Photo of E. T. Hedley-Whyte,   MBBS,  MD

E. T. Hedley-Whyte, MBBS, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-5154
Fax: (617) 724-1813


Tessa.Hedley-Whyte@mgh.harvard.edu

E. T. Hedley-Whyte, MBBS, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Pathology, Harvard Medical School
  • Neuropathologist, Neuropathology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Neuropathological Diagnosis and Investigation of brain and pituitary tumors with particular emphasis on correlation of morphological features and prognosis.

Publications

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  • Stein TD, Chae YS, Won N, Lee JH, Hedley-Whyte ET. A 34-year-old man with bitemporal hemianopsia. Brain Pathol 2013; 24:107-10. PubMed
  • Tritos NA, Eppakayala S, Swearingen B, Hedley-Whyte ET, Miller KK, Nachtigall LB, Grinspoon SK, Biller BM, Klibanski A. Pathologic and clinical features of pituitary adenomas showing TSH immunoreactivity. Pituitary 2013. PubMed
  • Aizer AA, Sethi RV, Hedley-Whyte ET, Ebb D, Tarbell NJ, Yock TI, Macdonald SM. Bifocal intracranial tumors of nongerminomatous germ cell etiology: diagnostic and therapeutic implications. 2013. PubMed
  • Margolin DH, Kousi M, Chan YM, Lim ET, Schmahmann JD, Hadjivassiliou M, Hall JE, Adam I, Dwyer A, Plummer L, Aldrin SV, O'Rourke J, Kirby A, Lage K, Milunsky A, Milunsky JM, Chan J, Hedley-Whyte ET, Daly MJ, Katsanis N, Seminara SB. Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination. N Engl J Med 2013. PubMed
  • Venna N, Coyle CM, Gonz├ílez RG, Hedley-Whyte ET. Case records of the Massachusetts General Hospital. Case 15-2012. A 48-year-old woman with diplopia, headaches, and papilledema. N Engl J Med 2012; 366:1924-34. PubMed
  • David WS, Chad DA, Kambadakone A, Hedley-Whyte ET. Case records of the Massachusetts General Hospital. Case 7-2012. A 79-year-old man with pain and weakness in the legs. N Engl J Med 2012; 366:944-54. PubMed
  • di Tomaso E, Snuderl M, Kamoun WS, Duda DG, Auluck PK, Fazlollahi L, Andronesi OC, Frosch MP, Wen PY, Plotkin SR, Hedley-Whyte ET, Sorensen AG, Batchelor TT, Jain RK. Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escape. Cancer Res 2011; 71:19-28. PubMed
  • Katavetin P, Cheunsuchon P, Grant E, Boepple PA, Hedley-Whyte ET, Misra M, Levitsky LL. Rathke's cleft cysts in children and adolescents: association with female puberty. J. Pediatr. Endocrinol. Metab. 2011; 23:1175-80. PubMed
  • McKee AC, Gavett BE, Stern RA, Nowinski CJ, Cantu RC, Kowall NW, Perl DP, Hedley-Whyte ET, Price B, Sullivan C, Morin P, Lee HS, Kubilus CA, Daneshvar DH, Wulff M, Budson AE. TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy. J Neuropathol Exp Neurol 2010; 69:918-29. PubMed
  • Katavetin P, Cheunsuchon P, Swearingen B, Hedley-Whyte ET, Misra M, Levitsky LL. Review: Pituitary adenomas in children and adolescents. J. Pediatr. Endocrinol. Metab. 2010; 23:427-31. PubMed
  • Deng HX, Klein CJ, Yan J, Shi Y, Wu Y, Fecto F, Yau HJ, Yang Y, Zhai H, Siddique N, Hedley-Whyte ET, Delong R, Martina M, Dyck PJ, Siddique T. Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4. Nat Genet 2010; 42:165-9. PubMed
  • Singhal AB, Kimberly WT, Schaefer PW, Hedley-Whyte ET. Case records of the Massachusetts General Hospital. Case 8-2009. A 36-year-old woman with headache, hypertension, and seizure 2 weeks post partum. N Engl J Med 2009; 360:1126-37. PubMed
  • Hedley-Whyte ET, Goldman JE, Nedergaard M, Friedman A, Han X, Schmidt RE, Powers JM. Hyaline protoplasmic astrocytopathy of neocortex. J Neuropathol Exp Neurol 2009; 68:136-47. PubMed
  • Freeman SH, Hyman BT, Sims KB, Hedley-Whyte ET, Vossough A, Frosch MP, Schmahmann JD. Adult Onset Leukodystrophy with Neuroaxonal Spheroids: Clinical, Neuroimaging and Neuropathologic Observations. Brain Pathol 2008; 19:39-47. PubMed
