Photo of Gregory Y. Lauwers,  MD

Gregory Y. Lauwers, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-2931
Fax: (617) 726-0982


glauwers@partners.org

Gregory Y. Lauwers, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Pathology, Harvard Medical School
  • Associate Professor, Pathology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My research interest is in the morphologic analysis and clinicopathologic evaluation of gastrointestinal neoplasias with a particular focus on preinvasive lesions ("dysplasia"). Working closely with gastroenterologists and surgeons I have been involved most particularly with esophageal and gastric maligancies as well as hepatocellular carcinoma and more recently pancreatic cancer. I have been using most particulary immunohistochemical techniques as well as new molecular techniques in collaboration.

Publications

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  • Huang Q, Shi J, Sun Q, Gold JS, Chen J, Wu H, Yu H, Zhang Y, Mashimo H, Yu C, Manasco T, Guan W, Lauwers GY. Clinicopathological characterisation of small (2 cm or less) proximal and distal gastric carcinomas in a Chinese population. Pathology 2015. PubMed
  • Ushiku T, Ishikawa S, Kakiuchi M, Tanaka A, Katoh H, Aburatani H, Lauwers GY, Fukayama M. RHOA mutation in diffuse-type gastric cancer: a comparative clinicopathology analysis of 87 cases. Gastric Cancer 2015. PubMed
  • Arnason T, Brown IS, Goldsmith JD, Anderson W, O'Brien BH, Wilson C, Winter H, Lauwers GY. Collagenous gastritis: a morphologic and immunohistochemical study of 40 patients. Mod Pathol 2015. PubMed
  • Traverso G, Schoellhammer CM, Schroeder A, Maa R, Lauwers GY, Polat BE, Anderson DG, Blankschtein D, Langer R. Microneedles for drug delivery via the gastrointestinal tract. J Pharm Sci 2015. PubMed
  • McCarthy AJ, Lauwers GY, Sheahan K. Iatrogenic pathology of the intestines. Histopathology 2015; 66:15-28. PubMed
  • Lauwers GY, Fasano A, Brown IS. Duodenal lymphocytosis with no or minimal enteropathy: much ado about nothing? Mod Pathol 2015; 28 Suppl 1:S22-9. PubMed
  • Ushiku T, Arnason T, Fukayama M, Lauwers GY. Extra-ampullary duodenal adenocarcinoma. Am J Surg Pathol 2014; 38:1484-93. PubMed
  • Sakurai U, Lauwers GY, Vieth M, Sawabe M, Arai T, Yoshida T, Aida J, Takubo K. Gastric high-grade dysplasia can be associated with submucosal invasion: evaluation of its prevalence in a series of 121 endoscopically resected specimens. Am J Surg Pathol 2014; 38:1545-50. PubMed
  • Masia R, Peyton S, Lauwers GY, Brown I. Gastrointestinal biopsy findings of autoimmune enteropathy: a review of 25 cases. Am J Surg Pathol 2014; 38:1319-29. PubMed
  • Arnason T, Lauwers GY. Extruded highly proliferative benign mucous neck cells: a peculiar histologic mimic of poorly cohesive gastric carcinoma. Int J Surg Pathol 2014; 22:623-8. PubMed
  • Arnason T, Liang WY, Alfaro E, Kelly P, Chung DC, Odze RD, Lauwers GY. Morphology and natural history of familial adenomatous polyposis-associated dysplastic fundic gland polyps. Histopathology 2014. PubMed
  • Kim JY, Park do Y, Kim GH, Jeon TY, Lauwers GY. Does clear cell carcinoma of stomach exist? Clinicopathological and prognostic significance of clear cell changes in gastric adenocarcinomas. Histopathology 2014; 65:90-9. PubMed
  • Suter MJ, Gora MJ, Lauwers GY, Arnason T, Sauk J, Gallagher KA, Kava L, Tan KM, Soomro AR, Gallagher TP, Gardecki JA, Bouma BE, Rosenberg M, Nishioka NS, Tearney GJ. Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study. Gastrointest Endosc 2014. PubMed
  • Lee SE, Kang SY, Cho J, Lee B, Chang DK, Woo H, Kim JW, Park HY, Do IG, Kim YE, Kushima R, Lauwers GY, Park CK, Kim KM. Pyloric gland adenoma in Lynch syndrome. Am J Surg Pathol 2014. PubMed
  • Misdraji J, Lauwers GY, Irving JA, Batts KP, Young RH. Appendiceal or cecal endometriosis with intestinal metaplasia: a potential mimic of appendiceal mucinous neoplasms. Am J Surg Pathol 2014; 38:698-705. PubMed
  • Chetty R, Bateman AC, Torlakovic E, Wang LM, Gill P, Al-Badri A, Arends M, Biddlestone L, Burroughs S, Carey F, Cowlishaw D, Crowther S, Da Costa P, Dada MA, d'Adhemar C, Dasgupta K, de Cates C, Deshpande V, Feakins RM, Foria B, Foria V, Fuller C, Green B, Greenson JK, Griffiths P, Hafezi-Bakhtiari S, Henry J, Jaynes E, Jeffers MD, Kaye P, Landers R, Lauwers GY, Loughrey M, Mapstone N, Novelli M, Odze R, Poller D, Rowsell C, Sanders S, Sarsfield P, Schofield JB, Sheahan K, Shepherd N, Sherif A, Sington J, Walsh S, Williams N, Wong N. A pathologist's survey on the reporting of sessile serrated adenomas/polyps. J Clin Pathol 2014; 67:426-30. PubMed
