck carcinoma. Cancer 2005; 104:1418-27. PubMed
  • Rao SR, Graubard BI, Schmid CH, Morton SC, Louis TA, Zaslavsky AM, Finkelstein DM. Meta-analysis of survey data: application to health services research 2008; 8:98-114.
  • FitzGerald MG, MacDonald DJ, Krainer M, Hoover I, O'Neil E, Unsal H, Silva-Arrieto S, Finkelstein DM, Beer-Romero P, Englert C, Sgroi DC, Smith BL, Younger JW, Garber JE, Duda RB, Mayzel KA, Isselbacher KJ, Friend SH, Haber DA. Germ-line BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancer. N Engl J Med 1996; 334:143-9. PubMed
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