Gary B. Ruvkun, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-5959
Fax: (617) 726-6893


ruvkun@molbio.mgh.harvard.edu

Gary B. Ruvkun, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Genetics, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Publications

Powered by Harvard Catalyst
  • Liu Y, Samuel BS, Breen PC, Ruvkun G. Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature 2014; 508:406-10. PubMed
  • Phillips CM, Montgomery BE, Breen PC, Roovers EF, Rim YS, Ohsumi TK, Newman MA, van Wolfswinkel JC, Ketting RF, Ruvkun G, Montgomery TA. MUT-14 and SMUT-1 DEAD Box RNA Helicases Have Overlapping Roles in Germline RNAi and Endogenous siRNA Formation. Curr Biol 2014; 24:839-44. PubMed
  • Fischer SE, Pan Q, Breen PC, Qi Y, Shi Z, Zhang C, Ruvkun G. Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Genes Dev 2013; 27:2678-95. PubMed
  • Schwartz S, Agarwala SD, Mumbach MR, Jovanovic M, Mertins P, Shishkin A, Tabach Y, Mikkelsen TS, Satija R, Ruvkun G, Carr SA, Lander ES, Fink GR, Regev A. High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell 2013; 155:1409-21. PubMed
  • Soukas AA, Carr CE, Ruvkun G. Genetic regulation of Caenorhabditis elegans lysosome related organelle function. PLoS Genet. 2013; 9:e1003908. PubMed
  • Shore DE, Ruvkun G. A cytoprotective perspective on longevity regulation. Trends Cell Biol 2013; 23:409-20. PubMed
  • Carr CE, Rowedder H, Lui CS, Zlatkovsky I, Papalias CW, Bolander J, Myers JW, Bustillo J, Rothberg JM, Zuber MT, Ruvkun G. Radiation resistance of sequencing chips for in situ life detection. Astrobiology 2013; 13:560-9. PubMed
  • Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman SK, Kingston RE, Dillin A, Asara JM, Ruvkun G. DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nat Cell Biol 2013. PubMed
  • Shi Z, Hayes G, Ruvkun G. Dual regulation of the lin-14 target mRNA by the lin-4 miRNA. PLoS ONE 2013; 8:e75475. PubMed
  • Tabach Y, Golan T, Hernández-Hernández A, Messer AR, Fukuda T, Kouznetsova A, Liu JG, Lilienthal I, Levy C, Ruvkun G. Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling. Mol Syst Biol 2013; 9:692. PubMed
  • Zhang C, Ruvkun G. New insights into siRNA amplification and RNAi. RNA Biol 2012. PubMed
  • Shore DE, Carr CE, Ruvkun G. Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. PLoS Genet. 2012; 8:e1002792. PubMed
  • Phillips CM, Montgomery TA, Breen PC, Ruvkun G. MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline. Genes Dev 2012; 26:1433-44. PubMed
  • Tacutu R, Shore DE, Budovsky A, de Magalhães JP, Ruvkun G, Fraifeld VE, Curran SP. Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks. PLoS ONE 2012; 7:e48282. PubMed
  • Wang MC, Min W, Freudiger CW, Ruvkun G, Xie XS. RNAi screening for fat regulatory genes with SRS microscopy. Nat Methods 2011; 8:135-8. PubMed
  • Zhang C, Montgomery TA, Gabel HW, Fischer SE, Phillips CM, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G. mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Proc Natl Acad Sci U S A 2011; 108:1201-8. PubMed
  • Wu X, Ruvkun G. Cancer. Germ cell genes and cancer. Science 2011; 330:1761-2. PubMed
  • Meli VS, Osuna B, Ruvkun G, Frand AR. MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans. Mol Biol Cell 2010; 21:1648-61. PubMed
  • O'Rourke EJ, Soukas AA, Carr CE, Ruvkun G. C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab 2009; 10:430-5. PubMed
  • Curran SP, Wu X, Riedel CG, Ruvkun G. A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature 2009; 459:1079-84. PubMed
  • Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT. RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS ONE 2009; 4:e8210. PubMed
  • Simon DJ,Madison JM,Conery AL,Thompson-Peer KL,Soskis M,Ruvkun GB,Kaplan JM,Kim JK. The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. Cell 2008; 133:903-15. PubMed
  • Gabel HW, Ruvkun G. The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi. Nat Struct Mol Biol 2008; 15:531-3. PubMed
  • Pierce ML, Weston MD, Fritzsch B, Gabel HW, Ruvkun G, Soukup GA. MicroRNA-183 family conservation and ciliated neurosensory organ expression. Evol Dev 2008; 10:106-13. PubMed
  • Parry DH, Xu J, Ruvkun G. A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Curr Biol 2007; 17:2013-22. PubMed
  • Samuelson AV, Carr CE, Ruvkun G. Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes Dev 2007; 21:2976-94. PubMed
  • Kim N, Dempsey CM, Kuan CJ, Zoval JV, O'Rourke E, Ruvkun G, Madou MJ, Sze JY. Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans. Genetics 2007; 177:835-45. PubMed
  • Curran SP, Ruvkun G. Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet 2007; 3:e56. PubMed
  • Ruvinsky I, Ohler U, Burge CB, Ruvkun G. Detection of broadly expressed neuronal genes in C. elegans. Dev Biol 2006; 302:617-26. PubMed
  • Hayes GD, Frand AR, Ruvkun G. The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Development 2006; 133:4631-41. PubMed
  • Hu PJ, Xu J, Ruvkun G. Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet 2006; 2:e99. PubMed
  • Sandoval GM, Duerr JS, Hodgkin J, Rand JB, Ruvkun G. A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans. Nat Neurosci 2006; 9:599-601. PubMed
  • Mak HY, Nelson LS, Basson M, Johnson CD, Ruvkun G. Polygenic control of Caenorhabditis elegans fat storage. Nat Genet 2006; 38:363-8. PubMed
  • Duchaine TF, Wohlschlegel JA, Kennedy S, Bei Y, Conte D, Pang K, Brownell DR, Harding S, Mitani S, Ruvkun G, Yates JR, Mello CC. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell 2006; 124:343-54. PubMed
  • Ruvkun G. Clarifications on miRNA and cancer. Science 2006; 311:36-7. PubMed
  • Hayes GD, Ruvkun G. Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs. Cold Spring Harb Symp Quant Biol 2007; 71:21-7. PubMed
  • Sieburth D, Ch'ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, Dupuy D, Rual JF, Hill DE, Vidal M, Ruvkun G, Kaplan JM. Systematic analysis of genes required for synapse structure and function. Nature 2005; 436:510-7. PubMed
  • Kim JK, Gabel HW, Kamath RS, Tewari M, Pasquinelli A, Rual JF, Kennedy S, Dybbs M, Bertin N, Kaplan JM, Vidal M, Ruvkun G. Functional genomic analysis of RNA interference in C. elegans. Science 2005; 308:1164-7. PubMed
  • Tewari M, Hu PJ, Ahn JS, Ayivi-Guedehoussou N, Vidalain PO, Li S, Milstein S, Armstrong CM, Boxem M, Butler MD, Busiguina S, Rual JF, Ibarrola N, Chaklos ST, Bertin N, Vaglio P, Edgley ML, King KV, Albert PS, Vandenhaute J, Pandey A, Riddle DL, Ruvkun G, Vidal M. Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Mol Cell 2004; 13:469-82. PubMed
  • Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc Natl Acad Sci U S A 2003; 101:360-5. PubMed
  • Nasrin N, Ogg S, Cahill CM, Biggs W, Nui S, Dore J, Calvo D, Shi Y, Ruvkun G, Alexander-Bridges MC. DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. Proc Natl Acad Sci U S A 2000; 97:10412-7. PubMed
  • Sze JY, Victor M, Loer C, Shi Y, Ruvkun G. Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant. Nature 2000; 403:560-4. PubMed
Hide