Photo of Edmund S. Cibas,  MD

Edmund S. Cibas, MD

Brigham And Women's Hospital

Brigham And Women's Hospital

Edmund S. Cibas, MD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Professor, Pathology, Harvard Medical School
  • Director, Cytopathology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My research interests include the application of cytology and cytologic methods, including fine needle aspiration and Pap testing, to cancer diagnosis and treatment response. Particular interests include thyroid cancer and related diseases, cervical cancer, mesothelioma, sarcoma, and lung cancer. We have demonstrated the value of cytogenetics and molecular cytogenetics as adjuncts to diagnostic cytology and have investigated the ability to use cytologic preparations to monitor treatment response. More recently, we have implemented the CellSearch instrument for enumerating circulating tumor cells and have embarked on collaborative studies to evaluate their clinical significance as well as their value in understanding the molecular mechanisms of metastasis.

Publications

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  • Pusztaszeri M, Wang H, Cibas ES, Powers CN, Bongiovanni M, Ali S, Khurana KK, Michaels PJ, Faquin WC. Fine-needle aspiration biopsy of secondary neoplasms of the thyroid gland: a multi-institutional study of 62 cases. Cancer Cytopathol 2015; 123:19-29. PubMed
  • Nagymanyoki Z, Mutter GL, Hornick JL, Cibas ES. ARID1A is a useful marker of malignancy in peritoneal washings for endometrial carcinoma. Cancer Cytopathol 2015. PubMed
  • Pusztaszeri MP, Krane JF, Cibas ES, Daniels G, Faquin WC. FNAB of benign thyroid nodules with papillary hyperplasia: A cytological and histological evaluation. Cancer Cytopathol 2014. PubMed
  • Jo VY, Cibas ES, Pinkus GS. Claudin-4 immunohistochemistry is highly effective in distinguishing adenocarcinoma from malignant mesothelioma in effusion cytology. Cancer Cytopathol 2014; 122:299-306. PubMed
  • Gupta A, Ly S, Castroneves LA, Frates MC, Benson CB, Feldman HA, Wassner AJ, Smith JR, Marqusee E, Alexander EK, Barletta J, Muyide F, Doubilet PM, Peters HE, Webb S, Modi BP, Paltiel HJ, Martins Y, Burmeister K, Kozakewich H, Hollowell M, Cibas ES, Moore FD, Shamberger RC, Larsen PR, Huang SA. How are childhood thyroid nodules discovered: opportunities for improving early detection. J Pediatr 2014; 164:658-60. PubMed
  • De Rienzo A, Yeap BY, Cibas ES, Richards WG, Dong L, Gill RR, Sugarbaker DJ, Bueno R. Gene expression ratio test distinguishes normal lung from lung tumors in solid tissue and FNA biopsies. J Mol Diagn 2014; 16:267-72. PubMed
  • Nou E, Kwong N, Alexander LK, Cibas ES, Marqusee E, Alexander EK. Determination of the optimal time interval for repeat evaluation after a benign thyroid nodule aspiration. J Clin Endocrinol Metab 2014; 99:510-6. PubMed
  • Mariño-Enríquez A, Hornick JL, Dal Cin P, Cibas ES, Qian X. Dedifferentiated liposarcoma and pleomorphic liposarcoma: a comparative study of cytomorphology and MDM2/CDK4 expression on fine-needle aspiration. Cancer Cytopathol 2014; 122:128-37. PubMed
