Photo of Donald P. Goldstein,  MD

Donald P. Goldstein, MD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 732-8840
Fax: (617) 738-5124


dpgoldstei@bics.bwh.harvard.edu

Donald P. Goldstein, MD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Professor, Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School
  • Founder and Director Emeritus, New England Trophoblastic Disease Center, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Major research interest has been early diagnosis of gestational trophoblastic tumors using BhCG test. This has enabled early intervention and improved outcome in patients who develop trophoblastic tumors following molar and non-molar pregnancies. In addition, we have helped to develop a practical staging system for trophoblastic tumors which allows better selection of therapeutic protocols based on severity of disease.

Publications

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  • Sun SY, Melamed A, Goldstein DP, Bernstein MR, Horowitz NS, Moron AF, Maestá I, Braga A, Berkowitz RS. Changing presentation of complete hydatidiform mole at the New England Trophoblastic Disease Center over the past three decades: Does early diagnosis alter risk for gestational trophoblastic neoplasia? Gynecol Oncol 2015; 138:46-9. PubMed
  • Maestá I, Berkowitz RS, Goldstein DP, Bernstein MR, Ramírez LA, Horowitz NS. Relationship between race and clinical characteristics, extent of disease, and response to chemotherapy in patients with low-risk gestational trophoblastic neoplasia. Gynecol Oncol 2015; 138:50-4. PubMed
  • Maestá I, Horowitz NS, Goldstein DP, Bernstein MR, Ramírez LA, Moulder J, Berkowitz RS. Response to Chemotherapy in Overweight/Obese Patients With Low-Risk Gestational Trophoblastic Neoplasia. Int J Gynecol Cancer 2015. PubMed
  • Worley MJ, Joseph NT, Berkowitz RS, Goldstein DP. Women with a partial mole during their first pregnancy and diagnosed earlier in gestation are at increased risk of developing gestational trophoblastic neoplasia. Int J Gynecol Cancer 2014; 24:941-5. PubMed
  • Maestá I, Growdon WB, Goldstein DP, Bernstein MR, Horowitz NS, Rudge MV, Berkowitz RS. Prognostic factors associated with time to hCG remission in patients with low-risk postmolar gestational trophoblastic neoplasia. Gynecol Oncol 2013; 130:312-6. PubMed
  • Berkowitz RS, Goldstein DP. Current advances in the management of gestational trophoblastic disease. Gynecol Oncol 2012. PubMed
  • Rodriguez N, Goldstein DP, Berkowitz RS. Treating gestational trophoblastic disease. Expert Opin Pharmacother 2010; 11:3027-39. PubMed
  • Seckl MJ, Savage PM, Hancock BW, Berkowitz RS, Goldstein DP, Lurain JR, Schink JC, Cagayan FM, Golfier F, Ngan H, Wake N, Osborne R, Sasaki S, Charry RC, Wong LC, Sekharan PK, Djamhoer MA, Massuger L, Belfort P, Kim SJ, Lee C, Jung SG. "Hyperglycosylated hCG in the management of quiescent and chemorefractory gestational trophoblastic diseases" Gynecol Oncol 2010; 117:505-6; author reply 506-7. PubMed
  • Berkowitz RS,Goldstein DP. Clinical practice. Molar pregnancy. N Engl J Med 2009; 360:1639-45. PubMed
  • Horowitz NS,Goldstein DP,Berkowitz RS. Management of gestational trophoblastic neoplasia. Semin Oncol 2009; 36:181-9. PubMed
  • Berkowitz RS,Goldstein DP. Current management of gestational trophoblastic diseases. Gynecol Oncol 2008; 112:654-62. PubMed
  • Growdon WB,Wolfberg AJ,Goldstein DP,Feltmate CM,Chinchilla ME,Lieberman ES,Berkowitz RS. Evaluating methotrexate treatment in patients with low-risk postmolar gestational trophoblastic neoplasia. Gynecol Oncol 2008; 112:353-7. PubMed
  • Sawka AM, Lakra DC, Lea J, Alshehri B, Tsang RW, Brierley JD, Straus S, Thabane L, Gafni A, Ezzat S, George SR, Goldstein DP. A systematic review examining the effects of therapeutic radioactive iodine on ovarian function and future pregnancy in female thyroid cancer survivors. Clin Endocrinol (Oxf) 2008; 69:479-90. PubMed
  • Garrett LA,Garner EI,Feltmate CM,Goldstein DP,Berkowitz RS. Subsequent pregnancy outcomes in patients with molar pregnancy and persistent gestational trophoblastic neoplasia. J Reprod Med 2008; 53:481-6. PubMed
