Photo of Jay S. Loeffler,  MD

Jay S. Loeffler, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 724-1548
Fax: (617) 724-9532


jloeffler@partners.org

Jay S. Loeffler, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Herman and Joan Suit Professor of Rad Onc, Radiation Oncology, Harvard Medical School
  • Chair, Radiation Oncology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Clinical research in innovative radiation techniques for benign and malignant brain tumors

Publications

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  • Lu-Emerson C, Duda DG, Emblem KE, Taylor JW, Gerstner ER, Loeffler JS, Batchelor TT, Jain RK. Lessons from anti-vascular endothelial growth factor and anti-vascular endothelial growth factor receptor trials in patients with glioblastoma. J Clin Oncol 2015; 33:1197-213. PubMed
  • Shih HA, Sherman JC, Nachtigall LB, Colvin MK, Fullerton BC, Daartz J, Winrich BK, Batchelor TT, Thornton LT, Mancuso SM, Saums MK, Oh KS, Curry WT, Loeffler JS, Yeap BY. Proton therapy for low-grade gliomas: Results from a prospective trial. Cancer 2015. PubMed
  • Niu NN, Niemierko A, Larvie M, Curtin H, Loeffler JS, McKenna MJ, Shih HA. Pretreatment Growth Rate Predicts Radiation Response in¬†Vestibular Schwannomas. Int J Radiat Oncol Biol Phys 2014; 89:113-9. PubMed
  • Kondziolka D, Kalkanis SN, Mehta M, Ahluwalia M, Loeffler JS. It is Time to Re-evaluate the Management of Patients with Brain Metastases. Neurosurgery 2014. PubMed
  • Aizer AA, Ancukiewicz M, Nguyen PL, Shih HA, Loeffler JS, Oh KS. Underutilization of radiation therapy in patients with glioblastoma: predictive factors and outcomes. Cancer 2014; 120:238-43. PubMed
  • Forst DA, Nahed BV, Loeffler JS, Batchelor TT. Low-grade gliomas. Oncologist 2014; 19:403-13. PubMed
  • Kondziolka D, Parry PV, Lunsford LD, Kano H, Flickinger JC, Rakfal S, Arai Y, Loeffler JS, Rush S, Knisely JP, Sheehan J, Friedman W, Tarhini AA, Francis L, Lieberman F, Ahluwalia MS, Linskey ME, McDermott M, Sperduto P, Stupp R. The accuracy of predicting survival in individual patients with cancer. J Neurosurg 2014; 120:24-30. PubMed
  • McDuff SG, Taich ZJ, Lawson JD, Sanghvi P, Wong ET, Barker FG, Hochberg FH, Loeffler JS, Warnke PC, Murphy KT, Mundt AJ, Carter BS, McDonald CR, Chen CC. Neurocognitive assessment following whole brain radiation therapy and radiosurgery for patients with cerebral metastases. J Neurol Neurosurg Psychiatry 2013; 84:1384-91. PubMed
  • Aizer AA, Ancukiewicz M, Nguyen PL, Macdonald SM, Yock TI, Tarbell NJ, Shih HA, Loeffler JS, Oh KS. Natural history and role of radiation in patients with supratentorial and infratentorial WHO grade II ependymomas: results from a population-based study. J. Neurooncol. 2013; 115:411-9. PubMed
  • Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, Lu-Emerson C, Iafrate AJ, Ivy SP, Rosen BR, Loeffler JS, Wen PY, Sorensen AG, Jain RK. Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation. Proc Natl Acad Sci U S A 2013; 110:19059-64. PubMed
  • Abazeed ME, Adams DJ, Hurov KE, Tamayo P, Creighton CJ, Sonkin D, Giacomelli AO, Du C, Fries DF, Wong KK, Mesirov JP, Loeffler JS, Schreiber SL, Hammerman PS, Meyerson M. Integrative radiogenomic profiling of squamous cell lung cancer. Cancer Res 2013; 73:6289-98. PubMed
  • Nabors LB, Ammirati M, Bierman PJ, Brem H, Butowski N, Chamberlain MC, DeAngelis LM, Fenstermaker RA, Friedman A, Gilbert MR, Hesser D, Holdhoff M, Junck L, Lawson R, Loeffler JS, Maor MH, Moots PL, Morrison T, Mrugala MM, Newton HB, Portnow J, Raizer JJ, Recht L, Shrieve DC, Sills AK, Tran D, Tran N, Vrionis FD, Wen PY, McMillian N, Ho M, . Central nervous system cancers. J Natl Compr Canc Netw 2013; 11:1114-51. PubMed