  • Cibas ES, Baloch ZW, Fellegara G, LiVolsi VA, Raab SS, Rosai J, Diggans J, Friedman L, Kennedy GC, Kloos RT, Lanman RB, Mandel SJ, Sindy N, Steward DL, Zeiger MA, Haugen BR, Alexander EK. A prospective assessment defining the limitations of thyroid nodule pathologic evaluation. Ann Intern Med 2013; 159:325-32. PubMed
  • Gupta A, Ly S, Castroneves LA, Frates MC, Benson CB, Feldman HA, Wassner AJ, Smith JR, Marqusee E, Alexander EK, Barletta J, Doubilet PM, Peters HE, Webb S, Modi BP, Paltiel HJ, Kozakewich H, Cibas ES, Moore FD, Shamberger RC, Larsen PR, Huang SA. A standardized assessment of thyroid nodules in children confirms higher cancer prevalence than in adults. J Clin Endocrinol Metab 2013; 98:3238-45. PubMed
  • Pillai V, Cibas ES, Dorfman DM. A simplified flow cytometric immunophenotyping procedure for the diagnosis of effusions caused by epithelial malignancies. Am J Clin Pathol 2013; 139:672-81. PubMed
  • Kuperman M, Florence RR, Pantanowitz L, Visintainer PF, Cibas ES, Otis CN. Distinguishing benign from malignant mesothelial cells in effusions by Glut-1, EMA, and Desmin expression: an evidence-based approach. Diagn Cytopathol 2013; 41:131-40. PubMed
  • Kamran SC, Marqusee E, Kim MI, Frates MC, Ritner J, Peters H, Benson CB, Doubilet PM, Cibas ES, Barletta J, Cho N, Gawande A, Ruan D, Moore FD, Pou K, Larsen PR, Alexander EK. Thyroid nodule size and prediction of cancer. J Clin Endocrinol Metab 2013; 98:564-70. PubMed
  • Dal Cin P, Qian X, Cibas ES. The marriage of Cytology and Cytogenetics. Cancer Cytopathol 2013. PubMed
  • Pusztaszeri MP, Sauder KJ, Cibas ES, Faquin WC. Fine-needle aspiration of primary Langerhans cell histiocytosis of the thyroid gland, a potential mimic of papillary thyroid carcinoma. Acta Cytol 2013; 57:406-12. PubMed
  • Alexander EK, Kennedy GC, Baloch ZW, Cibas ES, Chudova D, Diggans J, Friedman L, Kloos RT, LiVolsi VA, Mandel SJ, Raab SS, Rosai J, Steward DL, Walsh PS, Wilde JI, Zeiger MA, Lanman RB, Haugen BR. Preoperative diagnosis of benign thyroid nodules with indeterminate cytology. N Engl J Med 2012; 367:705-15. PubMed
  • Krajcovic M, Johnson NB, Sun Q, Normand G, Hoover N, Yao E, Richardson AL, King RW, Cibas ES, Schnitt SJ, Brugge JS, Overholtzer M. A non-genetic route to aneuploidy in human cancers. Nat Cell Biol 2011; 13:324-30. PubMed
  • Roh MH, Jo VY, Stelow EB, Faquin WC, Zou KH, Alexander EK, Larsen PR, Marqusee E, Benson CB, Frates MC, Gawande A, Moore FD, Cibas ES. The predictive value of the fine-needle aspiration diagnosis "suspicious for a follicular neoplasm, hurthle cell type" in patients with hashimoto thyroiditis. Am J Clin Pathol 2010; 135:139-45. PubMed
  • Chang MC, Cibas ES, Crum CP, Kindelberger DW. High-grade and low-grade pelvic serous neoplasms demonstrate differential p53 immunoreactivity in peritoneal washings. Acta Cytol 2010; 55:79-84. PubMed
  • Crippa S, Mazzucchelli L, Cibas ES, Ali SZ. The Bethesda System for reporting thyroid fine-needle aspiration specimens. Am J Clin Pathol 2010; 134:343-4; author reply 345. PubMed
  • Jarboe EA, Venkat P, Hirsch MS, Cibas ES, Crum CP, Garner EI. A weakly positive human papillomavirus Hybrid Capture II result correlates with a significantly lower risk of cervical intraepithelial neoplasia 2,3 after atypical squamous cells of undetermined significance cytology. J Low Genit Tract Dis 2010; 14:174-8. PubMed