  • Fleming EL,Garrett L,Growdon WB,Callahan M,Nevadunsky N,Ghosh S,Goldstein DP,Berkowitz RS. The changing role of thoracotomy in gestational trophoblastic neoplasia at the New England Trophoblastic Disease Center. J Reprod Med 2008; 53:493-8. PubMed
  • Moukarbel RV, Goldstein DP, O'Sullivan B, Gullane PJ, Brown DH, Wang L, Irish JC. Adenoid cystic carcinoma of the larynx: A 40-year experience. Head Neck 2008; 30:919-24. PubMed
  • Berkowitz RS,Goldstein DP. Gestational trophoblastic disease: presentations from the XLVTH World Congress on Gestational Trophoblastic Diseases. J Reprod Med 2008; 53:455-6. PubMed
  • Goldstein DP, Karnell LH, Yao M, Chamberlin GP, Nguyen TX, Funk GF. Outcomes following reirradiation of patients with head and neck cancer. Head Neck 2008; 30:765-70. PubMed
  • Sawka AM, Lea J, Alshehri B, Straus S, Tsang RW, Brierley JD, Thabane L, Rotstein L, Gafni A, Ezzat S, Goldstein DP. A systematic review of the gonadal effects of therapeutic radioactive iodine in male thyroid cancer survivors. Clin Endocrinol (Oxf) 2007; 68:610-7. PubMed
  • Sawka AM, Goldstein DP, Thabane L, Brierley JD, Tsang RW, Rotstein L, Kamalanathan S, Zhao B, Gafni A, Straus S, Ezzat S. Basis for physician recommendations for adjuvant radioiodine therapy in early-stage thyroid carcinoma: principal findings of the Canadian-American thyroid cancer survey. Endocr Pract 2008; 14:175-84. PubMed
  • Sawka AM, Rotstein L, Brierley JD, Tsang RW, Thabane L, Gafni A, Straus S, Kamalanathan S, Zhao B, Goldstein DP, Rambaldini G, Ezzat S. Regional differences in opinions on adjuvant radioactive iodine treatment of thyroid carcinoma within Canada and the United States. Thyroid 2007; 17:1235-42. PubMed
  • Subramanian S, Goldstein DP, Parlea L, Thabane L, Ezzat S, Ibrahim-Zada I, Straus S, Brierley JD, Tsang RW, Gafni A, Rotstein L, Sawka AM. Second primary malignancy risk in thyroid cancer survivors: a systematic review and meta-analysis. Thyroid 2007; 17:1277-88. PubMed
  • Shrime MG, Goldstein DP, Seaberg RM, Sawka AM, Rotstein L, Freeman JL, Gullane PJ. Cost-effective management of low-risk papillary thyroid carcinoma. Arch Otolaryngol Head Neck Surg 2007; 133:1245-53. PubMed
  • Lee A, Goldstein DP, Irish J, Gentili F, Perez-Ordonez B. Noncontiguous bilateral esthesioneuroblastoma: a case report. Skull Base 2008; 17:405-7. PubMed
  • Garner EI, Goldstein DP, Feltmate CM, Berkowitz RS. Gestational trophoblastic disease. Clin Obstet Gynecol 2007; 50:112-22. PubMed
  • Growdon WB, Wolfberg AJ, Feltmate CM, Goldstein DP, Genest DR, Chinchilla ME, Berkowitz RS, Lieberman ES. Postevacuation hCG levels and risk of gestational trophoblastic neoplasia among women with partial molar pregnancies. J Reprod Med 2006; 51:871-4. PubMed
  • Feltmate CM, Growdon WB, Wolfberg AJ, Goldstein DP, Genest DR, Chinchilla ME, Lieberman ES, Berkowitz RS. Clinical characteristics of persistent gestational trophoblastic neoplasia after partial hydatidiform molar pregnancy. J Reprod Med 2006; 51:902-6. PubMed
  • Wolfberg AJ, Growdon WB, Feltmate CM, Goldstein DP, Genest DR, Chinchilla ME, Berkowitz RS, Lieberman ES. Low risk of relapse after achieving undetectable HCG levels in women with partial molar pregnancy. Obstet Gynecol 2006; 108:393-6. PubMed
  • Garner EI, Feltmate CM, Goldstein DP, Berkowitz RS. The curative effect of a second curettage in persistent trophoblastic disease: a retrospective cohort survey. Gynecol Oncol 2005; 99:3-5. PubMed
  • Wolfberg AJ, Berkowitz RS, Goldstein DP, Feltmate C, Lieberman E. Postevacuation hCG levels and risk of gestational trophoblastic neoplasia in women with complete molar pregnancy. Obstet Gynecol 2005; 106:548-52. PubMed
  • Wenzel L, Dogan-Ates A, Habbal R, Berkowitz R, Goldstein DP, Bernstein M, Kluhsman BC, Osann K, Newlands E, Seckl MJ, Hancock B, Cella D. Defining and measuring reproductive concerns of female cancer survivors. J Natl Cancer Inst Monogr 2005. PubMed
  • Garner E, Goldstein DP, Berkowitz RS, Wenzel L. Psychosocial and reproductive outcomes of gestational trophoblastic diseases. Best Pract Res Clin Obstet Gynaecol 2003; 17:959-68. PubMed
