Photo of Francis D. Moore,  MD

Francis D. Moore, MD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 732-6830
Fax: (617) 739-1728


fmoore@partners.org

Francis D. Moore, MD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Francis D. Moore Professor of Surgery, Surgery, Harvard Medical School
  • Head, Endocrine Surgery Unit, Brigham And Women's Hospital

Research Abstract

The research relevant to this site is clinical and involves improved methods of thyroid cancer surgery and treatment of thyroid cancers. Particular focus has been on reduction in surgical mobidity and in the acquisition of new scnaiing techniques to locate and destroy cancerous tissue before and during surgery. Cooperative studies on basic aspects of cancer development have been done in the past.

Publications

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  • Giles WH, Maclellan RA, Gawande AA, Ruan DT, Alexander EK, Moore FD, Cho NL. False Negative Cytology in Large Thyroid Nodules. Ann Surg Oncol 2014. PubMed
  • Gupta A, Ly S, Castroneves LA, Frates MC, Benson CB, Feldman HA, Wassner AJ, Smith JR, Marqusee E, Alexander EK, Barletta J, Muyide F, Doubilet PM, Peters HE, Webb S, Modi BP, Paltiel HJ, Martins Y, Burmeister K, Kozakewich H, Hollowell M, Cibas ES, Moore FD, Shamberger RC, Larsen PR, Huang SA. How are childhood thyroid nodules discovered: opportunities for improving early detection. J Pediatr 2014; 164:658-60. PubMed
  • Gupta A, Ly S, Castroneves LA, Frates MC, Benson CB, Feldman HA, Wassner AJ, Smith JR, Marqusee E, Alexander EK, Barletta J, Doubilet PM, Peters HE, Webb S, Modi BP, Paltiel HJ, Kozakewich H, Cibas ES, Moore FD, Shamberger RC, Larsen PR, Huang SA. A standardized assessment of thyroid nodules in children confirms higher cancer prevalence than in adults. J Clin Endocrinol Metab 2013; 98:3238-45. PubMed
  • Nehs MA, Ruan DT, Gawande AA, Moore FD, Cho NL. Bilateral Neck Exploration Decreases Operative Time Compared to Minimally Invasive Parathyroidectomy in Patients with Discordant Imaging. World J Surg 2013. PubMed
  • Kamran SC, Marqusee E, Kim MI, Frates MC, Ritner J, Peters H, Benson CB, Doubilet PM, Cibas ES, Barletta J, Cho N, Gawande A, Ruan D, Moore FD, Pou K, Larsen PR, Alexander EK. Thyroid nodule size and prediction of cancer. J Clin Endocrinol Metab 2013; 98:564-70. PubMed
  • Lin CI, Du J, Shen WT, Whang EE, Donner DB, Griff N, He F, Moore FD, Clark OH, Ruan DT. Mitogen-inducible gene-6 is a multifunctional adaptor protein with tumor suppressor-like activity in papillary thyroid cancer. J Clin Endocrinol Metab 2011; 96:E554-65. PubMed
  • Roh MH, Jo VY, Stelow EB, Faquin WC, Zou KH, Alexander EK, Larsen PR, Marqusee E, Benson CB, Frates MC, Gawande A, Moore FD, Cibas ES. The predictive value of the fine-needle aspiration diagnosis "suspicious for a follicular neoplasm, hurthle cell type" in patients with hashimoto thyroiditis. Am J Clin Pathol 2010; 135:139-45. PubMed
  • Lin CI, Whang EE, Donner DB, Du J, Lorch J, He F, Jiang X, Price BD, Moore FD, Ruan DT. Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through Met inhibition in papillary thyroid cancer. Mol Cancer Res 2010; 8:1217-26. PubMed
  • Cho NL, Lin CI, Whang EE, Carothers AM, Moore FD, Ruan DT. Sulindac reverses aberrant expression and localization of beta-catenin in papillary thyroid cancer cells with the BRAFV600E mutation. Thyroid 2010; 20:615-22. PubMed
