Photo of George L. Mutter,  MD

George L. Mutter, MD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 732-6096
Fax: (617) 738-6996


gmutter@rics.bwh.harvard.edu

George L. Mutter, MD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Professor, Pathology, Harvard Medical School
  • Associate Pathologist, Pathology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

The molecular biology of gynecologic cancers is the focus of my lab, primarily endometrial carcinoma. We have developed molecular assays for premalignant disease, and used these to revise routine diagnostic practices and study the natural history of early carcinogenesis.

Publications

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  • Yang EJ, Mutter GL. Biomarker resolution of uterine smooth muscle tumor necrosis as benign vs malignant. Mod Pathol 2015. PubMed
  • Nagymanyoki Z, Mutter GL, Hornick JL, Cibas ES. ARID1A is a useful marker of malignancy in peritoneal washings for endometrial carcinoma. Cancer Cytopathol 2015. PubMed
  • Mutter GL, Monte NM, Neuberg D, Ferenczy A, Eng C. Emergence, Involution, and Progression to Carcinoma of Mutant Clones in Normal Endometrial Tissues. Cancer Res 2014. PubMed
  • Parra-Herran CE, Monte NM, Mutter GL. Endometrial intraepithelial neoplasia with secretory differentiation: diagnostic features and underlying mechanisms. Mod Pathol 2013. PubMed
  • Trimble CL, Method M, Leitao M, Lu K, Ioffe O, Hampton M, Higgins R, Zaino R, Mutter GL, . Management of Endometrial Precancers. Obstet Gynecol 2012; 120:1160-1175. PubMed
  • Quick CM, Laury AR, Monte NM, Mutter GL. Utility of PAX2 as a Marker for Diagnosis of Endometrial Intraepithelial Neoplasia. Am J Clin Pathol 2012; 138:678-84. PubMed
  • Huang EC, Mutter GL, Crum CP, Nucci MR. Clinical outcome in diagnostically ambiguous foci of 'gland crowding' in the endometrium. Mod Pathol 2010; 23:1486-91. PubMed
  • Jarboe EA, Mutter GL. Endometrial intraepithelial neoplasia. Semin Diagn Pathol 2011; 27:215-25. PubMed
  • Roh MH, Yassin Y, Miron A, Mehra KK, Mehrad M, Monte NM, Mutter GL, Nucci MR, Ning G, Mckeon FD, Hirsch MS, Wa X, Crum CP. High-grade fimbrial-ovarian carcinomas are unified by altered p53, PTEN and PAX2 expression. Mod Pathol 2010; 23:1316-24. PubMed
  • Chen EY, Mehra K, Mehrad M, Ning G, Miron A, Mutter GL, Monte N, Quade BJ, McKeon FD, Yassin Y, Xian W, Crum CP. Secretory cell outgrowth, PAX2 and serous carcinogenesis in the Fallopian tube. J Pathol 2010; 222:110-6. PubMed
  • Monte NM, Webster KA, Neuberg D, Dressler GR, Mutter GL. Joint loss of PAX2 and PTEN expression in endometrial precancers and cancer. Cancer Res 2010; 70:6225-32. PubMed
  • Jarboe EA,Miron A,Carlson JW,Hirsch MS,Kindelberger D,Mutter GL,Crum CP,Nucci MR. Coexisting Intraepithelial Serous Carcinomas of the Endometrium and Fallopian Tube: Frequency and Potential Significance. Int J Gynecol Pathol 2009; 28:308-15. PubMed
  • Lin MC,Burkholder KA,Viswanathan AN,Neuberg D,Mutter GL. Involution of latent endometrial precancers by hormonal and nonhormonal mechanisms. Cancer 2009; 115:2111-8. PubMed
