Photo of Helen A Shih,  MD

Helen A Shih, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 724-9627
Fax: (617) 724-9532

Helen A Shih, MD

Massachusetts General Hospital


  • Associate Professor, Radiation Oncology, Harvard Medical School
  • Chief, CNS & Eye Services, Radiation Oncology, Massachusetts General Hospital


Research Abstract

The area of cancer research that I am interested in include:

- optimizing radiation therapy in the management of brain tumors, such as brain metastases, gliomas, meningiomas, medulloblastoma, and other less common diagnoses

- understanding the effects of ionizing radiation on the brain and other normal tissues and developing methods to protect, prevent, or treat such adverse effects

- developing the role of proton therapy, especially within but not limited to brain tumors

- optimizing the role of radiation therapy for ocular tumors


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  • Miller JJ, Shih HA, Andronesi OC, Cahill DP. Isocitrate dehydrogenase-mutant glioma: Evolving clinical and therapeutic implications. Cancer 2017. PubMed
  • Sperduto PW, Jiang W, Brown PD, Braunstein S, Sneed P, Wattson DA, Shih HA, Bangdiwala A, Shanley R, Lockney NA, Beal K, Lou E, Amatruda T, Sperduto WA, Kirkpatrick JP, Yeh N, Gaspar LE, Molitoris JK, Masucci L, Roberge D, Yu J, Chiang V, Mehta M. The Prognostic Value of BRAF, C-KIT, and NRAS Mutations in Melanoma Patients With Brain Metastases. Int J Radiat Oncol Biol Phys 2017; 98:1069-1077. PubMed
  • Sanford NN, Yeap BY, Larvie M, Daartz J, Munzenrider JE, Liebsch NJ, Fullerton B, Pan E, Loeffler JS, Shih HA. Prospective, Randomized Study of Radiation Dose Escalation With Combined Proton-Photon Therapy for Benign Meningiomas. Int J Radiat Oncol Biol Phys 2017. PubMed
  • Preusser M, Brastianos P, Shih HA. Meningioma research-status quo and quo vadis. Chin Clin Oncol 2017; 6:S1. PubMed
  • Hwang KL, Hwang WL, Bussière MR, Shih HA. The role of radiotherapy in the management of high-grade meningiomas. Chin Clin Oncol 2017; 6:S5. PubMed
  • Kim D, Niemierko A, Hwang WL, Stemmer-Rachamimov AO, Curry WT, Barker FG, Martuza RL, Oh KS, Loeffler JS, Shih HA. Histopathological prognostic factors of recurrence following definitive therapy for atypical and malignant meningiomas. J Neurosurg 2017. PubMed
  • Kirkpatrick JP, Laack NN, Shih HA, Gondi V. Management of GBM: a problem of local recurrence. J. Neurooncol. 2017. PubMed
  • Grosshans DR, Mohan R, Gondi V, Shih HA, Mahajan A, Brown PD. The role of image-guided intensity modulated proton therapy in glioma. 2017; 19:ii30-ii37. PubMed
  • Roongpiboonsopit D, Kuijf HJ, Charidimou A, Xiong L, Vashkevich A, Martinez-Ramirez S, Shih HA, Gill CM, Viswanathan A, Dietrich J. Evolution of cerebral microbleeds after cranial irradiation in medulloblastoma patients. Neurology 2017; 88:789-796. PubMed
  • Geng C, Daartz J, Lam-Tin-Cheung K, Bussiere M, Shih HA, Paganetti H, Schuemann J. Limitations of analytical dose calculations for small field proton radiosurgery. Phys Med Biol 2016; 62:246-257. PubMed
  • Sperduto PW, Yang TJ, Beal K, Pan H, Brown PD, Bangdiwala A, Shanley R, Yeh N, Gaspar LE, Braunstein S, Sneed P, Boyle J, Kirkpatrick JP, Mak KS, Shih HA, Engelman A, Roberge D, Arvold ND, Alexander B, Awad MM, Contessa J, Chiang V, Hardie J, Ma D, Lou E, Sperduto W, Mehta MP. Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA). JAMA Oncol 2016. PubMed
  • Jafari-Khouzani K, Loebel F, Bogner W, Rapalino O, Gonzalez GR, Gerstner E, Chi AS, Batchelor TT, Rosen BR, Unkelbach J, Shih HA, Cahill DP, Andronesi OC. Volumetric relationship between 2-hydroxyglutarate and FLAIR hyperintensity has potential implications for radiotherapy planning of mutant IDH glioma patients. 2016. PubMed