  • Feltmate CM, Batorfi J, Fulop V, Goldstein DP, Doszpod J, Berkowitz RS. Human chorionic gonadotropin follow-up in patients with molar pregnancy: a time for reevaluation. Obstet Gynecol 2003; 101:732-6. PubMed
  • Garner EI, Meyerovitz M, Goldstein DP, Berkowitz RS. Successful term pregnancy after selective arterial embolization of symptomatic arteriovenous malformation in the setting of gestational trophoblastic tumor. Gynecol Oncol 2002; 88:69-72. PubMed
  • Garrett AP, Garner EO, Goldstein DP, Berkowitz RS. Methotrexate infusion and folinic acid as primary therapy for nonmetastatic and low-risk metastatic gestational trophoblastic tumors. 15 years of experience. J Reprod Med 2002; 47:355-62. PubMed
  • Garner EI, Lipson E, Bernstein MR, Goldstein DP, Berkowitz RS. Subsequent pregnancy experience in patients with molar pregnancy and gestational trophoblastic tumor. J Reprod Med 2002; 47:380-6. PubMed
  • Wenzel L, Berkowitz RS, Newlands E, Hancock B, Goldstein DP, Seckl MJ, Habbal R, Bernstein M, Kluhsman B, Kulchak-Rahm A, Strickland S, Higgins J. Quality of life after gestational trophoblastic disease. J Reprod Med 2002; 47:387-94. PubMed
  • Genest DR, Ruiz RE, Weremowicz S, Berkowitz RS, Goldstein DP, Dorfman DM. Do nontriploid partial hydatidiform moles exist? A histologic and flow cytometric reevaluation of nontriploid specimens. J Reprod Med 2002; 47:363-8. PubMed
  • Feltmate CM, Genest DR, Goldstein DP, Berkowitz RS. Advances in the understanding of placental site trophoblastic tumor. J Reprod Med 2002; 47:337-41. PubMed
  • Feltmate CM, Genest DR, Wise L, Bernstein MR, Goldstein DP, Berkowitz RS. Placental site trophoblastic tumor: a 17-year experience at the New England Trophoblastic Disease Center. Gynecol Oncol 2001; 82:415-9. PubMed
  • Berkowitz RS, Tuncer ZS, Bernstein MR, Goldstein DP. Management of gestational trophoblastic diseases: subsequent pregnancy experience. Semin Oncol 2000; 27:678-85. PubMed
  • Benson CB, Genest DR, Bernstein MR, Soto-Wright V, Goldstein DP, Berkowitz RS. Sonographic appearance of first trimester complete hydatidiform moles. Ultrasound Obstet Gynecol 2000; 16:188-91. PubMed
  • Goldstein DP. The past is prologue to the present: Milestones in the modern management of molar pregnancy and gestational trophoblastic neoplasia. J Reprod Med 2012; 57:189-96. PubMed
  • Elias KM, Goldstein DP, Berkowitz RS. Complete hydatidiform mole in women older than age 50. J Reprod Med 2010; 55:208-12. PubMed
  • Growdon WB, Wolfberg AJ, Goldstein DP, Feltmate CM, Chinchilla ME, Lieberman ES, Berkowitz RS. Low-risk gestational trophoblastic neoplasia and methotrexate resistance: predictors of response to treatment with actinomycin D and need for combination chemotherapy. J Reprod Med 2010; 55:279-84. PubMed
  • Goldstein DP. Gestational trophoblastic neoplasia: where we came from, where we stand today, where we are heading. Keynote address. J Reprod Med 2010; 55:184-93. PubMed
  • Shah NT, Barroilhet L, Berkowitz RS, Goldstein DP, Horowitz N. A cost analysis of first-line chemotherapy for low-risk gestational trophoblastic neoplasia. J Reprod Med 2012; 57:211-8. PubMed
  • Clark RM, Nevadunsky NS, Ghosh S, Goldstein DP, Berkowitz RS. The evolving role of hysterectomy in gestational trophoblastic neoplasia at the New England Trophoblastic Disease Center. J Reprod Med 2010; 55:194-8. PubMed
  • Braga A, Growdon WB, Bernstein M, Maestá I, Rudge MV, Goldstein DP, Berkowitz RS. Molar pregnancy in adolescents. J Reprod Med 2012; 57:225-30. PubMed
  • Elias KM, Shoni M, Bernstein M, Goldstein DP, Berkowitz RS. Complete hydatidiform mole in women aged 40 to 49 years. J Reprod Med 2012; 57:254-8. PubMed
  • Rauh-Hain JA, Growdon WB, Braga A, Goldstein DP, Berkowitz RS. Gestational trophoblastic neoplasia in adolescents. J Reprod Med 2012; 57:237-42. PubMed
  • Goldstein DP, Berkowitz RS. Current management of complete and partial molar pregnancy. J Reprod Med 1994; 39:139-46. PubMed
  • Goldstein DP, Aono T, Taymor ML, Jochelson K, Todd R, Hines E. Radioimmunoassay of serum chorionic gonadotropin activity in normal pregnancy. Am J Obstet Gynecol 1968; 102:110-4. PubMed
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