  • Freeman SH,Kandel R,Cruz L,Rozkalne A,Newell K,Frosch MP,Hedley-Whyte ET,Locascio JJ,Lipsitz LA,Hyman BT. Preservation of neuronal number despite age-related cortical brain atrophy in elderly subjects without Alzheimer disease. J Neuropathol Exp Neurol 2008; 67:1205-12. PubMed
  • Gejman R, Batista DL, Zhong Y, Zhou Y, Zhang X, Swearingen B, Stratakis CA, Hedley-Whyte ET, Klibanski A. Selective loss of MEG3 expression and intergenic differentially methylated region hypermethylation in the MEG3/DLK1 locus in human clinically nonfunctioning pituitary adenomas. J Clin Endocrinol Metab 2008; 93:4119-25. PubMed
  • Staley KJ,Sims KB,Grant PE,Hedley-Whyte ET. Case records of the Massachusetts General Hospital. Case 28-2008. An 8-day-old infant with congenital deafness, lethargy, and hypothermia. N Engl J Med 2008; 359:1156-67. PubMed
  • Hedley-Whyte ET. On being a pathologist: how does one plan a career, or does one? Hum Pathol 2008; 39:1269-74. PubMed
  • Seton M, Pless M, Fishman JA, Caruso PA, Hedley-Whyte ET. Case records of the Massachusetts General Hospital. Case 18-2008. A 68-year-old man with headache and visual changes after liver transplantation. N Engl J Med 2008; 358:2619-28. PubMed
  • Gejman R, Swearingen B, Hedley-Whyte ET. Role of Ki-67 proliferation index and p53 expression in predicting progression of pituitary adenomas. Hum Pathol 2008; 39:758-66. PubMed
  • Greer DM, Cagliero E, Krakauer EL, Gonzalez RG, Hedley-Whyte ET. Case records of the Massachusetts General Hospital. Case 21-2007. A 58-year-old woman with headaches, weakness, and strokelike episodes. N Engl J Med 2007; 357:164-73. PubMed
  • Vallat JM, Cros DP, Hedley-Whyte ET. Case records of the Massachusetts General Hospital. Case 9-2007. A 27-year-old woman with pain and swelling of the legs. N Engl J Med 2007; 356:1252-9. PubMed
  • Cha JH, Furie K, Kay J, Walensky RP, Mullins ME, Hedley-Whyte ET. Case records of the Massachusetts General Hospital. Case 39-2006. A 24-year-old woman with systemic lupus erythematosus, seizures, and right arm weakness. N Engl J Med 2006; 355:2678-89. PubMed
  • Vucic S, Tian D, Chong PS, Cudkowicz ME, Hedley-Whyte ET, Cros D. Facial onset sensory and motor neuronopathy (FOSMN syndrome): a novel syndrome in neurology. Brain 2006; 129:3384-90. PubMed
  • Batista DL, Zhang X, Gejman R, Ansell PJ, Zhou Y, Johnson SA, Swearingen B, Hedley-Whyte ET, Stratakis CA, Klibanski A. The effects of SOM230 on cell proliferation and adrenocorticotropin secretion in human corticotroph pituitary adenomas. J Clin Endocrinol Metab 2006; 91:4482-8. PubMed
  • Saenz A, Mandal R, Kradin R, Hedley-Whyte ET. Nephrogenic fibrosing dermopathy with involvement of the dura mater. Virchows Arch 2006; 449:389-91. PubMed
  • Chou RC, Henson JW, Tian D, Hedley-Whyte ET, Reginato AM. Successful treatment of rheumatoid meningitis with cyclophosphamide but not infliximab. Ann Rheum Dis 2006; 65:1114-6. PubMed
  • W. Characterization of lymphocytic infiltrates in progressive multifocal leukoencephalopathy: co-localization of CD8(+) T cells with JCV-infected glial cells. J Neurovirol 2006; 12:116-28. PubMed
  • Gaviani P, Mullins ME, Braga TA, Hedley-Whyte ET, Halpern EF, Schaefer PS, Henson JW. Improved detection of metastatic melanoma by T2*-weighted imaging. AJNR Am J Neuroradiol 2006; 27:605-8. PubMed
  • Klucken J, Ingelsson M, Shin Y, Irizarry MC, Hedley-Whyte ET, Frosch MP, Growdon JH, McLean PJ, Hyman BT. Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies. Acta Neuropathol 2006; 111:101-8. PubMed
  • Dahiya S, Sarkar C, Hedley-Whyte ET, Sharma MC, Zervas NT, Sridhar E, Louis DN. Spindle cell oncocytoma of the adenohypophysis: report of two cases. Acta Neuropathol 2005; 110:97-9. PubMed
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