Photo of Eva S. Schernhammer,  DrPH, MD

Eva S. Schernhammer, DrPH, MD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 525-4648
Fax: (617) 525-2008

Eva S. Schernhammer, DrPH, MD

Brigham And Women's Hospital


  • Associate Professor, Medicine, Harvard Medical School


Research Abstract

Major research interests:

1. Circadian phase: melatonin / cortisol as biomarkers for cancer risk

2. Shift work: light exposure and cancer etiology

3. Breast cancer: biomarkers, gene-environment interactions, and prevention

4. Gastrointestinal tumors: etiology and prevention

5. Parkinson’s disease: associations with cancer etiology

My research has examined the epidemiology of a variety of cancers, including breast, colon, and pancreatic cancer. I have recently become interested in studying new areas including Parkinson’s disease and its relation with cancer etiology, to further understand biological mechanisms in carcinogenesis.


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  • Vetter C, Schernhammer ES. Early, but not late chronotypes, are up during their biological night when working the night shift. Occup Environ Med 2015; 72:235. PubMed
  • Devore EE, Kim S, Ramin CA, Wegrzyn LR, Massa J, Holmes MD, Michels KB, Tamimi RM, Forman JP, Schernhammer ES. Antihypertensive medication use and incident breast cancer in women. Breast Cancer Res Treat 2015; 150:219-29. PubMed
  • Sigurdardottir LG, Markt SC, Rider JR, Haneuse S, Fall K, Schernhammer ES, Tamimi RM, Flynn-Evans E, Batista JL, Launer L, Harris T, Aspelund T, Stampfer MJ, Gudnason V, Czeisler CA, Lockley SW, Valdimarsdottir UA, Mucci LA. Urinary melatonin levels, sleep disruption, and risk of prostate cancer in elderly men. Eur Urol 2015. PubMed
  • Nishihara R, Wang M, Qian ZR, Baba Y, Yamauchi M, Mima K, Sukawa Y, Kim SA, Inamura K, Zhang X, Wu K, Giovannucci EL, Chan AT, Fuchs CS, Ogino S, Schernhammer ES. Alcohol, one-carbon nutrient intake, and risk of colorectal cancer according to tumor methylation level of IGF2 differentially methylated region. Am J Clin Nutr 2014; 100:1479-88. PubMed
  • Chen WY, Giobbie-Hurder A, Gantman K, Savoie J, Scheib R, Parker LM, Schernhammer ES. A randomized, placebo-controlled trial of melatonin on breast cancer survivors: impact on sleep, mood, and hot flashes. Breast Cancer Res Treat 2014. PubMed
  • Ramin C, Devore EE, Pierre-Paul J, Duffy JF, Hankinson SE, Schernhammer ES. Chronotype and breast cancer risk in a cohort of US nurses. Chronobiol. Int. 2013; 30:1181-6. PubMed
  • Schernhammer ES, Feskanich D, Liang G, Han J. Rotating night-shift work and lung cancer risk among female nurses in the United States. Am J Epidemiol 2013; 178:1434-41. PubMed
  • Zhang X, Giovannucci EL, Wu K, Gao X, Hu F, Ogino S, Schernhammer ES, Fuchs CS, Redline S, Willett WC, Ma J. Associations of self-reported sleep duration and snoring with colorectal cancer risk in men and women. Sleep 2013; 36:681-8. PubMed
  • Sigurdardottir LG, Valdimarsdottir UA, Mucci LA, Fall K, Rider JR, Schernhammer E, Czeisler CA, Launer L, Harris T, Stampfer MJ, Gudnason V, Lockley SW. Sleep disruption among older men and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 2013; 22:872-9. PubMed
  • Ogino S, Lochhead P, Chan AT, Nishihara R, Cho E, Wolpin BM, Meyerhardt JA, Meissner A, Schernhammer ES, Fuchs CS, Giovannucci E. Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease. Mod Pathol 2013; 26:465-84. PubMed
  • Ogino S, Nishihara R, Lochhead P, Imamura Y, Kuchiba A, Morikawa T, Yamauchi M, Liao X, Qian ZR, Sun R, Sato K, Kirkner GJ, Wang M, Spiegelman D, Meyerhardt JA, Schernhammer ES, Chan AT, Giovannucci E, Fuchs CS. Prospective study of family history and colorectal cancer risk by tumor LINE-1 methylation level. Journal of the National Cancer Institute 2013. PubMed
