Photo of Jin-Rong Zhou,  PhD

Jin-Rong Zhou, PhD

Beth Israel Deaconess Medical Center

Beth Israel Deaconess Medical Center
Phone: (617) 667-1280
Fax: (617) 667-1288


jrzhou@bidmc.harvard.edu

Jin-Rong Zhou, PhD

Beth Israel Deaconess Medical Center

EDUCATIONAL TITLES

  • Associate Professor, Surgery, Harvard Medical School
  • Director, Nutrition/Metabolism Laboratory, Beth Israel Deaconess Medical Center

DF/HCC PROGRAM AFFILIATION

Research Abstract

The focus of my research is the study of the role that diet and nutrition may play in the prevention and treatment of certain types of cancer such as breast, prostate, pancreatic and bladder cancers, and to investigate the mechanisms of action of active dietary and nutritional components. My important research strategies include application of an integrated research system to evaluate the efficacies of dietary/nutritional regimens, to elucidate underlying cellular, molecular and epigenetic mechanisms of actions, to identify novel anti-cancer components, and to define risk factors of cancer development and progression for designing effective nutritional regimens for cancer prevention. By using in vitro and clinically relevant animal models, we are identifying effective dietary/nutritional regimens for cancer prevention. We are applying cell function-guided extraction, fractionation and purification strategies to identify active components from Chinese herbal medicines for the prevention and therapy of cancer. In addition, we are investigating the roles that nutritional and natural components may play in targeting cancer stem cells. Our research findings can be directly translated into future clinical investigations.

