Francine Laden, ScD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 525-2711
Fax: (617) 525-2578


francine.laden@channing.harvard.edu

Francine Laden, ScD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Mark and Catherine Winkler Associate Professor of Environmental Epidemiology, Environmental Health, Harvard T.H. Chan School Of Public Health
  • Associate Professor, Medicine, Harvard Medical School
  • Assistant Professor, Medicine, Brigham And Women's Hospital
  • Instructor, Medicine, Brigham And Women's Hospital
  • Assistant Professor, Epidemiology, Harvard T.H. Chan School Of Public Health

DF/HCC PROGRAM AFFILIATION

Research Abstract

My research focuses on environmental risk factors of cancer, specifically breast cancer, non-Hodgkin's lymphoma, and lung cancer. I am studying the relationship of exposure to organochlorine chemicals with both breast cancer and NHL and the association of diesel exhaust and other sources of fine particulate matter with lung cancer mortality.

Publications

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  • Pearce NE, Blair A, Vineis P, Ahrens W, Andersen A, Anto JM, Armstrong BK, Baccarelli AA, Beland FA, Berrington A, Bertazzi PA, Birnbaum LS, Brownson RC, Bucher JR, Cantor KP, Cardis E, Cherrie JW, Christiani DC, Cocco P, Coggon D, Comba P, Demers PA, Dement JM, Douwes J, Eisen EA, Engel LS, Fenske RA, Fleming LE, Fletcher T, Fontham E, Forastiere F, Frentzel-Beyme R, Fritschi L, Gerin M, Goldberg M, Grandjean P, Grimsrud TK, Gustavsson P, Haines A, Hartge P, Hansen J, Hauptmann M, Heederik D, Hemminki K, Hemon D, Hertz-Picciotto I, Hoppin JA, Huff J, Jarvholm B, Kang D, Karagas MR, Kjaerheim K, Kjuus H, Kogevinas M, Kriebel D, Kristensen P, Kromhout H, Laden F, Lebailly P, LeMasters G, Lubin JH, Lynch CF, Lynge E, 't Mannetje A, McMichael AJ, McLaughlin JR, Marrett L, Martuzzi M, Merchant JA, Merler E, Merletti F, Miller A, Mirer FE, Monson R, Nordby KK, Olshan AF, Parent ME, Perera FP, Perry MJ, Pesatori AC, Pirastu R, Porta M, Pukkala E, Rice C, Richardson DB, Ritter L, Ritz B, Ronckers CM, Rushton L, Rusiecki JA, Rusyn I, Samet JM, Sandler DP, de Sanjose S, Schernhammer E, Seniori Constantini A, Seixas N, Shy C, Siemiatycki J, Silvermann DT, Simonato L, Smith AH, Smith MT, Spinelli JJ, Spitz MR, Stallones L, Stayner LT, Steenland K, Stenzel M, Stewart BW, Stewart PA, Symanski E, Terracini B, Tolbert PE, Vainio H, Vena J, Vermeulen R, Victora CG, Ward EM, Weinberg CR, Weisenburger D, Wesseling C, Weiderpass E, Zahm SH. IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans. Environ Health Perspect 2015. PubMed
  • Puett RC, Hart JE, Yanosky JD, Spiegelman D, Wang M, Fisher JA, Hong B, Laden F. Particulate matter air pollution exposure, distance to road, and incident lung cancer in the nurses' health study cohort. Environ Health Perspect 2014. PubMed
  • Hamra GB, Guha N, Cohen A, Laden F, Raaschou-Nielsen O, Samet JM, Vineis P, Forastiere F, Saldiva P, Yorifuji T, Loomis D. Outdoor Particulate Matter Exposure and Lung Cancer: A Systematic Review and Meta-Analysis. Environ Health Perspect 2014. PubMed
  • Wu S, Han J, Laden F, Qureshi AA. Long-term Ultraviolet Flux, Other Potential Risk Factors, and Skin Cancer Risk: A Cohort Study. Cancer Epidemiol Biomarkers Prev 2014; 23:1080-9. PubMed
