Photo of Hui Zheng,   PhD

Hui Zheng, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-0687


hzheng1@partners.org

Hui Zheng, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Medicine, Harvard Medical School
  • Assistant Professor, Biostatistics Center, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My clinical research interests include clinical, epidemiological and policy research in cancer, HIV/AIDS, and mental illnesses. My biostatistical interests include Bayesian hierarchical modeling, longitudinal analysis, nonparametric models, and survival analysis. I have more than four years of experience working with clinical investors in cancer and infectious diseases. I served as co-investigator or subcontract PI for a number of projects funded by NIH as well as within Harvard Medical School. I also co-mentored a number of medical fellows in MGH and Brigham and Women's Hospital.

Publications

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  • Dias-Santos D, Ferrone CR, Zheng H, Lillemoe KD, Castillo CF. The Charlson age comorbidity index predicts early mortality after surgery for pancreatic cancer. Surgery 2015. PubMed
  • Wu Y, Johnson KB, Roccaro G, Lopez J, Zheng H, Muiru A, Ufere N, Rajbhandari R, Kattan O, Chung RT. Poor Adherence to AASLD Guidelines for Chronic Hepatitis B Management and Treatment in a Large Academic Medical Center. Am J Gastroenterol 2014. PubMed
  • King LY, Johnson KB, Zheng H, Wei L, Gudewicz T, Hoshida Y, Corey KE, Ajayi T, Ufere N, Baumert TF, Chan AT, Tanabe KK, Fuchs BC, Chung RT. Host genetics predict clinical deterioration in HCV-related cirrhosis. PLoS ONE 2014; 9:e114747. PubMed
  • Chan JA, Blaszkowsky L, Stuart K, Zhu AX, Allen J, Wadlow R, Ryan DP, Meyerhardt J, Gonzalez M, Regan E, Zheng H, Kulke MH. A prospective, phase 1/2 study of everolimus and temozolomide in patients with advanced pancreatic neuroendocrine tumor. Cancer 2013; 119:3212-8. PubMed
  • Ferrone CR, Pieretti-Vanmarcke R, Bloom JP, Zheng H, Szymonifka J, Wargo JA, Thayer SP, Lauwers GY, Deshpande V, Mino-Kenudson M, Fernández-del Castillo C, Lillemoe KD, Warshaw AL. Pancreatic ductal adenocarcinoma: long-term survival does not equal cure. Surgery 2012; 152:S43-9. PubMed
  • Chan JA, Stuart K, Earle CC, Clark JW, Bhargava P, Miksad R, Blaszkowsky L, Enzinger PC, Meyerhardt JA, Zheng H, Fuchs CS, Kulke MH. Prospective study of bevacizumab plus temozolomide in patients with advanced neuroendocrine tumors. J Clin Oncol 2012; 30:2963-8. PubMed
  • Zheng H, Zhang W, Ayanian JZ, Zaborski LB, Zaslavsky AM. Profiling Hospitals by Survival of Patients with Colorectal Cancer. Health Serv Res 2011. PubMed
  • Konstantinidis IT, Dursun A, Zheng H, Wargo JA, Thayer SP, Fernandez-del Castillo C, Warshaw AL, Ferrone CR. Metastatic tumors in the pancreas in the modern era. J Am Coll Surg 2010; 211:749-53. PubMed
  • Wu J, Henderson C, Feun L, Van Veldhuizen P, Gold P, Zheng H, Ryan T, Blaszkowsky LS, Chen H, Costa M, Rosenzweig B, Nierodzik M, Hochster H, Muggia F, Abbadessa G, Lewis J, Zhu AX. Phase II study of darinaparsin in patients with advanced hepatocellular carcinoma. Invest New Drugs 2010; 28:670-6. PubMed
  • Méndez-Navarro J, Chirino RA, Corey KE, Gorospe EC, Zheng H, Morán S, Chung RT, Dehesa-Violante M. A Randomized Controlled Trial of Double Versus Triple Therapy with Amantadine for Genotype 1 Chronic Hepatitis C in Latino Patients. Dig Dis Sci 2010; 55:2629-35. PubMed
  • Méndez-Navarro J, Corey KE, Zheng H, Barlow LL, Jang JY, Lin W, Zhao H, Shao RX, McAfee SL, Chung RT. Hepatitis B screening, prophylaxis and re-activation in the era of rituximab-based chemotherapy. Liver Int 2010. PubMed