  • Schernhammer ES, Sperati F, Razavi P, Agnoli C, Sieri S, Berrino F, Krogh V, Abbagnato C, Grioni S, Blandino G, Schunemann HJ, Muti P. Endogenous sex steroids in premenopausal women and risk of breast cancer: the ORDET cohort. Breast Cancer Res 2014; 15:R46. PubMed
  • Schernhammer ES, Bertrand KA, Birmann BM, Sampson L, Willett WC, Feskanich D. Consumption of artificial sweetener- and sugar-containing soda and risk of lymphoma and leukemia in men and women. Am J Clin Nutr 2012; 96:1419-28. PubMed
  • Monsees GM, Kraft P, Hankinson SE, Hunter DJ, Schernhammer ES. Circadian genes and breast cancer susceptibility in rotating shift workers. Int J Cancer 2012; 131:2547-52. PubMed
  • Thompson CA, Waldhör T, Schernhammer ES, Hackl M, Vutuc C, Haidinger G. Smoking and lung cancer: current trends in Austria. Wien. Klin. Wochenschr. 2012; 124:493-9. PubMed
  • Sigurdardottir LG, Valdimarsdottir UA, Fall K, Rider JR, Lockley SW, Schernhammer E, Mucci LA. Circadian disruption, sleep loss, and prostate cancer risk: a systematic review of epidemiologic studies. Cancer Epidemiol Biomarkers Prev 2012; 21:1002-11. PubMed
  • Poole EM, Schernhammer ES, Tworoger SS. Rotating night shift work and risk of ovarian cancer. Cancer Epidemiol Biomarkers Prev 2011. PubMed
  • Schernhammer ES, Razavi P, Li TY, Qureshi AA, Han J. Rotating night shifts and risk of skin cancer in the nurses' health study. Journal of the National Cancer Institute 2011; 103:602-6. PubMed
  • Schernhammer ES, Giovannucci E, Kawasaki T, Rosner B, Fuchs C, Ogino S. Dietary Folate, Alcohol, and B Vitamins in Relation to LINE-1 Hypomethylation in Colon Cancer. Gut 2010; 59:794-9. PubMed
  • Bajaj A, Driver JA, Schernhammer ES. Parkinson's disease and cancer risk: a systematic review and meta-analysis. Cancer Causes Control 2010; 21:697-707. PubMed
  • Irahara N, Nosho K, Baba Y, Shima K, Lindeman NI, Hazra A, Schernhammer ES, Hunter DJ, Fuchs CS, Ogino S. Precision of pyrosequencing assay to measure LINE-1 methylation in colon cancer, normal colonic mucosa, and peripheral blood cells. J Mol Diagn 2010; 12:177-83. PubMed
  • Schernhammer ES, Berrino F, Krogh V, Secreto G, Micheli A, Venturelli E, Grioni S, Sempos CT, Cavalleri A, Schünemann HJ, Strano S, Muti P. Urinary 6-Sulphatoxymelatonin levels and risk of breast cancer in premenopausal women: the ORDET cohort. Cancer Epidemiol Biomarkers Prev 2010; 19:729-37. PubMed
  • Baba Y, Huttenhower C, Nosho K, Tanaka N, Shima K, Hazra A, Schernhammer ES, Hunter DJ, Giovannucci EL, Fuchs CS, Ogino S. Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors. Mol Cancer 2010; 9:125. PubMed
  • Flynn-Evans EE, Stevens RG, Tabandeh H, Schernhammer ES, Lockley SW. Total visual blindness is protective against breast cancer. Cancer Causes Control 2009; 20:1753-6. PubMed
  • Schernhammer ES, Haidinger G, Waldhör T, Vutuc C. Attitudes about the use of complementary and alternative medicine in cancer treatment. J Altern Complement Med 2009; 15:1115-20. PubMed
  • Schernhammer ES, Feskanich D, Niu C, Dopfel R, Holmes MD, Hankinson SE. Dietary correlates of urinary 6-sulfatoxymelatonin concentrations in the Nurses' Health Study cohorts. Am J Clin Nutr 2009; 90:975-85. PubMed
  • Viswanathan AN,Schernhammer ES. Circulating melatonin and the risk of breast and endometrial cancer in women. Cancer Lett 2009; 281:1-7. PubMed
  • Schernhammer ES,Hankinson SE. Urinary melatonin levels and postmenopausal breast cancer risk in the Nurses' Health Study cohort. Cancer Epidemiol Biomarkers Prev 2009; 18:74-9. PubMed