  • Mahalingaiah S, Hart JE, Laden F, Terry KL, Boynton-Jarrett R, Aschengrau A, Missmer SA. Air Pollution and Risk of Uterine Leiomyomata. Epidemiology 2014. PubMed
  • James P, Berrigan D, Hart JE, Aaron Hipp J, Hoehner CM, Kerr J, Major JM, Oka M, Laden F. Effects of buffer size and shape on associations between the built environment and energy balance. Health Place 2014; 27:162-70. PubMed
  • Burnett RT, Pope CA, Ezzati M, Olives C, Lim SS, Mehta S, Shin HH, Singh G, Hubbell B, Brauer M, Anderson HR, Smith KR, Balmes JR, Bruce NG, Kan H, Laden F, Prüss-Ustün A, Turner MC, Gapstur SM, Diver WR, Cohen A. An integrated risk function for estimating the global burden of disease attributable to ambient fine particulate matter exposure. Environ Health Perspect 2014; 122:397-403. PubMed
  • Mahalingaiah S, Hart JE, Laden F, Aschengrau A, Missmer SA. Air pollution exposures during adulthood and risk of endometriosis in the Nurses' Health Study II. Environ Health Perspect 2014; 122:58-64. PubMed
  • Kioumourtzoglou MA, Spiegelman D, Szpiro AA, Sheppard L, Kaufman JD, Yanosky JD, Williams R, Laden F, Hong B, Suh H. Exposure measurement error in PM2.5 health effects studies: a pooled analysis of eight personal exposure validation studies. Environ Health 2014; 13:2. PubMed
  • Hirsch JA, James P, Robinson JR, Eastman KM, Conley KD, Evenson KR, Laden F. Using MapMyFitness to Place Physical Activity into Neighborhood Context. Front Public Health 2014; 2:19. PubMed
  • Bertrand KA, Giovannucci E, Zhang SM, Laden F, Rosner B, Birmann BM. A prospective analysis of body size during childhood, adolescence, and adulthood and risk of non-Hodgkin lymphoma. Cancer Prev Res (Phila Pa) 2013; 6:864-73. PubMed
  • Berndt SI, Skibola CF, Joseph V, Camp NJ, Nieters A, Wang Z, Cozen W, Monnereau A, Wang SS, Kelly RS, Lan Q, Teras LR, Chatterjee N, Chung CC, Yeager M, Brooks-Wilson AR, Hartge P, Purdue MP, Birmann BM, Armstrong BK, Cocco P, Zhang Y, Severi G, Zeleniuch-Jacquotte A, Lawrence C, Burdette L, Yuenger J, Hutchinson A, Jacobs KB, Call TG, Shanafelt TD, Novak AJ, Kay NE, Liebow M, Wang AH, Smedby KE, Adami HO, Melbye M, Glimelius B, Chang ET, Glenn M, Curtin K, Cannon-Albright LA, Jones B, Diver WR, Link BK, Weiner GJ, Conde L, Bracci PM, Riby J, Holly EA, Smith MT, Jackson RD, Tinker LF, Benavente Y, Becker N, Boffetta P, Brennan P, Foretova L, Maynadie M, McKay J, Staines A, Rabe KG, Achenbach SJ, Vachon CM, Goldin LR, Strom SS, Lanasa MC, Spector LG, Leis JF, Cunningham JM, Weinberg JB, Morrison VA, Caporaso NE, Norman AD, Linet MS, De Roos AJ, Morton LM, Severson RK, Riboli E, Vineis P, Kaaks R, Trichopoulos D, Masala G, Weiderpass E, Chirlaque MD, Vermeulen RC, Travis RC, Giles GG, Albanes D, Virtamo J, Weinstein S, Clavel J, Zheng T, Holford TR, Offit K, Zelenetz A, Klein RJ, Spinelli JJ, Bertrand KA, Laden F, Giovannucci E, Kraft P, Kricker A, Turner J, Vajdic CM, Ennas MG, Ferri GM, Miligi L, Liang L, Sampson J, Crouch S, Park JH, North KE, Cox A, Snowden JA, Wright J, Carracedo A, Lopez-Otin C, Bea S, Salaverria I, Martin-Garcia D, Campo E, Fraumeni JF, de Sanjose S, Hjalgrim H, Cerhan JR, Chanock SJ, Rothman N, Slager SL. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Nat Genet 2013; 45:868-76. PubMed
  • Smith TJ, Davis ME, Hart JE, Blicharz A, Laden F, Garshick E, . Potential air toxics hot spots in truck terminals and cabs. Res Rep Health Eff Inst 2013. PubMed