  • Roh MH, Dal Cin P, Silverman SG, Cibas ES. The application of cytogenetics and fluorescence in situ hybridization to fine-needle aspiration in the diagnosis and subclassification of renal neoplasms. Cancer Cytopathol 2010; 118:137-45. PubMed
  • Flores LM, Kindelberger DW, Ligon AH, Capelletti M, Fiorentino M, Loda M, Cibas ES, Jänne PA, Krop IE. Improving the yield of circulating tumour cells facilitates molecular characterisation and recognition of discordant HER2 amplification in breast cancer. Br J Cancer 2010; 102:1495-502. PubMed
  • Cibas ES. Fine-needle aspiration in the work-up of thyroid nodules. Otolaryngol. Clin. North Am. 2010; 43:257-71, vii-viii. PubMed
  • Renshaw AA, Auger M, Birdsong G, Cibas ES, Henry M, Hughes JH, Moriarty A, Tench W, Wilbur DC, Elsheikh TM. ASC/SIL ratio for cytotechnologists: A survey of its utility in clinical practice. Diagn Cytopathol 2010; 38:180-3. PubMed
  • Cibas ES, Ali SZ. The Bethesda System for Reporting Thyroid Cytopathology. Thyroid 2009; 19:1159-65. PubMed
  • Cibas ES, Ali SZ, . The Bethesda System For Reporting Thyroid Cytopathology. Am J Clin Pathol 2009; 132:658-65. PubMed
  • Factor RE, Dal Cin P, Fletcher JA, Cibas ES. Cytogenetics and fluorescence in situ hybridization as adjuncts to cytology in the diagnosis of malignant mesothelioma. Cancer Cytopathol 2009; 117:247-53. PubMed
  • Suba EJ, Cibas ES, Raab SS. HPV screening for cervical cancer in rural India. N Engl J Med 2009; 361:304; author reply 306. PubMed
  • Shen J,Pinkus GS,Deshpande V,Cibas ES. Usefulness of EMA, GLUT-1, and XIAP for the cytologic diagnosis of malignant mesothelioma in body cavity fluids. Am J Clin Pathol 2009; 131:516-23. PubMed
  • Layfield LJ,Cibas ES,Gharib H,Mandel SJ. Thyroid aspiration cytology: current status. CA Cancer J Clin 2009; 59:99-110. PubMed
  • Smouse JH,Cibas ES,Janne PA,Joshi VA,Zou KH,Lindeman NI. EGFR mutations are detected comparably in cytologic and surgical pathology specimens of nonsmall cell lung cancer. Cancer Cytopathol 2009; 117:67-72. PubMed
  • Souza FF,Mortele KJ,Cibas ES,Erturk SM,Silverman SG. Predictive value of percutaneous imaging-guided biopsy of peritoneal and omental masses: results in 111 patients. AJR Am J Roentgenol 2008; 192:131-6. PubMed
  • Qian X,Goumnerova LC,De Girolami U,Cibas ES. Cerebrospinal fluid cytology in patients with ependymoma: a bi-institutional retrospective study. Cancer 2008; 114:307-14. PubMed
  • French CA,Fletcher JA,Cibas ES,Caulfield C,Allard P,Kroll TG. Molecular detection of PPAR gamma rearrangements and thyroid carcinoma in preoperative fine-needle aspiration biopsies. Endocr Pathol 2008; 19:166-74. PubMed
  • Pinto AP,Schlecht NF,Woo TY,Crum CP,Cibas ES. Biomarker (ProEx C, p16(INK4A), and MiB-1) distinction of high-grade squamous intraepithelial lesion from its mimics. Mod Pathol 2008; 21:1067-74. PubMed
  • Cibas ES,Alexander EK,Benson CB,de Agustin PP,Doherty GM,Faquin WC,Middleton WD,Miller T,Raab SS,White ML,Mandel SJ. Indications for thyroid FNA and pre-FNA requirements: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference. Diagn Cytopathol 2008; 36:390-9. PubMed