  • Konstantinidis IT, Deshpande V, Zheng H, Wargo JA, Fernandez-del Castillo C, Thayer SP, Androutsopoulos V, Lauwers GY, Warshaw AL, Ferrone CR. Does the mechanism of lymph node invasion affect survival in patients with pancreatic ductal adenocarcinoma? J Gastrointest Surg 2010; 14:261-7. PubMed
  • Méndez-Navarro J, Chirino RA, Corey KE, Gorospe EC, Zheng H, Morán S, Juarez JA, Chung RT, Dehesa-Violante M. Erratum to: A Randomized Controlled Trial of Double Versus Triple Therapy with Amantadine for Genotype 1 Chronic Hepatitis C in Latino Patients. Dig Dis Sci 2010. PubMed
  • Zhu AX, Meyerhardt JA, Blaszkowsky LS, Kambadakone AR, Muzikansky A, Zheng H, Clark JW, Abrams TA, Chan JA, Enzinger PC, Bhargava P, Kwak EL, Allen JN, Jain SR, Stuart K, Horgan K, Sheehan S, Fuchs CS, Ryan DP, Sahani DV. Efficacy and safety of gemcitabine, oxaliplatin, and bevacizumab in advanced biliary-tract cancers and correlation of changes in 18-fluorodeoxyglucose PET with clinical outcome: a phase 2 study. Lancet Oncol 2010; 11:48-54. PubMed
  • Corey KE, Kane E, Munroe C, Barlow LL, Zheng H, Chung RT. Hepatitis C virus infection and its clearance alter circulating lipids: implications for long-term follow-up. Hepatology 2009; 50:1030-7. PubMed
  • Schoenfeld DA, Hui Zheng , Finkelstein DM. Bayesian design using adult data to augment pediatric trials. Clin Trials 2009; 6:297-304. PubMed
  • Vora SR, Zheng H, Stadler ZK, Fuchs CS, Zhu AX. Serum alpha-fetoprotein response as a surrogate for clinical outcome in patients receiving systemic therapy for advanced hepatocellular carcinoma. Oncologist 2009; 14:717-25. PubMed
  • Corey KE,Shah N,Misdraji J,Abu Dayyeh BK,Zheng H,Bhan AK,Chung RT. The effect of angiotensin-blocking agents on liver fibrosis in patients with hepatitis C. Liver Int 2009; 29:748-53. PubMed
  • Konstantinidis IT,Deshpande V,Genevay M,Berger D,Fernandez-del Castillo C,Tanabe KK,Zheng H,Lauwers GY,Ferrone CR. Trends in presentation and survival for gallbladder cancer during a period of more than 4 decades: a single-institution experience. Arch Surg 2009; 144:441-7; discussion 447. PubMed
  • Kim KA,Lin W,Tai AW,Shao RX,Weinberg E,De Sa Borges CB,Bhan AK,Zheng H,Kamegaya Y,Chung RT. Hepatic SOCS3 expression is strongly associated with non-response to therapy and race in HCV and HCV/HIV infection. J Hepatol 2009; 50:705-11. PubMed
  • Placanica L,Tarassishin L,Yang G,Peethumnongsin E,Kim SH,Zheng H,Sisodia SS,Li YM. Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes. J Biol Chem 2008; 284:2967-77. PubMed
  • Bloom A,Jackson K,Kiviat A,Zheng H,Sax P,Gandhi R. Repeat hepatitis B vaccination may lead to seroprotection in HIV-infected patients who do not respond to an initial series. J Acquir Immune Defic Syndr 2008; 50:110-3. PubMed
  • Kallhoff-Munoz V,Hu L,Chen X,Pautler RG,Zheng H. Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death. J Neurosci 2008; 28:11421-31. PubMed
  • Al-Ayoubi A,Tarcsafalvi A,Zheng H,Sakati W,Eblen ST. ERK activation and nuclear signaling induced by the loss of cell/matrix adhesion stimulates anchorage-independent growth of ovarian cancer cells. J Cell Biochem 2008; 105:875-84. PubMed
  • Ferrone CR,Warshaw AL,Rattner DW,Berger D,Zheng H,Rawal B,Rodriguez R,Thayer SP,Fernandez-del Castillo C. Pancreatic fistula rates after 462 distal pancreatectomies: staplers do not decrease fistula rates. J Gastrointest Surg 2008; 12:1691-7; discussion 1697-8. PubMed
  • Zaslavsky AM, Zheng H, Adams J. Optimal sample allocation for design-consistent regression in a cancer services survey when design variables are known for aggregates. Survey Methodology 2009; 34:65-78. PubMed