  • Garshick E, Laden F, Hart JE, Davis ME, Eisen EA, Smith TJ. Lung cancer and elemental carbon exposure in trucking industry workers. Environ Health Perspect 2012; 120:1301-6. PubMed
  • Hart JE, Garshick E, Dockery DW, Smith TJ, Ryan L, Laden F. Long-term Ambient Multi-pollutant Exposures and Mortality. Am J Respir Crit Care Med 2011; 183:73-8. PubMed
  • Bertrand KA, Birmann BM, Chang ET, Spiegelman D, Aster JC, Zhang SM, Laden F. A prospective study of Epstein-Barr virus antibodies and risk of non-Hodgkin lymphoma. Blood 2010; 116:3547-53. PubMed
  • Abel GA, Bertrand KA, Earle CC, Laden F. Outcomes for lymphoid malignancies in the Nurses' Health Study (NHS) as compared to the Surveillance, Epidemiology and End Results (SEER) Program. Hematol Oncol 2010; 28:133-6. PubMed
  • Kim D, Masyn KE, Kawachi I, Laden F, Colditz GA. Neighborhood socioeconomic status and behavioral pathways to risks of colon and rectal cancer in women. Cancer 2010; 116:4187-96. PubMed
  • Gallicchio L, Helzlsouer KJ, Chow WH, Freedman DM, Hankinson SE, Hartge P, Hartmuller V, Harvey C, Hayes RB, Horst RL, Koenig KL, Kolonel LN, Laden F, McCullough ML, Parisi D, Purdue MP, Shu XO, Snyder K, Stolzenberg-Solomon RZ, Tworoger SS, Varanasi A, Virtamo J, Wilkens LR, Xiang YB, Yu K, Zeleniuch-Jacquotte A, Zheng W, Abnet CC, Albanes D, Bertrand K, Weinstein SJ. Circulating 25-hydroxyvitamin D and the risk of rarer cancers: Design and methods of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol 2010; 172:10-20. PubMed
  • McCullough ML, Weinstein SJ, Freedman DM, Helzlsouer K, Flanders WD, Koenig K, Kolonel L, Laden F, Le Marchand L, Purdue M, Snyder K, Stevens VL, Stolzenberg-Solomon R, Virtamo J, Yang G, Yu K, Zheng W, Albanes D, Ashby J, Bertrand K, Cai H, Chen Y, Gallicchio L, Giovannucci E, Jacobs EJ, Hankinson SE, Hartge P, Hartmuller V, Harvey C, Hayes RB, Horst RL, Shu XO. Correlates of circulating 25-hydroxyvitamin D: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol 2010; 172:21-35. PubMed
  • Purdue MP, Freedman DM, Gapstur SM, Helzlsouer KJ, Laden F, Lim U, Maskarinec G, Rothman N, Shu XO, Stevens VL, Zeleniuch-Jacquotte A, Albanes D, Bertrand K, Weinstein SJ, Yu K, Irish L, Horst RL, Hoffman-Bolton J, Giovannucci EL, Kolonel LN, Snyder K, Willett W, Arslan AA, Hayes RB, Zheng W, Xiang YB, Hartge P. Circulating 25-hydroxyvitamin D and risk of non-hodgkin lymphoma: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol 2010; 172:58-69. PubMed
  • Laden F, Bertrand KA, Altshul L, Aster JC, Korrick SA, Sagiv SK. Plasma organochlorine levels and risk of non-Hodgkin lymphoma in the Nurses' Health Study. Cancer Epidemiol Biomarkers Prev 2010; 19:1381-4. PubMed
  • Bertrand KA, Spiegelman D, Aster JC, Altshul LM, Korrick SA, Rodig SJ, Zhang SM, Kurth T, Laden F. Plasma organochlorine levels and risk of non-Hodgkin lymphoma in a cohort of men. Epidemiology 2010; 21:172-80. PubMed
  • Chiu YH, Hart JE, Spiegelman D, Garshick E, Smith TJ, Dockery DW, Hammond SK, Laden F. Workplace secondhand smoke exposure in the u.s. Trucking industry. Environ Health Perspect 2010; 118:216-21. PubMed
  • Sheesley RJ, Schauer JJ, Garshick E, Laden F, Smith TJ, Blicharz AP, Deminter JT. Tracking personal exposure to particulate diesel exhaust in a diesel freight terminal using organic tracer analysis. J Expo Sci Environ Epidemiol 2009; 19:172-86. PubMed