  • Fuchs BC, Hoshida Y, Fujii T, Wei L, Yamada S, Lauwers GY, McGinn CM, DePeralta DK, Chen X, Kuroda T, Lanuti M, Schmitt AD, Gupta S, Crenshaw A, Onofrio R, Taylor B, Winckler W, Bardeesy N, Caravan P, Golub TR, Tanabe KK. Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma. Hepatology 2014; 59:1577-90. PubMed
  • Chen Y, Huang Y, Reiberger T, Duyverman AM, Huang P, Samuel R, Hiddingh L, Roberge S, Koppel C, Lauwers GY, Zhu AX, Jain RK, Duda DG. Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice. Hepatology 2014. PubMed
  • Hagen CE, Lauwers GY, Mino-Kenudson M. Barrett esophagus: diagnostic challenges. Semin Diagn Pathol 2014; 31:100-13. PubMed
  • Gala MK, Mizukami Y, Le LP, Moriichi K, Austin T, Yamamoto M, Lauwers GY, Bardeesy N, Chung DC. Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas. Gastroenterology 2014; 146:520-9. PubMed
  • Lauwers GY. TP53 mutations of intestinal metaplasia--reply. Hum Pathol 2014; 45:431-2. PubMed
  • Lee SM, Yang S, Joo M, Kim KM, Park CK, Ahn S, Min BH, Lee JH, Kim S, Rhee JC, Kim JJ, Lauwers GY. Poorly differentiated component in gastric pinch biopsies predicts submucosal invasion. Diagn Pathol 2014; 9:34. PubMed
  • Liang WY, Arnason T, Lauwers GY. Re: Practical utility and objectivity: does evaluation of peritoneal elastic laminal invasion in colorectal cancer overcome these contrary problems? Am J Surg Pathol 2013; 38:145. PubMed
  • Kim JY, Kim WG, Jeon TY, Kim GH, Jeong EH, Kim DH, Park do Y, Lauwers GY. Lymph node metastasis in early gastric cancer: evaluation of a novel method for measuring submucosal invasion and development of a nodal predicting index. Hum Pathol 2013; 44:2829-36. PubMed
  • Schmidt B, Look-Hong N, Maduekwe UN, Chang K, Hong TS, Kwak EL, Lauwers GY, Rattner DW, Mullen JT, Yoon SS. Noncurative gastrectomy for gastric adenocarcinoma should only be performed in highly selected patients. Ann Surg Oncol 2013; 20:3512-8. PubMed
  • Liang WY, Chang WC, Hsu CY, Arnason T, Berger D, Hawkins AT, Sylla P, Lauwers GY. Retrospective evaluation of elastic stain in the assessment of serosal invasion of pT3N0 colorectal cancers. Am J Surg Pathol 2013; 37:1565-70. PubMed
  • Lennerz JK, Lauwers GY. Amelanotic adenoma. Int J Surg Pathol 2013; 21:504-5. PubMed
  • Sylla P, Bordeianou LG, Berger D, Han KS, Lauwers GY, Sahani DV, Sbeih MA, Lacy AM, Rattner DW. A pilot study of natural orifice transanal endoscopic total mesorectal excision with laparoscopic assistance for rectal cancer. Surg Endosc 2013. PubMed
  • Tse JY, Wu S, Shinagare SA, Lauwers GY, Yilmaz O, Wu CL, Deshpande V. Peutz-Jeghers syndrome: a critical look at colonic Peutz-Jeghers polyps. Mod Pathol 2013. PubMed
  • Schmidt B, Chang KK, Maduekwe UN, Look-Hong N, Rattner DW, Lauwers GY, Mullen JT, Yang HK, Yoon SS. D2 lymphadenectomy with surgical ex vivo dissection into node stations for gastric adenocarcinoma can be performed safely in Western patients and ensures optimal staging. Ann Surg Oncol 2013; 20:2991-9. PubMed
  • Kim DH, Shin N, Kim GH, Song GA, Jeon TY, Kim DH, Lauwers GY, Park do Y. Mucin expression in gastric cancer: reappraisal of its clinicopathologic and prognostic significance. Arch Pathol Lab Med 2013; 137:1047-53. PubMed
  • Shindoh J, Andreou A, Aloia TA, Zimmitti G, Lauwers GY, Laurent A, Nagorney DM, Belghiti J, Cherqui D, Poon RT, Kokudo N, Vauthey JN. Microvascular invasion does not predict long-term survival in hepatocellular carcinoma up to 2 cm: reappraisal of the staging system for solitary tumors. Ann Surg Oncol 2013; 20:1223-9. PubMed
  • Li Y, Chang X, Zhou W, Xiao Y, Nakatsuka LN, Chen J, Lauwers GY. Gastric intestinal metaplasia with basal gland atypia: a morphological and biologic evaluation in a large Chinese cohort. Hum Pathol 2013. PubMed
  • Gupta R, Khosroshahi A, Shinagare S, Fernandez C, Ferrone C, Lauwers GY, Stone JH, Deshpande V. Does autoimmune pancreatitis increase the risk of pancreatic carcinoma?: a retrospective analysis of pancreatic resections. Pancreas 2013; 42:506-10. PubMed
