Photo of Donna L. Berry,  PhD, RN, AOCN, FAAN

Donna L. Berry, PhD, RN, AOCN, FAAN

Dana-Farber Cancer Institute

Dana-Farber Cancer Institute
Phone: (617) 632-1909


donna_berry@dfci.harvard.edu

Donna L. Berry, PhD, RN, AOCN, FAAN

Dana-Farber Cancer Institute

EDUCATIONAL TITLES

  • Associate Professor, Medicine, Harvard Medical School
  • Director, Phyllis F. Cantor Center for Research in Nursing & Patient Care Services, Dana-Farber Cancer Institute

DF/HCC PROGRAM AFFILIATION

Research Abstract

OBJECTIVE: The purpose of this trial was to compare usual patient education plus the Internet-based, Personal Patient Profile-Prostate, versus usual education alone, on conflict associated with decision making, plus explore time-to-treatment and treatment choice.

METHODS: A randomized, multi-center clinical trial was conducted with measures at baseline, one and six months. Men with newly diagnosed localized prostate cancer who sought consultation at urology, radiation oncology or multi-disciplinary clinics in four geographically-distinct American cities were recruited. Intervention group participants used the Personal Patient Profile-Prostate, a decision support system comprised of customized text and video coaching regarding potential outcomes, influential factors, and communication with care providers. The primary outcome, patient-reported decisional conflict, was evaluated over time using Generalized Estimating Equations to fit generalized linear models. Additional outcomes, time-to-treatment, treatment choice and program acceptability/usefulness, were explored.

RESULTS: A total of 494 eligible men were randomized (266 intervention; 228 control). The intervention reduced adjusted decisional conflict over time as compared with the control group, for the uncertainty score (estimate -3.61; (confidence interval, -7.01,-0.22) and values clarity (estimate-3.57; confidence interval (-5.85,-1.30) Borderline effect was seen for the total decisional conflict score (estimate -1.75; confidence interval (-3.61,0.11). Time-to-treatment was comparable between groups, while undecided men in the intervention group chose brachytherapy more often than in the control group. Acceptability and usefulness were highly rated.

CONCLUSION: The Personal Patient Profile-Prostate is the first intervention to significantly reduce decisional conflict in a multi-center trial of American men with newly diagnosed localized prostate cancer. Our findings support efficacy of P3P for addressing decision uncertainty and facilitating patient selection of a prostate cancer treatment that is consistent with the patient values and preferences.

