For the past 21 years, I have focused my efforts on clinical research in breast cancer. As a clinical trialist, I have conducted phase I, II, and III studies with the goal of improving the treatment of women with breast cancer by defining more effective and less toxic approaches. Increasingly, these trials have also addressed translational questions in breast cancer. I direct the Breast Oncology Program at Dana-Farber Cancer Institute and I am the Breast Program Leader in the Dana-Farber/Harvard Cancer Center (DF/HCC). I am the co-chair of the Alliance (Alliance for Cooperative Trials in Oncology, formerly Cancer and Leukemia Group B) and serve as Co-Chief Scientific Advisor to Susan G. Komen for the Cure. I have collaborated closely throughout my career with clinical translational, basic, and population science researchers.