  • Konstantinidis IT, Warshaw AL, Allen JN, Blaszkowsky LS, Castillo CF, Deshpande V, Hong TS, Kwak EL, Lauwers GY, Ryan DP, Wargo JA, Lillemoe KD, Ferrone CR. Pancreatic ductal adenocarcinoma: is there a survival difference for R1 resections versus locally advanced unresectable tumors? What is a "true" R0 resection? Ann Surg 2013. PubMed
  • Sun Q, Huang Q, Feng AN, Fan XS, Wu HY, Mashimo H, Zhou Q, Chen J, Lauwers GY. Columnar-lined esophagus in Chinese patients with proximal gastric carcinomas. J Dig Dis 2013. PubMed
  • Huang Q, Shi J, Sun Q, Fan X, Feng A, Wu H, Zhou Q, Yu C, Mashimo H, Lauwers GY. Distal esophageal carcinomas in Chinese patients vary widely in histopathology, but adenocarcinomas remain rare. Hum Pathol 2012; 43:2138-48. PubMed
  • Khor TS, Badizadegan K, Ferrone C, Fernández-del Castillo C, Desai GS, Saenz A, Le L, Lauwers GY, Deshpande V. Acinar cystadenoma of the pancreas: a clinicopathologic study of 10 cases including multilocular lesions with mural nodules. Am J Surg Pathol 2012; 36:1579-91. PubMed
  • Fujita H, Lennerz JK, Chung DC, Patel D, Deshpande V, Yoon SS, Lauwers GY. Endoscopic surveillance of patients with hereditary diffuse gastric cancer: biopsy recommendations after topographic distribution of cancer foci in a series of 10 CDH1-mutated gastrectomies. Am J Surg Pathol 2012; 36:1709-17. PubMed
  • Puppa G, Senore C, Sheahan K, Vieth M, Lugli A, Zlobec I, Pecori S, Wang LM, Langner C, Mitomi H, Nakamura T, Watanabe M, Ueno H, Chasle J, Conley SA, Herlin P, Lauwers GY, Risio M. Diagnostic reproducibility of tumour budding in colorectal cancer: a multicentre, multinational study using virtual microscopy. Histopathology 2015. PubMed
  • Deshpande V, Zen Y, Chan JK, Yi EE, Sato Y, Yoshino T, Klöppel G, Heathcote JG, Khosroshahi A, Ferry JA, Aalberse RC, Bloch DB, Brugge WR, Bateman AC, Carruthers MN, Chari ST, Cheuk W, Cornell LD, Fernandez-Del Castillo C, Forcione DG, Hamilos DL, Kamisawa T, Kasashima S, Kawa S, Kawano M, Lauwers GY, Masaki Y, Nakanuma Y, Notohara K, Okazaki K, Ryu JK, Saeki T, Sahani DV, Smyrk TC, Stone JR, Takahira M, Webster GJ, Yamamoto M, Zamboni G, Umehara H, Stone JH. Consensus statement on the pathology of IgG4-related disease. Mod Pathol 2012; 25:1181-92. PubMed
  • Ferrone CR, Pieretti-Vanmarcke R, Bloom JP, Zheng H, Szymonifka J, Wargo JA, Thayer SP, Lauwers GY, Deshpande V, Mino-Kenudson M, Fernández-del Castillo C, Lillemoe KD, Warshaw AL. Pancreatic ductal adenocarcinoma: long-term survival does not equal cure. Surgery 2012; 152:S43-9. PubMed
  • Zhang YF, Shi J, Yu HP, Feng AN, Fan XS, Lauwers GY, Mashimo H, Gold JS, Chen G, Huang Q. Factors predicting survival in patients with proximal gastric carcinoma involving the esophagus. World J Gastroenterol 2012; 18:3602-9. PubMed
  • Farris AB, Demicco EG, Le LP, Finberg KE, Miller J, Mandal R, Fukuoka J, Cohen C, Gaissert HA, Zukerberg LR, Lauwers GY, Iafrate AJ, Mino-Kenudson M. Clinicopathologic and molecular profiles of microsatellite unstable Barrett Esophagus-associated adenocarcinoma. Am J Surg Pathol 2011. PubMed
  • Gonzalez-Obeso E, Fujita H, Deshpande V, Ogawa F, Lisovsky M, Genevay M, Grzyb K, Brugge W, Lennerz JK, Shimizu M, Srivastava A, Lauwers GY. Gastric hyperplastic polyps: a heterogeneous clinicopathologic group including a distinct subset best categorized as mucosal prolapse polyp. Am J Surg Pathol 2011. PubMed
  • Furukawa T, Hatori T, Fujita I, Yamamoto M, Kobayashi M, Ohike N, Morohoshi T, Egawa S, Unno M, Takao S, Osako M, Yonezawa S, Mino-Kenudson M, Lauwers GY, Yamaguchi H, Ban S, Shimizu M. Prognostic relevance of morphological types of intraductal papillary mucinous neoplasms of the pancreas. Gut 2011; 60:509-16. PubMed
  • Younes M, Lauwers GY, Ertan A, Ergun G, Verm R, Bridges M, Woods K, Meriano F, Schmulen C, Johnson C, Barroso A, Schwartz J, McKechnie J, Lechago J. The significance of "indefinite for dysplasia" grading in Barrett metaplasia. Arch Pathol Lab Med 2011; 135:430-2. PubMed
  • Deshpande V, Nduaguba A, Zimmerman SM, Kehoe SM, Macconaill LE, Lauwers GY, Ferrone C, Bardeesy N, Zhu AX, Hezel AF. Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma. BMC Cancer 2011; 11:60. PubMed
  • Kelly PJ, Lauwers GY. Clinical guidelines: Consensus for the management of patients with gastric polyps. Nat Rev Gastroenterol Hepatol 2011; 8:7-8. PubMed
