Photo of Harald von Boehmer,  MD, PhD

Harald von Boehmer, MD, PhD

Dana-Farber Cancer Institute

Dana-Farber Cancer Institute
Phone: (617) 632-6880
Fax: (617) 632-6881

Harald von Boehmer, MD, PhD

Dana-Farber Cancer Institute


  • Professor, Microbiology and Immunobiology, Harvard Medical School
  • Professor of Pathology, Cancer Immunology and Virology, Dana-Farber Cancer Institute


Research Abstract

The focus is on T cell development with implications for generation of distinct T cell lineages as well as acute lymphoblastic T cell leukemia (T-ALL). T cell receptor transgenic mice have been utilized to elucidate mechanisms of positive selection that result in the generation of CD8+ killer cells, CD4+ helper cells and CD4+ regulatory cells that express Foxp3. Presently, research focuses on T cell receptor and TGF-beta signaling pathways that permit conversion of naïve T cells into regulatory T cells in vivo and result in antigen-specific tolerance to transplantation antigens. In disease models it was determined that antigen-specific Tregs can suppress tumor-specific immune response by preventing exocytosis of cytolytic granules by CD8 T cells during the effector phase.

Experiments concerned with T cell receptor- and Notch-signaling have revealed that lineage commitment is instructed by the intensity of TCR signals and that Notch signaling is mandatory for the generation of alpha/beta but not gamma/delta lineage cells. Overexpression of intracellular Notch results in T-ALL with highly reproducible phenotypes making it feasible to determine the contribution of oncogenes, tumor suppressors, genomic instability and microRNAs to molecular pathways of malignancy.


