Photo of Harvey Mamon,  MD, PhD

Harvey Mamon, MD, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital


hmamon@lroc.harvard.edu

Harvey Mamon, MD, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Associate Professor, Radiation Oncology, Harvard Medical School
  • Clinical Director, Radiation Oncology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My research activities are focused on optimizing the combination of radiation with systemic therapies including conventional chemotherapy and newer targeted agents in the management of malignancies of the gastrointestinal tract. Ongoing projects include using two radiosensitizing chemotherapeutic agents, 5FU and Gemcitabine, with radiation in treating pancreatic cancer, adding Cox-2 inhibitors to chemotherapy and radiation for rectal cancer, and, in collaboration with Dr. Peter Enzinger, testing novel agents with combined chemotherapy and radiation for esophageal cancer. A parallel interest is the development of new techniques for delivery of radiaition therapy and measuring radiation effects on normal tissues. Projects include assessing the use of extractranial stereotactic radiosurgery for management of liver metastases, and assessment of changes in cardiac function following radiation for esophageal cancer. Lastly, I would like to expand my research activities to include translational projects such as identifying biomarkers as prognostic or predictive factors for the response to treatment, and development of targeted agents to act as a radiosensitizers.

Publications

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  • Wu AJ, Bosch WR, Chang DT, Hong TS, Jabbour SK, Kleinberg LR, Mamon HJ, Thomas CR, Goodman KA. Expert Consensus Contouring Guidelines for Intensity Modulated Radiation Therapy in Esophageal and Gastroesophageal Junction Cancer. Int J Radiat Oncol Biol Phys 2015; 92:911-20. PubMed
  • Buscariollo DL, Mamon HJ. Optimal management of resectable gastric adenocarcinoma. Expert Rev Anticancer Ther 2015. PubMed
  • Castellanos-Rizaldos E, Paweletz C, Song C, Oxnard GR, Mamon H, J√§nne PA, Makrigiorgos GM. Enhanced Ratio of Signals Enables Digital Mutation Scanning for Rare Allele Detection. J Mol Diagn 2015. PubMed
  • Steingisser L, Acker B, Berman S, Brenner MJ, Bornstein BA, Busse P, FitzGerald TJ, Jacobson JO, Jekowsky E, Kachnic LA, Mamon H, McKee A, Shulman LN, Stevenson MA, Wazer D, Fallon JA. Bending the cost curve: a unique collaboration between radiation oncologists and blue cross blue shield of massachusetts to optimize the use of advanced technology. J Oncol Pract 2014; 10:e321-7. PubMed
  • Hong TS, Bosch WR, Krishnan S, Kim TK, Mamon HJ, Shyn P, Ben-Josef E, Seong J, Haddock MG, Cheng JC, Feng MU, Stephans KL, Roberge D, Crane C, Dawson LA. Interobserver variability in target definition for hepatocellular carcinoma with and without portal vein thrombus: radiation therapy oncology group consensus guidelines. Int J Radiat Oncol Biol Phys 2014; 89:804-13. PubMed
  • Wolpin BM, Rubinson DA, Wang X, Chan JA, Cleary JM, Enzinger PC, Fuchs CS, McCleary NJ, Meyerhardt JA, Ng K, Schrag D, Sikora AL, Spicer BA, Killion L, Mamon H, Kimmelman AC. Phase II and Pharmacodynamic Study of Autophagy Inhibition Using Hydroxychloroquine in Patients With Metastatic Pancreatic Adenocarcinoma. Oncologist 2014; 19:637-8. PubMed
