Gary R. Strichartz, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 732-7802
Fax: (617) 730-2801


gstrichz@zeus.bwh.harvard.edu

Gary R. Strichartz, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Professor, Anesthesia, Harvard Medical School
  • Director, Pain Research Center, Brigham And Women's Hospital

Research Abstract

My laboratory investigates the molcules and mechanisms that contribute to abnormal pain from cancer, particularly metastases of cancer into bony tissue such as the spinal cord. Our major focus is on the naturally occurring peptide endothelin-1 (ET-1), which is synthesized and secreted by prostate tumor cells and which is known to cause pain directly as well as to sensitize the nervous system to other, normally innocuous stimuli, such as light touch. We seek to determine which receptors for ET-1, located on different cells in nerve tissues, skin and bones, are important for the activation of the pain-sensing neurons. I am personally also interested in the neurobiology of suffering, its physiological and neurochemical mechanisms, and in developing pharmacological and drug-free methods to reduce such suffering, tested through objective measurements.

Publications

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  • Cassinello F, Prieto I, Del Olmo M, Rivas S, Strichartz GR. Cancer surgery: how may anesthesia influence outcome? J Clin Anesth 2015. PubMed
  • Ji RR,Gereau RW 4th,Malcangio M,Strichartz GR. MAP kinase and pain. Brain Res Rev 2009; 60:135-48. PubMed
  • Gerner P, Strichartz GR. Sensory and motor complications of local anesthetics. Muscle Nerve 2008; 37:421-5. PubMed
  • Mujenda FH, Duarte AM, Reilly EK, Strichartz GR. Cutaneous endothelin-A receptors elevate post-incisional pain. Pain 2007; 133:161-73. PubMed
  • Zhang J, Hadlock T, Gent A, Strichartz GR. Tetracaine-membrane interactions: effects of lipid composition and phase on drug partitioning, location, and ionization. Biophys J 2007; 92:3988-4001. PubMed
  • McNally MA, Baek RC, Avila RL, Seyfried TN, Strichartz GR, Kirschner DA. Peripheral nervous system manifestations in a Sandhoff disease mouse model: nerve conduction, myelin structure, lipid analysis. J Negat Results Biomed 2007; 6:8. PubMed
  • Houck CS, Khodorova A, Reale AM, Strichartz GR, Davar G. Sensory fibers resistant to the actions of tetrodotoxin mediate nocifensive responses to local administration of endothelin-1 in rats. Pain 2004; 110:719-26. PubMed
  • Khodorova A, Navarro B, Jouaville LS, Murphy JE, Rice FL, Mazurkiewicz JE, Long-Woodward D, Stoffel M, Strichartz GR, Yukhananov R, Davar G. Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury. Nat Med 2003; 9:1055-61. PubMed
  • Khodorova A, Fareed MU, Gokin A, Strichartz GR, Davar G. Local injection of a selective endothelin-B receptor agonist inhibits endothelin-1-induced pain-like behavior and excitation of nociceptors in a naloxone-sensitive manner. J Neurosci 2002; 22:7788-96. PubMed
  • Zhou Z, Davar G, Strichartz G. Endothelin-1 (ET-1) selectively enhances the activation gating of slowly inactivating tetrodotoxin-resistant sodium currents in rat sensory neurons: a mechanism for the pain-inducing actions of ET-1. J Neurosci 2002; 22:6325-30. PubMed
  • Zhou QL, Strichartz G, Davar G. Endothelin-1 activates ET(A) receptors to increase intracellular calcium in model sensory neurons. Neuroreport 2001; 12:3853-7. PubMed