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  • Li N, Fassl A, Chick J, Inuzuka H, Li X, Mansour MR, Liu L, Wang H, King B, Shaik S, Gutierrez A, Ordureau A, Otto T, Kreslavsky T, Baitsch L, Bury L, Meyer CA, Ke N, Mulry KA, Kluk MJ, Roy M, Kim S, Zhang X, Geng Y, Zagozdzon A, Jenkinson S, Gale RE, Linch DC, Zhao JJ, Mullighan CG, Harper JW, Aster JC, Aifantis I, von Boehmer H, Gygi SP, Wei W, Look AT, Sicinski P. Cyclin C is a haploinsufficient tumour suppressor. Nat Cell Biol 2014; 16:1080-91. PubMed
  • von Boehmer H. The thymus in immunity and in malignancy. Cancer Immunol Res 2014; 2:592-7. PubMed
  • Von Boehmer H. Deciphering thymic development. 2014; 5:424. PubMed
  • Kreslavsky T, Kim HJ, Koralov SB, Ghitza D, Buch T, Cantor H, Rajewsky K, von Boehmer H. Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes. J Exp Med 2013; 210:1911-8. PubMed
  • Mansour MR, Sanda T, Lawton LN, Li X, Kreslavsky T, Novina CD, Brand M, Gutierrez A, Kelliher MA, Jamieson CH, von Boehmer H, Young RA, Look AT. The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia. J Exp Med 2013; 210:1545-57. PubMed
  • Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer M, Nolan G, Kobayashi K, von Boehmer H, Mathis D, Benoist C, , Best AJ, Knell J, Goldrath A, Jojic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Rao TN, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S. The transcriptional landscape of 留硫 T cell differentiation. Nat Immunol 2013. PubMed
  • von Boehmer H, Daniel C. Therapeutic opportunities for manipulating T(Reg) cells in autoimmunity and cancer. Nat Rev Drug Discov 2012; 12:51-63. PubMed
  • Kreslavsky T, Gleimer M, Miyazaki M, Choi Y, Gagnon E, Murre C, Sicinski P, von Boehmer H. 硫-Selection-Induced Proliferation Is Required for 留硫 T Cell Differentiation. Immunity 2012; 37:840-53. PubMed
  • Choi YJ, Li X, Hydbring P, Sanda T, Stefano J, Christie AL, Signoretti S, Look AT, Kung AL, von Boehmer H, Sicinski P. The requirement for cyclin D function in tumor maintenance. Cancer Cell 2012; 22:438-51. PubMed
  • Schlenner SM, Weigmann B, Ruan Q, Chen Y, von Boehmer H. Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut. J Exp Med 2012; 209:1529-35. PubMed
  • Gleimer M, von Boehmer H, Kreslavsky T. PLZF Controls the Expression of a Limited Number of Genes Essential for NKT Cell Function. 2012; 3:374. PubMed
  • Li X, Sanda T, Look AT, Novina CD, von Boehmer H. Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL. J Exp Med 2011. PubMed
  • Daniel C, Ploegh H, von Boehmer H. Antigen-specific induction of regulatory T cells in vivo and in vitro. Methods Mol Biol 2011; 707:173-85. PubMed
  • Kreslavsky T, Gleimer M, Garbe AI, Von Boehmer H. 留硫 versus 粒隆 fate choice: counting the T-cell lineages at the branch point. Immunol Rev 2010; 238:169-81. PubMed
  • Stern JN, Keskin DB, Kato Z, Waldner H, Schallenberg S, Anderson A, von Boehmer H, Kretschmer K, Strominger JL. Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells. Proc Natl Acad Sci U S A 2010; 107:17280-5. PubMed
  • Daniel C, Wennhold K, Kim HJ, von Boehmer H. Enhancement of antigen-specific Treg vaccination in vivo. Proc Natl Acad Sci U S A 2010; 107:16246-51. PubMed
  • Kreslavsky T, von Boehmer H. gammadeltaTCR ligands and lineage commitment. Semin Immunol 2010; 22:214-21. PubMed
  • Merkenschlager M, von Boehmer H. PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors. J Exp Med 2010; 207:1347-50. PubMed
  • Gleimer M, von Boehmer H. Thymocyte selection: chemokine signaling is not only about the destination. Curr Biol 2010; 20:R316-8. PubMed
  • Kreslavsky T, Gleimer M, von Boehmer H. alphabeta versus gammadelta lineage choice at the first TCR-controlled checkpoint. Curr Opin Immunol 2010; 22:185-92. PubMed
  • Feuerer M, Hill JA, Kretschmer K, von Boehmer H, Mathis D, Benoist C. Genomic definition of multiple ex vivo regulatory T cell subphenotypes. Proc Natl Acad Sci U S A 2010; 107:5919-24. PubMed
  • Sanda T, Li X, Gutierrez A, Ahn Y, Neuberg DS, O'Neil J, Strack PR, Winter CG, Winter SS, Larson RS, von Boehmer H, Look AT. Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia. Blood 2010; 115:1735-45. PubMed
  • Saran N, Łyszkiewicz M, Pommerencke J, Witzlau K, Vakilzadeh R, Ballmaier M, von Boehmer H, Krueger A. Multiple extrathymic precursors contribute to T-cell development with different kinetics. Blood 2010; 115:1137-44. PubMed
  • von Boehmer H, Melchers F. Checkpoints in lymphocyte development and autoimmune disease. Nat Immunol 2009; 11:14-20. PubMed