  • Loeffler JS, Durante M. Charged particle therapy--optimization, challenges and future directions. Nat Rev Clin Oncol 2013; 10:411-24. PubMed
  • Siddiqui JD, Loeffler JS, Murphy MA. Radiation Optic Neuropathy After Proton Beam Therapy for Optic Nerve Sheath Meningioma. J Neuroophthalmol 2013. PubMed
  • Walcott BP, Nahed BV, Brastianos PK, Loeffler JS. Radiation Treatment for WHO Grade II and III Meningiomas. 2013; 3:227. PubMed
  • Brem SS, Bierman PJ, Brem H, Butowski N, Chamberlain MC, Chiocca EA, Deangelis LM, Fenstermaker RA, Friedman A, Gilbert MR, Hesser D, Junck L, Linette GP, Loeffler JS, Maor MH, Michael M, Moots PL, Morrison T, Mrugala M, Nabors LB, Newton HB, Portnow J, Raizer JJ, Recht L, Shrieve DC, Sills AK, Vrionis FD, Wen PY. Central nervous system cancers. J Natl Compr Canc Netw 2011; 9:352-400. PubMed
  • Bassig BA, Inskip PD, Burdette L, Shapiro WR, Selker RG, Fine HA, Loeffler JS, Black PM, Dubrow R, Brenner AV. Selected human leukocyte antigen class II polymorphisms and risk of adult glioma. J Neuroimmunol 2011. PubMed
  • Kahn J, Loeffler JS, Niemierko A, Chiocca EA, Batchelor T, Chakravarti A. Long-Term Outcomes of Patients with Spinal Cord Gliomas Treated by Modern Conformal Radiation Techniques. Int J Radiat Oncol Biol Phys 2010. PubMed
  • Halasz LM, Bussi√®re MR, Dennis ER, Niemierko A, Chapman PH, Loeffler JS, Shih HA. Proton Stereotactic Radiosurgery for the Treatment of Benign Meningiomas. Int J Radiat Oncol Biol Phys 2010. PubMed
  • Plotkin SR, Halpin C, McKenna MJ, Loeffler JS, Batchelor TT, Barker FG. Erlotinib for progressive vestibular schwannoma in neurofibromatosis 2 patients. Otol. Neurotol. 2010; 31:1135-43. PubMed
  • Batchelor TT, Duda DG, di Tomaso E, Ancukiewicz M, Plotkin SR, Gerstner E, Eichler AF, Drappatz J, Hochberg FH, Benner T, Louis DN, Cohen KS, Chea H, Exarhopoulos A, Loeffler JS, Moses MA, Ivy P, Sorensen AG, Wen PY, Jain RK. Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J Clin Oncol 2010; 28:2817-23. PubMed
  • Rajaraman P, Hutchinson A, Wichner S, Black PM, Fine HA, Loeffler JS, Selker RG, Shapiro WR, Rothman N, Linet MS, Inskip PD. DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. 2010; 12:37-48. PubMed
  • Durante M, Loeffler JS. Charged particles in radiation oncology. Nat Rev Clin Oncol 2009; 7:37-43. PubMed
  • Olson JJ, Paleologos NA, Gaspar LE, Robinson PD, Morris RE, Ammirati M, Andrews DW, Asher AL, Burri SH, Cobbs CS, Kondziolka D, Linskey ME, Loeffler JS, McDermott M, Mehta MP, Mikkelsen T, Patchell RA, Ryken TC, Kalkanis SN. The role of emerging and investigational therapies for metastatic brain tumors: a systematic review and evidence-based clinical practice guideline of selected topics. J. Neurooncol. 2010; 96:115-42. PubMed
  • Ryken TC, McDermott M, Robinson PD, Ammirati M, Andrews DW, Asher AL, Burri SH, Cobbs CS, Gaspar LE, Kondziolka D, Linskey ME, Loeffler JS, Mehta MP, Mikkelsen T, Olson JJ, Paleologos NA, Patchell RA, Kalkanis SN. The role of steroids in the management of brain metastases: a systematic review and evidence-based clinical practice guideline. J. Neurooncol. 2010; 96:103-14. PubMed
  • Ammirati M, Cobbs CS, Linskey ME, Paleologos NA, Ryken TC, Burri SH, Asher AL, Loeffler JS, Robinson PD, Andrews DW, Gaspar LE, Kondziolka D, McDermott M, Mehta MP, Mikkelsen T, Olson JJ, Patchell RA, Kalkanis SN. The role of retreatment in the management of recurrent/progressive brain metastases: a systematic review and evidence-based clinical practice guideline. J. Neurooncol. 2010; 96:85-96. PubMed