  • Wang XL, Yin JL, Li XD, Li XY, Ou YX, Zhou Z, Zheng H. [PET/CT-based classification of delayed radiation encephalopathy following radiotherapy for nasopharyngeal carcinoma.] Nan Fang Yi Ke Da Xue Xue Bao 2008; 28:320-3. PubMed
  • He Q, Cheng R, Chen Z, Xiao X, Xiao Z, Li C, Li B, Zhang P, Zheng H, Feng D. Cell transformation and proteome alteration in QSG7701 cells transfected with hepatitis C virus non-structural protein 3. Acta Biochim Biophys Sin (Shanghai) 2007; 39:751-62. PubMed
  • Cui FQ, Lu Y, Wang FZ, Chen YS, Zheng H, Zhang Y, Gong XH, Han LL, Dong HJ, Chen C, Ling LY, Zhang L, Diao LQ, Shao XP, Fang G, Gao L, Liang XF. [Analysis on the proportion of reported hepatitis B cases through pilot surveillance in China during 2006] Zhonghua Liu Xing Bing Xue Za Zhi 2008; 28:872-4. PubMed
  • Li QH, Zhao L, Li HP, Shen YP, Zhang RX, Zheng H, Fan YM. [Application of quantitative polymerase chain reaction in the differentiation of sarcoidosis and proliferative tuberculosis] Zhonghua Jie He He Hu Xi Za Zhi 2007; 30:686-90. PubMed
  • Zheng H, McKay J, Buss JE. H-Ras does not need COP I- or COP II-dependent vesicular transport to reach the plasma membrane. J Biol Chem 2007; 282:25760-8. PubMed
  • Jiang L, Zheng H, Yi XH, Chen XF, Zhang P, Liu YL, Jiang GN, Ding JA. [Diffuse myxoid malignant fibrous histiocytoma of the pleura: a case report and review of the literature] Zhonghua Jie He He Hu Xi Za Zhi 2007; 30:565-8. PubMed
  • Xu BB, Gao W, Chen C, Wei N, Zheng H, Zhou Y, Zhang RX. [Result of surgical treatment and prognostic factors in giant mass lung cancer] Zhonghua Zhong Liu Za Zhi 2008; 29:632-5. PubMed
  • Pekow JR, Bhan AK, Zheng H, Chung RT. Hepatic steatosis is associated with increased frequency of hepatocellular carcinoma in patients with hepatitis C-related cirrhosis. Cancer 2007; 109:2490-6. PubMed
  • Zheng H, Li LL, Hu DS, Deng XY, Cao Y. Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma. Cell Mol Immunol 2007; 4:185-96. PubMed
  • Schwarze-Zander C, Blackard JT, Zheng H, Addo MM, Lin W, Robbins GK, Sherman KE, Zdunek D, Hess G, Chung RT,. GB virus C (GBV-C) infection in hepatitis C virus (HCV)/HIV-coinfected patients receiving HCV treatment: importance of the GBV-C genotype. J Infect Dis 2006; 194:410-9. PubMed
  • Zheng H, Yucel R, Ayanian JZ, Zaslavsky AM. Profiling providers on use of adjuvant chemotherapy by combining cancer registry and medical record data. Med Care 2005; 44:1-7. PubMed
  • Zheng, H. and Little, R.J.A. Inference for the Population Total from Probability-Proportional-to-Size Samples Based on Predictions from a Penalized Spline Nonparametric Model 2005; 21:1-20.
  • Kessler RC,Berglund P,Chiu WT,Demler O,Heeringa S,Hiripi E,Jin R,Pennell BE,Walters EE,Zaslavsky A,Zheng H. The US National Comorbidity Survey Replication (NCS-R): design and field procedures. Int J Methods Psychiatr Res 2004; 13:69-92. PubMed
  • Kessler RC,Abelson J,Demler O,Escobar JI,Gibbon M,Guyer ME,Howes MJ,Jin R,Vega WA,Walters EE,Wang P,Zaslavsky A,Zheng H. Clinical calibration of DSM-IV diagnoses in the World Mental Health (WMH) version of the World Health Organization (WHO) Composite International Diagnostic Interview (WMHCIDI). Int J Methods Psychiatr Res 2004; 13:122-39. PubMed
  • Zheng, H. and Little, R.J.A. Penalized-spline Nonparametric Mixed Models for Inference about a Finite Population Mean from Two-stage Samples 2004; 30:209-218.
  • Raz J,Zheng H,Ombao H,Turetsky B. Statistical tests for fMRI based on experimental randomization. Neuroimage 2003; 19:226-32. PubMed
  • Zheng, H. and Little, R.J.A . Penalized Spline Model-based Estimation of Finite Population Total From Probability-Proportional-to-Size Samples 2003; 19:99-117.
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