  • Cibas ES, Alonzo TA, Austin RM, Bolick DR, Glant MD, Henry MR, Moriarty AT, Molina JT, Rushing L, Slowman SD, Torno R, Eisenhut CC. The MonoPrep Pap Test for the Detection of Cervical Cancer and Its Precursors: Part I: Results of a Multicenter Clinical Trial. Am J Clin Pathol 2008; 129:193-201. PubMed
  • Cibas ES, Zou KH, Crum CP, Kuo F. Using the rate of positive high-risk HPV test results for ASC-US together with the ASC-US/SIL ratio in evaluating the performance of cytopathologists. Am J Clin Pathol 2007; 129:97-101. PubMed
  • Yassa L, Cibas ES, Benson CB, Frates MC, Doubilet PM, Gawande AA, Moore FD, Kim BW, Nos. Long-term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluation. Cancer 2007; 111:508-16. PubMed
  • Overholtzer M, Mailleux AA, Mouneimne G, Normand G, Schnitt SJ, King RW, Cibas ES, Brugge JS. A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell 2007; 131:966-79. PubMed
  • Nascimento AF, Cibas ES. The ASC/SIL ratio for cytopathologists as a quality control measure: a follow-up study. Am J Clin Pathol 2007; 128:653-6. PubMed
  • Silverman SG, Mortele KJ, Tuncali K, Jinzaki M, Cibas ES. Hyperattenuating renal masses: etiologies, pathogenesis, and imaging evaluation. Radiographics 2007; 27:1131-43. PubMed
  • Chang BS, Yang T, Cibas ES, Fletcher JA. An in vitro cytologic assay for evaluation of the KIT signaling pathway in gastrointestinal stromal tumors. Mod Pathol 2007; 20:579-83. PubMed
  • Cibas ES, Hong X, Crum CP, Feldman S. Age-specific detection of high risk HPV DNA in cytologically normal, computer-imaged ThinPrep Pap samples. Gynecol Oncol 2006; 104:702-6. PubMed
  • Frates MC, Benson CB, Charboneau JW, Cibas ES, Clark OH, Coleman BG, Cronan JJ, Doubilet PM, Evans DB, Goellner JR, Hay ID, Hertzberg BS, Intenzo CM, Jeffrey RB, Langer JE, Larsen PR, Mandel SJ, Middleton WD, Reading CC, Sherman SI, Tessler FN. Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement. Ultrasound Q 2006; 22:231-8; discussion 239-40. PubMed
  • Frates MC, Benson CB, Doubilet PM, Kunreuther E, Contreras M, Cibas ES, Orcutt J, Moore FD, Larsen PR, Marqusee E, Alexander EK. Prevalence and Distribution of Carcinoma in Patients with Solitary and Multiple Thyroid Nodules on Sonography. J Clin Endocrinol Metab 2006; 91:3411-7. PubMed
  • Silverman SG, Gan YU, Mortele KJ, Tuncali K, Cibas ES. Renal masses in the adult patient: the role of percutaneous biopsy. Radiology 2006; 240:6-22. PubMed
  • Chang BS, Pinkus GS, Cibas ES. Exfoliated endometrial cell clusters in cervical cytologic preparations are derived from endometrial stroma and glands. Am J Clin Pathol 2006; 125:77-81. PubMed
  • French CA, Alexander EK, Cibas ES, Nose V, Laguette J, Faquin W, Garber J, Moore F, Fletcher JA, Larsen PR, Kroll TG. Genetic and biological subgroups of low-stage follicular thyroid cancer. Am J Pathol 2003; 162:1053-60. PubMed
  • Bongiovanni M, De Saussure B, Kumar N, Pache JC, Cibas ES. A quality control study on cytotechnologist-cytopathologist concordance and its relationship to the number of dots on the slide. Acta Cytol 2009; 53:653-8. PubMed
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