  • Merchant TE, Pollack IF, Loeffler JS. Brain tumors across the age spectrum: biology, therapy, and late effects. Semin Radiat Oncol 2009; 20:58-66. PubMed
  • Linskey ME, Andrews DW, Asher AL, Burri SH, Kondziolka D, Robinson PD, Ammirati M, Cobbs CS, Gaspar LE, Loeffler JS, McDermott M, Mehta MP, Mikkelsen T, Olson JJ, Paleologos NA, Patchell RA, Ryken TC, Kalkanis SN. The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J. Neurooncol. 2010; 96:45-68. PubMed
  • Kalkanis SN, Kondziolka D, Gaspar LE, Burri SH, Asher AL, Cobbs CS, Ammirati M, Robinson PD, Andrews DW, Loeffler JS, McDermott M, Mehta MP, Mikkelsen T, Olson JJ, Paleologos NA, Patchell RA, Ryken TC, Linskey ME. The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J. Neurooncol. 2010; 96:33-43. PubMed
  • Mikkelsen T, Paleologos NA, Robinson PD, Ammirati M, Andrews DW, Asher AL, Burri SH, Cobbs CS, Gaspar LE, Kondziolka D, Linskey ME, Loeffler JS, McDermott M, Mehta MP, Olson JJ, Patchell RA, Ryken TC, Kalkanis SN. The role of prophylactic anticonvulsants in the management of brain metastases: a systematic review and evidence-based clinical practice guideline. J. Neurooncol. 2010; 96:97-102. PubMed
  • Mehta MP, Paleologos NA, Mikkelsen T, Robinson PD, Ammirati M, Andrews DW, Asher AL, Burri SH, Cobbs CS, Gaspar LE, Kondziolka D, Linskey ME, Loeffler JS, McDermott M, Olson JJ, Patchell RA, Ryken TC, Kalkanis SN. The role of chemotherapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J. Neurooncol. 2010; 96:71-83. PubMed
  • Gaspar LE, Mehta MP, Patchell RA, Burri SH, Robinson PD, Morris RE, Ammirati M, Andrews DW, Asher AL, Cobbs CS, Kondziolka D, Linskey ME, Loeffler JS, McDermott M, Mikkelsen T, Olson JJ, Paleologos NA, Ryken TC, Kalkanis SN. The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J. Neurooncol. 2010; 96:17-32. PubMed
  • Arvold ND,Lessell S,Bussiere M,Beaudette K,Rizzo JF,Loeffler JS,Shih HA. Visual Outcome and Tumor Control After Conformal Radiotherapy for Patients With Optic Nerve Sheath Meningioma. Int J Radiat Oncol Biol Phys 2009; 75:1166-72. PubMed
  • Gabeau-Lacet D, Engler D, Gupta S, Scangas GA, Betensky RA, Barker FG, Loeffler JS, Louis DN, Mohapatra G. Genomic profiling of atypical meningiomas associates gain of 1q with poor clinical outcome. J Neuropathol Exp Neurol 2009; 68:1155-65. PubMed
  • Truong MT, Kamat UR, Liebsch NJ, Curry WT, Lin DT, Barker FG, Loeffler JS, Chan AW. Proton radiation therapy for primary sphenoid sinus malignancies: treatment outcome and prognostic factors. Head Neck 2009; 31:1297-308. PubMed
  • Gabeau-Lacet D,Aghi M,Betensky RA,Barker FG,Loeffler JS,Louis DN. Bone involvement predicts poor outcome in atypical meningioma. J Neurosurg 2009; 111:464-71. PubMed
  • Jain RK,Duda DG,Willett CG,Sahani DV,Zhu AX,Loeffler JS,Batchelor TT,Sorensen AG. Biomarkers of response and resistance to antiangiogenic therapy. Nat Rev Clin Oncol 2009; 6:327-338. PubMed
  • Podoloff DA, Ball DW, Ben-Josef E, Benson AB, Cohen SJ, Coleman RE, Delbeke D, Ho M, Ilson DH, Kalemkerian GP, Lee RJ, Loeffler JS, Macapinlac HA, Morgan RJ, Siegel BA, Singhal S, Tyler DS, Wong RJ. NCCN task force: clinical utility of PET in a variety of tumor types. J Natl Compr Canc Netw 2009; 7 Suppl 2:S1-26. PubMed
  • Coble JB,Dosemeci M,Stewart PA,Blair A,Bowman J,Fine HA,Shapiro WR,Selker RG,Loeffler JS,Black PM,Linet MS,Inskip PD. Occupational exposure to magnetic fields and the risk of brain tumors. Neuro-oncol 2009; 11:242-9. PubMed
