Photo of Jack L. Strominger,  MD

Jack L. Strominger, MD

Dana-Farber Cancer Institute

Dana-Farber Cancer Institute
Phone: (617) 632-3083
Fax: (617) 632-2662


jlstrom@fas.harvard.edu

Jack L. Strominger, MD

Dana-Farber Cancer Institute

EDUCATIONAL TITLES

  • Higgins Professor, Biochemistry, Harvard University
  • Higgins Professor of Biochemistry in the Department of Stem Cell and Regenerative Biology, Stem Cell and Regenerative Biology, Harvard Medical School
  • Professor, Cancer Immunology and Virology, Dana-Farber Cancer Institute

DF/HCC PROGRAM AFFILIATION

Publications

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  • Tilburgs T, Strominger JL. Decidual endothelium, Notch1 and TGFβ, gatekeepers for Treg accumulation at the maternal-fetal interface. Immunol Cell Biol 2016. PubMed
  • Guo Z, Tilburgs T, Wong B, Strominger JL. Dysfunction of dendritic cells in aged C57BL/6 mice leads to failure of natural killer cell activation and of tumor eradication. Proc Natl Acad Sci U S A 2014; 111:14199-204. PubMed
  • Tilburgs T, Strominger JL. CD8+ effector T cells at the fetal-maternal interface, balancing fetal tolerance and antiviral immunity. Am J Reprod Immunol 2013; 69:395-407. PubMed
  • Kawamoto N, Ohnishi H, Kondo N, Strominger JL. The role of dendritic cells in the generation of CD4(+) CD25(HI) Foxp3(+) T cells induced by amino acid copolymers. Int Immunol 2013. PubMed
  • Houser BL, Tilburgs T, Hill J, Nicotra ML, Strominger JL. Two unique human decidual macrophage populations. J Immunol 2011; 186:2633-42. PubMed
  • Stern JN, Keskin DB, Kato Z, Waldner H, Schallenberg S, Anderson A, von Boehmer H, Kretschmer K, Strominger JL. Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells. Proc Natl Acad Sci U S A 2010; 107:17280-5. PubMed
  • Park B, Spooner E, Houser BL, Strominger JL, Ploegh HL. The HCMV membrane glycoprotein US10 selectively targets HLA-G for degradation. J Exp Med 2010; 207:2033-41. PubMed
  • Allan DS, Rybalov B, Awong G, Zúñiga-Pflücker JC, Kopcow HD, Carlyle JR, Strominger JL. TGF-硫 affects development and differentiation of human natural killer cell subsets. Eur J Immunol 2010; 40:2289-95. PubMed
  • Doyle C, Strominger JL. Interaction between CD4 and class II MHC molecules mediates cell adhesion. 1987. J Immunol 2010; 184:5935-8. PubMed
  • Strominger JL. An Alternative Path for Antigen Presentation: Group 1 CD1 Proteins. J Immunol 2010; 184:3303-5. PubMed
  • Yin H, Vistica BP, Chan CC, Strominger JL, Gery I. Inhibition of experimental autoimmune uveitis by amino acid copolymers. J Neuroimmunol 2009; 215:43-8. PubMed
  • Li C,Houser BL,Nicotra ML,Strominger JL. HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells. Proc Natl Acad Sci U S A 2009; 106:5767-72. PubMed
  • Zhang H,Stern JN,Strominger JL. T cell receptors in an IL-10-secreting amino acid copolymer-specific regulatory T cell line that mediates bystander immunosuppression. Proc Natl Acad Sci U S A 2009; 106:3336-41. PubMed
  • Pallandre JR,Krzewski K,Bedel R,Ryffel B,Caignard A,Rohrlich PS,Pivot X,Tiberghien P,Zitvogel L,Strominger JL,Borg C. Dendritic cell and natural killer cell cross-talk: a pivotal role of CX3CL1 in NK cytoskeleton organization and activation. Blood 2008; 112:4420-4. PubMed
  • Kato Z,Stern JN,Nakamura HK,Kuwata K,Kondo N,Strominger JL. Positioning of autoimmune TCR-Ob.2F3 and TCR-Ob.3D1 on the MBP85-99/HLA-DR2 complex. Proc Natl Acad Sci U S A 2008; 105:15523-8. PubMed
  • Krzewski K,Strominger JL. The killer's kiss: the many functions of NK cell immunological synapses. Curr Opin Cell Biol 2008; 20:597-605. PubMed
  • Yu MC,Su LL,Zou L,Liu Y,Wu N,Kong L,Zhuang ZH,Sun L,Liu HP,Hu JH,Li D,Strominger JL,Zang JW,Pei G,Ge BX. An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells. Nat Immunol 2008; 9:898-907. PubMed
  • Yang XH, Richardson AL, Torres-Arzayus MI, Zhou P, Sharma C, Kazarov AR, Andzelm MM, Strominger JL, Brown M, Hemler ME. CD151 accelerates breast cancer by regulating alpha 6 integrin function, signaling, and molecular organization. Cancer Res 2008; 68:3204-13. PubMed
  • Li C, Ge B, Nicotra M, Stern JN, Kopcow HD, Chen X, Strominger JL. JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity. Proc Natl Acad Sci U S A 2008; 105:3017-22. PubMed
  • Strominger JL. Bacterial cell walls, innate immunity and immunoadjuvants. Nat Immunol 2007; 8:1269-71. PubMed
  • Andzelm MM, Chen X, Krzewski K, Orange JS, Strominger JL. Myosin IIA is required for cytolytic granule exocytosis in human NK cells. J Exp Med 2007; 204:2285-91. PubMed
  • Chen X, Allan DS, Krzewski K, Ge B, Kopcow H, Strominger JL. CD28-stimulated ERK2 phosphorylation is required for polarization of the microtubule organizing center and granules in YTS NK cells. Proc Natl Acad Sci U S A 2006; 103:10346-51. PubMed
  • Yang XH, Kovalenko OV, Kolesnikova TV, Andzelm MM, Rubinstein E, Strominger JL, Hemler ME. Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization. J Biol Chem 2006; 281:12976-85. PubMed
  • Krzewski K, Chen X, Orange JS, Strominger JL. Formation of a WIP-, WASp-, actin-, and myosin IIA-containing multiprotein complex in activated NK cells and its alteration by KIR inhibitory signaling. J Cell Biol 2006; 173:121-32. PubMed
  • Boyson JE, Nagarkatti N, Nizam L, Exley MA, Strominger JL. Gestation stage-dependent mechanisms of invariant natural killer T cell-mediated pregnancy loss. Proc Natl Acad Sci U S A 2006; 103:4580-5. PubMed
  • Kato Z, Stern JN, Nakamura HK, Miyashita N, Kuwata K, Kondo N, Strominger JL. The autoimmune TCR-Ob.2F3 can bind to MBP85-99/HLA-DR2 having an unconventional mode as in TCR-Ob.1A12. Mol Immunol 2010; 48:314-20. PubMed
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