Photo of Jeffrey A. Gelfand,  MD

Jeffrey A. Gelfand, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-1796
Fax: (617) 726-7416


jgelfand@partners.org

Jeffrey A. Gelfand, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Medicine, Harvard Medical School
  • Physician, Infectious Disease Unit, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

We have developed a novel approach for targeting (tumor) antigens whose sequence may not be known or structure even identified. We have linked scFV's to MycobacteriumTb HeatShockProtein 70, thus developing a novel fusion protein vaccine for presenting antigen to APCs in order to generate both a CD-4 and CD -8 response. The scFV痴 can be selected for their binding to an uncharacterized antigen or to a characterized antigen by binding studies, and the appropriate V-genes can then be selected. The scFV genes are fused to the gene for MTb HSP 70, and the new fusion gene is expressed as the fusion protein in E. coli. We have succeeded in generating a fusion vaccine targeting Folate Receptor-alpha, hyper-expressed in ovarian and many breast tumors.

Publications

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  • Brauns T, Leblanc P, Gelfand JA, Poznanski M. Could mycobacterial Hsp70-containing fusion protein lead the way to an affordable therapeutic cancer vaccine? 2015; 14:435-46. PubMed
  • Chen X, Kim P, Farinelli B, Doukas A, Yun SH, Gelfand JA, Anderson RR, Wu MX. A novel laser vaccine adjuvant increases the motility of antigen presenting cells. PLoS ONE 2010; 5:e13776. PubMed
  • Wysocka M, Newton S, Benoit BM, Introcaso C, Hancock AS, Chehimi J, Richardson SK, Gelfand JM, Montaner LJ, Rook AH. Synthetic imidazoquinolines potently and broadly activate the cellular immune response of patients with cutaneous T-cell lymphoma: synergy with interferon-gamma enhances production of interleukin-12. Clin Lymphoma Myeloma 2007; 7:524-34. PubMed
  • Eichhorn JH, Brauns TA, Gelfand JA, Crothers BA, Wilbur DC. A novel automated screening and interpretation process for cervical cytology using the internet transmission of low-resolution images: a feasibility study. Cancer 2005; 105:199-206. PubMed
  • Ryan CM, Atkins MB, Mier JW, Gelfand JA, Tompkins RG. Effects of malignancy and interleukin-2 infusion on gut macromolecular permeability. Crit Care Med 1995; 23:1801-6. PubMed