Publications

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  • Boucher J, Lucca J, Hooper C, Pedulla L, Berry DL. A Structured Nursing Intervention to Address 窶ィOral Chemotherapy Adherence in Patients 窶ィWith Non-Small Cell Lung Cancer. Oncol Nurs Forum 2015; 42:383-9. PubMed
  • Morgans AK, van Bommel AC, Stowell C, Abrahm JL, Basch E, Bekelman JE, Berry DL, Bossi A, Davis ID, de Reijke TM, Denis LJ, Evans SM, Fleshner NE, George DJ, Kiefert J, Lin DW, Matthew AG, McDermott R, Payne H, Roos IA, Schrag D, Steuber T, Tombal B, van Basten JP, van der Hoeven JJ, Penson DF, . Development of a Standardized Set of Patient-centered Outcomes for Advanced Prostate Cancer: An International Effort for a Unified Approach. Eur Urol 2015. PubMed
  • Wolpin SE, Parks J, Galligan M, Russell KJ, Berry DL. Information Needs of Men with Localized Prostate Cancer During Radiation Therapy. J Cancer Educ 2015. PubMed
  • Underhill ML, Chicko L, Berry DL. A nurse-led evidence-based practice project to monitor and improve the management of chemotherapy-induced nausea and vomiting. 2015; 19:38-40. PubMed
  • Wu WW, Tsai SY, Liang SY, Liu CY, Jou ST, Berry DL. The Mediating Role of Resilience on Quality of Life and Cancer Symptom Distress in Adolescent Patients With Cancer. J Pediatr Oncol Nurs 2015. PubMed
  • Berry DL, Blonquist TM, Patel RA, Halpenny B, McReynolds J. Exposure to a patient-centered, web-based intervention for managing cancer symptom and quality of life issues: impact on symptom distress. J Med Internet Res 2015; 17:e136. PubMed
  • Sheldon LK, Blonquist TM, Hilaire DM, Hong F, Berry DL. Patient cues and symptoms of psychosocial distress: what predicts assessment and treatment of distress by oncology clinicians? 2014. PubMed
  • Tariman JD, Doorenbos A, Schepp KG, Singhal S, Berry DL. Older adults newly diagnosed with symptomatic myeloma and treatment decision making. Oncol Nurs Forum 2014; 41:411-9. PubMed
  • Cooley ME, Blonquist TM, Catalano PJ, Lobach DF, Halpenny B, McCorkle R, Johns EB, Braun IM, Rabin MS, Mataoui FZ, Finn K, Berry DL, Abrahm JL. Feasibility of Using Algorithm-Based Clinical Decision Support for Symptom Assessment and Management in Lung Cancer. J Pain Symptom Manage 2014. PubMed
  • Underhill ML, Sheldon LK, Halpenny B, Berry DL. Communication About Symptoms and Quality of Life Issues in Patients With Cancer: Provider Perceptions. J Cancer Educ 2014. PubMed
  • Artherholt SB, Hong F, Berry DL, Fann JR. Risk Factors for Depression in Patients Undergoing Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant 2014. PubMed
  • Berry DL, Cunningham T, Eisenberg S, Wickline M, Hammer M, Berg C. Improving patient knowledge of discharge medications in an oncology setting. 2014; 18:35-7. PubMed
  • Berry DL, Hong F, Halpenny B, Partridge AH, Fann JR, Wolpin S, Lober WB, Bush NE, Parvathaneni U, Back AL, Amtmann D, Ford R. Electronic self-report assessment for cancer and self-care support: results of a multicenter randomized trial. J Clin Oncol 2014; 32:199-205. PubMed
  • Tariman JD, Doorenbos A, Schepp KG, Singhal S, Berry DL. Information Needs Priorities in Patients Diagnosed With Cancer: A Systematic Review. J Adv Pract Oncol 2014; 2014:115-122. PubMed
  • Berry DL, Hong F, Halpenny B, Partridge A, Fox E, Fann JR, Wolpin S, Lober WB, Bush N, Parvathaneni U, Amtmann D, Ford R. The electronic self report assessment and intervention for cancer: promoting patient verbal reporting of symptom and quality of life issues in a randomized controlled trial. BMC Cancer 2014; 14:513. PubMed
  • Underhill ML, Hong F, Berry DL. When study site contributes to outcomes in a multi-center randomized trial: a secondary analysis of decisional conflict in men with localized prostate cancer. Health Qual Life Outcomes 2015; 12:159. PubMed
  • Hussain M, Tangen CM, Berry DL, Higano CS, Crawford ED, Liu G, Wilding G, Prescott S, Kanaga Sundaram S, Small EJ, Dawson NA, Donnelly BJ, Venner PM, Vaishampayan UN, Schellhammer PF, Quinn DI, Raghavan D, Ely B, Moinpour CM, Vogelzang NJ, Thompson IM. Intermittent versus continuous androgen deprivation in prostate cancer. N Engl J Med 2013; 368:1314-25. PubMed
  • McCleary NJ, Wigler D, Berry D, Sato K, Abrams T, Chan J, Enzinger P, Ng K, Wolpin B, Schrag D, Fuchs CS, Hurria A, Meyerhardt JA. Feasibility of computer-based self-administered cancer-specific geriatric assessment in older patients with gastrointestinal malignancy. Oncologist 2013; 18:64-72. PubMed
  • Sheldon LK, Kazmi M, Klein C, Berry DL. Concerns of stem cell transplant patients during routine ambulatory assessment. Patient Prefer Adherence 2013; 7:15-20. PubMed