  • Ahmadiyeh N, Cho NL, Kellogg KC, Lipsitz SR, Moore FD, Ashley SW, Zinner MJ, Breen EM. Career satisfaction of women in surgery: perceptions, factors, and strategies. J Am Coll Surg 2010; 210:23-8. PubMed
  • Lin CI, Whang EE, Abramson MA, Jiang X, Price BD, Donner DB, Moore FD, Ruan DT. Autophagy: a new target for advanced papillary thyroid cancer therapy. Surgery 2009; 146:1208-14. PubMed
  • Lin CI, Whang EE, Donner DB, Jiang X, Price BD, Carothers AM, Delaine T, Leffler H, Nilsson UJ, Nose V, Moore FD, Ruan DT. Galectin-3 targeted therapy with a small molecule inhibitor activates apoptosis and enhances both chemosensitivity and radiosensitivity in papillary thyroid cancer. Mol Cancer Res 2009; 7:1655-62. PubMed
  • Berne JD, Villarreal DH, McGovern TM, Rowe SA, Moore FO, Norwood SH. A Fatal Case of Posttraumatic Gastric Mucormycosis. J Trauma 2009; 66:933-5. PubMed
  • Lin CI,Whang EE,Abramson MA,Donner DB,Bertagnolli MM,Moore FD Jr,Ruan DT. Galectin-3 regulates apoptosis and doxorubicin chemoresistance in papillary thyroid cancer cells. Biochem Biophys Res Commun 2009; 379:626-31. PubMed
  • Ortis F, Pirot P, Naamane N, Kreins AY, Rasschaert J, Moore F, Theatre E, Verhaeghe C, Magnusson NE, Chariot A, Orntoft TF, Eizirik DL. Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells. Diabetologia 2008; 51:1213-25. PubMed
  • Moore FA, Nelson T, McKinley BA, Moore EE, Nathens AB, Rhee P, Puyana JC, Beilman GJ, Cohn SM. Massive transfusion in trauma patients: tissue hemoglobin oxygen saturation predicts poor outcome. J Trauma 2008; 64:1010-23. PubMed
  • Chan RK, Ruan DT, Gawande AA, Moore FD Jr. Surgery for hyperparathyroidism in image-negative patients. Arch Surg 2008; 143:335-7. PubMed
  • Demetriades D, Velmahos GC, Scalea TM, Jurkovich GJ, Karmy-Jones R, Teixeira PG, Hemmila MR, O'Connor JV, McKenney MO, Moore FO, London J, Singh MJ, Lineen E, Spaniolas K, Keel M, Sugrue M, Wahl WL, Hill J, Wall MJ, Moore EE, Margulies D, Malka V, Chan LS. Operative repair or endovascular stent graft in blunt traumatic thoracic aortic injuries: results of an American Association for the Surgery of Trauma Multicenter Study. J Trauma 2008; 64:561-70; discussion 570-1. PubMed
  • Cocanour CS, Dial ED, Lichtenberger LM, Gonzalez EA, Kozar RA, Moore FA, Mercer DW. Gastric alkalinization after major trauma. J Trauma 2008; 64:681-7. PubMed
  • Corbett SM, Montoya ID, Moore FA. Propofol-related infusion syndrome in intensive care patients. Pharmacotherapy 2008; 28:250-8. PubMed
  • Sucher JF, Moore FA, Todd SR, Sailors RM, McKinley BA. Computerized clinical decision support: a technology to implement and validate evidence based guidelines. J Trauma 2008; 64:520-37. PubMed
  • Dial E, Lopez-Storey M, Adams S, Lichtenberger L, Gonzalez E, McKinley B, Moore F, Mercer D. A report on associations among gastric pH, bleeding, duodenogastric reflux, and outcomes after trauma. J Trauma 2008; 64:105-10. PubMed
  • Yassa L, Cibas ES, Benson CB, Frates MC, Doubilet PM, Gawande AA, Moore FD, Kim BW, Nos. Long-term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluation. Cancer 2007; 111:508-16. PubMed
  • Moore FA. Evidence-based medical information technology: the next generation. J Trauma 2008; 63:1195-205. PubMed
  • Weeks C, Moratz C, Zacharia A, Stracener C, Egan R, Peckham R, Moore FD Jr, Tsokos GC. Decay-accelerating factor attenuates remote ischemia-reperfusion-initiated organ damage. Clin Immunol 2007; 124:311-27. PubMed
