My research interests continue to focus on the many facets of CLL. I am Director of the DFCI CLL Center, with focus on clinical and translational investigation. We run clinical trials for all phases of the disease and I have a particular interest in the development of novel therapies that target the recurrent somatic mutations in CLL that we and others have recently described. We are also using genomics to further characterize specific subgroups of CLL and to identify resistance mechanisms. We maintain a well annotated tissue bank of nearly 1000 CLLs which are available for collaborative investigations. Another specific research interest is in the genetics of familial CLL and characterizing the heritability of CLL, and to that end we also have a large tissue bank of families with familial CLL and LPDs.