Frederick C. Wang, MD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 525-4258
Fax: (617) 525-4257


fcwang@partners.org

Frederick C. Wang, MD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Professor, Medicine, Harvard Medical School
  • Professor, Microbiology and Immunobiology, Harvard Medical School
  • Medical Director, Clinical Virology Laboratory, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Epstein-Barr Virus (EBV) is a human herpesvirus in the lymphocryptovirus subgroup which infects and persists asymptomatically for life in most humans. EBV infection is also associated with the development of Burkitt's Lymphoma, nasopharyngeal carcinoma, and B cell lymphomas in AIDS and other immunosuppressed patients. Our research is focused on the molecular pathogenesis of lymphocryptoviruses and utilizes a rhesus monkey model for EBV infection that we have recently developed. We are specifically interested in the role of specific LCV genes during acute infection in a natural host, during persistent infection, and for tumorigenesis. We are focusing on the virus: host interactions in immunocompetent, as well as immunosuppressed (eg HIV and SIV infected) hosts that are important for control of EBV infection and EBV-induced lymphoproliferative disease. The interaction of LCV with epithelial cells in the oropharynx is also an important issue that is being addressed in the animal model and which has important implications for EBV-associated nasopharyngeal carcinoma.

Publications

Powered by Harvard Catalyst
  • Wang F, Arun P, Friedman J, Chen Z, Van Waes C. Current and potential inflammation targeted therapies in head and neck cancer. Curr Opin Pharmacol 2009; 9:389-95. PubMed
  • Fogg MH,Wirth LJ,Posner M,Wang F. Decreased EBNA-1-specific CD8+ T cells in patients with Epstein-Barr virus-associated nasopharyngeal carcinoma. Proc Natl Acad Sci U S A 2009; 106:3318-23. PubMed
  • Chen A, Zhao B, Kieff E, Aster JC, Wang F. EBNA-3B- and EBNA-3C-regulated cellular genes in Epstein-Barr virus-immortalized lymphoblastoid cell lines. J Virol 2006; 80:10139-50. PubMed
  • Li J, Wang F, Mamon H, Kulke MH, Harris L, Maher E, Wang L, Makrigiorgos GM. Antiprimer quenching-based real-time PCR and its application to the analysis of clinical cancer samples. Clin Chem 2006; 52:624-33. PubMed
  • Smith PG, Wang F, Wilkinson KN, Savage KJ, Klein U, Neuberg DS, Bollag G, Shipp MA, Aguiar RC. The phosphodiesterase PDE4B limits cAMP associated, PI3K-AKT dependent, apoptosis in diffuse large B-cell lymphoma. Blood 2004; 105:308-16. PubMed
  • Rivailler P, Cho YG, Wang F. Complete genomic sequence of an Epstein-Barr virus-related herpesvirus naturally infecting a new world primate: a defining point in the evolution of oncogenic lymphocryptoviruses. J Virol 2002; 76:12055-68. PubMed
  • Schmidtko J, Wang R, Wu CL, Mauiyyedi S, Harris NL, Della Pelle P, Brousaides N, Zagachin L, Ferry JA, Wang F, Kawai T, Sachs DH, Cosimi BA, Colvin RB. Posttransplant lymphoproliferative disorder associated with an Epstein-Barr-related virus in cynomolgus monkeys. Transplantation 2002; 73:1431-9. PubMed
  • Rivailler P, Jiang H, Cho YG, Quink C, Wang F. Complete nucleotide sequence of the rhesus lymphocryptovirus: genetic validation for an Epstein-Barr virus animal model. J Virol 2001; 76:421-6. PubMed
  • Cho Y, Ramer J, Rivailler P, Quink C, Garber RL, Beier DR, Wang F. An Epstein-Barr-related herpesvirus from marmoset lymphomas. Proc Natl Acad Sci U S A 2001; 98:1224-9. PubMed
  • Cho YG, Gordadze AV, Ling PD, Wang F. Evolution of two types of rhesus lymphocryptovirus similar to type 1 and type 2 Epstein-Barr virus. J Virol 1999; 73:9206-12. PubMed
  • Blake NW, Moghaddam A, Rao P, Kaur A, Glickman R, Cho YG, Marchini A, Haigh T, Johnson RP, Rickinson AB, Wang F. Inhibition of antigen presentation by the glycine/alanine repeat domain is not conserved in simian homologues of Epstein-Barr virus nuclear antigen 1. J Virol 1999; 73:7381-9. PubMed
  • Ridker PM, Hennekens CH, Stampfer MJ, Wang F. Prospective study of herpes simplex virus, cytomegalovirus, and the risk of future myocardial infarction and stroke. Circulation 1998; 98:2796-9. PubMed
  • Moghaddam A, Rosenzweig M, Lee-Parritz D, Annis B, Johnson RP, Wang F. An animal model for acute and persistent Epstein-Barr virus infection. Science 1997; 276:2030-3. PubMed
  • Franken M, Estabrooks A, Cavacini L, Sherburne B, Wang F, Scadden DT. Epstein-Barr virus-driven gene therapy for EBV-related lymphomas. Nat Med 1996; 2:1379-82. PubMed
Hide