  • Coco DP, Goldblum JR, Hornick JL, Lauwers GY, Montgomery E, Srivastava A, Wang H, Odze RD. Interobserver variability in the diagnosis of crypt dysplasia in Barrett esophagus. Am J Surg Pathol 2010; 35:45-54. PubMed
  • Lisovsky M, Ogawa F, Dresser K, Woda B, Lauwers GY. Loss of cell polarity protein Lgl2 in foveolar-type gastric dysplasia: correlation with expression of the apical marker aPKC-zeta. Virchows Arch 2010; 457:635-42. PubMed
  • Klos CL, Shellito PC, Rattner DW, Hodin RA, Cusack JC, Bordeianou L, Sylla P, Hong TS, Blaszkowsky L, Ryan DP, Lauwers GY, Chang Y, Berger DL. The effect of neoadjuvant chemoradiation therapy on the prognostic value of lymph nodes after rectal cancer surgery. Am J Surg 2010; 200:440-5. PubMed
  • Lennerz JK, Kim SH, Oates EL, Huh WJ, Doherty JM, Tian X, Bredemeyer AJ, Goldenring JR, Lauwers GY, Shin YK, Mills JC. The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma. Am J Pathol 2010; 177:1514-33. PubMed
  • Kang HJ, Kim DH, Jeon TY, Lee SH, Shin N, Chae SH, Kim GH, Song GA, Kim DH, Srivastava A, Park do Y, Lauwers GY. Lymph node metastasis from intestinal-type early gastric cancer: experience in a single institution and reassessment of the extended criteria for endoscopic submucosal dissection. Gastrointest Endosc 2010; 72:508-15. PubMed
  • Roh JH, Srivastava A, Lauwers GY, An J, Jang KT, Park CK, Sohn TS, Kim S, Kim KM. Micropapillary carcinoma of stomach: a clinicopathologic and immunohistochemical study of 11 cases. Am J Surg Pathol 2010; 34:1139-46. PubMed
  • Lauwers GY. Biopsy diagnosis of non-IBD colitis. Int J Surg Pathol 2010; 18:48S-52S. PubMed
  • Lauwers GY. Gastritis: beyond Helicobacter pylori. Int J Surg Pathol 2010; 18:28S-32S. PubMed
  • Brown IS, Whiteman DC, Lauwers GY. Foveolar type dysplasia in Barrett esophagus. Mod Pathol 2010; 23:834-43. PubMed
  • Geboes K, Lauwers GY. Gastrointestinal pathology: a continuing challenge. Arch Pathol Lab Med 2010; 134:812-4. PubMed
  • Maduekwe UN, Lauwers GY, Fernandez-Del-Castillo C, Berger DL, Ferguson CM, Rattner DW, Yoon SS. New Metastatic Lymph Node Ratio System Reduces Stage Migration in Patients Undergoing D1 Lymphadenectomy for Gastric Adenocarcinoma. Ann Surg Oncol 2010; 17:1267-77. PubMed
  • Deshpande V, Hsu M, Kumarasinghe MP, Lauwers GY. The Clinical Significance of Incidental Chronic Colitis: A Study of 17 Cases. Am J Surg Pathol 2010; 34:463-9. PubMed
  • Strobel O, Rosow DE, Rakhlin EY, Lauwers GY, Trainor AG, Alsina J, Fernández-Del Castillo C, Warshaw AL, Thayer SP. Pancreatic duct glands are distinct ductal compartments that react to chronic injury and mediate Shh-induced metaplasia. Gastroenterology 2010; 138:1166-77. PubMed
  • Rubbia-Brandt L, Lauwers GY, Wang H, Majno PE, Tanabe K, Zhu AX, Brezault C, Soubrane O, Abdalla EK, Vauthey JN, Mentha G, Terris B. Sinusoidal obstruction syndrome and nodular regenerative hyperplasia are frequent oxaliplatin-associated liver lesions and partially prevented by bevacizumab in patients with hepatic colorectal metastasis. Histopathology 2010; 56:430-9. PubMed
  • Suter MJ, Jillella PA, Vakoc BJ, Halpern EF, Mino-Kenudson M, Lauwers GY, Bouma BE, Nishioka NS, Tearney GJ. Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine. Gastrointest Endosc 2010; 71:346-53. PubMed
  • Crippa S, Fernández-Del Castillo C, Salvia R, Finkelstein D, Bassi C, Domínguez I, Muzikansky A, Thayer SP, Falconi M, Mino-Kenudson M, Capelli P, Lauwers GY, Partelli S, Pederzoli P, Warshaw AL. Mucin-producing neoplasms of the pancreas: an analysis of distinguishing clinical and epidemiologic characteristics. Clin Gastroenterol Hepatol 2010; 8:213-9. PubMed
  • Lauwers GY, Fujita H, Nagata K, Shimizu M. Pathology of non-Helicobacter pylori gastritis: extending the histopathologic horizons. J Gastroenterol 2010; 45:131-45. PubMed
  • Konstantinidis IT, Deshpande V, Zheng H, Wargo JA, Fernandez-del Castillo C, Thayer SP, Androutsopoulos V, Lauwers GY, Warshaw AL, Ferrone CR. Does the mechanism of lymph node invasion affect survival in patients with pancreatic ductal adenocarcinoma? J Gastrointest Surg 2010; 14:261-7. PubMed
  • Geyer JT, Ferry JA, Harris NL, Stone JH, Zukerberg LR, Lauwers GY, Pilch BZ, Deshpande V. Chronic sclerosing sialadenitis (K端ttner tumor) is an IgG4-associated disease. Am J Surg Pathol 2010; 34:202-10. PubMed
