Photo of Frank Slack,  PhD

Frank Slack, PhD

Beth Israel Deaconess Medical Center

Beth Israel Deaconess Medical Center
Phone: (617) 735-2601


fslack@bidmc.harvard.edu

Frank Slack, PhD

Beth Israel Deaconess Medical Center

EDUCATIONAL TITLES

  • Professor, Pathology, Harvard Medical School
  • Professor, Pathology, Beth Israel Deaconess Medical Center
  • Director, Institute for RNA Medicine, BIDMC Cancer Center, Beth Israel Deaconess Medical Center

DF/HCC PROGRAM AFFILIATION

Publications

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  • Smith-Vikos T, Liu Z, Parsons C, Gorospe M, Ferrucci L, Gill TM, Slack FJ. A serum miRNA profile of human longevity: findings from the Baltimore Longitudinal Study of Aging (BLSA). Aging (Albany NY) 2016; 8:2971-2987. PubMed
  • Zhang WC, Slack FJ. ADARs Edit MicroRNAs to Promote Leukemic Stem Cell Activity. Cell Stem Cell 2016; 19:141-2. PubMed
  • Pincus Z, Mazer TC, Slack FJ. Autofluorescence as a measure of senescence in C. elegans: look to red, not blue or green. Aging (Albany NY) 2016. PubMed
  • Kim M, Kogan N, Slack FJ. Cis-acting elements in its 3' UTR mediate post-transcriptional regulation of KRAS. 2016. PubMed
  • Adams BD, Wali VB, Cheng CJ, Inukai S, Booth CJ, Agarwal S, Rimm DL, Győrffy B, Santarpia L, Pusztai L, Saltzman WM, Slack FJ. miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple-Negative Breast Cancer. Cancer Res 2016; 76:927-39. PubMed
  • Rupaimoole R, Slack FJ. A role for miR-34 in colon cancer stem cell homeostasis. Stem Cell Investig 2016; 3:42. PubMed
  • Salzman DW, Nakamura K, Nallur S, Dookwah MT, Metheetrairut C, Slack FJ, Weidhaas JB. miR-34 activity is modulated through 5'-end phosphorylation in response to DNA damage. Nat Commun 2016; 7:10954. PubMed
  • Adams BD, Parsons C, Slack FJ. The tumor-suppressive and potential therapeutic functions of miR-34a in epithelial carcinomas. Expert Opin Ther Targets 2015. PubMed
  • Adams BD, Anastasiadou E, Esteller M, He L, Slack FJ. The Inescapable Influence of Noncoding RNAs in Cancer. Cancer Res 2015. PubMed
  • Coira IF, Rufino-Palomares EE, Romero OA, Peinado P, Metheetrairut C, Boyero-Corral L, Carretero J, Farez-Vidal E, Cuadros M, Reyes-Zurita FJ, Lupiáñez JA, Sánchez-Cespedes M, Slack FJ, Medina PP. Expression inactivation of SMARCA4 by microRNAs in lung tumors. Hum Mol Genet 2015; 24:1400-9. PubMed
  • Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM, Saltzman WM, Slack FJ. MicroRNA silencing for cancer therapy targeted to the tumour microenvironment. Nature 2015; 518:107-10. PubMed
  • McVeigh TP, Jung SY, Kerin MJ, Salzman DW, Nallur S, Nemec AA, Dookwah M, Sadofsky J, Paranjape T, Kelly O, Chan E, Miller N, Sweeney KJ, Zelterman D, Sweasy J, Pilarski R, Telesca D, Slack FJ, Weidhaas JB. Estrogen withdrawal, increased breast cancer risk and the KRAS-variant. Cell Cycle 2015; 14:2091-9. PubMed
  • Stahlhut C, Slack FJ. Combinatorial Action of MicroRNAs let-7 and miR-34 Effectively Synergizes with Erlotinib to Suppress Non-small Cell Lung Cancer Cell Proliferation. Cell Cycle 2015. PubMed
  • Anastasiadou E, Slack FJ. Cancer. Malicious exosomes. Science 2014; 346:1459-60. PubMed
  • Smith-Vikos T, de Lencastre A, Inukai S, Shlomchik M, Holtrup B, Slack FJ. MicroRNAs mediate dietary-restriction-induced longevity through PHA-4/FOXA and SKN-1/Nrf transcription factors. Curr Biol 2014; 24:2238-46. PubMed
  • Gerstein MB, Rozowsky J, Yan KK, Wang D, Cheng C, Brown JB, Davis CA, Hillier L, Sisu C, Li JJ, Pei B, Harmanci AO, Duff MO, Djebali S, Alexander RP, Alver BH, Auerbach R, Bell K, Bickel PJ, Boeck ME, Boley NP, Booth BW, Cherbas L, Cherbas P, Di C, Dobin A, Drenkow J, Ewing B, Fang G, Fastuca M, Feingold EA, Frankish A, Gao G, Good PJ, Guigó R, Hammonds A, Harrow J, Hoskins RA, Howald C, Hu L, Huang H, Hubbard TJ, Huynh C, Jha S, Kasper D, Kato M, Kaufman TC, Kitchen RR, Ladewig E, Lagarde J, Lai E, Leng J, Lu Z, MacCoss M, May G, McWhirter R, Merrihew G, Miller DM, Mortazavi A, Murad R, Oliver B, Olson S, Park PJ, Pazin MJ, Perrimon N, Pervouchine D, Reinke V, Reymond A, Robinson G, Samsonova A, Saunders GI, Schlesinger F, Sethi A, Slack FJ, Spencer WC, Stoiber MH, Strasbourger P, Tanzer A, Thompson OA, Wan KH, Wang G, Wang H, Watkins KL, Wen J, Wen K, Xue C, Yang L, Yip K, Zaleski C, Zhang Y, Zheng H, Brenner SE, Graveley BR, Celniker SE, Gingeras TR, Waterston R. Comparative analysis of the transcriptome across distant species. Nature 2014; 512:445-8. PubMed
  • Kim M, Slack FJ. MicroRNA-mediated regulation of KRAS in cancer. J Hematol Oncol 2015; 7:84. PubMed
  • Medina PP, Nolde M, Slack FJ. OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature 2010; 467:86-90. PubMed
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