Frank B. Hu, MD, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 432-0113
Fax: (617) 432-3435


frank.hu@channing.harvard.edu

Frank B. Hu, MD, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Professor, Medicine, Harvard Medical School
  • Professor, Nutrition, Harvard T.H. Chan School Of Public Health
  • Professor, Medicine, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Dr. Hu's research is focused on determinants and consequences of obesity and type 2 diabetes. He is the Principal Investigator of the diabetes component of the Nurses' Health Study. He has extensive experience in investigating nutritional, biochemical, environmental, and genetic factors of diabetes and its cardiovascular complications. Dr. Hu has published more than 400 original papers and reviews and is the principle author of the textbook “Obesity Epidemiology” (Oxford University Press 2008). He is Co-Director of Program in Obesity Epidemiology and Prevention at Harvard and also serves as Director of Epidemiology and Genetics Core at Boston Obesity Nutrition Research Center. Dr. Hu currently serves on the Obesity Guideline Expert Panel at NHLBI and Gene, Environment Association Studies (GENEVA) Steering Committee at NHGRI. He is the receipt of the 2010 Kelly West Award in Outstanding Achievement in Diabetes Epidemiology. As a co-investigator for the current project, Dr. Hu will share his tremendous expertise and experiences in diabetes research with the PI, Dr. Grandjean, and will primarily contribute to epidemiologic study design, statistical analysis, and result interpretation.

Publications

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  • Rhee JJ, Sampson L, Cho E, Hughes MD, Hu FB, Willett WC. Comparison of methods to account for implausible reporting of energy intake in epidemiologic studies. Am J Epidemiol 2015; 181:225-33. PubMed
  • Satija A, Spiegelman D, Giovannucci E, Hu FB. Type 2 diabetes and risk of cancer. BMJ 2015; 350:g7707. PubMed
  • Satija A, Yu E, Willett WC, Hu FB. Understanding nutritional epidemiology and its role in policy. Adv Nutr 2015; 6:5-18. PubMed
  • Yuan C, Rubinson DA, Qian ZR, Wu C, Kraft P, Bao Y, Ogino S, Ng K, Clancy TE, Swanson RS, Gorman MJ, Brais LK, Li T, Stampfer MJ, Hu FB, Giovannucci EL, Kulke MH, Fuchs CS, Wolpin BM. Survival among patients with pancreatic cancer and long-standing or recent-onset diabetes mellitus. J Clin Oncol 2014; 33:29-35. PubMed
  • Shi Y, Hu FB. The global implications of diabetes and cancer. Lancet 2014; 383:1947-8. PubMed
  • Nimptsch K, Malik VS, Fung TT, Pischon T, Hu FB, Willett WC, Fuchs CS, Ogino S, Chan AT, Giovannucci E, Wu K. Dietary patterns during high school and risk of colorectal adenoma in a cohort of middle-aged women. Int J Cancer 2014; 134:2458-67. PubMed
  • Huang T, Qi Q, Li Y, Hu FB, Bray GA, Sacks FM, Williamson DA, Qi L. FTO genotype, dietary protein, and change in appetite: the Preventing Overweight Using Novel Dietary Strategies trial. Am J Clin Nutr 2014; 99:1126-30. PubMed
  • Song M, Chan AT, Fuchs CS, Ogino S, Hu FB, Mozaffarian D, Ma J, Willett WC, Giovannucci EL, Wu K. Dietary intake of fish, ω-3 and ω-6 fatty acids and risk of colorectal cancer: A prospective study in U.S. men and women. Int J Cancer 2014. PubMed
  • Fontana L, Hu FB. Optimal body weight for health and longevity: bridging basic, clinical, and population research. Aging Cell 2014. PubMed
  • Qi Q, Chu AY, Kang JH, Huang J, Rose LM, Jensen MK, Liang L, Curhan GC, Pasquale LR, Wiggs JL, De Vivo I, Chan AT, Choi HK, Tamimi RM, Ridker PM, Hunter DJ, Willett WC, Rimm EB, Chasman DI, Hu FB, Qi L. Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies. BMJ 2014; 348:g1610. PubMed