  • Plotkin SR,Halpin C,Blakeley JO,Slattery WH 3rd,Welling DB,Chang SM,Loeffler JS,Harris GJ,Sorensen AG,McKenna MJ,Barker FG 2nd. Suggested response criteria for phase II antitumor drug studies for neurofibromatosis type 2 related vestibular schwannoma. J Neurooncol 2009; 93:61-77. PubMed
  • Gerstner ER,Duda DG,di Tomaso E,Ryg PA,Loeffler JS,Sorensen AG,Ivy P,Jain RK,Batchelor TT. VEGF inhibitors in the treatment of cerebral edema in patients with brain cancer. Nat Rev Clin Oncol 2009; 6:229-36. PubMed
  • Rajaraman P,Hutchinson A,Rothman N,Black PM,Fine HA,Loeffler JS,Selker RG,Shapiro WR,Linet MS,Inskip PD. Oxidative response gene polymorphisms and risk of adult brain tumors. Neuro-oncol 2008; 10:709-15. PubMed
  • Lonn S,Rothman N,Shapiro WR,Fine HA,Selker RG,Black PM,Loeffler JS,Hutchinson AA,Inskip PD. Genetic variation in insulin-like growth factors and brain tumor risk. Neuro-oncol 2008; 10:553-9. PubMed
  • Loeffler JS. Technology assessment in radiation oncology: time for reassessment? Nat Clin Pract Oncol 2008; 5:299. PubMed
  • Sher DJ, Henson JW, Avutu B, Hochberg FH, Batchelor TT, Martuza RL, Barker FG 2nd, Loeffler JS, Chakravarti A. The added value of concurrently administered temozolomide versus adjuvant temozolomide alone in newly diagnosed glioblastoma. J Neurooncol 2008; 88:43-50. PubMed
  • Suit H, Kooy H, Trofimov A, Farr J, Munzenrider J, DeLaney T, Loeffler J, Clasie B, Safai S, Paganetti H. Should positive phase III clinical trial data be required before proton beam therapy is more widely adopted? No. Radiother Oncol 2008; 86:148-53. PubMed
  • Petit JH, Biller BM, Yock TI, Swearingen B, Coen JJ, Chapman P, Ancukiewicz M, Bussiere M, Klibanski A, Loeffler JS. Proton stereotactic radiotherapy for persistent adrenocorticotropin-producing adenomas. J Clin Endocrinol Metab 2007; 93:393-9. PubMed
  • Lawenda BD, Smith DE, Xu L, Niemierko A, Silverstein JR, Boucher Y, Kashiwagi S, Held KD, Jain RK, Loeffler JS, Eisenberg DM, Blumberg JB. Do the dietary supplements epigallocatechin gallate or vitamin e cause a radiomodifying response on tumors in vivo? A pilot study with murine breast carcinoma. J Soc Integr Oncol 2007; 5:11-7. PubMed
  • Petit JH, Biller BM, Coen JJ, Swearingen B, Ancukiewicz M, Bussiere M, Chapman P, Klibanski A, Loeffler JS. Proton stereotactic radiosurgery in management of persistent acromegaly. Endocr Pract 2008; 13:726-34. PubMed
  • Rajaraman P, Wang SS, Rothman N, Brown MM, Black PM, Fine HA, Loeffler JS, Selker RG, Shapiro WR, Chanock SJ, Inskip PD. Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors in adults. Cancer Epidemiol Biomarkers Prev 2007; 16:1655-61. PubMed
  • Jain RK, di Tomaso E, Duda DG, Loeffler JS, Sorensen AG, Batchelor TT. Angiogenesis in brain tumours. Nat Rev Neurosci 2007; 8:610-22. PubMed
  • Eichler AF, Loeffler JS. Multidisciplinary management of brain metastases. Oncologist 2007; 12:884-98. PubMed
  • Parodi K, Paganetti H, Shih HA, Michaud S, Loeffler JS, Delaney TF, Liebsch NJ, Munzenrider JE, Fischman AJ, Knopf A, Bortfeld T. Patient study of in vivo verification of beam delivery and range, using positron emission tomography and computed tomography imaging after proton therapy. Int J Radiat Oncol Biol Phys 2007; 68:920-34. PubMed
  • Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen PJ, Zhu M, Ancukiewicz M, Mrugala MM, Plotkin S, Drappatz J, Louis DN, Ivy P, Scadden DT, Benner T, Loeffler JS, Wen PY, Jain RK. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 2007; 11:83-95. PubMed