  • Jarboe EA, S Pizer E, Miron A, Monte N, Mutter GL, Crum CP. Evidence for a latent precursor (p53 signature) that may precede serous endometrial intraepithelial carcinoma. Mod Pathol 2009; 22:345-50. PubMed
  • Ioffe OB,Zaino RJ,Mutter GL. Endometrial changes from short-term therapy with CDB-4124, a selective progesterone receptor modulator. Mod Pathol 2009; 22:450-9. PubMed
  • Lin MC,Lomo L,Baak JP,Eng C,Ince TA,Crum CP,Mutter GL. Squamous morules are functionally inert elements of premalignant endometrial neoplasia. Mod Pathol 2009; 22:167-74. PubMed
  • Lacey JV Jr,Mutter GL,Nucci MR,Ronnett BM,Ioffe OB,Rush BB,Glass AG,Richesson DA,Chatterjee N,Langholz B,Sherman ME. Risk of subsequent endometrial carcinoma associated with endometrial intraepithelial neoplasia classification of endometrial biopsies. Cancer 2008; 113:2073-81. PubMed
  • Lomo L,Nucci MR,Lee KR,Lin MC,Hirsch MS,Crum CP,Mutter GL. Histologic and immunohistochemical decision-making in endometrial adenocarcinoma. Mod Pathol 2008; 21:937-42. PubMed
  • Lacey JV Jr,Mutter GL,Ronnett BM,Ioffe OB,Duggan MA,Rush BB,Glass AG,Richesson DA,Chatterjee N,Langholz B,Sherman ME. PTEN expression in endometrial biopsies as a marker of progression to endometrial carcinoma. Cancer Res 2008; 68:6014-20. PubMed
  • Mutter GL, Kauderer J, Baak JP, Alberts D. Biopsy histomorphometry predicts uterine myoinvasion by endometrial carcinoma: a Gynecologic Oncology Group study. Hum Pathol 2008; 39:866-74. PubMed
  • Mutter GL, Bergeron C, Deligdisch L, Ferenczy A, Glant M, Merino M, Williams AR, Blithe DL. The spectrum of endometrial pathology induced by progesterone receptor modulators. Mod Pathol 2008; 21:591-8. PubMed
  • Patocs A, Zhang L, Xu Y, Weber F, Caldes T, Mutter GL, Platzer P, Eng C. Breast-cancer stromal cells with TP53 mutations and nodal metastases. N Engl J Med 2007; 357:2543-51. PubMed
  • Mutter GL, Zaino RJ, Baak JP, Bentley RC, Robboy SJ. Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia. Int J Gynecol Pathol 2007; 26:103-14. PubMed
  • Hecht JL, Mutter GL. Molecular and pathologic aspects of endometrial carcinogenesis. J Clin Oncol 2006; 24:4783-91. PubMed
  • . Regression of latent endometrial precancers by progestin infiltrated intrauterine device. Cancer Res 2006; 66:5613-7. PubMed
  • Berman JJ, Albores-Saavedra J, Bostwick D, Delellis R, Eble J, Hamilton SR, Hruban RH, Mutter GL, Page D, Rohan T, Travis W, Henson DE. Precancer: a conceptual working definition -- results of a Consensus Conference. Cancer Detect Prev 2006; 30:387-94. PubMed
  • Baak JP, Mutter GL, Robboy S, van Diest PJ, Uyterlinde AM, Orbo A, Palazzo J, Fiane B, L. The molecular genetics and morphometry-based endometrial intraepithelial neoplasia classification system predicts disease progression in endometrial hyperplasia more accurately than the 1994 World Health Organization classification system. Cancer 2005; 103:2304-12. PubMed
  • Weber F, Fukino K, Sawada T, Williams N, Sweet K, Brena RM, Plass C, Caldes T, Mutter GL, Villalona-Calero MA, Eng C. Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors. Br J Cancer 2005; 92:1922-6. PubMed