  • Falbe J, Rosner B, Willett WC, Sonneville KR, Hu FB, Field AE. Adiposity and different types of screen time. Pediatrics 2013; 132:e1497-505. PubMed
  • Tee MC, Cao Y, Warnock GL, Hu FB, Chavarro JE. Effect of bariatric surgery on oncologic outcomes: a systematic review and meta-analysis. Surg Endosc 2013; 27:4449-56. PubMed
  • Bao Y, Han J, Hu FB, Giovannucci EL, Stampfer MJ, Willett WC, Fuchs CS. Association of nut consumption with total and cause-specific mortality. N Engl J Med 2013; 369:2001-11. PubMed
  • Stefan N, Häring HU, Hu FB, Schulze MB. Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications. Lancet Diabetes Endocrinol 2014; 1:152-62. PubMed
  • Varga TV, Hallmans G, Hu FB, Renström F, Franks PW. Smoking status, snus use, and variation at the CHRNA5-CHRNA3-CHRNB4 locus in relation to obesity: the GLACIER study. Am J Epidemiol 2013; 178:31-7. PubMed
  • Fung TT, Chiuve SE, Willett WC, Hankinson SE, Hu FB, Holmes MD. Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women. Breast Cancer Res Treat 2013; 138:925-30. PubMed
  • Patterson RE, Colditz GA, Hu FB, Schmitz KH, Ahima RS, Brownson RC, Carson KR, Chavarro JE, Chodosh LA, Gehlert S, Gill J, Glanz K, Haire-Joshu D, Herbst KL, Hoehner CM, Hovmand PS, Irwin ML, Jacobs LA, James AS, Jones LW, Kerr J, Kibel AS, King IB, Ligibel JA, Meyerhardt JA, Natarajan L, Neuhouser ML, Olefsky JM, Proctor EK, Redline S, Rock CL, Rosner B, Sarwer DB, Schwartz JS, Sears DD, Sesso HD, Stampfer MJ, Subramanian SV, Taveras EM, Tchou J, Thompson B, Troxel AB, Wessling-Resnick M, Wolin KY, Thornquist MD. The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) initiative: rationale and design. Cancer Causes Control 2013; 24:695-704. PubMed
  • He M, Wu C, Xu J, Guo H, Yang H, Zhang X, Sun J, Yu D, Zhou L, Peng T, He Y, Gao Y, Yuan J, Deng Q, Dai X, Tan A, Feng Y, Zhang H, Min X, Yang X, Zhu J, Zhai K, Chang J, Qin X, Tan W, Hu Y, Lang M, Tao S, Li Y, Li Y, Feng J, Li D, Kim ST, Zhang S, Zhang H, Zheng SL, Gui L, Wang Y, Wei S, Wang F, Fang W, Liang Y, Zhai Y, Chen W, Miao X, Zhou G, Hu FB, Lin D, Mo Z, Wu T. A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and 留 fetoprotein and their associations with cancer risk. Gut 2013. PubMed
  • Izano MA, Fung TT, Chiuve SS, Hu FB, Holmes MD. Are diet quality scores after breast cancer diagnosis associated with improved breast cancer survival? Nutr Cancer 2013; 65:820-6. PubMed
  • Ahmad S, Rukh G, Varga TV, Ali A, Kurbasic A, Shungin D, Ericson U, Koivula RW, Chu AY, Rose LM, Ganna A, Qi Q, Stančáková A, Sandholt CH, Elks CE, Curhan G, Jensen MK, Tamimi RM, Allin KH, Jørgensen T, Brage S, Langenberg C, Aadahl M, Grarup N, Linneberg A, Paré G, , , Magnusson PK, Pedersen NL, Boehnke M, Hamsten A, Mohlke KL, Pasquale LT, Pedersen O, Scott RA, Ridker PM, Ingelsson E, Laakso M, Hansen T, Qi L, Wareham NJ, Chasman DI, Hallmans G, Hu FB, Renström F, Orho-Melander M, Franks PW. Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry. PLoS Genet. 2013; 9:e1003607. PubMed
  • He Y, Jiang B, Li LS, Li LS, Ko L, Wu L, Sun DL, He SF, Liang BQ, Hu FB, Lam TH. Secondhand smoke exposure predicted COPD and other tobacco-related mortality in a 17-year cohort study in China. Chest 2013; 142:909-18. PubMed
  • Pan A, Lucas M, Sun Q, van Dam RM, Franco OH, Willett WC, Manson JE, Rexrode KM, Ascherio A, Hu FB. Increased mortality risk in women with depression and diabetes mellitus. Arch Gen Psychiatry 2011; 68:42-50. PubMed
  • Pan A, Lucas M, Sun Q, van Dam RM, Franco OH, Manson JE, Willett WC, Ascherio A, Hu FB. Bidirectional association between depression and type 2 diabetes mellitus in women. Arch Intern Med 2010; 170:1884-91. PubMed
  • He M, Cornelis MC, Franks PW, Zhang C, Hu FB, Qi L. Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus. Arterioscler Thromb Vasc Biol 2010; 30:327-32. PubMed