  • Chakravarti A, Tyndall E, Palanichamy K, Mehta M, Aldape K, Loeffler J. Impact of molecular profiling on clinical trial design for glioblastoma. Curr Oncol Rep 2006; 9:71-9. PubMed
  • Bluhm EC, Zahm SH, Fine HA, Black PM, Loeffler JS, Shapiro WR, Selker RG, Inskip PD. Personal hair dye use and risks of glioma, meningioma, and acoustic neuroma among adults. Am J Epidemiol 2006; 165:63-71. PubMed
  • Rajaraman P, Stewart PA, Samet JM, Schwartz BS, Linet MS, Zahm SH, Rothman N, Yeager M, Fine HA, Black PM, Loeffler J, Shapiro WR, Selker RG, Inskip PD. Lead, genetic susceptibility, and risk of adult brain tumors. Cancer Epidemiol Biomarkers Prev 2006; 15:2514-20. PubMed
  • Patchell RA, Regine WF, Renschler M, Loeffler JS, Sawaya R, Chin LS, Andrews DW. Comments about the prospective randomized trial by Aoyama et al. Surg Neurol 2006; 66:459-60. PubMed
  • Patchell RA, Regine WF, Loeffler JS, Sawaya R, Andrews DW, Chin LS. Radiosurgery plus whole-brain radiation therapy for brain metastases. JAMA 2006; 296:2089-90; author reply 209. PubMed
  • Pommier P, Liebsch NJ, Deschler DG, Lin DT, McIntyre JF, Barker FG, Adams JA, Lopes VV, Varvares M, Loeffler JS, Chan AW. Proton beam radiation therapy for skull base adenoid cystic carcinoma. Arch Otolaryngol Head Neck Surg 2006; 132:1242-9. PubMed
  • Chakravarti A, Erkkinen MG, Nestler U, Stupp R, Mehta M, Aldape K, Gilbert MR, Black PM, Loeffler JS. Temozolomide-mediated radiation enhancement in glioblastoma: a report on underlying mechanisms. Clin Cancer Res 2006; 12:4738-46. PubMed
  • Byrne TN, Borges LF, Loeffler JS. Metastatic epidural spinal cord compression: update on management. Semin Oncol 2006; 33:307-11. PubMed
  • Batchelor T, Loeffler JS. Primary CNS lymphoma. J Clin Oncol 2006; 24:1281-8. PubMed
  • MacDonald SM, DeLaney TF, Loeffler JS. Proton beam radiation therapy. Cancer Invest 2006; 24:199-208. PubMed
  • Jain RK, Duda DG, Clark JW, Loeffler JS. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol 2006; 3:24-40. PubMed
  • Rabinov JD, Cheng LL, Lee PL, Brisman JL, Loeffler JS, Cole AJ, Cosgrove GR, Bussiere MR, Chaves T, Gonzalez RG. MR spectroscopic changes in the rat hippocampus following proton radiosurgery. Stereotact Funct Neurosurg 2006; 84:147-54. PubMed
  • Shih HA, Betensky RA, Dorfman MV, Louis DN, Loeffler JS, Batchelor TT. Genetic analyses for predictors of radiation response in glioblastoma. Int J Radiat Oncol Biol Phys 2005; 63:704-10. PubMed
  • Chakravarti A, Zhai GG, Zhang M, Malhotra R, Latham DE, Delaney MA, Robe P, Nestler U, Song Q, Loeffler J. Survivin enhances radiation resistance in primary human glioblastoma cells via caspase-independent mechanisms. Oncogene 2004; 23:7494-506. PubMed
  • Chakravarti A, Zhai G, Suzuki Y, Sarkesh S, Black PM, Muzikansky A, Loeffler JS. The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas. J Clin Oncol 2004; 22:1926-33. PubMed
  • Loeffler JS, Niemierko A, Chapman PH. Second tumors after radiosurgery: tip of the iceberg or a bump in the road? Neurosurgery 2003; 52:1436-40; discussion 1440-. PubMed
  • Inskip PD, Tarone RE, Hatch EE, Wilcosky TC, Fine HA, Black PM, Loeffler JS, Shapiro WR, Selker RG, Linet MS. Sociodemographic indicators and risk of brain tumours. Int J Epidemiol 2003; 32:225-33. PubMed
  • Inskip PD, Tarone RE, Hatch EE, Wilcosky TC, Selker RG, Fine HA, Black PM, Loeffler JS, Shapiro WR, Linet MS. Laterality of brain tumors. Neuroepidemiology 2003; 22:130-8. PubMed
