Photo of Fernando Camargo,  PhD

Fernando Camargo, PhD

Boston Children's Hospital

Boston Children's Hospital


fernando.camargo@childrens.harvard.edu

Fernando Camargo, PhD

Boston Children's Hospital

EDUCATIONAL TITLES

  • Associate Professor, Stem Cell and Regenerative Biology, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Research Abstract

The Camargo laboratory’s ultimate goal is to understand the signals that regulate adult stem cell maturation and tissue regeneration. Currently, the main focus of the lab is the study and identification of the signals that regulate organ size and control tissue symmetry. The biology of the signals that sense the size and limit the expansion of tissues is one of the least understood aspects of developmental biology, and one that could have important implications for regenerative medicine. In addition, this research may also shed light on the relationship between tissue size checkpoints and tumor suppression. The Camargo laboratory also has a strong interest in studying the cellular and molecular biology of hematopoietic stem cells. Our group’s studies focus primarily on the in vivo roles of transcription factors and microRNAs in stem cell fate decisions, differentiation, and malignancy.

Publications

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  • Gentner B, Pochert N, Rouhi A, Boccalatte F, Plati T, Berg T, Sun SM, Mah SM, Mirkovic-Hösle M, Ruschmann J, Muranyi A, Leierseder S, Argiropoulos B, Starczynowski DT, Karsan A, Heuser M, Hogge D, Camargo FD, Engelhardt S, Döhner H, Buske C, Jongen-Lavrencic M, Naldini L, Humphries RK, Kuchenbauer F. MicroRNA-223 dose-levels fine-tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia. Exp Hematol 2015. PubMed
  • Sun J, Ramos A, Chapman B, Johnnidis JB, Le L, Ho YJ, Klein A, Hofmann O, Camargo FD. Clonal dynamics of native haematopoiesis. Nature 2014; 514:322-7. PubMed
  • Ganem NJ, Cornils H, Chiu SY, O'Rourke KP, Arnaud J, Yimlamai D, Théry M, Camargo FD, Pellman D. Cytokinesis failure triggers hippo tumor suppressor pathway activation. Cell 2014; 158:833-48. PubMed
  • Tremblay AM, Missiaglia E, Galli GG, Hettmer S, Urcia R, Carrara M, Judson RN, Thway K, Nadal G, Selfe JL, Murray G, Calogero RA, De Bari C, Zammit PS, Delorenzi M, Wagers AJ, Shipley J, Wackerhage H, Camargo FD. The Hippo transducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation. Cancer Cell 2014; 26:273-87. PubMed
  • Zhao R, Fallon TR, Saladi SV, Pardo-Saganta A, Villoria J, Mou H, Vinarsky V, Gonzalez-Celeiro M, Nunna N, Hariri LP, Camargo F, Ellisen LW, Rajagopal J. Yap tunes airway epithelial size and architecture by regulating the identity, maintenance, and self-renewal of stem cells. Dev Cell 2014; 30:151-65. PubMed
  • Yimlamai D, Christodoulou C, Galli GG, Yanger K, Pepe-Mooney B, Gurung B, Shrestha K, Cahan P, Stanger BZ, Camargo FD. Hippo pathway activity influences liver cell fate. Cell 2014; 157:1324-38. PubMed
  • Mori M, Triboulet R, Mohseni M, Schlegelmilch K, Shrestha K, Camargo FD, Gregory RI. Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer. Cell 2014; 156:893-906. PubMed
  • Mohseni M, Sun J, Lau A, Curtis S, Goldsmith J, Fox VL, Wei C, Frazier M, Samson O, Wong KK, Wong KK, Kim C, Camargo FD. A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway. Nat Cell Biol 2013; 16:108-17. PubMed
  • Halder G, Camargo FD. The hippo tumor suppressor network: from organ size control to stem cells and cancer. Cancer Res 2013; 73:6389-92. PubMed
  • Barry ER, Morikawa T, Butler BL, Shrestha K, de la Rosa R, Yan KS, Fuchs CS, Magness ST, Smits R, Ogino S, Kuo CJ, Camargo FD. Restriction of intestinal stem cell expansion and the regenerative response by YAP. Nature 2013; 493:106-10. PubMed
  • Tumaneng K, Schlegelmilch K, Russell RC, Yimlamai D, Basnet H, Mahadevan N, Fitamant J, Bardeesy N, Camargo FD, Guan KL. YAP mediates crosstalk between the Hippo and PI(3)K-TOR pathways by suppressing PTEN via miR-29. Nat Cell Biol 2012. PubMed
  • Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez JR, Zhou D, Kreger BT, Vasioukhin V, Avruch J, Brummelkamp TR, Camargo FD. Yap1 Acts Downstream of 留-Catenin to Control Epidermal Proliferation. Cell 2011; 144:782-95. PubMed
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