  • Lauwers GY, Black-Schaffer S, Salto-Tellez M. Molecular pathology in contemporary diagnostic pathology laboratory: an opinion for the active role of surgical pathologists. Am J Surg Pathol 2009; 34:115-7. PubMed
  • Willett CG, Duda DG, Ancukiewicz M, Shah M, Czito BG, Bentley R, Poleski M, Fujita H, Lauwers GY, Carroll M, Tyler D, Mantyh C, Shellito P, Chung DC, Clark JW, Jain RK. A Safety and Survival Analysis of Neoadjuvant Bevacizumab with Standard Chemoradiation in a Phase I/II Study Compared with Standard Chemoradiation in Locally Advanced Rectal Cancer. Oncologist 2010; 15:845-51. PubMed
  • Park do Y, Srivastava A, Kim GH, Mino-Kenudson M, Deshpande V, Zukerberg LR, Song GA, Lauwers GY. CDX2 expression in the intestinal-type gastric epithelial neoplasia: frequency and significance. Mod Pathol 2010; 23:54-61. PubMed
  • Duda DG, Willett CG, Ancukiewicz M, di Tomaso E, Shah M, Czito BG, Bentley R, Poleski M, Lauwers GY, Carroll M, Tyler D, Mantyh C, Shellito P, Clark JW, Jain RK. Plasma soluble VEGFR-1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer. Oncologist 2010; 15:577-83. PubMed
  • Kang D, Suter MJ, Boudoux C, Yoo H, Yachimski PS, Puricelli WP, Nishioka NS, Mino-Kenudson M, Lauwers GY, Bouma BE, Tearney GJ. Comprehensive imaging of gastroesophageal biopsy samples by spectrally encoded confocal microscopy. Gastrointest Endosc 2010; 71:35-43. PubMed
  • Wilbur DC, Madi K, Colvin RB, Duncan LM, Faquin WC, Ferry JA, Frosch MP, Houser SL, Kradin RL, Lauwers GY, Louis DN, Mark EJ, Mino-Kenudson M, Misdraji J, Nielsen GP, Pitman MB, Rosenberg AE, Smith RN, Sohani AR, Stone JR, Tambouret RH, Wu CL, Young RH, Zembowicz A, Klietmann W. Whole-slide imaging digital pathology as a platform for teleconsultation: a pilot study using paired subspecialist correlations. Arch Pathol Lab Med 2009; 133:1949-53. PubMed
  • Zhou D, Conrad C, Xia F, Park JS, Payer B, Yin Y, Lauwers GY, Thasler W, Lee JT, Avruch J, Bardeesy N. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell 2009; 16:425-38. PubMed
  • Cleary JM, Tanabe KT, Lauwers GY, Zhu AX. Hepatic toxicities associated with the use of preoperative systemic therapy in patients with metastatic colorectal adenocarcinoma to the liver. Oncologist 2009; 14:1095-105. PubMed
  • Xu L, Duda DG, di Tomaso E, Ancukiewicz M, Chung DC, Lauwers GY, Samuel R, Shellito P, Czito BG, Lin PC, Poleski M, Bentley R, Clark JW, Willett CG, Jain RK. Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer. Cancer Res 2009; 69:7905-10. PubMed
  • Deshpande V, Sainani NI, Chung RT, Pratt DS, Mentha G, Rubbia-Brandt L, Lauwers GY. IgG4-associated cholangitis: a comparative histological and immunophenotypic study with primary sclerosing cholangitis on liver biopsy material. Mod Pathol 2009; 22:1287-95. PubMed
  • Lisovsky M,Dresser K,Baker S,Fisher A,Woda B,Banner B,Lauwers GY. Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study. Mod Pathol 2009; 22:977-84. PubMed
  • Willett CG,Duda DG,di Tomaso E,Boucher Y,Ancukiewicz M,Sahani DV,Lahdenranta J,Chung DC,Fischman AJ,Lauwers GY,Shellito P,Czito BG,Wong TZ,Paulson E,Poleski M,Vujaskovic Z,Bentley R,Chen HX,Clark JW,Jain RK. Efficacy, Safety, and Biomarkers of Neoadjuvant Bevacizumab, Radiation Therapy, and Fluorouracil in Rectal Cancer: A Multidisciplinary Phase II Study. J Clin Oncol 2009; 27:3020-6. PubMed
  • Kwak EL, Hong TS, Berger DL, Forcione DG, Uppot RN, Lauwers GY. Case records of the Massachusetts General Hospital. Case 19-2009. A 63-year-old woman with carcinoma of the gastroesophageal junction. N Engl J Med 2009; 360:2656-64. PubMed
  • Wang WL, Farris AB, Lauwers GY, Deshpande V. Autoimmune pancreatitis-related cholecystitis: a morphologically and immunologically distinctive form of lymphoplasmacytic sclerosing cholecystitis. Histopathology 2009; 54:829-36. PubMed
  • Carmack SW,Genta RM,Graham DY,Lauwers GY. Management of gastric polyps: a pathology-based guide for gastroenterologists. Nat Rev Gastroenterol Hepatol 2009; 6:331-41. PubMed
  • Konstantinidis IT,Deshpande V,Genevay M,Berger D,Fernandez-del Castillo C,Tanabe KK,Zheng H,Lauwers GY,Ferrone CR. Trends in presentation and survival for gallbladder cancer during a period of more than 4 decades: a single-institution experience. Arch Surg 2009; 144:441-7; discussion 447. PubMed
