Photo of Edmond J. Yunis,   M.D.

Edmond J. Yunis, M.D.

Dana-Farber Cancer Institute

Dana-Farber Cancer Institute
Phone: (617) 632-3343
Fax: (617) 632-4466


edmond_yunis@dfci.harvard.edu

Edmond J. Yunis, M.D.

Dana-Farber Cancer Institute

EDUCATIONAL TITLES

  • Professor, Pathology, Harvard Medical School
  • Chief, Immunogenetics, Dana-Farber Cancer Institute

Research Abstract

The laboratory is involved in studies of 1) human genetic polymorphisms including the MHC, 2) genetics of life span 3) genetics of drug induced hematopoetic complications and 4) genetics of the progression of clinical tuberculosis.

Publications

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  • Larsen CE, Alford DR, Trautwein MR, Jalloh YK, Tarnacki JL, Kunnenkeri SK, Fici DA, Yunis EJ, Awdeh ZL, Alper CA. Dominant Sequences of Human Major Histocompatibility Complex Conserved Extended Haplotypes from HLA-DQA2 to DAXX. PLoS Genet. 2014; 10:e1004637. PubMed
  • Szilágyi A, Bánlaki Z, Pozsonyi E, Yunis EJ, Awdeh ZL, Hossó A, Rajczy K, Larsen CE, Fici DA, Alper CA, Füst G. Frequent occurrence of conserved extended haplotypes (CEHs) in two Caucasian populations. Mol Immunol 2010; 47:1899-904. PubMed
  • Zúñiga J, Romero V, Azocar J, Terreros D, Vargas-Rojas MI, Torres-García D, Jiménez-Alvarez L, Vargas-Alarcón G, Granados-Montiel J, Husain Z, Chung RT, Alper CA, Yunis EJ. Protective KIR-HLA interactions for HCV infection in intravenous drug users. Mol Immunol 2009; 46:2723-7. PubMed
  • Cantu de Leon D,Perez-Montiel D,Villavicencio V,Garcia Carranca A,Mohar Betancourt A,Acuna-Alonzo V,Lopez-Tello A,Vargas-Alarcon G,Barquera R,Yu N,Yunis EJ,Granados J. High resolution human leukocyte antigen (HLA) class I and class II allele typing in Mexican mestizo women with sporadic breast cancer: case-control study. BMC Cancer 2009; 9:48. PubMed
  • Romero V, Azocar J, Zuniga J, Clavijo OP, Terreros D, Gu X, Husain Z, Chung RT, Amos C, Yunis EJ. Interaction of NK inhibitory receptor genes with HLA-C and MHC class II alleles in Hepatitis C virus infection outcome. Mol Immunol 2008; 45:2429-36. PubMed
  • Boussiotis VA, Tsai EY, Yunis EJ, Thim S, Delgado JC, Dascher CC, Berezovskaya A, Rousset D, Reynes JM, Goldfeld AE. IL-10-producing T cells suppress immune responses in anergic tuberculosis patients. J Clin Invest 2000; 105:1317-25. PubMed
  • Clavijo OP, Delgado JC, Awdeh ZL, Fici D, Turbay D, Alper CA, Truedsson L, Yunis EJ. HLA-Cw alleles associated with HLA extended haplotypes and C2 deficiency. Tissue Antigens 1998; 52:282-5. PubMed
  • Yu N, Ohashi M, Alosco S, Salazar M, Cao K, Fernandez Vina M, Yunis EJ. Typing of HLA-B*15 alleles using sequence-specific primers. Tissue Antigens 1998; 52:260-9. PubMed
  • Goldfeld AE, Delgado JC, Thim S, Bozon MV, Uglialoro AM, Turbay D, Cohen C, Yunis EJ. Association of an HLA-DQ allele with clinical tuberculosis. JAMA 1998; 279:226-8. PubMed
  • Delgado JC, Hameed A, Yunis JJ, Bhol K, Rojas AI, Rehman SB, Khan AA, Ahmad M, Alper CA, Ahmed AR, Yunis EJ. Pemphigus vulgaris autoantibody response is linked to HLA-DQB1*0503 in Pakistani patients. Hum Immunol 1998; 57:110-9. PubMed
  • Mobini N, Yunis EJ, Alper CA, Yunis JJ, Delgado JC, Yunis DE, Firooz A, Dowlati Y, Bahar K, Gregersen PK, Ahmed AR. Identical MHC markers in non-Jewish Iranian and Ashkenazi Jewish patients with pemphigus vulgaris: possible common central Asian ancestral origin. Hum Immunol 1998; 57:62-7. PubMed
  • Simon S, Truedsson L, Marcus-Bagley D, Awdeh Z, Eisenbarth GS, Brink SJ, Yunis EJ, Alper CA. Relationship between protein complotypes and DNA variant haplotypes: complotype-RFLP constellations (CRC). Hum Immunol 1998; 57:27-36. PubMed
  • Turbay D, Lieberman J, Alper CA, Delgado JC, Corzo D, Yunis JJ, Yunis EJ. Tumor necrosis factor constellation polymorphism and clozapine-induced agranulocytosis in two different ethnic groups. Blood 1997; 89:4167-74. PubMed
  • Delgado JC, Yunis DE, Boz. MHC class II alleles and haplotypes in patients with pemphigus vulgaris from India. Tissue Antigens 1996; 48:668-72. PubMed
  • Salazar M, Granja CB, Selvakumar A, Fresia B, Alosco S, Dupont B, Yunis EJ. New HLA-DR haplotypes containing the DRB6 pseudogene. Tissue Antigens 1996; 48:575-9. PubMed
  • Garcia-Merino A, Alper CA, Usuku K, Marcus-Bagley D, Lincoln R, Awdeh Z, Yunis EJ, Eisenbarth GS, Brink SJ, Hauser SL. Tumor necrosis factor (TNF) microsatellite haplotypes in relation to extended haplotypes, susceptibility to diseases associated with the major histocompatibility complex and TNF secretion. Hum Immunol 1996; 50:11-21. PubMed
  • Yunis EJ. The Rose Payne Award lecture of 1992 revisited. Hum Immunol 1996; 48:139-47. PubMed
  • White FV, Anthony DC, Yunis EJ, Tarbell NJ, Scott RM, Schofield DE. Nonrandom chromosomal gains in pilocytic astrocytomas of childhood. Hum Pathol 1995; 26:979-86. PubMed
  • Dubey DP, Alper CA, Mirza NM, Awdeh Z, Yunis EJ. Polymorphic Hh genes in the HLA-B(C) region control natural killer cell frequency and activity. J Exp Med 1994; 179:1193-203. PubMed
  • Yang SY, Chang A, Olivero R, Relias V, Yunis EJ. IEF patterns of HLA-B13 antigens from Orientals and Caucasians. Immunogenetics 1984; 21:125-34. PubMed
  • Yunis EJ, Awdeh Z, Johnson A, Suciu-Foca N, Robinson MA, Hartzman R, Raum D, Fleischnick E, Alper CA. Complotype genetic loci segregate more frequently with HLA-DR than with HLA-B. Immunogenetics 1984; 21:25-31. PubMed
  • Yang SY, Morishima Y, Collins NH, Alton T, Pollack MS, Yunis EJ, Dupont B. Comparison of one-dimensional IEF patterns for serologically detectable HLA-A and B allotypes. Immunogenetics 1983; 19:217-31. PubMed
  • Awdeh ZL, Raum D, Yunis EJ, Alper CA. Extended HLA/complement allele haplotypes: evidence for T/t-like complex in man. Proc Natl Acad Sci U S A 1982; 80:259-63. PubMed
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