Photo of Jay Rajagopal,  MD

Jay Rajagopal, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 803-9740


Rajagopal.jayaraj@mgh.harvard.edu

Jay Rajagopal, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Associate Professor, Medicine, Harvard Medical School
  • Associate Professor, Otology and Laryngology, Harvard Medical School
  • Associate Professor, Stem Cell and Regenerative Biology, Harvard Medical School
  • Investigator, Center for Regenerative Medicine, Massachusetts General Hospital
  • Principal Faculty, CRM, Harvard Stem Cell Institute
  • Associate, Stem Cell & Regenerative Biology, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Research Abstract

Our laboratory focuses on lung regeneration and the application of developmental biology to lung human disease. We seek to clarify the mechanistic basis of lung stem and progenitor cell proliferation and differentiation, and these inquiries into the molecular mechanisms underlying embryonic lung development and adult lung epithelial regeneration serve as a framework within which we seek to understand how the reactivation and distortion of normal developmental processes results in human lung disease. We are also exploring methods for the in vivo engraftment of lung epithelial stem cells as a basis for regenerative medical therapies and the production of iPS cells from individuals with lung diseases, including Cystic Fibrosis.

Publications

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  • Pardo-Saganta A, Law BM, Tata PR, Villoria J, Saez B, Mou H, Zhao R, Rajagopal J. Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations. Cell Stem Cell 2015; 16:184-97. PubMed
  • Guha A, Vasconcelos M, Zhao R, Gower AC, Rajagopal J, Cardoso WV. Analysis of Notch signaling-dependent gene expression in developing airways reveals diversity of Clara cells. PLoS ONE 2014; 9:e88848. PubMed
  • Tata PR, Mou H, Pardo-Saganta A, Zhao R, Prabhu M, Law BM, Vinarsky V, Cho JL, Breton S, Sahay A, Medoff BD, Rajagopal J. Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature 2013; 503:218-23. PubMed
  • Pardo-Saganta A, Law BM, Gonzalez-Celeiro M, Vinarsky V, Rajagopal J. Ciliated cells of pseudostratified airway epithelium do not become mucous cells after ovalbumin challenge. Am J Respir Cell Mol Biol 2013; 48:364-73. PubMed
  • Watanabe H, Francis JM, Woo MS, Etemad B, Lin W, Fries DF, Peng S, Snyder EL, Tata PR, Izzo F, Schinzel AC, Cho J, Hammerman PS, Verhaak RG, Hahn WC, Rajagopal J, Jacks T, Meyerson M. Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target. Genes Dev 2013; 27:197-210. PubMed
  • Kim JK, Vinarsky V, Wain JC, Zhao R, Jung K, Choi J, Lam A, Pardo-Saganta A, Breton S, Rajagopal J, Yun SH. In vivo imaging of tracheal epithelial cells in mice during airway regeneration. Am J Respir Cell Mol Biol 2012. PubMed
  • Muzykewicz DA, Black ME, Muse V, Numis AL, Rajagopal J, Thiele EA, Sharma A. Multifocal micronodular pneumocyte hyperplasia: computed tomographic appearance and follow-up in tuberous sclerosis complex. J Comput Assist Tomogr 2012; 36:518-22. PubMed
  • Guseh JS, Bores SA, Stanger BZ, Zhou Q, Anderson WJ, Melton DA, Rajagopal J. Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development 2009; 136:1751-9. PubMed
  • Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008; 455:627-32. PubMed
  • Rajagopal J, Carroll TJ, Guseh JS, Bores SA, Blank LJ, Anderson WJ, Yu J, Zhou Q, McMahon AP, Melton DA. Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development 2008; 135:1625-34. PubMed
  • Shaw AT, Meissner A, Dowdle JA, Crowley D, Magendantz M, Ouyang C, Parisi T, Rajagopal J, Blank LJ, Bronson RT, Stone JR, Tuveson DA, Jaenisch R, Jacks T. Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev 2007; 21:694-707. PubMed
  • Rajagopal J, Anderson WJ, Kume S, Martinez OI, Melton DA. Insulin staining of ES cell progeny from insulin uptake. Science 2003; 299:363. PubMed
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