The Camargo laboratory's ultimate goal is to understand the signals that regulate adult stem cell maturation and tissue regeneration. Currently, the main focus of the lab is the study and identification of the signals that regulate organ size and control tissue symmetry. The biology of the signals that sense the size and limit the expansion of tissues is one of the least understood aspects of developmental biology, and one that could have important implications for regenerative medicine. In addition, this research may also shed light on the relationship between tissue size checkpoints and tumor suppression. The Camargo laboratory also has a strong interest in studying the cellular and molecular biology of hematopoietic stem cells. Our group's studies focus primarily on the in vivo roles of transcription factors and microRNAs in stem cell fate decisions, differentiation, and malignancy.