James M. Cunningham, MD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 355-9058
Fax: (617) 355-9061


jcunningham@rics.bwh.harvard.edu

James M. Cunningham, MD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Associate Professor, Medicine, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Research Abstract

My laboratory is interested in the pathogenesis of virus-induced leukemia. In particular, we study the mechanism of infection by retroviruses that cause leukemia in mice. As part of these studies, we have identified the receptors that these viruses use to gain entry into cells. Our focus is now on determining how viruses recognize and bind to these receptors and how receptor function is altered in virus-infected cells. Our goal is to understand the entry mechanism in sufficient detail to design small molecules that inhibit infection and to alter the virus to redirect infection for the purposes of virus-directed gene therapy.

Publications

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  • White KL, Vierkant RA, Fogarty Z, Charbonneau B, Block MS, Pharoah PD, Chenevix-Trench G, Rossing MA, Cramer DW, Pearce L, Schildkraut JM, Menon U, Kruger Kjær S, Levine DA, Gronwald J, Anton-Culver H, Whittemore AS, Karlan BY, Lambrechts D, Wentzensen N, Kupryjanczyk J, Chang-Claude J, Bandera EV, Hogdall EV, Heitz F, Kaye S, Fasching PA, Campbell IG, Goodman MT, Pejovic T, Bean YT, Lurie G, Eccles D, Hein A, Beckmann MW, Ekici AB, Paul J, Brown R, Flanagan JM, Harter P, du Bois A, Schwaab I, Hogdall CK, Lundvall L, Olson SH, Orlow I, Paddock LE, Rudolph A, Eilber U, Dansonka-Mieszkowska A, Rzepecka IK, Ziolkowska-Seta I, Brinton LA, Yang HP, Garcia-Closas M, Despierre E, Lambrechts S, Vergote I, Walsh C, Lester J, Sieh W, McGuire V, Rothstein JH, Ziogas A, Lubinski J, Cybulski C, Menkiszak J, Jensen A, Gayther SA, Ramus SJ, Gentry-Maharaj A, Berchuck A, Wu AH, Pike MC, Van Den Berg D, Terry KL, Vitonis AF, Doherty JA, Johnatty SE, Defazio A, Song H, Tyrer J, Sellers TA, Phelan CM, Kalli KR, Cunningham JM, Fridley BL, Goode EL. Analysis of Over 10,000 Cases Finds No Association between Previously-Reported Candidate Polymorphisms and Ovarian Cancer Outcome. Cancer Epidemiol Biomarkers Prev 2013. PubMed
  • Pearce CL, Rossing MA, Lee AW, Ness RB, Webb PM, Chenevix-Trench G, Jordan SJ, Stram DA, Chang-Claude J, Hein R, Nickels S, Lurie G, Thompson PJ, Carney ME, Goodman MT, Moysich KB, Hogdall EV, Jensen A, Goode EL, Fridley BL, Cunningham JM, Vierkant RA, Weber RP, Ziogas A, Anton-Culver H, Gayther SA, Gentry-Maharaj A, Menon U, Ramus SJ, Brinton LA, Wentzensen N, Lissowska J, Garcia-Closas M, Massuger L, Kiemeney LA, van Altena AM, Aben KK, Berchuck A, Doherty JA, Iversen E, McGuire V, Moorman PG, Pharoah PD, Pike MC, Risch HA, Sieh W, Stram DO, Terry KL, Whittemore AS, Wu A, Schildkraut JM, Kjaer SK. Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer. Cancer Epidemiol Biomarkers Prev 2013. PubMed
  • Chandran K, Sullivan NJ, Felbor U, Whelan SP, Cunningham JM. Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science 2005; 308:1643-5. PubMed
  • Smith JG, Mothes W, Blacklow SC, Cunningham JM. The mature avian leukosis virus subgroup A envelope glycoprotein is metastable, and refolding induced by the synergistic effects of receptor binding and low pH is coupled to infection. J Virol 2004; 78:1403-10. PubMed
  • Barnett AL, Cunningham JM. Receptor binding transforms the surface subunit of the mammalian C-type retrovirus envelope protein from an inhibitor to an activator of fusion. J Virol 2001; 75:9096-105. PubMed
  • Barnett AL, Davey RA, Cunningham JM. Modular organization of the Friend murine leukemia virus envelope protein underlies the mechanism of infection. Proc Natl Acad Sci U S A 2001; 98:4113-8. PubMed
  • Davey RA, Zuo Y, Cunningham JM. Identification of a receptor-binding pocket on the envelope protein of friend murine leukemia virus. J Virol 1999; 73:3758-63. PubMed
  • Davey RA, Hamson CA, Healey JJ, Cunningham JM. In vitro binding of purified murine ecotropic retrovirus envelope surface protein to its receptor, MCAT-1. J Virol 1997; 71:8096-102. PubMed
  • Fass D, Davey RA, Hamson CA, Kim PS, Cunningham JM, Berger JM. Structure of a murine leukemia virus receptor-binding glycoprotein at 2.0 angstrom resolution. Science 1997; 277:1662-6. PubMed
  • Perkins CP, Mar V, Shutter JR, del Castillo J, Danilenko DM, Medlock ES, Ponting IL, Graham M, Stark KL, Zuo Y, Cunningham JM, Bosselman RA. Anemia and perinatal death result from loss of the murine ecotropic retrovirus receptor mCAT-1. Genes Dev 1997; 11:914-25. PubMed
  • Marigo V, Davey RA, Zuo Y, Cunningham JM, Tabin CJ. Biochemical evidence that patched is the Hedgehog receptor. Nature 1996; 384:176-9. PubMed
  • Albritton LM, Bowcock AM, Eddy RL, Morton CC, Tseng L, Farrer LA, Cavalli-Sforza LL, Shows TB, Cunningham JM. The human cationic amino acid transporter (ATRC1): physical and genetic mapping to 13q12-q14. Genomics 1992; 12:430-4. PubMed
  • Scadden DT, Fuller B, Cunningham JM. Human cells infected with retrovirus vectors acquire an endogenous murine provirus. J Virol 1990; 64:424-7. PubMed
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