  • King SD, Fitchett G, Berry DL. Screening for religious/spiritual struggle in blood and marrow transplant patients. Support Care Cancer 2012. PubMed
  • Berry DL, Wang Q, Halpenny B, Hong F. Decision preparation, satisfaction and regret in a multi-center sample of men with newly diagnosed localized prostate cancer. Patient Educ Couns 2012; 88:262-7. PubMed
  • Sommers RM, Miller K, Berry DL. Feasibility pilot on medication adherence and knowledge in ambulatory patients with gastrointestinal cancer. Oncol Nurs Forum 2012; 39:E373-9. PubMed
  • Stuver SO, Isaac T, Weeks JC, Block S, Berry DL, Davis RB, Weingart SN. Factors associated with pain among ambulatory patients with cancer with advanced disease at a comprehensive cancer center. J Oncol Pract 2012; 8:e17-23. PubMed
  • Zhu J, Davis RB, Stuver SO, Berry DL, Block S, Weeks JC, Weingart SN. A longitudinal study of pain variability and its correlates in ambulatory patients with advanced stage cancer. Cancer 2012. PubMed
  • Weingart SN, Cleary A, Stuver SO, Lynch M, Brandoff D, Schaefer KG, Zhu J, Berry DL, Block S, Weeks JC. Assessing the quality of pain care in ambulatory patients with advanced stage cancer. J Pain Symptom Manage 2012; 43:1072-81. PubMed
  • Bosco JL, Halpenny B, Berry DL. Personal preferences and discordant prostate cancer treatment choice in an intervention trial of men newly diagnosed with localized prostate cancer. Health Qual Life Outcomes 2012; 10:123. PubMed
  • Berry DL, Blumenstein BA, Halpenny B, Wolpin S, Fann JR, Austin-Seymour M, Bush N, Karras BT, Lober WB, McCorkle R. Enhancing patient-provider communication with the electronic self-report assessment for cancer: a randomized trial. J Clin Oncol 2011; 29:1029-35. PubMed
  • Wu WW, Johnson R, Schepp KG, Berry DL. Electronic Self-report Symptom and Quality of Life for Adolescent Patients With Cancer: A Feasibility Study. Cancer Nurs 2011. PubMed
  • Potter P, Eisenberg S, Cain KC, Berry DL. Orange Interventions for Symptoms Associated With Dimethyl Sulfoxide During Stem Cell Reinfusions: A Feasibility Study. Cancer Nurs 2011. PubMed
  • Tariman JD, Berry DL, Halpenny B, Wolpin S, Schepp K. Validation and testing of the Acceptability E-scale for web-based patient-reported outcomes in cancer care. Appl Nurs Res 2011; 24:53-8. PubMed
  • Chan CW, Tam W, Cheng KK, Chui YY, So WK, Mok T, Wong C, McReynolds J, Berry DL. Piloting electronic self report symptom assessment - Cancer (ESRA-C) in Hong Kong: A mixed method approach. Eur J Oncol Nurs 2010. PubMed
  • Allen JD, Othus MK, Hart A, Tom L, Li Y, Berry D, Bowen D. A randomized trial of a computer-tailored decision aid to improve prostate cancer screening decisions: results from the take the wheel trial. Cancer Epidemiol Biomarkers Prev 2010; 19:2172-86. PubMed
  • Hammer MJ, Motzer SA, Voss JG, Berry DL. Glycemic Control Among Older Adult Hematopoietic Cell Transplant Recipients. 2010. PubMed
  • Berry DL, Halpenny B, Wolpin S, Davison BJ, Ellis WJ, Lober WB, McReynolds J, Wulff J. Development and evaluation of the personal patient profile-prostate (P3P), a Web-based decision support system for men newly diagnosed with localized prostate cancer. J Med Internet Res 2010; 12:e67. PubMed
  • Henrikson NB,Ellis WJ,Berry DL. "It's not like I can change my mind later": Reversibility and decision timing in prostate cancer treatment decision-making. Patient Educ Couns 2009; 77:302-7. PubMed
  • Fann JR,Berry DL,Wolpin S,Austin-Seymour M,Bush N,Halpenny B,Lober WB,McCorkle R. Depression screening using the Patient Health Questionnaire-9 administered on a touch screen computer. Psychooncology 2008; 18:14-22. PubMed
  • Wolpin S,Berry D,Austin-Seymour M,Bush N,Fann JR,Halpenny B,Lober WB,McCorkle R. Acceptability of an Electronic Self-Report Assessment Program for patients with cancer. Comput Inform Nurs 2008; 26:332-8. PubMed
  • Berry DL,Ellis WJ,Russell KJ,Blasko JC,Bush N,Blumenstein B,Lange PH. Factors that predict treatment choice and satisfaction with the decision in men with localized prostate cancer. Clin Genitourin Cancer 2007; 5:219-26. PubMed
  • Reid Ponte P, Hayman LL, Berry DL, Cooley ME. A new model for postdoctoral training: The Nursing Postdoctoral Program in Cancer and Health Disparities. Nurs Outlook 2015; 63:189-203. PubMed
  • Isaac T, Stuver SO, Davis RB, Block S, Weeks JC, Berry DL, Weingart SN. Incidence of severe pain in newly diagnosed ambulatory patients with stage IV cancer. Pain Res Manag 2012; 17:347-52. PubMed
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