  • Mandal RV,Forcione DG,Brugge WR,Nishioka NS,Mino-Kenudson M,Lauwers GY. Effect of tumor characteristics and duplication of the muscularis mucosae on the endoscopic staging of superficial Barrett esophagus-related neoplasia. Am J Surg Pathol 2008; 33:620-5. PubMed
  • Lauwers GY,Forcione DG,Nishioka NS,Deshpande V,Lisovsky MY,Brugge WR,Mino-Kenudson M. Novel endoscopic therapeutic modalities for superficial neoplasms arising in Barrett's esophagus: a primer for surgical pathologists. Mod Pathol 2009; 22:489-98. PubMed
  • Jordan KW,Nordenstam J,Lauwers GY,Rothenberger DA,Alavi K,Garwood M,Cheng LL. Metabolomic characterization of human rectal adenocarcinoma with intact tissue magnetic resonance spectroscopy. Dis Colon Rectum 2009; 52:520-5. PubMed
  • Fritz S,Fernandez-del Castillo C,Mino-Kenudson M,Crippa S,Deshpande V,Lauwers GY,Warshaw AL,Thayer SP,Iafrate AJ. Global genomic analysis of intraductal papillary mucinous neoplasms of the pancreas reveals significant molecular differences compared to ductal adenocarcinoma. Ann Surg 2009; 249:440-7. PubMed
  • Goulart BH,Clark JW,Lauwers GY,Ryan DP,Grenon N,Muzikansky A,Zhu AX. Long term survivors with metastatic pancreatic adenocarcinoma treated with gemcitabine: a retrospective analysis. J Hematol Oncol 2009; 2:13. PubMed
  • Willingham FF,Gee DW,Sylla P,Lauwers GY,Rattner DW,Brugge WR. En bloc esophageal mucosectomy for concentric circumferential mucosal resection (with video). Gastrointest Endosc 2008; 69:147-51. PubMed
  • Ryan JL,Morgan DR,Dominguez RL,Thorne LB,Elmore SH,Mino-Kenudson M,Lauwers GY,Booker JK,Gulley ML. High levels of Epstein-Barr virus DNA in latently infected gastric adenocarcinoma. Lab Invest 2008; 89:80-90. PubMed
  • Sepehr A,Mino-Kenudson M,Ogawa F,Brugge WR,Deshpande V,Lauwers GY. IgG4+ to IgG+ plasma cells ratio of ampulla can help differentiate autoimmune pancreatitis from other "mass forming" pancreatic lesions. Am J Surg Pathol 2008; 32:1770-9. PubMed
  • Harris EI,Lewin DN,Wang HL,Lauwers GY,Srivastava A,Shyr Y,Shakhtour B,Revetta F,Washington MK. Lymphovascular invasion in colorectal cancer: an interobserver variability study. Am J Surg Pathol 2008; 32:1816-21. PubMed
  • Kang HJ,Park do Y,Kim KH,Song GA,Lauwers GY. [Pathologic diagnosis of gastric epithelial neoplasia] Korean J Gastroenterol 2008; 52:273-80. PubMed
  • Ogawa F,Mino-Kenudson M,Shimizu M,Ligato S,Lauwers GY. Gastroduodenitis associated with yttrium 90-microsphere selective internal radiation: an iatrogenic complication in need of recognition. Arch Pathol Lab Med 2008; 132:1734-8. PubMed
  • Weylandt KH,Nadolny A,Kahlke L,Kohnke T,Schmocker C,Wang J,Lauwers GY,Glickman JN,Kang JX. Reduction of inflammation and chronic tissue damage by omega-3 fatty acids in fat-1 transgenic mice with pancreatitis. Biochim Biophys Acta 2008; 1782:634-41. PubMed
  • Sabo E,Meitner PA,Tavares R,Corless CL,Lauwers GY,Moss SF,Resnick MB. Expression analysis of Barrett's esophagus-associated high-grade dysplasia in laser capture microdissected archival tissue. Clin Cancer Res 2008; 14:6440-8. PubMed
  • Suter MJ,Vakoc BJ,Yachimski PS,Shishkov M,Lauwers GY,Mino-Kenudson M,Bouma BE,Nishioka NS,Tearney GJ. Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging. Gastrointest Endosc 2008; 68:745-53. PubMed
  • Oble DA,Mino-Kenudson M,Goldsmith J,Hodi FS,Seliem RM,Dranoff G,Mihm M,Hasserjian R,Lauwers GY. Alpha-CTLA-4 mAb-associated panenteritis: a histologic and immunohistochemical analysis. Am J Surg Pathol 2008; 32:1130-7. PubMed
  • Farris AB,Lauwers GY,Ferry JA,Zukerberg LR. The rectal tonsil: a reactive lymphoid proliferation that may mimic lymphoma. Am J Surg Pathol 2008; 32:1075-9. PubMed
  • Belsley NA, Pitman MB, Lauwers GY, Brugge WR, Deshpande V. Serous cystadenoma of the pancreas: limitations and pitfalls of endoscopic ultrasound-guided fine-needle aspiration biopsy. Cancer 2008; 114:102-10. PubMed
  • Park DY, Srivastava A, Kim GH, Mino-Kenudson M, Deshpande V, Zukerberg LR, Song GA, Lauwers GY. Adenomatous and Foveolar Gastric Dysplasia: Distinct Patterns of Mucin Expression and Background Intestinal Metaplasia. Am J Surg Pathol 2008; 32:524-33. PubMed
  • Takayama T, Makuuchi M, Kojiro M, Lauwers GY, Adams RB, Wilson SR, Jang HJ, Charnsangavej C, Taouli B. Early hepatocellular carcinoma: pathology, imaging, and therapy. Ann Surg Oncol 2008; 15:972-8. PubMed
