Giulia Fulci, PhD

Massachusetts General Hospital

Massachusetts General Hospital


gfulci@partners.org

Giulia Fulci, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Assistant Virologist, Neurosurgical Service, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My research focuses on increasing efficacy of oncolytic virotherapy for brain tumors. I started working in this field as a research fellow in Dr. Chiocca's laboratory. My goal was to understand the mechanisms through which cyclophosphamide enhances intratumoral viral spread and conseuquent survival of rodents with establsihed gliomas. Through this work I realized that oncolytic viruses elicit a strong innate immune response early after their intratumoral injection. This response is detrimental for viral replication, spread and presistance in brain tumors. Thus, my major goal now is to understand the mechanisms that regulate this innate immune response in order to identify novel targets for therapeutic intervention. To improve the efficacy of this therapeutc strategy I am also in the process of establishing a new MRI technology that can detect virus replication, intratumoral infiltration of innate immune cells and tumor response during one MRI imaging session. This will strongly increase our diagnostic capacities of such treatment. Finally, I am testing the efficacy of oncolytic virotherapy when performed in combination with FDA-approved anti-angiogenic and immuno-suppressive drugs.

Publications

Powered by Harvard Catalyst
  • Farrar CT, Buhrman JS, Liu G, Kleijn A, Lamfers ML, McMahon MT, Gilad AA, Fulci G. Establishing the Lysine-rich Protein CEST Reporter Gene as a CEST MR Imaging Detector for Oncolytic Virotherapy. Radiology 2015. PubMed
  • Kleijn A, Kloezeman J, Treffers-Westerlaken E, Fulci G, Leenstra S, Dirven C, Debets R, Lamfers M. The In Vivo Therapeutic Efficacy of the Oncolytic Adenovirus Delta24-RGD Is Mediated by Tumor-Specific Immunity. PLoS ONE 2014; 9:e97495. PubMed
  • Zhang W, Fulci G, Wakimoto H, Cheema TA, Buhrman JS, Jeyaretna DS, Stemmer Rachamimov AO, Rabkin SD, Martuza RL. Combination of oncolytic herpes simplex viruses armed with angiostatin and IL-12 enhances antitumor efficacy in human glioblastoma models. Neoplasia 2013; 15:591-9. PubMed
  • Prabhakar S, Taherian M, Gianni D, Conlon TJ, Fulci G, Brockmann J, Stemmer-Rachamimov A, Sena-Esteves M, Breakefield XO, Brenner GJ. Regression of schwannomas induced by adeno-associated virus-mediated delivery of caspase-1. Hum Gene Ther 2013; 24:152-62. PubMed
  • Fulci G, Passer B. Analysis of HSV oncolytic virotherapy in organotypic cultures. Methods Mol Biol 2009; 542:75-86. PubMed
  • Kurozumi K, Hardcastle J, Thakur R, Yang M, Christoforidis G, Fulci G, Hochberg FH, Weissleder R, Carson W, Chiocca EA, Kaur B. Effect of tumor microenvironment modulation on the efficacy of oncolytic virus therapy. Journal of the National Cancer Institute 2007; 99:1768-81. PubMed
  • Fulci G, Dmitrieva N, Gianni D, Fontana EJ, Pan X, Lu Y, Kaufman CS, Kaur B, Lawler SE, Lee RJ, Marsh CB, Brat DJ, van Rooijen N, Stemmer-Rachamimov AO, Hochberg FH, Weissleder R, Martuza RL, Chiocca EA. Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses. Cancer Res 2007; 67:9398-406. PubMed
  • Fulci G, Chiocca EA. The status of gene therapy for brain tumors. Expert Opin Biol Ther 2007; 7:197-208. PubMed
  • Lamfers ML, Fulci G, Gianni D, Tang Y, Kurozumi K, Kaur B, Moeniralm S, Saeki Y, Carette JE, Weissleder R, Vandertop WP, van Beusechem VW, Dirven CM, Chiocca EA. Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging. Mol Ther 2006; 14:779-88. PubMed
  • Fulci G, Breymann L, Gianni D, Kurozomi K, Rhee SS, Yu J, Kaur B, Louis DN, Weissleder R, Caligiuri MA, Chiocca EA. Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses. Proc Natl Acad Sci U S A 2006; 103:12873-8. PubMed
  • Friedman A, Tian JP, Fulci G, Chiocca EA, Wang J. Glioma virotherapy: effects of innate immune suppression and increased viral replication capacity. Cancer Res 2006; 66:2314-9. PubMed
  • Post DE, Fulci G, Chiocca EA, Van Meir EG. Replicative oncolytic herpes simplex viruses in combination cancer therapies. Curr Gene Ther 2004; 4:41-51. PubMed
  • Wakimoto H, Fulci G, Tyminski E, Antonio Chiocca E. Altered expression of antiviral cytokine mRNAs associated with cyclophosphamide's enhancement of viral oncolysis. Gene Ther 2004; 11:214-23. PubMed
  • Fulci G, Chiocca EA. Oncolytic viruses for the therapy of brain tumors and other solid malignancies: a review. Front Biosci 2003; 8:e346-60. PubMed
  • Chiocca EA, Aghi M, Fulci G. Viral therapy for glioblastoma. Cancer J 2003; 9:167-79. PubMed
Hide