Photo of Francis W. Luscinskas,  PhD

Francis W. Luscinskas, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 525-4337
Fax: (617) 525-4333


fluscinskas@rics.bwh.harvard.edu

Francis W. Luscinskas, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Professor, Pathology, Harvard Medical School
  • Associate Director, Vascular Research Division, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Publications

Powered by Harvard Catalyst
  • Brown JD, Lin CY, Duan Q, Griffin G, Federation AJ, Paranal RM, Bair S, Newton G, Lichtman AH, Kung AL, Yang T, Wang H, Luscinskas FW, Croce KJ, Bradner JE, Plutzky J. NF-虜B Directs Dynamic Super Enhancer Formation in Inflammation and Atherogenesis. Mol Cell 2014. PubMed
  • Massaad MJ, Oyoshi MK, Kane J, Koduru S, Alcaide P, Nakamura F, Ramesh N, Luscinskas FW, Hartwig J, Geha RS. Binding of WIP to Actin is Essential for T Cell Actin Cytoskeleton Integrity and Tissue Homing. Mol Cell Biol 2014. PubMed
  • Luscinskas FW, Imhof BA. Introduction for the special issue on new paradigms in leukocyte trafficking, lessons for therapeutics. Semin Immunopathol 2014; 36:133-6. PubMed
  • Martinelli R, Newton G, Carman CV, Greenwood J, Luscinskas FW. Novel role of CD47 in rat microvascular endothelium: signaling and regulation of T-cell transendothelial migration. Arterioscler Thromb Vasc Biol 2013; 33:2566-76. PubMed
  • Azcutia V, Routledge M, Williams MR, Newton G, Frazier WA, Manica A, Croce KJ, Parkos CA, Schmider AB, Turman MV, Soberman RJ, Luscinskas FW. CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions. Mol Biol Cell 2013; 24:3358-68. PubMed
  • Adams WJ, Zhang Y, Cloutier J, Kuchimanchi P, Newton G, Sehrawat S, Aird WC, Mayadas TN, Luscinskas FW, García-Cardeña G. Functional vascular endothelium derived from human induced pluripotent stem cells. Stem Cell Reports 2013; 1:105-13. PubMed
  • Azcutia V, Stefanidakis M, Tsuboi N, Mayadas T, Croce KJ, Fukuda D, Aikawa M, Newton G, Luscinskas FW. Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo. J Immunol 2012; 189:2553-62. PubMed
  • Alcaide P, Martinelli R, Newton G, Williams MR, Adam A, Vincent PA, Luscinskas FW. p120-Catenin prevents neutrophil transmigration independently of RhoA inhibition by impairing Src dependent VE-cadherin phosphorylation. Am J Physiol Cell Physiol 2012; 303:C385-95. PubMed
  • Griffin GK, Newton G, Tarrio ML, Bu DX, Maganto-Garcia E, Azcutia V, Alcaide P, Grabie N, Luscinskas FW, Croce KJ, Lichtman AH. IL-17 and TNF-留 sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation. J Immunol 2012; 188:6287-99. PubMed
  • Zhang J, Alcaide P, Liu L, Sun J, He A, Luscinskas FW, Shi GP. Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils. PLoS ONE 2011; 6:e14525. PubMed
  • Koduru S, Kumar L, Massaad MJ, Ramesh N, Le Bras S, Ozcan E, Oyoshi MK, Kaku M, Fujiwara Y, Kremer L, King S, Fuhlbrigge R, Rodig S, Sage P, Carman C, Alcaide P, Luscinskas FW, Geha RS. Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking. Proc Natl Acad Sci U S A 2010; 107:16252-6. PubMed
  • Luscinskas FW. Neutrophil CD44 rafts and rolls. Blood 2010; 116:314-5. PubMed
  • Alcaide P,Auerbach S,Luscinskas FW. Neutrophil recruitment under shear flow: it's all about endothelial cell rings and gaps. Microcirculation 2008; 16:43-57. PubMed
  • Alcaide P,Newton G,Auerbach S,Sehrawat S,Mayadas TN,Golan DE,Yacono P,Vincent P,Kowalczyk A,Luscinskas FW. p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation. Blood 2008; 112:2770-9. PubMed
  • Stefanidakis M,Newton G,Lee WY,Parkos CA,Luscinskas FW. Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro. Blood 2008; 112:1280-9. PubMed
  • Rabodzey A, Alcaide P, Luscinskas FW, Ladoux B. Mechanical forces induced by the transendothelial migration of human neutrophils. Biophys J 2008; 95:1428-38. PubMed
  • Ghandour H, Cullere X, Alvarez A, Luscinskas FW, Mayadas TN. Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion. Blood 2007; 110:3682-90. PubMed
  • Rabodzey A, Yao Y, Luscinskas FW, Shaw SK, Dewey CF Jr. Early response of endothelial cells to flow is mediated by VE-cadherin. Cell Commun Adhes 2007; 14:195-209. PubMed
  • Rao RM, Yang L, Garcia-Cardena G, Luscinskas FW. Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall. Circ Res 2007; 101:234-47. PubMed
  • Alcaide P, King SL, Dimitroff CJ, Lim YC, Fuhlbrigge RC, Luscinskas FW. The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo. J Invest Dermatol 2007; 127:1964-72. PubMed
  • Alcaide P, Jones TG, Lord GM, Glimcher LH, Hallgren J, Arinobu Y, Akashi K, Paterson AM, Gurish MA, Luscinskas FW. Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue. J Exp Med 2007; 204:431-9. PubMed
  • Yang L, Kowalski JR, Zhan X, Thomas SM, Luscinskas FW. Endothelial cell cortactin phosphorylation by Src contributes to polymorphonuclear leukocyte transmigration in vitro. Circ Res 2005; 98:394-402. PubMed
  • Lord GM, Rao RM, Choe H, Sullivan BM, Lichtman AH, Luscinskas FW, Glimcher LH. T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Blood 2005; 106:3432-9. PubMed
  • Yang L, Froio RM, Sciuto TE, Dvorak AM, Alon R, Luscinskas FW. ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow. Blood 2005; 106:584-92. PubMed
  • Cullere X, Shaw SK, Andersson L, Hirahashi J, Luscinskas FW, Mayadas TN. Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase. Blood 2004; 105:1950-5. PubMed
Hide