I am a practicing Urological Pathologist at the Beth Israel Deaconess Medical Center. My main research interest is to study molecular characteristics of aggressive prostate cancer, to distinguish them from indolent ones, with an ultimately goal to increase early detection of aggressive prostate cancer and to improve management of patients with indolent cancer. In collaboration with Dr. Steven Balk, one of my main projects is to identify genetic characteristics of different Gleason grades of prostate cancer and to study molecular mechanisms of progression from low to high grade cancer. Another main project of mine is to study prognostic values of potential biomarkers for Gleason upgrading in active surveillance patients. Finally, I study resistant mechanisms in high risk prostate cancer that are treated with neoadjuvant intense androgen deprivation therapy.