  • Hong TS, Ryan DP, Borger DR, Blaszkowsky LS, Yeap BY, Ancukiewicz M, Deshpande V, Shinagare S, Wo JY, Boucher Y, Wadlow RC, Kwak EL, Allen JN, Clark JW, Zhu AX, Ferrone CR, Mamon HJ, Adams J, Winrich B, Grillo T, Jain RK, DeLaney TF, Fernandez-Del Castillo C, Duda DG. A Phase 1/2 and Biomarker Study of Preoperative Short Course Chemoradiation With Proton Beam Therapy and Capecitabine Followed By Early Surgery for Resectable Pancreatic Ductal Adenocarcinoma. Int J Radiat Oncol Biol Phys 2014. PubMed
  • Patel SA, Chen YH, Hornick JL, Catalano P, Nowak JA, Zukerberg LR, Bleday R, Shellito PC, Hong TS, Mamon HJ. Early-stage rectal cancer: clinical and pathologic prognostic markers of time to local recurrence and overall survival after resection. Dis Colon Rectum 2014; 57:449-59. PubMed
  • Russo AL, Ryan DP, Borger DR, Wo JY, Szymonifka J, Liang WY, Kwak EL, Blaszkowsky LS, Clark JW, Allen JN, Zhu AX, Berger DL, Cusack JC, Mamon HJ, Haigis KM, Hong TS. Mutational and clinical predictors of pathologic complete response in the treatment of locally advanced rectal cancer. J Gastrointest Cancer 2014; 45:34-9. PubMed
  • Schoenfeld JD, Wo JY, Mamon HJ, Kwak EL, Mullen JT, Enzinger PZ, Blaskowsky LS, Ryan DP, Hong TS. The Impact of Positive Margins on Outcome Among Patients With Gastric Cancer Treated With Radiation. Am J Clin Oncol 2014. PubMed
  • Mamon HJ, Tepper JE. Combination chemoradiation therapy: the whole is more than the sum of the parts. J Clin Oncol 2014; 32:367-9. PubMed
  • Wo JY, Mamon HJ, Ferrone CR, Ryan DP, Blaszkowsky LS, Kwak EL, Tseng YD, Napolitano BN, Ancukiewicz M, Swanson RS, Lillemoe KD, Fernandez-del Castillo C, Hong TS. Phase I study of neoadjuvant accelerated short course radiation therapy with photons and capecitabine for resectable pancreatic cancer. Radiother Oncol 2014; 110:160-4. PubMed
  • Pretz JL, Wo JY, Mamon HJ, Kachnic LA, Hong TS. Chemoradiation therapy: localized esophageal, gastric, and pancreatic cancer. Surg Oncol Clin N Am 2013; 22:511-24. PubMed
  • Shulman LN, Mamon H, Jacobson JO, Steingisser L, Dodek A, Fallon JA. Partnership between a cancer center and payer: opportunities for improved quality of care and cost reduction. J Oncol Pract 2013; 9:133-4. PubMed
  • Guha M, Castellanos-Rizaldos E, Liu P, Mamon H, Makrigiorgos GM. Differential strand separation at critical temperature: a minimally disruptive enrichment method for low-abundance unknown DNA mutations. Nucleic Acids Res 2013; 41:e50. PubMed
  • Lee MS, Mamon HJ, Hong TS, Choi NC, Fidias PM, Kwak EL, Meyerhardt JA, Ryan DP, Bueno R, Donahue DM, Jaklitsch MT, Lanuti M, Rattner DW, Fuchs CS, Enzinger PC. Preoperative cetuximab, irinotecan, Cisplatin, and radiation therapy for patients with locally advanced esophageal cancer. Oncologist 2013; 18:281-7. PubMed
  • Castellanos-Rizaldos E, Liu P, Milbury CA, Guha M, Brisci A, Cremonesi L, Ferrari M, Mamon H, Makrigiorgos GM. Temperature-tolerant COLD-PCR reduces temperature stringency and enables robust mutation enrichment. Clin Chem 2012; 58:1130-8. PubMed
  • Margalit DN, Mamon HJ, Ancukiewicz M, Kobayashi W, Ryan DP, Blaszkowsky LS, Clark J, Willett CG, Hong TS. Tolerability of Combined Modality Therapy for Rectal Cancer in Elderly Patients Aged 75 Years and Older. Int J Radiat Oncol Biol Phys 2011. PubMed