  • Rabinov JD, Lee PL, Barker FG, Louis DN, Harsh GR, Cosgrove GR, Chiocca EA, Thornton AF, Loeffler JS, Henson JW, Gonzalez RG. In vivo 3-T MR spectroscopy in the distinction of recurrent glioma versus radiation effects: initial experience. Radiology 2002; 225:871-9. PubMed
  • Harsh GR, Thornton AF, Chapman PH, Bussiere MR, Rabinov JD, Loeffler JS. Proton beam stereotactic radiosurgery of vestibular schwannomas. Int J Radiat Oncol Biol Phys 2002; 54:35-44. PubMed
  • Chakravarti A, Chakladar A, Delaney MA, Latham DE, Loeffler JS. The epidermal growth factor receptor pathway mediates resistance to sequential administration of radiation and chemotherapy in primary human glioblastoma cells in a RAS-dependent manner. Cancer Res 2002; 62:4307-15. PubMed
  • Hoh BL, Chapman PH, Loeffler JS, Carter BS, Ogilvy CS. Results of multimodality treatment for 141 patients with brain arteriovenous malformations and seizures: factors associated with seizure incidence and seizure outcomes. Neurosurgery 2002; 51:303-9; discussion 309-11. PubMed
  • Jeter MD, J. Gemcitabine-induced radiation recall. Int J Radiat Oncol Biol Phys 2002; 53:394-400. PubMed
  • Paganetti H, Niemierko A, Ancukiewicz M, Gerweck LE, Goitein M, Loeffler JS, Suit HD. Relative biological effectiveness (RBE) values for proton beam therapy. Int J Radiat Oncol Biol Phys 2002; 53:407-21. PubMed
  • Chakravarti A, Noll E, Black PM, Finkelstein DF, Finkelstein DM, Dyson NJ, Loeffler JS. Quantitatively determined survivin expression levels are of prognostic value in human gliomas. J Clin Oncol 2002; 20:1063-8. PubMed
  • Chakravarti A, Loeffler JS, Dyson NJ. Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling. Cancer Res 2002; 62:200-7. PubMed
  • Chon BH, Loeffler JS. The effect of nonmalignant systemic disease on tolerance to radiation therapy. Oncologist 2002; 7:136-43. PubMed
  • Chakravarti A, Delaney MA, Noll E, Black PM, Loeffler JS, Muzikansky A, Dyson NJ. Prognostic and pathologic significance of quantitative protein expression profiling in human gliomas. Clin Cancer Res 2001; 7:2387-95. PubMed
  • Hodgson DC, Goumnerova LC, Loeffler JS, Dutton S, Black PM, Alexander E, Xu R, Kooy H, Silver B, Tarbell NJ. Radiosurgery in the management of pediatric brain tumors. Int J Radiat Oncol Biol Phys 2001; 50:929-35. PubMed
  • Pai HH, Thornton A, Katznelson L, Finkelstein DM, Adams JA, Fullerton BC, Loeffler JS, Leibsch NJ, Klibanski A, Munzenrider JE. Hypothalamic/pituitary function following high-dose conformal radiotherapy to the base of skull: demonstration of a dose-effect relationship using dose-volume histogram analysis. Int J Radiat Oncol Biol Phys 2001; 49:1079-92. PubMed
  • Chan AW, Loeffler JS. Controversies in the management of patients with brain metastases. Cancer J 2001; 7:105-7. PubMed
  • Inskip PD, Tarone RE, Hatch EE, Wilcosky TC, Shapiro WR, Selker RG, Fine HA, Black PM, Loeffler JS, Linet MS. Cellular-telephone use and brain tumors. N Engl J Med 2001; 344:79-86. PubMed
  • Black PM, Villavicencio AT, Rhouddou C, Loeffler JS. Aggressive surgery and focal radiation in the management of meningiomas of the skull base: preservation of function with maintenance of local control. Acta Neurochir (Wien) 2001; 143:555-62. PubMed
  • Hartford AC, Loeffler JS. Radiosurgery for benign tumors and arteriovenous malformations of the central nervous system. Front Radiat Ther Oncol 2001; 35:30-47. PubMed
  • Nguyen P, Chakravarti A, Batchelor T, Hochberg F, Loeffler J. Results of Whole-Brain Radiation as Salvage of Methotrexate Failure in Patients with Primary Central Nervous System Lymphoma. J Am Diet Assoc 2006.