  • Baak JP, Van Diermen B, Steinbakk A, Janssen E, Skaland I, Mutter GL, Fiane B, L. Lack of PTEN expression in endometrial intraepithelial neoplasia is correlated with cancer progression. Hum Pathol 2005; 36:555-61. PubMed
  • Hecht JL, Ince TA, Baak JP, Baker HE, Ogden MW, Mutter GL. Prediction of endometrial carcinoma by subjective endometrial intraepithelial neoplasia diagnosis. Mod Pathol 2004; 18:324-30. PubMed
  • Baak JP, Mutter GL. EIN and WHO94. J Clin Pathol 2004; 58:1-6. PubMed
  • Fukino K, Shen L, Matsumoto S, Morrison CD, Mutter GL, Eng C. Combined total genome loss of heterozygosity scan of breast cancer stroma and epithelium reveals multiplicity of stromal targets. Cancer Res 2004; 64:7231-6. PubMed
  • Styer AK, Cekleniak NA, Legedza A, Mutter GL, Hornstein MD. Factors associated with disposition of cryopreserved reproductive tissue. Fertil Steril 2003; 80:584-9. PubMed
  • Ince TA, Cviko AP, Quade BJ, Yang A, McKeon FD, Mutter GL, Crum CP. p63 Coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tract. Am J Pathol 2002; 161:1111-7. PubMed
  • Wright TC, Holinka CF, Ferenczy A, Gatsonis CA, Mutter GL, Nicosia S, Richart RM. Estradiol-induced hyperplasia in endometrial biopsies from women on hormone replacement therapy. Am J Surg Pathol 2002; 26:1269-75. PubMed
  • Mutter GL. Diagnosis of premalignant endometrial disease. J Clin Pathol 2002; 55:326-31. PubMed
  • Hsiao LL, Dangond F, Yoshida T, Hong R, Jensen RV, Misra J, Dillon W, Lee KF, Clark KE, Haverty P, Weng Z, Mutter GL, Frosch MP, Macdonald ME, Milford EL, Crum CP, Bueno R, Pratt RE, Mahadevappa M, Warrington JA, Stephanopoulos G, Stephanopoulos G, Gullans SR. A compendium of gene expression in normal human tissues. Physiol Genomics 2002; 7:97-104. PubMed
  • Mutter GL, Baak JP, Fitzgerald JT, Gray R, Neuberg D, Kust GA, Gentleman R, Gullans SR, Wei LJ, Wilcox M. Global expression changes of constitutive and hormonally regulated genes during endometrial neoplastic transformation. Gynecol Oncol 2001; 83:177-85. PubMed
  • Johnson EB, Muto MG, Yanushpolsky EH, Mutter GL. Phytoestrogen supplementation and endometrial cancer. Obstet Gynecol 2001; 98:947-50. PubMed
  • Mutter GL, Ince TA, Baak JP, Kust GA, Zhou XP, Eng C. Molecular identification of latent precancers in histologically normal endometrium. Cancer Res 2001; 61:4311-4. PubMed
  • Mutter GL. Pten, a protean tumor suppressor. Am J Pathol 2001; 158:1895-8. PubMed
  • O'Connell JT, Mutter GL, Cviko A, Nucci M, Quade BJ, Kozakewich HP, Neffen E, Sun D, Yang A, McKeon FD, Crum CP. Identification of a basal/reserve cell immunophenotype in benign and neoplastic endometrium: a study with the p53 homologue p63. Gynecol Oncol 2001; 80:30-6. PubMed
  • Biswas DK, Cruz A, Pettit N, Mutter GL, Pardee AB. A therapeutic target for hormone-independent estrogen receptor-positive breast cancers. Mol Med 2001; 7:59-67. PubMed
  • Mutter GL. Histopathology of genetically defined endometrial precancers. Int J Gynecol Pathol 2000; 19:301-9. PubMed
  • Faquin WC, Fitzgerald JT, Boynton KA, Mutter GL. Intratumoral genetic heterogeneity and progression of endometrioid type endometrial adenocarcinomas. Gynecol Oncol 2000; 78:152-7. PubMed