  • Crippa S, Salvia R, Warshaw AL, Dominguez I, Bassi C, Falconi M, Thayer SP, Zamboni G, Lauwers GY, Mino-Kenudson M, Capelli P, Pederzoli P, Castillo CF. Mucinous cystic neoplasm of the pancreas is not an aggressive entity: lessons from 163 resected patients. Ann Surg 2008; 247:571-9. PubMed
  • Park do Y, Lauwers GY. Gastric polyps: classification and management. Arch Pathol Lab Med 2008; 132:633-40. PubMed
  • Tanabe KK, Lemoine A, Finkelstein DM, Kawasaki H, Fujii T, Chung RT, Lauwers GY, Kulu Y, Muzikansky A, Kuruppu D, Lanuti M, Goodwin JM, Azoulay D, Fuchs BC. Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis. JAMA 2008; 299:53-60. PubMed
  • Hornick JL, Mino-Kenudson M, Lauwers GY, Liu W, Goyal R, Odze RD. Buried Barrett's Epithelium Following Photodynamic Therapy Shows Reduced Crypt Proliferation and Absence of DNA Content Abnormalities. Am J Gastroenterol 2007; 103:38-47. PubMed
  • Farris AB, Misdraji J, Srivastava A, Muzikansky A, Deshpande V, Lauwers GY, Mino-Kenudson M. Sessile serrated adenoma: challenging discrimination from other serrated colonic polyps. Am J Surg Pathol 2007; 32:30-5. PubMed
  • Robert ME, Lamps L, Lauwers GY. Recommendations for the reporting of gastric carcinoma. Hum Pathol 2007; 39:9-14. PubMed
  • Strobel O, Dor Y, Alsina J, Stirman A, Lauwers G, Trainor A, Castillo CF, Warshaw AL, Thayer SP. In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia. Gastroenterology 2007; 133:1999-2009. PubMed
  • Lauwers GY, Srivastava A. Gastric preneoplastic lesions and epithelial dysplasia. Gastroenterol Clin North Am 2007; 36:813-29, vi. PubMed
  • Park do Y, Sakamoto H, Kirley SD, Ogino S, Kawasaki T, Kwon E, Mino-Kenudson M, Lauwers GY, Chung DC, Rueda BR, Zukerberg LR. The Cables gene on chromosome 18q is silenced by promoter hypermethylation and allelic loss in human colorectal cancer. Am J Pathol 2007; 171:1509-19. PubMed
  • Srivastava A, Odze RD, Lauwers GY, Redston M, Antonioli DA, Glickman JN. Morphologic features are useful in distinguishing Barrett esophagus from carditis with intestinal metaplasia. Am J Surg Pathol 2007; 31:1733-41. PubMed
  • Koreishi A, Lauwers GY, Misdraji J. Pneumatosis intestinalis: a challenging biopsy diagnosis. Am J Surg Pathol 2007; 31:1469-75. PubMed
  • Cornell LD, Chicano SL, Deshpande V, Collins AB, Selig MK, Lauwers GY, Barisoni L, Colvin RB. Pseudotumors due to IgG4 immune-complex tubulointerstitial nephritis associated with autoimmune pancreatocentric disease. Am J Surg Pathol 2007; 31:1586-97. PubMed
  • Mino-Kenudson M, Hull MJ, Brown I, Muzikansky A, Srivastava A, Glickman J, Park DY, Zuckerberg L, Misdraji J, Odze RD, Lauwers GY. EMR for Barrett's esophagus-related superficial neoplasms offers better diagnostic reproducibility than mucosal biopsy. Gastrointest Endosc 2007; 66:660-6; quiz 767, 769. PubMed
  • Merritt R, Zeitels SM, Austen WG Jr, Lauwers GY, Gaissert HA. Staged closure of tracheogastrocutaneous fistula after esophagectomy for infiltrative granular cell tumor. J Thorac Cardiovasc Surg 2007; 134:805-7. PubMed
  • Shields HM, Shaffer K, O'farrell RP, Travers R, Hayward JN, Becker LS, Lauwers GY. Gastrointestinal manifestations of dermatologic disorders. Clin Gastroenterol Hepatol 2007; 5:1010-7; quiz 1005-6. PubMed
  • Choi MY, Lauwers GY, Hur C, Willett CG, Chung DC. Microsatellite instability is frequently observed in rectal cancer and influenced by neoadjuvant chemoradiation. Int J Radiat Oncol Biol Phys 2007; 68:1584. PubMed
  • Chung DC, Yoon SS, Lauwers GY, Patel D. Case records of the Massachusetts General Hospital. Case 22-2007. A woman with a family history of gastric and breast cancer. N Engl J Med 2007; 357:283-91. PubMed
  • Zen Y, Adsay NV, Bardadin K, Colombari R, Ferrell L, Haga H, Hong SM, Hytiroglou P, Kl. Biliary intraepithelial neoplasia: an international interobserver agreement study and proposal for diagnostic criteria. Mod Pathol 2007; 20:701-9. PubMed
  • Willett CG, Duda DG, di Tomaso E, Boucher Y, Czito BG, Vujaskovic Z, Vlahovic G, Bendell J, Cohen KS, Hurwitz HI, Bentley R, Lauwers GY, Poleski M, Wong TZ, Paulson E, Ludwig KA, Jain RK. Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer. Nat Clin Pract Oncol 2007; 4:316-21. PubMed
