Photo of Donald E. Ingber,  MD, PhD

Donald E. Ingber, MD, PhD

Boston Children's Hospital

Boston Children's Hospital
Phone: (617) 432-7044
Fax: (617) 432-7828


don.ingber@wyss.harvard.edu

Donald E. Ingber, MD, PhD

Boston Children's Hospital

EDUCATIONAL TITLES

  • Judah Folkman Professor of Vascular Biology, Pathology, Harvard Medical School
  • Research Associate, Pathology, Brigham And Women's Hospital
  • Research Associate, Vascular Biology Program, Boston Children's Hospital
  • Director, Executive Team, Wyss Institute for Biologically Inspired Engineering at Harvard Univ

Research Abstract

Dr. Ingber's research group focuses on the importance of extracellular matrix (ECM), integrins, and cytoskeletal structure for control of angiogenesis. They combine methods from diverse fields, including molecular cell biology, mechanical engineering, chemistry, and materials science, to address fundamental questions relating to the mechanism of capillary cell growth, differentiation, migration and apoptosis. Ingber was one of the first investigators to show that chemical modulators of ECM turnover can inhibit angiogenesis and induce capillary regression. His discovery also led to the development of the angiogenesisinhibitor, TNP-470, that is currently in human clinical trials.

Publications

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  • Huebsch N, Lippens E, Lee K, Mehta M, Koshy ST, Darnell MC, Desai RM, Madl CM, Xu M, Zhao X, Chaudhuri O, Verbeke C, Kim WS, Alim K, Mammoto A, Ingber DE, Duda GN, Mooney DJ. Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation. Nat Mater 2015. PubMed
  • Brock A, Krause S, Ingber DE. Control of cancer formation by intrinsic genetic noise and microenvironmental cues. Nat Rev Cancer 2015. PubMed
  • Werfel J, Ingber DE, Bar-Yam Y. Programed Death is Favored by Natural Selection in Spatial Systems. Phys Rev Lett 2015; 114:238103. PubMed
  • Mammoto T, Mammoto A, Jiang A, Jiang E, Hashmi B, Ingber DE. Mesenchymal condensation-dependent accumulation of collagen VI stabilizes organ-specific cell fates during embryonic tooth formation. Dev Dyn 2015. PubMed
  • Diaz MF, Li N, Lee HJ, Adamo L, Evans SM, Willey HE, Arora N, Torisawa YS, Vickers DA, Morris SA, Naveiras O, Murthy SK, Ingber DE, Daley GQ, García-Cardeña G, Wenzel PL. Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis. J Exp Med 2015; 212:665-80. PubMed
  • Lucio AA, Ingber DE, Campàs O. Generation of biocompatible droplets for in vivo and in vitro measurement of cell-generated mechanical stresses. Methods Cell Biol. 2015; 125:373-90. PubMed
  • Kanapathipillai M, Brock A, Ingber DE. Nanoparticle targeting of anti-cancer drugs that alter intracellular signaling or influence the tumor microenvironment. Adv Drug Deliv Rev 2014. PubMed
  • Leslie DC, Waterhouse A, Berthet JB, Valentin TM, Watters AL, Jain A, Kim P, Hatton BD, Nedder A, Donovan K, Super EH, Howell C, Johnson CP, Vu TL, Bolgen DE, Rifai S, Hansen AR, Aizenberg M, Super M, Aizenberg J, Ingber DE. A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling. Nat Biotechnol 2014. PubMed
  • Yang Z, Liu Q, Mannix RJ, Xu X, Li H, Ma Z, Ingber DE, Allen PD, Wang Y. Mononuclear cells from dedifferentiation of mouse myotubes display remarkable regenerative capability. Stem Cells 2014. PubMed
  • Bhatia SN, Ingber DE. Microfluidic organs-on-chips. Nat Biotechnol 2014; 32:760-72. PubMed
  • German AE, Mammoto T, Jiang E, Ingber DE, Mammoto A. Paxillin controls endothelial cell migration and tumor angiogenesis by altering neuropilin 2 expression. J Cell Sci 2014; 127:1672-83. PubMed
  • Ingber DE, Wang N, Stamenovic D. Tensegrity, cellular biophysics, and the mechanics of living systems. Rep Prog Phys 2014; 77:046603. PubMed