  • Tian J, Dang H, von Boehmer H, Jaeckel E, Kaufman DL. Transgenically induced GAD tolerance curtails the development of early beta-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other beta-cell antigens. Diabetes 2009; 58:2843-50. PubMed
  • Nolting J, Daniel C, Reuter S, Stuelten C, Li P, Sucov H, Kim BG, Letterio JJ, Kretschmer K, Kim HJ, von Boehmer H. Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. J Exp Med 2009; 206:2131-9. PubMed
  • Cao Z, Wara AK, Icli B, Sun X, Packard RR, Esen F, Stapleton CJ, Subramaniam M, Kretschmer K, Apostolou I, von Boehmer H, Hansson GK, Spelsberg TC, Libby P, Feinberg MW. Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells. J Biol Chem 2009; 284:24914-24. PubMed
  • von Boehmer H. Central tolerance: essential for preventing autoimmune disease? Eur J Immunol 2009; 39:2313-6. PubMed
  • Kreslavsky T, Savage AK, Hobbs R, Gounari F, Bronson R, Pereira P, Pandolfi PP, Bendelac A, von Boehmer H. TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity. Proc Natl Acad Sci U S A 2009; 106:12453-8. PubMed
  • Daniel C, Nolting J, von Boehmer H. Mechanisms of self-nonself discrimination and possible clinical relevance. 2010; 1:631-644. PubMed
  • Saint-Ruf C,Ungewiss K,Groettrup M,Bruno L,Fehling HJ,von Boehmer H. Analysis and expression of a cloned pre-T cell receptor gene. Science. 1994. 266: 1208-1212. J Immunol 2009; 182:5165-9. PubMed
  • von Boehmer H. Notch 1 keeps pro-T cells on track. Immunity 2009; 30:5-7. PubMed
  • Li X,Gounari F,Protopopov A,Khazaie K,von Boehmer H. Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1. J Exp Med 2008; 205:2851-61. PubMed
  • Apostolou I,Verginis P,Kretschmer K,Polansky J,Huhn J,von Boehmer H. Peripherally induced Treg: mode, stability, and role in specific tolerance. J Clin Immunol 2008; 28:619-24. PubMed
  • Polansky JK,Kretschmer K,Freyer J,Floess S,Garbe A,Baron U,Olek S,Hamann A,von Boehmer H,Huehn J. DNA methylation controls Foxp3 gene expression. Eur J Immunol 2008; 38:1654-63. PubMed
  • von Boehmer H. Positive and negative selection in Basel. Nat Immunol 2008; 9:571-3. PubMed
  • Kreslavsky T, Garbe AI, Krueger A, von Boehmer H. T cell receptor-instructed {alpha}{beta} versus {gamma}{delta} lineage commitment revealed by single-cell analysis. J Exp Med 2008; 205:1173-86. PubMed
  • Rajewsky K,von Boehmer H. Lymphocyte development: overview. Curr Opin Immunol 2008; 20:127-30. PubMed
  • Verginis P, McLaughlin KA, Wucherpfennig KW, von Boehmer H, Apostolou I. Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression. Proc Natl Acad Sci U S A 2008; 105:3479-84. PubMed
  • von Boehmer H, Nolting J. What turns on Foxp3? Nat Immunol 2008; 9:121-2. PubMed
  • Egawa T, Kreslavsky T, Littman DR, von Boehmer H. Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping. PLoS ONE 2008; 3:e1512. PubMed
  • Fasseu M, Aplan PD, Chopin M, Boissel N, Bories JC, Soulier J, von Boehmer H, Sigaux F, Regnault A. p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not preTCR deficiency inhibit TAL1-linked T-lineage leukemogenesis. Blood 2007; 110:2610-9. PubMed
  • Guo Z, Dose M, Kovalovsky D, Chang R, O'neil J, Look AT, von Boehmer H, Khazaie K, Gounari F. {beta}-Catenin stabilization stalls the transition from Double-Positive to Single Positive stage and predisposes thymocytes to malignant transformation. Blood 2007; 109:5463-72. PubMed
  • Bhandoola A, von Boehmer H, Petrie HT, Zuniga-Pflucker JC. Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from. Immunity 2007; 26:678-89. PubMed
  • Garbe AI, von Boehmer H. TCR and Notch synergize in alphabeta versus gammadelta lineage choice. Trends Immunol 2007; 28:124-31. PubMed
  • Marson A, Kretschmer K, Frampton GM, Jacobsen ES, Polansky JK, MacIsaac KD, Levine SS, Fraenkel E, von Boehmer H, Young RA. Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature 2007; 445:931-5. PubMed
  • Krueger A, von Boehmer H. Identification of a T lineage-committed progenitor in adult blood. Immunity 2007; 26:105-16. PubMed
  • von Boehmer H. Can studies of tolerance ever lead to therapy? Ann Rheum Dis 2006; 65 Suppl 3:iii41-3. PubMed
  • Dose M, Khan I, Guo Z, Kovalovsky D, Krueger A, von Boehmer H, Khazaie K, Gounari F. c-Myc mediates preTCR induced proliferation but not developmental progression. Blood 2006; 108:2669-77. PubMed
  • Krueger A, Garbe AI, von Boehmer H. Phenotypic plasticity of T cell progenitors upon exposure to Notch ligands. J Exp Med 2006; 203:1977-84. PubMed