  • Vagefi PA, Razo O, Deshpande V, McGrath DJ, Lauwers GY, Thayer SP, Warshaw AL, Fern. Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 2005. Arch Surg 2007; 142:347-54. PubMed
  • Mino-Kenudson M, Ban S, Ohana M, Puricelli W, Deshpande V, Shimizu M, Nishioka NS, Lauwers GY. Buried dysplasia and early adenocarcinoma arising in barrett esophagus after porfimer-photodynamic therapy. Am J Surg Pathol 2007; 31:403-9. PubMed
  • Zorzi D, Laurent A, Pawlik TM, Lauwers GY, Vauthey JN, Abdalla EK. Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases. Br J Surg 2007; 94:274-86. PubMed
  • Deshpande V, Lauwers GY. Cystic pancreatic endocrine tumor: a variant commonly confused with cystic adenocarcinoma. Cancer 2006; 111:47-53. PubMed
  • Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, Hezel AF, Horner J, Lauwers GY, Hanahan D, DePinho RA. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev 2006; 20:3130-46. PubMed
  • Bartlett DL, Berlin J, Lauwers GY, Messersmith WA, Petrelli NJ, Venook AP. Chemotherapy and regional therapy of hepatic colorectal metastases: expert consensus statement. Ann Surg Oncol 2006; 13:1284-92. PubMed
  • Misdraji J, Oliva E, Goldblum JR, Lauwers GY, Compton CC,. Protocol for the examination of specimens from patients with invasive carcinomas of the appendix. Arch Pathol Lab Med 2006; 130:1433-9. PubMed
  • Kwak EL, Jankowski J, Thayer SP, Lauwers GY, Brannigan BW, Harris PL, Okimoto RA, Haserlat SM, Driscoll DR, Ferry D, Muir B, Settleman J, Fuchs CS, Kulke MH, Ryan DP, Clark JW, Sgroi DC, Haber DA, Bell DW. Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas. Clin Cancer Res 2006; 12:4283-7. PubMed
  • Vauthey JN, Pawlik TM, Ribero D, Wu TT, Zorzi D, Hoff PM, Xiong HQ, Eng C, Lauwers GY, Mino-Kenudson M, Risio M, Muratore A, Capussotti L, Curley SA, Abdalla EK. Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases. J Clin Oncol 2006; 24:2065-72. PubMed
  • Mitsuhashi T, Lauwers GY, Ban S, Mino-Kenudson M, Shimizu Y, Ogawa F, Ota S, Shimizu M. Post-Gastric Endoscopic Mucosal Resection Surveillance Biopsies: Evaluation of Mucosal Changes and Recognition of Potential Mimics of Residual Adenocarcinoma. Am J Surg Pathol 2006; 30:650-656. PubMed
  • Nishioka NS, Lauwers GY. Case records of the Massachusetts General Hospital. Case 10-2006. A 66-year-old woman with Barrett's esophagus with high-grade dysplasia. N Engl J Med 2006; 354:1403-9. PubMed
  • Sahani DV, Kadavigere R, Blake M, Fernandez-Del Castillo C, Lauwers GY, Hahn PF. Intraductal papillary mucinous neoplasm of pancreas: multi-detector row CT with 2D curved reformations--correlation with MRCP. Radiology 2006; 238:560-9. PubMed
  • Bendell JC, Lauwers GY, Willett C, Clark JW, Warshaw AL, Wain JC, Ryan DP. Pancreatoblastoma in a teenage patient. Clin Adv Hematol Oncol 2006; 4:150-3; discussion 154. PubMed
  • Farrell JJ, Lauwers GY, Brugge WR. Endoscopic mucosal resection using a cap-fitted endoscope improves tissue resection and pathology interpretation: an animal study. Gastric Cancer 2006; 9:3-8. PubMed
  • Hruban RH, Adsay NV, Albores-Saavedra J, Anver MR, Biankin AV, Boivin GP, Furth EE, Furukawa T, Klein A, Klimstra DS, Kloppel G, Lauwers GY, Longnecker DS, Luttges J, Maitra A, Offerhaus GJ, P. Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations. Cancer Res 2006; 66:95-106. PubMed
  • Evans JA, Poneros JM, Bouma BE, Bressner J, Halpern EF, Shishkov M, Lauwers GY, Mino-Kenudson M, Nishioka NS, Tearney GJ. Optical coherence tomography to identify intramucosal carcinoma and high-grade dysplasia in Barrett's esophagus. Clin Gastroenterol Hepatol 2006; 4:38-43. PubMed
  • Willett CG, Boucher Y, Duda DG, di Tomaso E, Munn LL, Tong RT, Kozin SV, Petit L, Jain RK, Chung DC, Sahani DV, Kalva SP, Cohen KS, Scadden DT, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Shellito PC, Mino-Kenudson M, Lauwers GY. Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients. J Clin Oncol 2005; 23:8136-9. PubMed
  • Deshpande V, Fernandez-del Castillo C, Muzikansky A, Deshpande A, Zukerberg L, Warshaw AL, Lauwers GY. Cytokeratin 19 is a powerful predictor of survival in pancreatic endocrine tumors. Am J Surg Pathol 2004; 28:1145-53. PubMed
  • Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RK. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 2004; 10:145-7. PubMed
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