Gabriel Corfas, PhD

Boston Children's Hospital

Boston Children's Hospital
Phone: (617) 355-7364
Fax: (617) 738-1542


gabriel.corfas@childrens.harvard.edu

Gabriel Corfas, PhD

Boston Children's Hospital

EDUCATIONAL TITLES

  • Professor, Neurology, Harvard Medical School
  • Professor, Otology and Laryngology, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Research Abstract

A major focus in our laboratory is the role of the erbB receptors and their ligands, the neuregulins, in the development and function of the nervous system. Using molecular and cellular biological techniques, as well as genetically modified mice we are studying the role of erbB receptor signaling in glial poliferation, differentiation and function. Since overexpression of erbB receptors (in particular erbB2/neu) can lead to oncogenesis we are also studying the molecular mechanisms that regulate the expression of these receptors.

Publications

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  • Giera S, Deng Y, Luo R, Ackerman SD, Mogha A, Monk KR, Ying Y, Jeong SJ, Makinodan M, Bialas AR, Chang BS, Stevens B, Corfas G, Piao X. The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development. Nat Commun 2015; 6:6121. PubMed
  • Hedstrom KL, Murtie JC, Albers K, Calcutt NA, Corfas G. Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFR留/RET receptor signaling. Proc Natl Acad Sci U S A 2014; 111:2325-30. PubMed
  • Xu P, Rosen KM, Hedstrom K, Rey O, Guha S, Hart C, Corfas G. Nerve injury induces glial cell line-derived neurotrophic factor (gdnf) expression in schwann cells through purinergic signaling and the pkc-pkd pathway. Glia 2013. PubMed
  • Ross SE, Mardinly AR, McCord AE, Zurawski J, Cohen S, Jung C, Hu L, Mok SI, Shah A, Savner EM, Tolias C, Corfas R, Chen S, Inquimbert P, Xu Y, McInnes RR, Rice FL, Corfas G, Ma Q, Woolf CJ, Greenberg ME. Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron 2010; 65:886-98. PubMed
  • Koirala S, Corfas G. Identification of novel glial genes by single-cell transcriptional profiling of Bergmann glial cells from mouse cerebellum. PLoS ONE 2010; 5:e9198. PubMed
  • Koirala S, Jin Z, Piao X, Corfas G. GPR56-regulated granule cell adhesion is essential for rostral cerebellar development. J Neurosci 2009; 29:7439-49. PubMed
  • Lok J,Sardi SP,Guo S,Besancon E,Ha DM,Rosell A,Kim WJ,Corfas G,Lo EH. Neuregulin-1 signaling in brain endothelial cells. J Cereb Blood Flow Metab 2008; 29:39-43. PubMed
  • Benny O,Fainaru O,Adini A,Cassiola F,Bazinet L,Adini I,Pravda E,Nahmias Y,Koirala S,Corfas G,D'Amato RJ,Folkman J. An orally delivered small-molecule formulation with antiangiogenic and anticancer activity. Nat Biotechnol 2008; 26:799-807. PubMed
  • Li S,Jin Z,Koirala S,Bu L,Xu L,Hynes RO,Walsh CA,Corfas G,Piao X. GPR56 regulates pial basement membrane integrity and cortical lamination. J Neurosci 2008; 28:5817-26. PubMed
  • Murtie JC, Macklin WB, Corfas G. Morphometric analysis of oligodendrocytes in the adult mouse frontal cortex. J Neurosci Res 2007; 85:2080-6. PubMed
  • Sugawara M, Murtie JC, Stankovic KM, Liberman MC, Corfas G. Dynamic patterns of neurotrophin 3 expression in the postnatal mouse inner ear. J Comp Neurol 2007; 501:30-7. PubMed
  • Sardi SP, Murtie J, Koirala S, Patten BA, Corfas G. Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell 2006; 127:185-97. PubMed
  • Rieff HI, Corfas G. ErbB receptor signalling regulates dendrite formation in mouse cerebellar granule cells in vivo. Eur J Neurosci 2006; 23:2225-9. PubMed
  • Patten BA, Sardi SP, Koirala S, Nakafuku M, Corfas G. Notch1 signaling regulates radial glia differentiation through multiple transcriptional mechanisms. J Neurosci 2006; 26:3102-8. PubMed
  • Chen S, Velardez MO, Warot X, Yu ZX, Miller SJ, Cros D, Corfas G. Neuregulin 1-erbB signaling is necessary for normal myelination and sensory function. J Neurosci 2006; 26:3079-86. PubMed