  • Milbury CA, Chen CC, Mamon H, Liu P, Santagata S, Makrigiorgos GM. Multiplex amplification coupled with COLD-PCR and high resolution melting enables identification of low-abundance mutations in cancer samples with low DNA content. J Mol Diagn 2011; 13:220-32. PubMed
  • Hong TS, Ryan DP, Blaszkowsky LS, Mamon HJ, Kwak EL, Mino-Kenudson M, Adams J, Yeap B, Winrich B, Delaney TF, Fernandez-Del Castillo C. Phase I Study of Preoperative Short-Course Chemoradiation with Proton Beam Therapy and Capecitabine for Resectable Pancreatic Ductal Adenocarcinoma of the Head. Int J Radiat Oncol Biol Phys 2010; 79:151-7. PubMed
  • Mamon HJ, Niedzwiecki D, Hollis D, Tan BR, Mayer RJ, Tepper JE, Goldberg RM, Blackstock AW, Fuchs CS, . A phase 2 trial of gemcitabine, 5-florouracil, and radiation therapy in locally advanced nonmetastatic pancreatic adenocarcinoma : cancer and Leukemia Group B (CALGB) 80003. Cancer 2010. PubMed
  • Bunnell CA, Weingart SN, Swanson S, Mamon HJ, Shulman LN. Models of multidisciplinary cancer care: physician and patient perceptions in a comprehensive cancer center. J Oncol Pract 2011; 6:283-8. PubMed
  • Mak RH, McCarthy EP, Das P, Hong TS, Mamon HJ, Hoffman KE. Adoption of Preoperative Radiation Therapy for Rectal Cancer From 2000 to 2006: A Surveillance, Epidemiology, and End Results Patterns-of-Care Study. Int J Radiat Oncol Biol Phys 2010. PubMed
  • Arvold ND, Niemierko A, Mamon HJ, Fernandez-Del Castillo C, Hong TS. Pancreatic Cancer Tumor Size on CT Scan Versus Pathologic Specimen: Implications for Radiation Treatment Planning. Int J Radiat Oncol Biol Phys 2010. PubMed
  • Miyamoto DT, Mamon HJ, Ryan DP, Willett CG, Ancukiewicz M, Kobayashi WK, Blaszkowsky L, Castillo CF, Hong TS. Outcomes and Tolerability of Chemoradiation Therapy for Pancreatic Cancer Patients Aged 75 Years or Older. Int J Radiat Oncol Biol Phys 2010; 77:1171-7. PubMed
  • Mak RH, Mamon HJ, Ryan DP, Miyamoto DT, Ancukiewicz M, Kobayashi WK, Willett CG, Choi NC, Blaszkowsky LS, Hong TS. Toxicity and outcomes after chemoradiation for esophageal cancer in patients age 75 or older. 2010; 23:316-23. PubMed
  • Chen RC, Mamon HJ, Chen YH, Gelman RS, Suh WW, Talcott JA, Clark JW, Hong TS. Patient-reported acute gastrointestinal symptoms during concurrent chemoradiation treatment for rectal cancer. Cancer 2010; 116:1879-86. PubMed
  • Park SJ, Ionascu D, Hacker F, Mamon H, Berbeco R. Automatic marker detection and 3D position reconstruction using cine EPID images for SBRT verification. Med Phys 2009; 36:4536-46. PubMed
  • Hattangadi JA, Hong TS, Yeap BY, Mamon HJ. Results and patterns of failure in patients treated with adjuvant combined chemoradiation therapy for resected pancreatic adenocarcinoma. Cancer 2009; 115:3640-50. PubMed
  • Hong TS,Killoran JH,Mamede M,Mamon HJ. Impact of manual and automated interpretation of fused PET/CT data on esophageal target definitions in radiation planning. Int J Radiat Oncol Biol Phys 2008; 72:1612-8. PubMed
  • Nanda A,Mamon HJ,Fuchs CS. Sign of Leser-Trelat in newly diagnosed advanced gastric adenocarcinoma. J Clin Oncol 2008; 26:4992-3. PubMed
  • Mamon H,Hader C,Li J,Wang L,Kulke M,Amicarelli G,Shehi E,Adlerstein D,Roper K,Killion L,Hooshmand S,Makrigiorgos GM. Preferential amplification of apoptotic DNA from plasma: potential for enhancing detection of minor DNA alterations in circulating DNA. Clin Chem 2008; 54:1582-4. PubMed
