Jack Szostak

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-5981
Fax: (617) 726-6893


szostak@molbio.mgh.harvard.edu

Jack Szostak

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Genetics, Harvard Medical School
  • Alex. A. Rich Distinguished Investigator, Molecular Biology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Publications

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  • Powner MW, Zheng SL, Szostak JW. Multicomponent assembly of proposed DNA precursors in water. J Am Chem Soc 2012; 134:13889-95. PubMed
  • Budin I, Szostak JW. Physical effects underlying the transition from primitive to modern cell membranes. Proc Natl Acad Sci U S A 2011; 108:5249-54. PubMed
  • Subtelny AO, Hartman MC, Szostak JW. Optimal codon choice can improve the efficiency and fidelity of N-methyl amino Acid incorporation into peptides by in-vitro translation. Angew Chem Int Ed Engl 2011; 50:3164-7. PubMed
  • Powner MW, Sutherland JD, Szostak JW. Chemoselective multicomponent one-pot assembly of purine precursors in water. J Am Chem Soc 2011; 133:4149-50. PubMed
  • Powner MW, Sutherland JD, Szostak JW. Chemoselective multicomponent one-pot assembly of purine precursors in water. J Am Chem Soc 2010; 132:16677-88. PubMed
  • Szostak JW. DNA Ends: Just the Beginning (Nobel Lecture). Angew Chem Int Ed Engl 2010; 49:7386-404. PubMed
  • Schrum JP, Zhu TF, Szostak JW. The Origins of Cellular Life. Cold Spring Harb Perspect Biol 2010; 2:a002212. PubMed
  • Elenko MP, Szostak JW, van Oijen AM. Single-molecule binding experiments on long time scales. Rev Sci Instrum 2010; 81:083705. PubMed
  • Rajamani S, Ichida JK, Antal T, Treco DA, Leu K, Nowak MA, Szostak JW, Chen IA. Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication. J Am Chem Soc 2010; 132:5880-5. PubMed
  • Lin S, Horning DP, Szostak JW, Chaput JC. Conformational analysis of DNA repair intermediates by time-resolved fluorescence spectroscopy. J Phys Chem A 2009; 113:9585-7. PubMed
  • Elenko MP, Szostak JW, van Oijen AM. Single-molecule imaging of an in vitro-evolved RNA aptamer reveals homogeneous ligand binding kinetics. J Am Chem Soc 2009; 131:9866-7. PubMed
  • Szostak JW. Origins of life: Systems chemistry on early Earth. Nature 2009; 459:171-2. PubMed
  • Litovchick A,Szostak JW. Retraction for Litovchick and Szostak, Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display. Proc Natl Acad Sci U S A 2009; 106:7263. PubMed
  • Zhu TF,Szostak JW. Coupled Growth and Division of Model Protocell Membranes. J Am Chem Soc 2010; 131:5705-13. PubMed
  • Chen JJ,Cai X,Szostak JW. N2'-->p3' phosphoramidate glycerol nucleic acid as a potential alternative genetic system. J Am Chem Soc 2009; 131:2119-21. PubMed
  • Zhu TF,Szostak JW. Preparation of large monodisperse vesicles. PLoS ONE 2009; 4:e5009. PubMed
  • Chen JJ,Tsai CH,Cai X,Horhota AT,McLaughlin LW,Szostak JW. Enzymatic primer-extension with glycerol-nucleoside triphosphates on DNA templates. PLoS ONE 2009; 4:e4949. PubMed
  • Litovchick A,Szostak JW. Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display. Proc Natl Acad Sci U S A 2008; 105:15293-8. PubMed
  • Mansy SS,Szostak JW. Thermostability of model protocell membranes. Proc Natl Acad Sci U S A 2008; 105:13351-5. PubMed
  • Mansy SS,Schrum JP,Krishnamurthy M,Tobe S,Treco DA,Szostak JW. Template-directed synthesis of a genetic polymer in a model protocell. Nature 2008; 454:122-5. PubMed
  • Subtelny AO, Hartman MC, Szostak JW. Ribosomal synthesis of N-methyl peptides. J Am Chem Soc 2008; 130:6131-6. PubMed
  • Monnard PA, Szostak JW. Metal-ion catalyzed polymerization in the eutectic phase in water-ice: A possible approach to template-directed RNA polymerization. J Inorg Biochem 2008; 102:1104-11. PubMed
  • Tsai CH, Chen J, Szostak JW. Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template. Proc Natl Acad Sci U S A 2007; 104:14598-603. PubMed
  • Seelig B, Szostak JW. Selection and evolution of enzymes from a partially randomized non-catalytic scaffold. Nature 2007; 448:828-31. PubMed
  • Mansy SS, Zhang J, Kummerle R, Nilsson M, Chou JJ, Szostak JW, Chaput JC. Structure and evolutionary analysis of a non-biological ATP-binding protein. J Mol Biol 2007; 371:501-13. PubMed
  • Hartman MC, Josephson K, Lin CW, Szostak JW. An expanded set of amino acid analogs for the ribosomal translation of unnatural peptides. PLoS ONE 2007; 2:e972. PubMed
  • Hartman MC, Josephson K, Szostak JW. Enzymatic aminoacylation of tRNA with unnatural amino acids. Proc Natl Acad Sci U S A 2006; 103:4356-61. PubMed
  • Cho GS, Szostak JW. Directed evolution of ATP binding proteins from a zinc finger domain by using mRNA display. Chem Biol 2006; 13:139-47. PubMed
  • Hanczyc MM, Fujikawa SM, Szostak JW. Experimental models of primitive cellular compartments: encapsulation, growth, and division. Science 2003; 302:618-22. PubMed
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