  • Qi Q, Li H, Loos RJ, Liu C, Hu FB, Wu H, Yu Z, Lin X. Association of PCSK1 rs6234 with obesity and related traits in a Chinese Han population. PLoS ONE 2010; 5:e10590. PubMed
  • Cornelis MC, Qi L, Kraft P, Hu FB. TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women. Am J Clin Nutr 2009; 89:1256-62. PubMed
  • Qi L, Kraft P, Hunter DJ, Hu FB. The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women. Hum Mol Genet 2008; 17:3502-8. PubMed
  • Qi L,Kang K,Zhang C,van Dam RM,Kraft P,Hunter D,Lee CH,Hu FB. Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. Diabetes 2008; 57:3145-51. PubMed
  • Loos RJ,Lindgren CM,Li S,Wheeler E,Zhao JH,Prokopenko I,Inouye M,Freathy RM,Attwood AP,Beckmann JS,Berndt SI,Jacobs KB,Chanock SJ,Hayes RB,Bergmann S,Bennett AJ,Bingham SA,Bochud M,Brown M,Cauchi S,Connell JM,Cooper C,Smith GD,Day I,Dina C,De S,Dermitzakis ET,Doney AS,Elliott KS,Elliott P,Evans DM,Sadaf Farooqi I,Froguel P,Ghori J,Groves CJ,Gwilliam R,Hadley D,Hall AS,Hattersley AT,Hebebrand J,Heid IM,Lamina C,Gieger C,Illig T,Meitinger T,Wichmann HE,Herrera B,Hinney A,Hunt SE,Jarvelin MR,Johnson T,Jolley JD,Karpe F,Keniry A,Khaw KT,Luben RN,Mangino M,Marchini J,McArdle WL,McGinnis R,Meyre D,Munroe PB,Morris AD,Ness AR,Neville MJ,Nica AC,Ong KK,O'Rahilly S,Owen KR,Palmer CN,Papadakis K,Potter S,Pouta A,Qi L,Randall JC,Rayner NW,Ring SM,Sandhu MS,Scherag A,Sims MA,Song K,Soranzo N,Speliotes EK,Syddall HE,Teichmann SA,Timpson NJ,Tobias JH,Uda M,Vogel CI,Wallace C,Waterworth DM,Weedon MN,Willer CJ,Wraight,Yuan X,Zeggini E,Hirschhorn JN,Strachan DP,Ouwehand WH,Caulfield MJ,Samani NJ,Frayling TM,Vollenweider P,Waeber G,Mooser V,Deloukas P,McCarthy MI,Wareham NJ,Barroso I,Jacobs KB,Chanock SJ,Hayes RB,Lamina C,Gieger C,Illig T,Meitinger T,Wichmann HE,Kraft P,Hankinson SE,Hunter DJ,Hu FB,Lyon HN,Voight BF,Ridderstrale M,Groop L,Scheet P,Sanna S,Abecasis GR,Albai G,Nagaraja R,Schlessinger D,Jackson AU,Tuomilehto J,Collins FS,Boehnke M,Mohlke KL. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008; 40:768-75. PubMed
  • Lettre G, Jackson AU, Gieger C, Schumacher FR, Berndt SI, Sanna S, Eyheramendy S, Voight BF, Butler JL, Guiducci C, Illig T, Hackett R, Heid IM, Jacobs KB, Lyssenko V, Uda M, , , , , , , Boehnke M, Chanock SJ, Groop LC, Hu FB, Isomaa B, Kraft P, Peltonen L, Salomaa V, Schlessinger D, Hunter DJ, Hayes RB, Abecasis GR, Wichmann HE, Mohlke KL, Hirschhorn JN. Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet 2008; 40:584-91. PubMed
  • Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PI, Abecasis GR, Almgren P, Andersen G, Ardlie K, Bostrom KB, Bergman RN, Bonnycastle LL, Borch-Johnsen K, Burtt NP, Chen H, Chines PS, Daly MJ, Deodhar P, Ding CJ, Doney AS, Duren WL, Elliott KS, Erdos MR, Frayling TM, Freathy RM, Gianniny L, Grallert H, Grarup N, Groves CJ, Guiducci C, Hansen T, Herder C, Hitman GA, Hughes TE, Isomaa B, Jackson AU, Jorgensen T, Kong A, Kubalanza K, Kuruvilla FG, Kuusisto J, Langenberg C, Lango H, Lauritzen T, Li Y, Lindgren CM, Lyssenko V, Marvelle AF, Meisinger C, Midthjell K, Mohlke KL, Morken MA, Morris AD, Narisu N, Nilsson P, Owen KR, Palmer CN, Payne F, Perry JR, Pettersen E, Platou C, Prokopenko I, Qi L, Qin L, Rayner NW, Rees M, Roix JJ, Sandbaek A, Shields B, Sjogren M, Steinthorsdottir V, Stringham HM, Swift AJ, Thorleifsson G, Thorsteinsdottir U, Timpson NJ, Tuomi T, Tuomilehto J, Walker M, Watanabe RM, Weedon MN, Willer CJ, Illig T, Hveem K, Hu FB, Laakso M, Stefansson K, Pedersen O, Wareham NJ, Barroso I, Hattersley AT, Collins FS, Groop L, McCarthy MI, Boehnke M, Altshuler D. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 2008; 40:638-45. PubMed
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