  • Lyatskaya Y, James S, Killoran JH, Soto R, Mamon HJ, Chin L, Allen AM. Infrared-Guided Patient Setup for Lung Cancer Patients. Int J Radiat Oncol Biol Phys 2008; 71:1124-33. PubMed
  • Berbeco RI, Hacker F, Zatwarnicki C, Park SJ, Ionascu D, O'Farrell D, Mamon HJ. A novel method for estimating SBRT delivered dose with beam's-eye-view images. Med Phys 2008; 35:3225-31. PubMed
  • Li J, Wang L, Mamon H, Kulke MH, Berbeco R, Makrigiorgos GM. Replacing PCR with COLD-PCR enriches variant DNA sequences and redefines the sensitivity of genetic testing. Nat Med 2008; 14:579-84. PubMed
  • Berbeco RI, Hacker F, Ionascu D, Mamon HJ. Clinical feasibility of using an EPID in CINE mode for image-guided verification of stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys 2007; 69:258-66. PubMed
  • Wang F, Wang L, Briggs C, Sicinska E, Gaston SM, Mamon H, Kulke MH, Zamponi R, Loda M, Maher E, Ogino S, Fuchs CS, Li J, Hader C, Makrigiorgos GM. DNA degradation test predicts success in whole-genome amplification from diverse clinical samples. J Mol Diagn 2007; 9:441-51. PubMed
  • Mamede M, Abreu-E-Lima P, Oliva MR, Nose V, Mamon H, Gerbaudo VH. FDG-PET/CT tumor segmentation-derived indices of metabolic activity to assess response to neoadjuvant therapy and progression-free survival in esophageal cancer: correlation with histopathology results. Am J Clin Oncol 2007; 30:377-88. PubMed
  • Mamon H, Willett CG. Is radiation therapy required for patients with intermediate-risk rectal cancer? Clin Adv Hematol Oncol 2007; 5:638-44, 585. PubMed
  • Kozak KR, Kachnic LA, Adams J, Crowley EM, Alexander BM, Mamon HJ, Fernandez-Del Castillo C, Ryan DP, DeLaney TF, Hong TS. Dosimetric feasibility of hypofractionated proton radiotherapy for neoadjuvant pancreatic cancer treatment. Int J Radiat Oncol Biol Phys 2007; 68:1557-66. PubMed
  • Wolpin BM, Meyerhardt JA, Mamon HJ, Mayer RJ. Adjuvant treatment of colorectal cancer. CA Cancer J Clin 2007; 57:168-85. PubMed
  • Hong TS, Crowley EM, Killoran J, Mamon HJ. Considerations in treatment planning for esophageal cancer. Semin Radiat Oncol 2006; 17:53-61. PubMed
  • Li J, Wang F, Mamon H, Kulke MH, Harris L, Maher E, Wang L, Makrigiorgos GM. Antiprimer quenching-based real-time PCR and its application to the analysis of clinical cancer samples. Clin Chem 2006; 52:624-33. PubMed
  • Li J, Harris L, Mamon H, Kulke MH, Liu WH, Zhu P, Mike Makrigiorgos G. Whole genome amplification of plasma-circulating DNA enables expanded screening for allelic imbalance in plasma. J Mol Diagn 2006; 8:22-30. PubMed
  • Chen AB, Killoran J, Kim H, Mamon H. Treatment planning for resected abdominal tumors: differences in organ position between diagnostic and radiation-planning computed tomography scans. Int J Radiat Oncol Biol Phys 2005; 63:1613-20. PubMed
  • Mamon HJ, Yeap BY, J. High risk of brain metastases in surgically staged IIIA non-small-cell lung cancer patients treated with surgery, chemotherapy, and radiation. J Clin Oncol 2005; 23:1530-7. PubMed
  • Aitken C, Breen E, Mamon HJ. Sphincter preservation therapy for rectal cancer. Clin Adv Hematol Oncol 2005; 1:735-40. PubMed
  • Mamon HJ, Dahlberg W, Nagasawa H, Azzam EA, Muto MG and Little JB. Differing effects of BRCA1 and ATM mutations on cellular responses to ionizing radiation Int J Radiat Biol 2003; 79:817-829.
