Photo of Fernando Camargo,  PhD

Fernando Camargo, PhD

Boston Children's Hospital

Boston Children's Hospital


fernando.camargo@childrens.harvard.edu

Fernando Camargo, PhD

Boston Children's Hospital

EDUCATIONAL TITLES

  • Associate Professor, Stem Cell and Regenerative Biology, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Research Abstract

The Camargo laboratory’s ultimate goal is to understand the signals that regulate adult stem cell maturation and tissue regeneration. Currently, the main focus of the lab is the study and identification of the signals that regulate organ size and control tissue symmetry. The biology of the signals that sense the size and limit the expansion of tissues is one of the least understood aspects of developmental biology, and one that could have important implications for regenerative medicine. In addition, this research may also shed light on the relationship between tissue size checkpoints and tumor suppression. The Camargo laboratory also has a strong interest in studying the cellular and molecular biology of hematopoietic stem cells. Our group’s studies focus primarily on the in vivo roles of transcription factors and microRNAs in stem cell fate decisions, differentiation, and malignancy.

Publications

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  • Yimlamai D, Christodoulou C, Galli GG, Yanger K, Pepe-Mooney B, Gurung B, Shrestha K, Cahan P, Stanger BZ, Camargo FD. Hippo pathway activity influences liver cell fate. Cell 2014; 157:1324-38. PubMed
  • Mori M, Triboulet R, Mohseni M, Schlegelmilch K, Shrestha K, Camargo FD, Gregory RI. Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer. Cell 2014; 156:893-906. PubMed
  • Mohseni M, Sun J, Lau A, Curtis S, Goldsmith J, Fox VL, Wei C, Frazier M, Samson O, Wong KK, Wong KK, Kim C, Camargo FD. A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway. Nat Cell Biol 2013; 16:108-17. PubMed
  • Halder G, Camargo FD. The hippo tumor suppressor network: from organ size control to stem cells and cancer. Cancer Res 2013; 73:6389-92. PubMed
  • Barry ER, Morikawa T, Butler BL, Shrestha K, de la Rosa R, Yan KS, Fuchs CS, Magness ST, Smits R, Ogino S, Kuo CJ, Camargo FD. Restriction of intestinal stem cell expansion and the regenerative response by YAP. Nature 2013; 493:106-10. PubMed
  • Tumaneng K, Schlegelmilch K, Russell RC, Yimlamai D, Basnet H, Mahadevan N, Fitamant J, Bardeesy N, Camargo FD, Guan KL. YAP mediates crosstalk between the Hippo and PI(3)K-TOR pathways by suppressing PTEN via miR-29. Nat Cell Biol 2012. PubMed
  • Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez JR, Zhou D, Kreger BT, Vasioukhin V, Avruch J, Brummelkamp TR, Camargo FD. Yap1 Acts Downstream of 留-Catenin to Control Epidermal Proliferation. Cell 2011; 144:782-95. PubMed