  • Mutter GL, Lin MC, Fitzgerald JT, Kum JB, Baak JP, Lees JA, Weng LP, Eng C. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. J Natl Cancer Inst 2000; 92:924-30. PubMed
  • Mutter GL, Lin MC, Fitzgerald JT, Kum JB, Eng C. Changes in endometrial PTEN expression throughout the human menstrual cycle. J Clin Endocrinol Metab 2000; 85:2334-8. PubMed
  • Gimm O, Perren A, Weng LP, Marsh DJ, Yeh JJ, Ziebold U, Gil E, Hinze R, Delbridge L, Lees JA, Mutter GL, Robinson BG, Komminoth P, Dralle H, Eng C. Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors. Am J Pathol 2000; 156:1693-700. PubMed
  • Martin KJ, Kritzman BM, Price LM, Koh B, Kwan CP, Zhang X, Mackay A, O'Hare MJ, Kaelin CM, Mutter GL, Pardee AB, Sager R. Linking gene expression patterns to therapeutic groups in breast cancer. Cancer Res 2000; 60:2232-8. PubMed
  • Yeh JJ, Lunetta KL, van Orsouw NJ, Moore FD, Mutter GL, Vijg J, Dahia PL, Eng C. Somatic mitochondrial DNA (mtDNA) mutations in papillary thyroid carcinomas and differential mtDNA sequence variants in cases with thyroid tumours. Oncogene 2000; 19:2060-6. PubMed
  • Faquin WC, Fitzgerald JT, Lin MC, Boynton KA, Muto MG, Mutter GL. Sporadic microsatellite instability is specific to neoplastic and preneoplastic endometrial tissues. Am J Clin Pathol 2000; 113:576-82. PubMed
  • Mutter GL, Baak JP, Crum CP, Richart RM, Ferenczy A, Faquin WC. Endometrial precancer diagnosis by histopathology, clonal analysis, and computerized morphometry. J Pathol 2000; 190:462-9. PubMed
  • Mutter GL. Endometrial intraepithelial neoplasia (EIN): will it bring order to chaos? The Endometrial Collaborative Group. Gynecol Oncol 2000; 76:287-90. PubMed
  • Lomo L, Nucci MR, Lee KR, Lin MC, Hirsch MS, Crum CP, Mutter GL. Histologic and immunohistochemical decision-making in endometrial adenocarcinoma. Mod Pathol 2008; 21:937-42.
  • Nucci MR, Prasad CJ, Crum CP, Mutter GL. Mucinous endometrial epithelial proliferations: a morphologic spectrum of changes with diverse clinical significance. Mod Pathol 2000; 12:1137-42. PubMed
  • Mutter GL, Wada H, Faquin WC, Enomoto T. K-ras mutations appear in the premalignant phase of both microsatellite stable and unstable endometrial carcinogenesis. Mol Pathol 2000; 52:257-62. PubMed
  • Perren A, Weng LP, Boag AH, Ziebold U, Thakore K, Dahia PL, Komminoth P, Lees JA, Mulligan LM, Mutter GL, Eng C. Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast. Am J Pathol 1999; 155:1253-60. PubMed
  • Pinto AP, Lin MC, Mutter GL, Sun D, Villa LL, Crum CP. Allelic loss in human papillomavirus-positive and -negative vulvar squamous cell carcinomas. Am J Pathol 1999; 154:1009-15. PubMed
  • Ford HL, Kabingu EN, Bump EA, Mutter GL, Pardee AB. Abrogation of the G2 cell cycle checkpoint associated with overexpression of HSIX1: a possible mechanism of breast carcinogenesis. Proc Natl Acad Sci U S A 1998; 95:12608-13. PubMed
  • Lin MC, Mutter GL, Trivijisilp P, Boynton KA, Sun D, Crum CP. Patterns of allelic loss (LOH) in vulvar squamous carcinomas and adjacent noninvasive epithelia. Am J Pathol 1998; 152:1313-8. PubMed
  • Mutter GL. Role of imprinting in abnormal human development. Mutat Res 1998; 396:141-7. PubMed