  • Moore FD, Dluhy RG. Prophylactic thyroidectomy in MEN-2A--a stitch in time? N Engl J Med 2005; 353:1162-4. PubMed
  • Shankar KB, Posner M, Moore FD, O'Rourke N. Laryngeal nerve monitoring during thyroid surgery in pregnancy. J Clin Anesth 2005; 17:369-71. PubMed
  • Abonia JP, Friend DS, Austen WG, Moore FD, Carroll MC, Chan R, Afnan J, Humbles A, Gerard C, Knight P, Kanaoka Y, Yasuda S, Morokawa N, Austen KF, Stevens RL, Gurish MF. Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle. J Immunol 2005; 174:7285-91. PubMed
  • Weeks C, Moore FD, Ferzoco SJ, Gates J. Blunt trauma to the thyroid: a case report. Am Surg 2005; 71:518-21. PubMed
  • Chan RK, Ibrahim SI, Pil P, Tanasijevic M, Moore FD. Validation of a method to replace frozen section during parathyroid exploration by using the rapid parathyroid hormone assay on parathyroid aspirates. Arch Surg 2005; 140:371-3. PubMed
  • Chan RK, Austen WG, Ibrahim S, Ding GY, Verna N, Hechtman HB, Moore FD. Reperfusion injury to skeletal muscle affects primarily type II muscle fibers. J Surg Res 2004; 122:54-60. PubMed
  • Chan RK, Ding G, Verna N, Ibrahim S, Oakes S, Austen WG, Hechtman HB, Moore FD. IgM binding to injured tissue precedes complement activation during skeletal muscle ischemia-reperfusion. J Surg Res 2004; 122:29-35. PubMed
  • Austen WG, Zhang M, Chan R, Friend D, Hechtman HB, Carroll MC, Moore FD. Murine hindlimb reperfusion injury can be initiated by a self-reactive monoclonal IgM. Surgery 2004; 136:401-6. PubMed
  • Zhang M, Austen WG, Chiu I, Alicot EM, Hung R, Ma M, Verna N, Xu M, Hechtman HB, Moore FD, Carroll MC. Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injury. Proc Natl Acad Sci U S A 2004; 101:3886-91. PubMed
  • Kifor O, McElduff A, LeBoff MS, Moore FD, Butters R, Gao P, Cantor TL, Kifor I, Brown EM. Activating antibodies to the calcium-sensing receptor in two patients with autoimmune hypoparathyroidism. J Clin Endocrinol Metab 2004; 89:548-56. PubMed
  • Yeh JJ, Lunetta KL, van Orsouw NJ, Moore FD, Mutter GL, Vijg J, Dahia PL, Eng C. Somatic mitochondrial DNA (mtDNA) mutations in papillary thyroid carcinomas and differential mtDNA sequence variants in cases with thyroid tumours. Oncogene 2000; 19:2060-6. PubMed
  • Williams JP, Pechet TT, Weiser MR, Reid R, Kobzik L, Moore FD, Carroll MC, Hechtman HB. Intestinal reperfusion injury is mediated by IgM and complement. J Appl Physiol 1999; 86:938-42. PubMed
  • Weiser MR, Pechet TT, Williams JP, Ma M, Frenette PS, Moore FD, Kobzik L, Hines RO, Wagner DD, Carroll MC, Hechtman HB. Experimental murine acid aspiration injury is mediated by neutrophils and the alternative complement pathway. J Appl Physiol 1997; 83:1090-5. PubMed
  • Fischer MB, Prodeus AP, Nicholson-Weller A, Ma M, Murrow J, Reid RR, Warren HB, Lage AL, Moore FD, Rosen FS, Carroll MC. Increased susceptibility to endotoxin shock in complement C3- and C4-deficient mice is corrected by C1 inhibitor replacement. J Immunol 1997; 159:976-82. PubMed
  • Moore FD, Jack RM, Antin JH. Peripheral blood neutrophils in chronically neutropenic patients respond to granulocyte-macrophage colony-stimulating factor with a specific increase in CR1 expression and CR1 transcription. Blood 1992; 79:1667-71. PubMed
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