  • Wen PY, Loeffler JS. Management of brain metastases. Oncology (Huntingt) 1999; 13:941-54, 957-61; discussio. PubMed
  • Shulman LN, Buswell L, Riese N, Doherty N, Loeffler JS, von Roemeling RW, Coleman CN. Phase I trial of the hypoxic cell cytotoxin tirapazamine with concurrent radiation therapy in the treatment of refractory solid tumors. Int J Radiat Oncol Biol Phys 2000; 44:349-53. PubMed
  • Mitsumori M, Shrieve DC, Alexander E, Kaiser UB, Richardson GE, Black PM, Loeffler JS. Initial clinical results of LINAC-based stereotactic radiosurgery and stereotactic radiotherapy for pituitary adenomas. Int J Radiat Oncol Biol Phys 1998; 42:573-80. PubMed
  • Cormack RA, Kooy HM, Bellerive MR, Loeffler JS, Petersen RA, Tarbell NJ. A stereotactic radiation therapy device for retinoblastoma using a noncircular collimator and intensity filter. Med Phys 1998; 25:1438-42. PubMed
  • Schwartz RB, Holman BL, Polak JF, Garada BM, Schwartz MS, Folkerth R, Carvalho PA, Loeffler JS, Shrieve DC, Black PM, Alexander E. Dual-isotope single-photon emission computerized tomography scanning in patients with glioblastoma multiforme: association with patient survival and histopathological characteristics of tumor after high-dose radiotherapy. J Neurosurg 1998; 89:60-8. PubMed
  • Hakim R, Alexander E, Loeffler JS, Shrieve DC, Wen P, Fallon MP, Stieg PE, Black PM. Results of linear accelerator-based radiosurgery for intracranial meningiomas. Neurosurgery 1998; 42:446-53; discussion 453-4. PubMed
  • Chang EL, Loeffler JS, Riese NE, Wen PY, Alexander E, Black PM, Coleman CN. Survival results from a phase I study of etanidazole (SR2508) and radiotherapy in patients with malignant glioma. Int J Radiat Oncol Biol Phys 1998; 40:65-70. PubMed
  • Loeffler JS, Smith AR, Suit HD. The potential role of proton beams in radiation oncology. Semin Oncol 1998; 24:686-95. PubMed
  • Schulder M, Black PM, Shrieve DC, Alexander E, Loeffler JS. Permanent low-activity iodine-125 implants for cerebral metastases. J Neurooncol 1997; 33:213-21. PubMed
  • Fine HA, Wen PY, Robertson M, O'Neill A, Kowal J, Loeffler JS, Black PM. A phase I trial of a new recombinant human beta-interferon (BG9015) for the treatment of patients with recurrent gliomas. Clin Cancer Res 1998; 3:381-7. PubMed
  • Hakim R, Loeffler JS, Anthony DC, Black PM. Gangliogliomas in adults. Cancer 1997; 79:127-31. PubMed
  • Bakardjiev AI, Barnes PD, Goumnerova LC, Black PM, Scott RM, Pomeroy SL, Billett A, Loeffler JS, Tarbell NJ. Magnetic resonance imaging changes after stereotactic radiation therapy for childhood low grade astrocytoma. Cancer 1996; 78:864-73. PubMed
  • Varlotto JM, Shrieve DC, Alexander E, Kooy HM, Black PM, Loeffler JS. Fractionated stereotactic radiotherapy for the treatment of acoustic neuromas: preliminary results. Int J Radiat Oncol Biol Phys 1996; 36:141-5. PubMed
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