Photo of Jacqueline S. Garcia,  MD

Jacqueline S. Garcia, MD

Dana-Farber Cancer Institute

Dana-Farber Cancer Institute


jacqueline_garcia@dfci.harvard.edu

Jacqueline S. Garcia, MD

Dana-Farber Cancer Institute

EDUCATIONAL TITLES

  • Instructor, Medicine, Harvard Medical School
  • Instructor in Medicine, Medical Oncology, Dana-Farber Cancer Institute

DF/HCC PROGRAM AFFILIATION

Research Abstract

The focus of my research is to develop novel proof-of-concept studies to gain insight on the underlying pathophysiology of acute leukemia and to identify biological predictors of response by partnering with Dana-Farber Cancer Institute laboratory investigators. The ultimate goal of this project is to develop targeted interventions to improve front-line therapies for patients with acute leukemia.

Publications

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  • Garcia JS, Stone RM. The Development of FLT3 Inhibitors in Acute Myeloid Leukemia. Hematol Oncol Clin North Am 2017; 31:663-680. PubMed
  • Huang M, Garcia JS, Thomas D, Zhu L, Nguyen LX, Chan SM, Majeti R, Medeiros BC, Mitchell BS. Autophagy mediates proteolysis of NPM1 and HEXIM1 and sensitivity to BET inhibition in AML cells. 2016. PubMed
  • Townsend EC, Murakami MA, Christodoulou A, Christie AL, K√∂ster J, DeSouza TA, Morgan EA, Kallgren SP, Liu H, Wu SC, Plana O, Montero J, Stevenson KE, Rao P, Vadhi R, Andreeff M, Armand P, Ballen KK, Barzaghi-Rinaudo P, Cahill S, Clark RA, Cooke VG, Davids MS, DeAngelo DJ, Dorfman DM, Eaton H, Ebert BL, Etchin J, Firestone B, Fisher DC, Freedman AS, Galinsky IA, Gao H, Garcia JS, Garnache-Ottou F, Graubert TA, Gutierrez A, Halilovic E, Harris MH, Herbert ZT, Horwitz SM, Inghirami G, Intlekoffer AM, Ito M, Izraeli S, Jacobsen ED, Jacobson CA, Jeay S, Jeremias I, Kelliher MA, Koch R, Konopleva M, Kopp N, Kornblau SM, Kung AL, Kupper TS, LaBoeuf N, LaCasce AS, Lees E, Li LS, Look AT, Murakami M, Muschen M, Neuberg D, Ng SY, Odejide OO, Orkin SH, Paquette RR, Place AE, Roderick JE, Ryan JA, Sallan SE, Shoji B, Silverman LB, Soiffer RJ, Steensma DP, Stegmaier K, Stone RM, Tamburini J, Thorner AR, van Hummelen P, Wadleigh M, Wiesmann M, Weng AP, Wuerthner JU, Williams DA, Wollison BM, Lane AA, Letai A, Bertagnolli MM, Ritz J, Brown M, Long H, Aster JC, Shipp MA, Griffin JD, Weinstock DM. The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell 2016; 29:574-86. PubMed
  • Garcia JS, Huang M, Medeiros BC, Mitchell BS. Selective toxicity of investigational ixazomib for human leukemia cells expressing mutant cytoplasmic NPM1: Role of reactive oxygen species. Clin Cancer Res 2015. PubMed
  • Narayan R, Garcia JS, Percival MM, Berube C, Coutre S, Gotlib J, Greenberg P, Liedtke M, Hewitt R, Regan K, Williamson C, Doykan C, Cardone MH, McMillan A, Medeiros BC. Sequential azacitidine plus lenalidomide in previously treated elderly patients with acute myeloid leukemia and higher risk myelodysplastic syndrome. Leuk Lymphoma 2015. PubMed
  • Nguyen le XT, Raval A, Garcia JS, Mitchell BS. Regulation of ribosomal gene expression in cancer. J Cell Physiol 2015; 230:1181-8. PubMed
  • Garcia JS, Medeiros BC. Monosomal karyotype acute myeloid leukemia: tread lightly. Acta Haematol 2015; 133:324-6. PubMed
  • Garcia JS, Medeiros BC, Appelbaum FR. Blood consult: monosomal karyotype acute myeloid leukemia. Blood 2012; 119:5659-60. PubMed
  • Churpek JE, Garcia JS, Madzo J, Jackson SA, Onel K, Godley LA. Identification and molecular characterization of a novel 3′ mutation in RUNX1 in a family with familial platelet disorder. Leuk Lymphoma 2010; 51:1931-5. PubMed
  • Garcia JS, Jain N, Godley LA. An update on the safety and efficacy of decitabine in the treatment of myelodysplastic syndromes. Onco Targets Ther 2010; 3:1-13. PubMed
  • Tobe BT, Kitazono AA, Garcia JS, Gerber RA, Bevis BJ, Choy JS, Chasman D, Kron SJ. Morphogenesis signaling components influence cell cycle regulation by cyclin dependent kinase. Cell Div 2009; 4:12. PubMed
  • Suen JK, Bressler L, Shord SS, Warso M, Villano JL. Cutaneous squamous cell carcinoma responding serially to single-agent cetuximab. 2007; 18:827-9. PubMed
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