  • Mamon HJ, Dahlberg W, Azzam EI, Nagasawa H, Muto MG, Little JB. Differing effects of breast cancer 1, early onset (BRCA1) and ataxia-telangiectasia mutated (ATM) mutations on cellular responses to ionizing radiation. Int J Radiat Biol 2003; 79:817-29. PubMed
  • Wenz F, Mamon H. Perioperative radiotherapy for cancer of the esophagus. Semin Surg Oncol 2001; 20:33-9. PubMed
  • Jabbour SK, Hashem SA, Bosch W, Kim TK, Finkelstein SE, Anderson BM, Ben-Josef E, Crane CH, Goodman KA, Haddock MG, Herman JM, Hong TS, Kachnic LA, Mamon HJ, Pantarotto JR, Dawson LA. Upper abdominal normal organ contouring guidelines and atlas: A Radiation Therapy Oncology Group consensus. 2014; 4:82-9. PubMed
  • Wo JY, Childs SK, Szymonifka J, Mamon HJ, Ryan DP, Blaszkowsky LS, Kwak EL, Ferrone CR, Allen JN, Zhu AX, Wolpin BM, Chan JA, Abrams TA, McCleary NJ, Fernandez-Del Castillo C, Hong TS. Delaying chemoradiation until after completion of adjuvant chemotherapy for pancreatic cancer may not impact local control. 2014; 4:e117-23. PubMed
  • Tseng YD, Krishnan MS, Jones JA, Sullivan AJ, Gorman D, Taylor A, Pacold M, Kalinowski B, Mamon HJ, Abrahm J, Balboni TA. Supportive and palliative radiation oncology service: impact of a dedicated service on palliative cancer care. 2014; 4:247-53. PubMed
  • Hong TS, DeLaney TF, Mamon HJ, Willett CG, Yeap BY, Niemierko A, Wolfgang JA, Lu HM, Adams J, Weyman EA, Arellano RS, Blaszkowsky LS, Allen JN, Tanabe KK, Ryan DP, Zhu AX. A prospective feasibility study of respiratory-gated proton beam therapy for liver tumors. 2014; 4:316-22. PubMed
  • Mamon HJ, Wen PY, Burns AC, Loeffler JS. Allergic skin reactions to anticonvulsant medications in patients receiving cranial radiation therapy. Epilepsia 1999; 40:341-4. PubMed
  • Fu H, Xia K, Pallas DC, Cui C, Conroy K, Narsimhan RP, Mamon H, Collier RJ, Roberts TM. Interaction of the protein kinase Raf-1 with 14-3-3 proteins. Science 1994; 266:126-9. PubMed
  • Montross L, Watkins S, Moreland RB, Mamon H, Caspar DL, Garcea RL. Nuclear assembly of polyomavirus capsids in insect cells expressing the major capsid protein VP1. J Virol 1991; 65:4991-8. PubMed
  • Zmuidzinas A, Mamon HJ, Roberts TM, Smith KA. Interleukin-2-triggered Raf-1 expression, phosphorylation, and associated kinase activity increase through G1 and S in CD3-stimulated primary human T cells. Mol Cell Biol 1991; 11:2794-803. PubMed
  • Li P, Wood K, Mamon H, Haser W, Roberts T. Raf-1: a kinase currently without a cause but not lacking in effects. Cell 1991; 64:479-82. PubMed
  • Kanakura Y, Druker B, Wood KW, Mamon HJ, Okuda K, Roberts TM, Griffin JD. Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce rapid phosphorylation and activation of the proto-oncogene Raf-1 in a human factor-dependent myeloid cell line. Blood 1991; 77:243-8. PubMed
  • Mamon H, Williams N, Wood K, Frazier AL, Li P, Zmuidzinas A, Kremer N, D'Acangelo G, Qi H, Smith K. New perspectives on Raf-1: the involvement of p21ras in the activation of Raf-1 and a potential role for Raf-1 in events occurring later in the cell cycle. Cold Spring Harb Symp Quant Biol 1991; 56:251-63. PubMed
  • Druker BJ, Mamon HJ, Roberts TM. Oncogenes, growth factors, and signal transduction. N Engl J Med 1989; 321:1383-91. PubMed
  • Roberts TM, Kaplan D, Morgan W, Keller T, Mamon H, Piwnica-Worms H, Druker B, Cohen B, Schaffhausen B, Whitman M. Tyrosine phosphorylation in signal transduction. Cold Spring Harb Symp Quant Biol 1987; 53 Pt 1:161-71. PubMed
  • Bikel I, Mamon H, Brown EL, Boltax J, Agha M, Livingston DM. The t-unique coding domain is important to the transformation maintenance function of the simian virus 40 small t antigen. Mol Cell Biol 1986; 6:1172-8. PubMed
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