  • Chiu YH,Hart JE,Smith TJ,Hammond SK,Garshick E,Laden F. Nicotine contamination in particulate matter sampling. Int J Environ Res Public Health 2009; 6:601-7. PubMed
  • Lee ML,Whitmore GA,Laden F,Hart JE,Garshick E. A case-control study relating railroad worker mortality to diesel exhaust exposure using a threshold regression model. Journal of Statistical Planning and Inference 2009; 139:1633-1642. PubMed
  • Garshick E,Laden F,Hart JE,Rosner B,Davis ME,Eisen EA,Smith TJ. Lung cancer and vehicle exhaust in trucking industry workers. Environ Health Perspect 2008; 116:1327-32. PubMed
  • Yanosky JD, Paciorek CJ, Schwartz J, Laden F, Puett R, Suh HH. Spatio-temporal modeling of chronic PM10 exposure for the Nurses' Health Study. 2009; 42:4047-4062. PubMed
  • Qureshi AA, Laden F, Colditz GA, Hunter DJ. Geographic variation and risk of skin cancer in US women. Differences between melanoma, squamous cell carcinoma, and basal cell carcinoma. Arch Intern Med 2008; 168:501-7. PubMed
  • Sheesley RJ, Schauer JJ, Smith TJ, Garshick E, Laden F, Marr LC, Molina LT. Assessment of diesel particulate matter exposure in the workplace: freight terminals. J Environ Monit 2008; 10:305-14. PubMed
  • Davis ME, Smith TJ, Laden F, Hart JE, Blicharz AP, Reaser P, Garshick E. Driver exposure to combustion particles in the U.S. Trucking industry. J Occup Environ Hyg 2007; 4:848-54. PubMed
  • Davis ME, Blicharz AP, Hart JE, Laden F, Garshick E, Smith TJ. Occupational exposure to volatile organic compounds and aldehydes in the U.S. trucking industry. Environ Sci Technol 2007; 41:7152-8. PubMed
  • Laden F, Hart JE, Smith TJ, Davis ME, Garshick E. Cause-specific mortality in the unionized U.S. trucking industry. Environ Health Perspect 2007; 115:1192-6. PubMed
  • Baxter LK, Clougherty JE, Laden F, Levy JI. Predictors of concentrations of nitrogen dioxide, fine particulate matter, and particle constituents inside of lower socioeconomic status urban homes. J Expo Sci Environ Epidemiol 2006; 17:433-44. PubMed
  • Engel LS, Laden F, Andersen A, Strickland PT, Blair A, Needham LL, Barr DB, Wolff MS, Helzlsouer K, Hunter DJ, Lan Q, Cantor KP, Comstock GW, Brock JW, Bush D, Hoover RN, Rothman N. Polychlorinated biphenyl levels in peripheral blood and non-Hodgkin's lymphoma: a report from three cohorts. Cancer Res 2007; 67:5545-52. PubMed
  • Garshick E, Laden F, Hart JE, Smith TJ, Rosner B. Smoking imputation and lung cancer in railroad workers exposed to diesel exhaust. Am J Ind Med 2006; 49:709-18. PubMed
  • Laden F, Hart JE, Eschenroeder A, Smith TJ, Garshick E. Historical estimation of diesel exhaust exposure in a cohort study of U.S. railroad workers and lung cancer. Cancer Causes Control 2006; 17:911-919. PubMed
  • Hart JE, Laden F, Schenker MB, Garshick E. Chronic obstructive pulmonary disease mortality in diesel-exposed railroad workers. Environ Health Perspect 2006; 114:1013-7. PubMed
  • Davis ME, Smith TJ, Laden F, Hart JE, Ryan LM, Garshick E. Modeling particle exposure in U.S. trucking terminals. Environ Sci Technol 2006; 40:4226-32. PubMed
  • Schernhammer ES, Kroenke CH, Laden F, Hankinson SE. Night work and risk of breast cancer. Epidemiology 2005; 17:108-11. PubMed
  • Megdal SP, Kroenke CH, Laden F, Pukkala E, Schernhammer ES. Night work and breast cancer risk: a systematic review and meta-analysis. Eur J Cancer 2005; 41:2023-32. PubMed