  • Unkelbach J, Bussière MR, Chapman PH, Loeffler JS, Shih HA. Spatiotemporal Fractionation Schemes for Irradiating Large Cerebral Arteriovenous Malformations. Int J Radiat Oncol Biol Phys 2016. PubMed
  • Hwang WL, Marciscano AE, Niemierko A, Kim DW, Stemmer-Rachamimov AO, Curry WT, Barker FG, Martuza RL, Loeffler JS, Oh KS, Shih HA, Larvie M. Imaging and extent of surgical resection predict risk of meningioma recurrence better than WHO histopathological grade. 2015. PubMed
  • Sherman JC, Colvin MK, Mancuso SM, Batchelor TT, Oh KS, Loeffler JS, Yeap BY, Shih HA. Neurocognitive effects of proton radiation therapy in adults with low-grade glioma. J. Neurooncol. 2015. PubMed
  • Marciscano AE, Stemmer-Rachamimov AO, Niemierko A, Larvie M, Curry WT, Barker FG, Martuza RL, McGuone D, Oh KS, Loeffler JS, Shih HA. Benign meningiomas (WHO Grade I) with atypical histological features: correlation of histopathological features with clinical outcomes. J Neurosurg 2015. PubMed
  • Shih HA, Sherman JC, Nachtigall LB, Colvin MK, Fullerton BC, Daartz J, Winrich BK, Batchelor TT, Thornton LT, Mancuso SM, Saums MK, Oh KS, Curry WT, Loeffler JS, Yeap BY. Proton therapy for low-grade gliomas: Results from a prospective trial. Cancer 2015. PubMed
  • Wattson DA, Sullivan RJ, Niemierko A, Merritt RM, Lawrence DP, Oh KS, Flaherty KT, Shih HA. Survival patterns following brain metastases for patients with melanoma in the MAP-kinase inhibitor era. J. Neurooncol. 2015; 123:75-84. PubMed
  • Mak KS, Gainor JF, Niemierko A, Oh KS, Willers H, Choi NC, Loeffler JS, Sequist LV, Shaw AT, Shih HA. Significance of targeted therapy and genetic alterations in EGFR, ALK, or KRAS on survival in patients with non-small cell lung cancer treated with radiotherapy for brain metastases. 2015. PubMed
  • Kamran SC, Collier JM, Lane AM, Kim I, Niemierko A, Chen YL, MacDonald SM, Munzenrider JE, Gragoudas E, Shih HA. Outcomes of proton therapy for the treatment of uveal metastases. Int J Radiat Oncol Biol Phys 2014; 90:1044-50. PubMed
  • Mouw KW, Sethi RV, Yeap BY, MacDonald SM, Chen YL, Tarbell NJ, Yock TI, Munzenrider JE, Adams J, Grabowski E, Mukai S, Shih HA. Proton radiation therapy for the treatment of retinoblastoma. Int J Radiat Oncol Biol Phys 2014. PubMed
  • Wattson DA, Tanguturi SK, Spiegel DY, Niemierko A, Biller BM, Nachtigall LB, Bussière MR, Swearingen B, Chapman PH, Loeffler JS, Shih HA. Outcomes of proton therapy for patients with functional pituitary adenomas. Int J Radiat Oncol Biol Phys 2014; 90:532-9. PubMed
  • Niu NN, Niemierko A, Larvie M, Curtin H, Loeffler JS, McKenna MJ, Shih HA. Pretreatment growth rate predicts radiation response in vestibular schwannomas. Int J Radiat Oncol Biol Phys 2014; 89:113-9. PubMed
  • Hattangadi-Gluth JA, Chapman PH, Kim D, Niemierko A, Bussière MR, Stringham A, Daartz J, Ogilvy C, Loeffler JS, Shih HA. Single-Fraction Proton Beam Stereotactic Radiosurgery for Cerebral Arteriovenous Malformations. Int J Radiat Oncol Biol Phys 2014. PubMed
  • Cabrera AR, Kirkpatrick JP, Fiveash JB, Shih HA, Koay EJ, Lutz S, Petit J, Chao ST, Brown PD, Vogelbaum M, Reardon DA, Chakravarti A, Wen PY, Chang E. Radiation therapy for glioblastoma: Executive summary of an American Society for Radiation Oncology Evidence-Based Clinical Practice Guideline. 2016; 6:217-25. PubMed
  • Mouw KW, Yeap BY, Caruso P, Fay A, Misra M, Sethi RV, MacDonald SM, Chen YL, Tarbell NJ, Yock TI, Freitag SK, Munzenrider JE, Grabowski E, Katz M, Kuhlthau K, DeCastro D, Heidary G, Ciralsky J, Mukai S, Shih HA. Analysis of patient outcomes following proton radiation therapy for retinoblastoma. Adv Radiat Oncol 2017; 2:44-52. PubMed