  • Ogino S,Nosho K,Kirkner GJ,Kawasaki T,Chan AT,Schernhammer ES,Giovannucci EL,Fuchs CS. A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer. Journal of the National Cancer Institute 2008; 100:1734-8. PubMed
  • Schernhammer ES,Giovannuccci E,Fuchs CS,Ogino S. A prospective study of dietary folate and vitamin B and colon cancer according to microsatellite instability and KRAS mutational status. Cancer Epidemiol Biomarkers Prev 2008; 17:2895-8. PubMed
  • Schernhammer ES,Ogino S,Fuchs CS. Folate and vitamin B6 intake and risk of colon cancer in relation to p53 expression. Gastroenterology 2008; 135:770-80. PubMed
  • Schernhammer ES,Berrino F,Krogh V,Secreto G,Micheli A,Venturelli E,Sieri S,Sempos CT,Cavalleri A,Schunemann HJ,Strano S,Muti P. Urinary 6-sulfatoxymelatonin levels and risk of breast cancer in postmenopausal women. Journal of the National Cancer Institute 2008; 100:898-905. PubMed
  • Viswanathan AN, Feskanich D, Schernhammer ES, Hankinson SE. Aspirin, NSAID, and acetaminophen use and the risk of endometrial cancer. Cancer Res 2008; 68:2507-13. PubMed
  • Nosho K,Irahara N,Shima K,Kure S,Kirkner GJ,Schernhammer ES,Hazra A,Hunter DJ,Quackenbush J,Spiegelman D,Giovannucci EL,Fuchs CS,Ogino S. Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample. PLoS ONE 2008; 3:e3698. PubMed
  • Chan AT, Giovannucci EL, Meyerhardt JA, Schernhammer ES, Wu K, Fuchs CS. Aspirin dose and duration of use and risk of colorectal cancer in men. Gastroenterology 2007; 134:21-8. PubMed
  • Viswanathan AN, Hankinson SE, Schernhammer ES. Night shift work and the risk of endometrial cancer. Cancer Res 2007; 67:10618-22. PubMed
  • Schernhammer ES, Tworoger SS, Eliassen AH, Missmer SA, Holly JM, Pollak MN, Hankinson SE. Body shape throughout life and correlations with IGFs and GH. Endocr Relat Cancer 2007; 14:721-32. PubMed
  • Wolpin BM, Michaud DS, Giovannucci EL, Schernhammer ES, Stampfer MJ, Manson JE, Cochrane BB, Rohan TE, Ma J, Pollak MN, Fuchs CS. Circulating insulin-like growth factor binding protein-1 and the risk of pancreatic cancer. Cancer Res 2007; 67:7923-8. PubMed
  • Wolpin BM, Michaud DS, Giovannucci EL, Schernhammer ES, Stampfer MJ, Manson JE, Cochrane BB, Rohan TE, Ma J, Pollak MN, Fuchs CS. Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts. Br J Cancer 2007; 97:98-104. PubMed
  • Schernhammer E, Wolpin B, Rifai N, Cochrane B, Manson JA, Ma J, Giovannucci E, Thomson C, Stampfer MJ, Fuchs C. Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts. Cancer Res 2007; 67:5553-60. PubMed
  • Schernhammer ES, Holly JM, Hunter DJ, Pollak MN, Hankinson SE. Insulin-like growth factor-I, its binding proteins (IGFBP-1 and IGFBP-3), and growth hormone and breast cancer risk in The Nurses Health Study II. Endocr Relat Cancer 2006; 13:583-92. PubMed
  • Schernhammer ES, Tranah GJ, Giovannucci E, Chan AT, Ma J, Colditz GA, Hunter DJ, Willett WC, Fuchs CS. Cyclin D1 A870G polymorphism and the risk of colorectal cancer and adenoma. Br J Cancer 2006; 94:928-34. PubMed
  • Kroenke CH, Kubzansky LD, Schernhammer ES, Holmes MD, Kawachi I. Social networks, social support, and survival after breast cancer diagnosis. J Clin Oncol 2006; 24:1105-11. PubMed
  • Schernhammer ES, Kang JH, Chan AT, Michaud DS, Skinner HG, Giovannucci E, Colditz GA, Fuchs CS. A prospective study of aspirin use and the risk of pancreatic cancer in women. J Natl Cancer Inst 2004; 96:22-8. PubMed
  • Schernhammer ES, Ogino S, Fuchs CS. Folate and Vitamin B(6) Intake and Risk of Colon Cancer in Relation to p53 Expression. Gastroenterology 2008.