Publications

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  • Jeong JY, Zhou JR, Gao C, Feldman L, Sytkowski AJ. Human selenium binding protein-1 (hSP56) is a negative regulator of HIF-1留 and suppresses the malignant characteristics of prostate cancer cells. BMB Rep 2014. PubMed
  • Li Y, Gong Y, Li L, Abdolmaleky HM, Zhou JR. Bioactive tanshinone I inhibits the growth of lung cancer in part via downregulation of Aurora A function. Mol Carcinog 2012. PubMed
  • Ni F, Gong Y, Li L, Abdolmaleky HM, Zhou JR. Flavonoid ampelopsin inhibits the growth and metastasis of prostate cancer in vitro and in mice. PLoS ONE 2012; 7:e38802. PubMed
  • Gong Y, Li Y, Abdolmaleky HM, Li L, Zhou JR. Tanshinones inhibit the growth of breast cancer cells through epigenetic modification of Aurora A expression and function. PLoS ONE 2012; 7:e33656. PubMed
  • Zerbini LF, de Vasconcellos JF, Czibere A, Wang Y, Paccez JD, Gu X, Zhou JR, Libermann TA. JunD-mediated repression of GADD45留 and 粒 regulates escape from cell death in prostate cancer. Cell Cycle 2011; 10:2583-91. PubMed
  • Papageorgis P, Cheng K, Ozturk S, Gong Y, Lambert AW, Abdolmaleky HM, Zhou JR, Thiagalingam S. Smad4 inactivation promotes malignancy and drug resistance of colon cancer. Cancer Res 2011; 71:998-1008. PubMed
  • Zerbini LF, Tamura RE, Correa RG, Czibere A, Cordeiro J, Bhasin M, Simabuco FM, Wang Y, Gu X, Li L, Sarkar D, Zhou JR, Fisher PB, Libermann TA. Combinatorial Effect of Non-Steroidal Anti-inflammatory Drugs and NF-虜B Inhibitors in Ovarian Cancer Therapy. PLoS ONE 2011; 6:e24285. PubMed
  • Gong Y, Li Y, Lu Y, Li L, Abdolmaleky H, Blackburn GL, Zhou JR. Bioactive tanshinones in Salvia Miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice. Int J Cancer 2010. PubMed
  • Feng JF,Wu JZ,Hu SN,Gao CM,Shi MQ,Lu ZH,Sun XC,Zhou JR,Chen BA. Polymorphisms of the ribonucleotide reductase M1 gene and sensitivity to platin-based chemotherapy in non-small cell lung cancer. Lung Cancer 2009; 66:344-9. PubMed
  • Hagen SJ,Ohtani M,Zhou JR,Taylor NS,Rickman BH,Blackburn GL,Fox JG. Inflammation and foveolar hyperplasia are reduced by supplemental dietary glutamine during Helicobacter pylori infection in mice. J Nutr 2009; 139:912-8. PubMed
  • Abdolmaleky HM,Zhou JR,Thiagalingam S,Smith CL. Epigenetic and pharmacoepigenomic studies of major psychoses and potentials for therapeutics. Pharmacogenomics 2008; 9:1809-23. PubMed
  • Nasca MM,Zhou JR,Welty FK. Effect of soy nuts on adhesion molecules and markers of inflammation in hypertensive and normotensive postmenopausal women. Am J Cardiol 2008; 102:84-6. PubMed
  • Abdolmaleky HM, Smith CL, Zhou JR, Thiagalingam S. Epigenetic alterations of the dopaminergic system in major psychiatric disorders. Methods Mol Biol 2008; 448:187-212. PubMed
  • Zhou JR, Li L, Pan W. Dietary soy and tea combinations for prevention of breast and prostate cancers by targeting metabolic syndrome elements in mice. Am J Clin Nutr 2008; 86:s882-8. PubMed
  • Zhou JR, Blackburn GL, Walker WA. Symposium introduction: metabolic syndrome and the onset of cancer. Am J Clin Nutr 2008; 86:s817-9. PubMed
  • Mai Z, Blackburn GL, Zhou JR. Genistein sensitizes inhibitory effect of tamoxifen on the growth of estrogen receptor-positive and HER2-overexpressing human breast cancer cells. Mol Carcinog 2007; 46:534-42. PubMed
  • Mai Z, Blackburn GL, Zhou JR. Soy phytochemicals synergistically enhance the preventive effect of tamoxifen on the growth of estrogen-dependent human breast carcinoma in mice. Carcinogenesis 2007; 28:1217-23. PubMed
  • Welty FK, Lee KS, Lew NS, Zhou JR. Effect of soy nuts on blood pressure and lipid levels in hypertensive, prehypertensive, and normotensive postmenopausal women. Arch Intern Med 2007; 167:1060-7. PubMed
  • Welty FK, Lee KS, Lew NS, Nasca M, Zhou JR. The association between soy nut consumption and decreased menopausal symptoms. J Womens Health (Larchmt) 2007; 16:361-9. PubMed
  • Jiang RW, Zhou JR, Hon PM, Li SL, Zhou Y, Li LL, Ye WC, Xu HX, Shaw PC, But PP. Lignans from Dysosma versipellis with inhibitory effects on prostate cancer cell lines. J Nat Prod 2007; 70:283-6. PubMed
  • Zerbini LF, Czibere A, Wang Y, Correa RG, Otu H, Joseph M, Takayasu Y, Silver M, Gu X, Ruchusatsawat K, Li L, Sarkar D, Zhou JR, Fisher PB, Libermann TA. A novel pathway involving melanoma differentiation associated gene-7/interleukin-24 mediates nonsteroidal anti-inflammatory drug-induced apoptosis and growth arrest of cancer cells. Cancer Res 2006; 66:11922-31. PubMed
  • Singh AV, Franke AA, Blackburn GL, Zhou JR. Soy phytochemicals prevent orthotopic growth and metastasis of bladder cancer in mice by alterations of cancer cell proliferation and apoptosis and tumor angiogenesis. Cancer Res 2006; 66:1851-8. PubMed
  • Zhou JR. Soy and the prevention of lifestyle-related diseases. Clin Exp Pharmacol Physiol 2005; 31 Suppl 2:S14-9. PubMed
  • Zerbini LF, Wang Y, Czibere A, Correa RG, Cho JY, Ijiri K, Wei W, Joseph M, Gu X, Grall F, Goldring MB, Zhou JR, Libermann TA. NF-{kappa}B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45{alpha} and {gamma} is essential for cancer cell survival. Proc Natl Acad Sci U S A 2004; 101:13618-13623. PubMed
  • Zhou JR, Yu L, Zerbini LF, Libermann TA, Blackburn GL. Progression to androgen-independent LNCaP human prostate tumors: cellular and molecular alterations. Int J Cancer 2004; 110:800-6. PubMed
  • Zhou JR, Yu L, Mai Z, Blackburn GL. Combined inhibition of estrogen-dependent human breast carcinoma by soy and tea bioactive components in mice. Int J Cancer 2003; 108:8-14. PubMed
  • Yu L, Blackburn GL, Zhou JR. Genistein and daidzein downregulate prostate androgen-regulated transcript-1 (PART-1) gene expression induced by dihydrotestosterone in human prostate LNCaP cancer cells. J Nutr 2003; 133:389-92. PubMed
  • Zhou JR, Yu L, Zhong Y, Blackburn GL. Soy phytochemicals and tea bioactive components synergistically inhibit androgen-sensitive human prostate tumors in mice. J Nutr 2003; 133:516-21. PubMed
  • Zhou JR, Yu L, Zhong Y, Nassr RL, Franke AA, Gaston SM, Blackburn GL. Inhibition of orthotopic growth and metastasis of androgen-sensitive human prostate tumors in mice by bioactive soybean components. Prostate 2002; 53:143-53. PubMed
  • Jones JL, Daley BJ, Enderson BL, Zhou JR, Karlstad MD. Genistein inhibits tamoxifen effects on cell proliferation and cell cycle arrest in T47D breast cancer cells. Am Surg 2002; 68:575-7; discussion 577-8. PubMed
  • Zhou JR, Gugger ET, Tanaka T, Guo Y, Blackburn GL, Clinton SK. Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice. J Nutr 1999; 129:1628-35. PubMed
  • Mukherjee P, Sotnikov AV, Mangian HJ, Zhou JR, Visek WJ, Clinton SK. Energy intake and prostate tumor growth, angiogenesis, and vascular endothelial growth factor expression. J Natl Cancer Inst 1999; 91:512-23. PubMed
  • Zhou JR, Mukherjee P, Gugger ET, Tanaka T, Blackburn GL, Clinton SK. Inhibition of murine bladder tumorigenesis by soy isoflavones via alterations in the cell cycle, apoptosis, and angiogenesis. Cancer Res 1998; 58:5231-8. PubMed
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