  • Quade BJ, McLachlin CM, Soto-Wright V, Zuckerman J, Mutter GL, Morton CC. Disseminated peritoneal leiomyomatosis. Clonality analysis by X chromosome inactivation and cytogenetics of a clinically benign smooth muscle proliferation. Am J Pathol 1997; 150:2153-66. PubMed
  • Tate JE, Mutter GL, Boynton KA, Crum CP. Monoclonal origin of vulvar intraepithelial neoplasia and some vulvar hyperplasias. Am J Pathol 1997; 150:315-22. PubMed
  • Menke DB, Mutter GL, Page DC. Expression of DAZ, an azoospermia factor candidate, in human spermatogonia. Am J Hum Genet 1997; 60:237-41. PubMed
  • Sinnock KL, Perez-Atayde AR, Boynton KA, Mutter GL. Clonal analysis of sacrococcygeal "teratomas". Pediatr Pathol Lab Med 1996; 16:865-75. PubMed
  • Mutter GL, Boynton KA, Faquin WC, Ruiz RE, Jovanovic AS. Allelotype mapping of unstable microsatellites establishes direct lineage continuity between endometrial precancers and cancer. Cancer Res 1996; 56:4483-6. PubMed
  • Jovanovic AS, Boynton KA, Mutter GL. Uteri of women with endometrial carcinoma contain a histopathological spectrum of monoclonal putative precancers, some with microsatellite instability. Cancer Res 1996; 56:1917-21. PubMed
  • Mutter GL, Boynton KA. X chromosome inactivation in the normal female genital tract: implications for identification of neoplasia. Cancer Res 1995; 55:5080-4. PubMed
  • Mutter GL, Boynton KA. PCR bias in amplification of androgen receptor alleles, a trinucleotide repeat marker used in clonality studies. Nucleic Acids Res 1995; 23:1411-8. PubMed
  • Mutter GL, Chaponot ML, Fletcher JA. A polymerase chain reaction assay for non-random X chromosome inactivation identifies monoclonal endometrial cancers and precancers. Am J Pathol 1995; 146:501-8. PubMed
  • Tate JE, Mutter GL, Prasad CJ, Berkowitz R, Goodman H, Crum CP. Analysis of HPV-positive and -negative vulvar carcinomas for alterations in c-myc, Ha-, Ki-, and N-ras genes. Gynecol Oncol 1994; 53:78-83. PubMed
  • Mutter GL, Stewart CL, Chaponot ML, Pomponio RJ. Oppositely imprinted genes H19 and insulin-like growth factor 2 are coexpressed in human androgenetic trophoblast. Am J Hum Genet 1993; 53:1096-102. PubMed
  • Iwaoki Y, Matsuda H, Mutter GL, Watrin F, Wolgemuth DJ. Differential expression of the proto-oncogenes c-abl and c-mos in developing mouse germ cells. Exp Cell Res 1993; 206:212-9. PubMed
  • Martin DI, Zon LI, Mutter G, Orkin SH. Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages. Nature 1990; 344:444-7. PubMed
  • Mutter GL, Grills GS, Wolgemuth DJ. Evidence for the involvement of the proto-oncogene c-mos in mammalian meiotic maturation and possibly very early embryogenesis. EMBO J 1988; 7:683-9. PubMed
  • Mutter GL, Wolgemuth DJ. Distinct developmental patterns of c-mos protooncogene expression in female and male mouse germ cells. Proc Natl Acad Sci U S A 1987; 84:5301-5. PubMed
  • Mutter GL, Stacey A, Wolgemuth DJ. Differential expression in murine somatic and germinal tissues of transcripts homologous to an abundant embryonal-carcinoma-cell mRNA. Differentiation 1986; 34:126-30. PubMed
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