  • Garshick E, Laden F, Hart JE, Rosner B, Smith TJ, Dockery DW, Speizer FE. Lung cancer in railroad workers exposed to diesel exhaust. Environ Health Perspect 2004; 112:1539-43. PubMed
  • Quintana PJ, Delfino RJ, Korrick S, Ziogas A, Kutz FW, Jones EL, Laden F, Garshick E. Adipose tissue levels of organochlorine pesticides and polychlorinated biphenyls and risk of non-Hodgkin's lymphoma. Environ Health Perspect 2004; 112:854-61. PubMed
  • Schernhammer ES, Rosner B, Willett WC, Laden F, Colditz GA, Hankinson SE. Epidemiology of urinary melatonin in women and its relation to other hormones and night work. Cancer Epidemiol Biomarkers Prev 2004; 13:936-43. PubMed
  • Laden F, Stampfer MJ, Walker AM. Lung cancer and mesothelioma among male automobile mechanics: a review. Rev Environ Health 2004; 19:39-61. PubMed
  • Garshick E, Laden F, Hart JE, Caron A. Residence near a major road and respiratory symptoms in U.S. Veterans. Epidemiology 2003; 14:728-36. PubMed
  • Schernhammer ES, Laden F, Speizer FE, Willett WC, Hunter DJ, Kawachi I, Fuchs CS, Colditz GA. Night-shift work and risk of colorectal cancer in the nurses' health study. J Natl Cancer Inst 2003; 95:825-8. PubMed
  • Laden F, Ishibe N, Hankinson SE, Wolff MS, Gertig DM, Hunter DJ, Kelsey KT. Polychlorinated biphenyls, cytochrome P450 1A1, and breast cancer risk in the Nurses' Health Study. Cancer Epidemiol Biomarkers Prev 2002; 11:1560-5. PubMed
  • Laden F, Collman G, Iwamoto K, Alberg AJ, Berkowitz GS, Freudenheim JL, Hankinson SE, Helzlsouer KJ, Holford TR, Huang HY, Moysich KB, Tessari JD, Wolff MS, Zheng T, Hunter DJ. 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and polychlorinated biphenyls and breast cancer: combined analysis of five U.S. studies. J Natl Cancer Inst 2001; 93:768-76. PubMed
  • Laden F, Hankinson SE, Wolff MS, Colditz GA, Willett WC, Speizer FE, Hunter DJ. Plasma organochlorine levels and the risk of breast cancer: an extended follow-up in the Nurses' Health Study. Int J Cancer 2001; 91:568-74. PubMed
  • Laden F, Neas LM, Tolbert PE, Holmes MD, Hankinson SE, Spiegelman D, Speizer FE, Hunter DJ. Electric blanket use and breast cancer in the Nurses' Health Study. Am J Epidemiol 2000; 152:41-9. PubMed
  • Laden F, Neas LM, Spiegelman D, Hankinson SE, Willett WC, Ireland K, Wolff MS, Hunter DJ. Predictors of plasma concentrations of DDE and PCBs in a group of U.S. women. Environ Health Perspect 1999; 107:75-81. PubMed
  • Laden F, Hunter DJ. Environmental risk factors and female breast cancer. Annu Rev Public Health 1998; 19:101-23. PubMed
  • Hunter DJ, Hankinson SE, Laden F, Colditz GA, Manson JE, Willett WC, Speizer FE, Wolff MS. Plasma organochlorine levels and the risk of breast cancer. N Engl J Med 1997; 337:1253-8. PubMed
  • Laden F, Spiegelman D, Neas LM, Colditz GA, Hankinson SE, Manson JE, Byrne C, Rosner BA, Speizer FE, Hunter DJ. Geographic variation in breast cancer incidence rates in a cohort of U.S. women. J Natl Cancer Inst 1997; 89:1373-8. PubMed
  • Laden F, Wolff MS, Niguidula NJ, Spiegelman D, Hankinson SE, Hunter DJ. Reduced aliquot size for a plasma organochlorine assay for use in epidemiological studies. Cancer Epidemiol Biomarkers Prev 1997; 6:333-8. PubMed
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