  • Ge W, He F, Kim KJ, Blanchi B, Coskun V, Nguyen L, Wu X, Zhao J, Heng JI, Martinowich K, Tao J, Wu H, Castro D, Sobeih MM, Corfas G, Gleeson JG, Greenberg ME, Guillemot F, Sun YE. Coupling of cell migration with neurogenesis by proneural bHLH factors. Proc Natl Acad Sci U S A 2006; 103:1319-24. PubMed
  • Sahin M, Greer PL, Lin MZ, Poucher H, Eberhart J, Schmidt S, Wright TM, Shamah SM, O'connell S, Cowan CW, Hu L, Goldberg JL, Debant A, Corfas G, Krull CE, Greenberg ME. Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse. Neuron 2005; 46:191-204. PubMed
  • Borghesani PR, Peyrin JM, Klein R, Rubin J, Carter AR, Schwartz PM, Luster A, Corfas G, Segal RA. BDNF stimulates migration of cerebellar granule cells. Development 2002; 129:1435-42. PubMed
  • Mason HA, Ito S, Corfas G. Extracellular signals that regulate the tangential migration of olfactory bulb neuronal precursors: inducers, inhibitors, and repellents. J Neurosci 2001; 21:7654-63. PubMed
  • Rieff HI, Raetzman LT, Sapp DW, Yeh HH, Siegel RE, Corfas G. Neuregulin induces GABA(A) receptor subunit expression and neurite outgrowth in cerebellar granule cells. J Neurosci 1999; 19:10757-66. PubMed
  • Elenius K, Corfas G, Paul S, Choi CJ, Rio C, Plowman GD, Klagsbrun M. A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester. J Biol Chem 1997; 272:26761-8. PubMed
  • Rio C, Rieff HI, Qi P, Khurana TS, Corfas G. Neuregulin and erbB receptors play a critical role in neuronal migration. Neuron 1997; 19:39-50. PubMed
  • Goodearl AD, Yee AG, Sandrock AW, Corfas G, Fischbach GD. ARIA is concentrated in the synaptic basal lamina of the developing chick neuromuscular junction. J Cell Biol 1995; 130:1423-34. PubMed
  • Corfas G, Rosen KM, Aratake H, Krauss R, Fischbach GD. Differential expression of ARIA isoforms in the rat brain. Neuron 1995; 14:103-15. PubMed
  • Vartanian T, Corfas G, Li Y, Fischbach GD, Stefansson K. A role for the acetylcholine receptor-inducing protein ARIA in oligodendrocyte development. Proc Natl Acad Sci U S A 1994; 91:11626-30. PubMed
  • Fischbach GD, Aratake H, Corfas G, Falls DL, Goodearl A, Rosen KM. Trophic interactions at developing synapses. Prog Clin Biol Res 1994; 390:173-90. PubMed
  • Corfas G, Fischbach GD. The number of Na+ channels in cultured chick muscle is increased by ARIA, an acetylcholine receptor-inducing activity. J Neurosci 1993; 13:2118-25. PubMed
  • Falls DL, Rosen KM, Corfas G, Lane WS, Fischbach GD. ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family. Cell 1993; 72:801-15. PubMed
  • Corfas G, Falls DL, Fischbach GD. ARIA, a protein that stimulates acetylcholine receptor synthesis, also induces tyrosine phosphorylation of a 185-kDa muscle transmembrane protein. Proc Natl Acad Sci U S A 1993; 90:1624-8. PubMed
  • Corfas G, Dudai Y. Morphology of a sensory neuron in Drosophila is abnormal in memory mutants and changes during aging. Proc Natl Acad Sci U S A 1991; 88:7252-6. PubMed
  • Corfas G, Dudai Y. Pharmacological evidence for the involvement of the cAMP cascade in sensory fatigue in Drosophila. J Comp Physiol [A] 1990; 167:437-40. PubMed
  • Corfas G, Dudai Y. Adaptation and fatigue of a mechanosensory neuron in wild-type Drosophila and in memory mutants. J Neurosci 1990; 10:491-9. PubMed
  • Corfas G, Dudai Y. Habituation and dishabituation of a cleaning reflex in normal and mutant Drosophila. J Neurosci 1988; 9:56-62. PubMed
  • Dudai Y, Corfas G, Hazvi S. What is the possible contribution of Ca2+-stimulated adenylate cyclase to acquisition, consolidation and retention of an associative olfactory memory in Drosophila. J Comp Physiol [A] 1987; 162:101-9. PubMed
  • Dudai Y, Buxbaum J, Corfas G, Orgad S, Segal D, Sher B, Uzzan A, Zvi S. Defective cAMP metabolism and defective memory in Drosophila. Acta Biochim Biophys Hung 1985; 21:177-92. PubMed
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