My background is in the field of neurology and immunology. My laboratory has had a long-term interest in the immunologic aspects of MS and the use of the mucosal immune system to treat autoimmune and other diseases I established and direct the Partners Multiple Sclerosis Center at Brigham and Womenâ€™s Hospital, which combines clinical evaluation, immunologic monitoring and MRI imaging and is the first integrated MS center that brings these disciplines to the individual care of the MS patient. I have endeavored over the years to investigate the underlying immune mechanisms associated with disease progression and response to therapy. This has involved the study of effector cell populations, regulatory T cells and the role of the innate immune system in different stages of MS and development of biomarkers. My laboratory interests include: immunoregulation in the EAE model of MS, mucosal immunology, microglia and immune mechanisms in other neurological diseases including Alzheimerâ€™s disease amyotrophic lateral sclerosis, and brain tumors.