  • Polacheck WJ, German AE, Mammoto A, Ingber DE, Kamm RD. Mechanotransduction of fluid stresses governs 3D cell migration. Proc Natl Acad Sci U S A 2014; 111:2447-52. PubMed
  • Campàs O, Mammoto T, Hasso S, Sperling RA, O'Connell D, Bischof AG, Maas R, Weitz DA, Mahadevan L, Ingber DE. Quantifying cell-generated mechanical forces within living embryonic tissues. Nat Methods 2014; 11:183-9. PubMed
  • Brock A, Krause S, Li H, Kowalski M, Goldberg MS, Collins JJ, Ingber DE. Silencing HoxA1 by intraductal injection of siRNA lipidoid nanoparticles prevents mammary tumor progression in mice. Sci Transl Med 2014; 6:217ra2. PubMed
  • Dolatshahi-Pirouz A, Nikkhah M, Gaharwar AK, Hashmi B, Guermani E, Aliabadi H, Camci-Unal G, Ferrante T, Foss M, Ingber DE, Khademhosseini A. A combinatorial cell-laden gel microarray for inducing osteogenic differentiation of human mesenchymal stem cells. Sci Rep 2014; 4:3896. PubMed
  • Huh D, Kim HJ, Fraser JP, Shea DE, Khan M, Bahinski A, Hamilton GA, Ingber DE. Microfabrication of human organs-on-chips. Nat Protoc 2013; 8:2135-57. PubMed
  • Deiss F, Mazzeo A, Hong E, Ingber DE, Derda R, Whitesides GM. Platform for high-throughput testing of the effect of soluble compounds on 3D cell cultures. Anal Chem 2013; 85:8085-94. PubMed
  • Kim HJ, Ingber DE. Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation. Integr Biol (Camb) 2013; 5:1130-40. PubMed
  • Panigrahy D, Kalish BT, Huang S, Bielenberg DR, Le HD, Yang J, Edin ML, Lee CR, Benny O, Mudge DK, Butterfield CE, Mammoto A, Mammoto T, Inceoglu B, Jenkins RL, Simpson MA, Akino T, Lih FB, Tomer KB, Ingber DE, Hammock BD, Falck JR, Manthati VL, Kaipainen A, D'Amore PA, Puder M, Zeldin DC, Kieran MW. Epoxyeicosanoids promote organ and tissue regeneration. Proc Natl Acad Sci U S A 2013; 110:13528-33. PubMed
  • Bischof AG, Yüksel D, Mammoto T, Mammoto A, Krause S, Ingber DE. Breast cancer normalization induced by embryonic mesenchyme is mediated by extracellular matrix biglycan. Integr Biol (Camb) 2013; 5:1045-56. PubMed
  • Gee EP, Yüksel D, Stultz CM, Ingber DE. SLLISWD sequence in the 10FNIII domain initiates fibronectin fibrillogenesis. J Biol Chem 2013; 288:21329-40. PubMed
  • Werfel J, Krause S, Bischof AG, Mannix RJ, Tobin H, Bar-Yam Y, Bellin RM, Ingber DE. How changes in extracellular matrix mechanics and gene expression variability might combine to drive cancer progression. PLoS ONE 2013; 8:e76122. PubMed
  • Mammoto T, Mammoto A, Ingber DE. Mechanobiology and developmental control. Annu Rev Cell Dev Biol 2013; 29:27-61. PubMed
  • Mammoto A, Mammoto T, Kanapathipillai M, Wing Yung C, Jiang E, Jiang A, Lofgren K, Gee EP, Ingber DE. Control of lung vascular permeability and endotoxin-induced pulmonary oedema by changes in extracellular matrix mechanics. Nat Commun 2013; 4:1759. PubMed
  • Krause S, Brock A, Ingber DE. Intraductal injection for localized drug delivery to the mouse mammary gland. 2013. PubMed
  • Mammoto A, Mammoto T, Ingber DE. Mechanosensitive mechanisms in transcriptional regulation. J Cell Sci 2012; 125:3061-73. PubMed
  • Kanapathipillai M, Mammoto A, Mammoto T, Kang JH, Jiang E, Ghosh K, Korin N, Gibbs A, Mannix R, Ingber DE. Inhibition of mammary tumor growth using lysyl oxidase-targeting nanoparticles to modify extracellular matrix. Nano Lett 2012; 12:3213-7. PubMed
  • Xu Y, Bismar TA, Su J, Xu B, Kristiansen G, Varga Z, Teng L, Ingber DE, Mammoto A, Kumar R, Alaoui-Jamali MA. Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion. J Exp Med 2010; 207:2421-37. PubMed
  • Mammoto T, Ingber DE. Mechanical control of tissue and organ development. Development 2010; 137:1407-20. PubMed
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