  • Kretschmer K, Apostolou I, Jaeckel E, Khazaie K, von Boehmer H. Making regulatory T cells with defined antigen specificity: role in autoimmunity and cancer. Immunol Rev 2006; 212:163-9. PubMed
  • Mempel TR, Pittet MJ, Khazaie K, Weninger W, Weissleder R, von Boehmer H, von Andrian UH. Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity 2006; 25:129-41. PubMed
  • Ciofani M, Knowles GC, Wiest DL, von Boehmer H, Z. Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation. Immunity 2006; 25:105-16. PubMed
  • Campese AF, Garbe AI, Zhang F, Grassi F, Screpanti I, von Boehmer H. Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling. Blood 2006; 108:305-10. PubMed
  • Garbe AI, Krueger A, Gounari F, Z. Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate. J Exp Med 2006; 203:1579-90. PubMed
  • Aifantis I, Bassing CH, Garbe AI, Sawai K, Alt FW, von Boehmer H. The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells. J Exp Med 2006; 203:1543-50. PubMed
  • Scimone ML, Aifantis I, Apostolou I, von Boehmer H, von Andrian UH. A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus. Proc Natl Acad Sci U S A 2006; 103:7006-11. PubMed
  • Grabher C, von Boehmer H, Look AT. Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nat Rev Cancer 2006; 6:347-59. PubMed
  • von Boehmer H. Immunology. Thoracic thymus, exclusive no longer. Science 2006; 312:206-7. PubMed
  • Jaeckel E, Kretschmer K, Apostolou I, von Boehmer H. Instruction of Treg commitment in peripheral T cells is suited to reverse autoimmunity. Semin Immunol 2006; 18:89-92. PubMed
  • Khazaie K, von Boehmer H. The impact of CD4+CD25+ Treg on tumor specific CD8+ T cell cytotoxicity and cancer. Semin Cancer Biol 2006; 16:124-36. PubMed
  • von Boehmer H, Kisielow P. Negative selection of the T-cell repertoire: where and when does it occur? Immunol Rev 2006; 209:284-9. PubMed
  • Kretschmer K, Apostolou I, Hawiger D, Khazaie K, Nussenzweig MC, von Boehmer H. Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol 2005; 6:1219-27. PubMed
  • von Boehmer H. Shaping the T cell repertoire. J Immunol 2005; 175:7067-8. PubMed
  • Bruder D, Westendorf AM, Hansen W, Prettin S, Gruber AD, Qian Y, von Boehmer H, Mahnke K, Buer J. On the edge of autoimmunity: T-cell stimulation by steady-state dendritic cells prevents autoimmune diabetes. Diabetes 2005; 54:3395-401. PubMed
  • von Boehmer H. Notch in lymphopoiesis and T cell polarization. Nat Immunol 2005; 6:641-2. PubMed
  • von Boehmer H. Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate. Nat Rev Immunol 2005; 5:571-7. PubMed
  • von Boehmer H. Peptide-based instruction of suppressor commitment in nae T cells and dynamics of immunosuppression in vivo. Scand J Immunol 2005; 62 Suppl 1:49-54. PubMed
  • von Boehmer H. Mechanisms of suppression by suppressor T cells. Nat Immunol 2005; 6:338-44. PubMed
  • Mandal M, Borowski C, Palomero T, Ferrando AA, Oberdoerffer P, Meng F, Ruiz-Vela A, Ciofani M, Zuniga-Pflucker JC, Screpanti I, Look AT, Korsmeyer SJ, Rajewsky K, von Boehmer H, Aifantis I. The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med 2005; 201:603-14. PubMed
  • Jaeckel E, von Boehmer H, Manns MP. Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes. Diabetes 2004; 54:306-10. PubMed
  • Chen ML, Pittet MJ, Gorelik L, Flavell RA, Weissleder R, von Boehmer H, Khazaie K. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci U S A 2004; 102:419-24. PubMed
  • Jaeckel E, Lipes MA, von Boehmer H. Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes. Nat Immunol 2004; 5:1028-35. PubMed
  • Von Boehmer H, Nussenzweig MC. The manipulation of immunity. EMBO Rep 2004; 5:765-70. PubMed
  • Von Boehmer H. Type 1 diabetes: focus on prevention. Nat Med 2004; 10:783-4. PubMed
  • Apostolou I, Von Boehmer H. In vivo instruction of suppressor commitment in naive T cells. J Exp Med 2004; 199:1401-8. PubMed
  • Apostolou I, Von Boehmer H. The TCR-HA, INS-HA transgenic model of autoimmune diabetes: limitations and expectations. J Autoimmun 2004; 22:111-4. PubMed
  • Borowski C, Li X, Aifantis I, Gounari F, Von Boehmer H. Pre-TCR{alpha} and TCR{alpha} Are Not Interchangeable Partners of TCR{beta} during T Lymphocyte Development. J Exp Med 2004; 199:607-615. PubMed
  • Von Boehmer H. Selection of the T-cell repertoire: receptor-controlled checkpoints in T-cell development. Adv Immunol 2004; 84:201-38. PubMed
