Helen M. Shields, MD

Beth Israel Deaconess Medical Center

Beth Israel Deaconess Medical Center

Helen M. Shields, MD

Beth Israel Deaconess Medical Center

EDUCATIONAL TITLES

  • Professor, Medicine, Harvard Medical School
  • Associate Master, Oliver Wendell Holmes Society, Harvard Medical School
  • Physician, Gastroenterology, Beth Israel Deaconess Medical Center

DF/HCC PROGRAM AFFILIATION

Research Abstract

1) Barrett's Esophagus

I initially described Barrett's esophagus' topographical appearance using scanning electron microscopy and light microscopy comparisons. I and my team identified a distinctive cell using scanning electron microscopy that expresses ultrastructural characteristics of both columnar and squamous mucosa. By light microscopy we also described a multilayered epithelium that by cytokeratin immunocytochemistry has both columnar and squamous-type cytokeratins. This hybrid type of epithelium may be of great importance to our understanding the cell of origin of Barrett?s esophagus. Currently I am collaborating on a series of projects designed to elucidate the role of multilayered epithelium in the development and progression of Barrett's epithelium as a precancerous entity.

2) Colon Cancer Screening

I have recently completed a study of the factors that influence doctors in their decision-making process when presented with a positive stool for occult blood in a middle-aged or elderly person. The patient's family history, the patient's anxiety over the possibility of having colon cancer, number of positive Hemoccult windows, and male gender were all important factors contributing to significantly more evaluation tests being done.

Publications

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  • Shields HM, Stoffel EM, Chung DC, Sequist TD, Li JW, Pelletier SR, Spencer J, Silk JM, Austin BL, Diguette S, Furbish JE, Lederman R, Weingart SN. Disparities in evaluation of patients with rectal bleeding 40 years and older. Clin Gastroenterol Hepatol 2014; 12:669-75; quiz e33. PubMed
  • Shields HM,Recht A,Wang HH. Exposure to Both Radiation and Chemotherapy Increases the Risk of Barrett's and Multilayered Epithelium. Dig Dis Sci 2009; 54:2143-9. PubMed
  • Shields H. Reply. Clin Gastroenterol Hepatol 2008; 6:601. PubMed
  • Shields HM, Shaffer K, O'farrell RP, Travers R, Hayward JN, Becker LS, Lauwers GY. Gastrointestinal manifestations of dermatologic disorders. Clin Gastroenterol Hepatol 2007; 5:1010-7; quiz 1005-6. PubMed
  • Upton MP, Nishioka NS, Ransil BJ, Rosenberg SJ, Puricelli WP, Zwas FR, Shields HM. Multilayered epithelium may be found in patients with Barrett's epithelium and dysplasia or adenocarcinoma. Dig Dis Sci 2006; 51:1783-90. PubMed
  • Boch JA, Shields HM, Antonioli DA, Zwas F, Sawhney RA, Trier JS. Distribution of cytokeratin markers in Barrett's specialized columnar epithelium. Gastroenterology 1997; 112:760-5. PubMed
  • Sawhney RA, Shields HM, Allan CH, Boch JA, Trier JS, Antonioli DA. Morphological characterization of the squamocolumnar junction of the esophagus in patients with and without Barrett's epithelium. Dig Dis Sci 1996; 41:1088-98. PubMed
  • Shields HM, Zwas F, Antonioli DA, Doos WG, Kim S, Spechler SJ. Detection by scanning electron microscopy of a distinctive esophageal surface cell at the junction of squamous and Barrett's epithelium. Dig Dis Sci 1993; 38:97-108. PubMed
  • Zwas F, Shields HM, Doos WG, Antonioli DA, Goldman H, Ransil BJ, Spechler SJ. Scanning electron microscopy of Barrett's epithelium and its correlation with light microscopy and mucin stains. Gastroenterology 1986; 90:1932-41. PubMed
  • Shields HM, Bates ML, Goldman H, Zuckerman GR, Mills BA, Best CJ, Bair FA, Goran DA, DeSchryver-Kecskemeti K. Scanning electron microscopic appearance of chronic ulcerative colitis with and without dysplasia. Gastroenterology 1985; 89:62-72. PubMed
  • Shields HM, Bates ML, Yedlin ST, Best CJ. Distribution of immunoreactive alkaline phosphatase in the adult rat ileum by immunoperoxidase staining at the light microscopic level. Gastroenterology 1984; 87:827-35. PubMed
  • Goran DA, Shields HM, Bates ML, Zuckerman GR, DeSchryver-Kecskemeti K. Esophageal dysplasia. Assessment by light microscopy and scanning electron microscopy. Gastroenterology 1983; 86:39-50. PubMed
  • Shields HM, Bair FA, Bates ML, Yedlin ST, Alpers DH. Localization of immunoreactive alkaline phosphatase in the rat small intestine at the light microscopic level by immunocytochemistry. Gastroenterology 1981; 82:39-45. PubMed
  • Shields HM, Levine GM, Yezdimir EA, Bielunas JC, Bair FA. Effect of pentagastrin on rabbit stomach and small intestinal protein synthesis. Dig Dis Sci 1980; 25:769-75. PubMed
  • Shields HM, Yedlin ST, Bair FA, Goodwin CL, Alpers DH. Successful maintenance of suckling rat ileum in organ culture. Am J Anat 1979; 155:375-89. PubMed
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