  • Sicinska E, Aifantis I, Le Cam L, Swat W, Borowski C, Yu Q, Ferrando AA, Levin SD, Geng Y, von Boehmer H, Sicinski P. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell 2004; 4:451-61. PubMed
  • Talora C, Campese AF, Bellavia D, Pascucci M, Checquolo S, Groppioni M, Frati L, von Boehmer H, Gulino A, Screpanti I. Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma. EMBO Rep 2003; 4:1067-72. PubMed
  • Apostolou I, Hao Z, Rajewsky K, von Boehmer H. Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes. J Exp Med 2003; 198:1103-6. PubMed
  • von Boehmer H. Dynamics of suppressor T cells: in vivo veritas. J Exp Med 2003; 198:845-9. PubMed
  • Martin CH, Aifantis I, Scimone ML, von Andrian UH, Reizis B, von Boehmer H, Gounari F. Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential. Nat Immunol 2003; 4:866-73. PubMed
  • Walter U, Toepfer T, Dittmar KE, Kretschmer K, Lauber J, Weiss S, Servos G, Lechner O, Scherbaum WA, Bornstein SR, Von Boehmer H, Buer J. Pancreatic NOD beta cells express MHC class II protein and the frequency of I-A(g7) mRNA-expressing beta cells strongly increases during progression to autoimmune diabetes. Diabetologia 2003; 46:1106-14. PubMed
  • Klein L, Khazaie K, von Boehmer H. In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc Natl Acad Sci U S A 2003; 15:8886-8891.
  • Haughn L, Hawley RG, Morrison DK, von Boehmer H, Hockenbery DM. BCL-2 and BCL-XL restrict lineage choice during hematopoietic differentiation. J Biol Chem 2003; 278:25158-65. PubMed
  • Jaeckel E, Klein L, Martin-Orozco N, von Boehmer H. Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase. J Exp Med 2003; 197:1635-44. PubMed
  • Klein L, Trautman L, Psarras S, Schnell S, Siermann A, Liblau R, von Boehmer H, Khazaie K. Visualizing the course of antigen-specific CD8 and CD4 T cell responses to a growing tumor. Eur J Immunol 2003; 33:806-14. PubMed
  • Von Boehmer H, Aifantis I, Gounari F, Azogui O, Haughn L, Apostolou I, Jaeckel E, Grassi F, Klein L. Thymic selection revisited: how essential is it? Immunol Rev 2003; 191:62-78. PubMed
  • Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, Turley SJ, von Boehmer H, Bronson R, Dierich A, Benoist C, Mathis D. Projection of an immunological self shadow within the thymus by the aire protein. Science 2002; 298:1395-401. PubMed
  • Ito Y, Arai S, van Oers NS, Aifantis I, von Boehmer H, Miyazaki T. Positive selection by the pre-TCR yields mature CD8+ T cells J Immunol 2002; 169:4913-9. PubMed
  • Apostolou I, Sarukhan A, Klein L, von Boehmer H. Origin of regulatory T cells with known specificity for antigen. Nat Immunol 2002; 3:756-63. PubMed
  • Panigada M, Porcellini S, Barbier E, Hoeflinger S, Cazenave PA, Gu H, Band H, von Boehmer H, Grassi F. Constitutive endocytosis and degradation of the pre-T cell receptor. J Exp Med 2002; 195:1585-97. PubMed
  • Gounari F, Signoretti S, Bronson R, Klein L, Sellers WR, Kum J, Siermann A, Taketo MM, von Boehmer H, Khazaie K. Stabilization of beta-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia. Oncogene 2002; 21:4099-107. PubMed
  • Gounari F, Aifantis I, Martin C, Fehling HJ, Hoeflinger S, Leder P, von Boehmer H, Reizis B. Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene. Nat Immunol 2002; 3:489-96. PubMed
  • Aifantis I, Borowski C, Gounari F, Lacorazza HD, Nikolich-Zugich J, von Boehmer H. A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development. Nat Immunol 2002; 3:483-8. PubMed
  • Borowski C, Martin C, Gounari F, Haughn L, Aifantis I, Grassi F, von Boehmer H. On the brink of becoming a T cell. Curr Opin Immunol 2002; 14:200-6. PubMed
  • Casares S, Hurtado A, McEvoy RC, Sarukhan A, von Boehmer H, Brumeanu TD. Down-regulation of diabetogenic CD4+ T cells by a soluble dimeric peptide-MHC class II chimera. Nat Immunol 2002; 3:383-91. PubMed
  • Bellavia D, Campese AF, Checquolo S, Balestri A, Biondi A, Cazzaniga G, Lendahl U, Fehling HJ, Hayday AC, Frati L, von Boehmer H, Gulino A, Screpanti I. Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. Proc Natl Acad Sci U S A 2002; 99:3788-93. PubMed
  • Lambolez F, Azogui O, Joret AM, Garcia C, von Boehmer H, Di Santo J, Ezine S, Rocha B. Characterization of T cell differentiation in the murine gut. J Exp Med 2002; 195:437-49. PubMed
  • Miyoshi K, Shillingford JM, Le Provost F, Gounari F, Bronson R, von Boehmer H, Taketo MM, Cardiff RD, Hennighausen L, Khazaie K. Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias. Proc Natl Acad Sci U S A 2002; 99:219-24. PubMed