Photo of John C. Wain,  MD

John C. Wain, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-5200
Fax: (617) 726-7667


jwain@partners.org

John C. Wain, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Surgery, Harvard Medical School
  • Visiting Surgeon, Surgery, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

I have a background in molecular biology and clinical outcomes research. To date, I have participated in a program project grant on molecular epidemology of carcinogen metabolism that used case control studies of lung cancer patients, and epigenetic analysis of tumor samples, to confirm the role of differences in carcinogen metabolism in susceptibility to lung cancer. Currently, I am pursuing outcome analysis of resected lung cancer patients with varying anatomic sites of lymph node metastasis and further molecular epidemiologic studies of adenocarcinoma of the lung.

Publications

Powered by Harvard Catalyst
  • Tapias LF, Mathisen DJ, Wright CD, Wain JC, Gaissert HA, Muniappan A, Lanuti M, Donahue DM, Morse CR. Outcomes With Open and Minimally Invasive Ivor Lewis Esophagectomy After Neoadjuvant Therapy. Ann Thorac Surg 2015. PubMed
  • Zhou H, Tapias LF, Gaissert HA, Muniappan A, Wright CD, Wain JC, Donahue DM, Morse CR, Mathisen DJ, Lanuti M. Lymph Node Assessment and Impact on Survival in Video-Assisted Thoracoscopic Lobectomy or Segmentectomy. Ann Thorac Surg 2015. PubMed
  • Zhai R, Wei Y, Su L, Liu G, Kulke MH, Wain JC, Christiani DC. Whole-miRNome profiling identifies prognostic serum miRNAs in esophageal adenocarcinoma: the influence of Helicobacter pylori infection status. Carcinogenesis 2015; 36:87-93. PubMed
  • Kinsey CM, Estepar RS, Zhao Y, Yu X, Diao N, Heist RS, Wain JC, Mark EJ, Washko G, Christiani DC. Invasive adenocarcinoma of the lung is associated with the upper lung regions. Lung Cancer 2014; 84:145-50. PubMed
  • Wain JC. Invasive staging and aggressive surgical resection: essential to management of central NSCLC. Oncology (Huntingt) 2014; 28:228, 230. PubMed
  • Zhai R, Yu X, Shafer A, Wain JC, Christiani DC. The impact of coexisting COPD on survival of patients with early-stage non-small cell lung cancer undergoing surgical resection. Chest 2014; 145:346-53. PubMed
  • Tapias LF, Mino-Kenudson M, Lee H, Wright C, Gaissert HA, Wain JC, Mathisen DJ, Lanuti M. Risk factor analysis for the recurrence of resected solitary fibrous tumours of the pleura: a 33-year experience and proposal for a scoring system. 2013. PubMed
  • Tapias LF, Muniappan A, Wright CD, Gaissert HA, Wain JC, Morse CR, Donahue DM, Mathisen DJ, Lanuti M. Short and long-term outcomes after esophagectomy for cancer in elderly patients. Ann Thorac Surg 2013; 95:1741-8. PubMed
  • Muniappan A, Wain JC, Wright CD, Donahue DM, Gaissert H, Lanuti M, Mathisen DJ. Surgical treatment of nonmalignant tracheoesophageal fistula: a thirty-five year experience. Ann Thorac Surg 2013. PubMed
  • Kim JK, Vinarsky V, Wain J, Zhao R, Jung K, Choi J, Lam A, Pardo-Saganta A, Breton S, Rajagopal J, Yun SH. In vivo imaging of tracheal epithelial cells in mice during airway regeneration. Am J Respir Cell Mol Biol 2012. PubMed
  • Zeitels SM, Wain JC, Barbu AM, Bryson PC, Burns JA. Aortic homograft reconstruction of partial laryngectomy defects: a new technique. Ann. Otol. Rhinol. Laryngol. 2012; 121:301-6. PubMed
  • Lanuti M, DeDelva P, Morse CR, Wright CD, Wain JC, Gaissert HA, Donahue DM, Mathisen DJ. Management of delayed gastric emptying after esophagectomy with endoscopic balloon dilatation of the pylorus. Ann Thorac Surg 2011; 91:1019-24. PubMed
  • Sequist LV, Waltman BA, Dias-Santagata D, Digumarthy S, Turke AB, Fidias P, Bergethon K, Shaw AT, Gettinger S, Cosper AK, Akhavanfard S, Heist RS, Temel J, Christensen JG, Wain JC, Lynch TJ, Vernovsky K, Mark EJ, Lanuti M, Iafrate AJ, Mino-Kenudson M, Engelman JA. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med 2011; 3:75ra26. PubMed
  • Lee MS, Su L, Mark EJ, Wain JC, Christiani DC. Genetic Modifiers of Carcinogen DNA Adducts in Target Lung and Peripheral Blood Mononuclear Cells. Carcinogenesis 2010; 31:2091-6. PubMed
  • Liberman M, Wain JC. Balloon-guided, tapered, Polyflex stent guidance: An atraumatic technique for successful stent placement through tight, rigid airway stenoses. J Thorac Cardiovasc Surg 2010; 140:248-9, 249.e1. PubMed
  • Honings J, Gaissert HA, Weinberg AC, Mark EJ, Wright CD, Wain JC, Mathisen DJ. Prognostic value of pathologic characteristics and resection margins in tracheal adenoid cystic carcinoma. 2010; 37:1438-44. PubMed
  • Zhai R, Chen F, Liu G, Su L, Kulke MH, Asomaning K, Lin X, Heist RS, Nishioka NS, Sheu CC, Wain JC, Christiani DC. Interactions among genetic variants in apoptosis pathway genes, reflux symptoms, body mass index, and smoking indicate two distinct etiologic patterns of esophageal adenocarcinoma. J Clin Oncol 2010; 28:2445-51. PubMed
  • Liberman M, Muzikansky A, Wright CD, Wain JC, Donahue DM, Allan JS, Gaissert HA, Morse CR, Mathisen DJ, Lanuti M. Incidence and risk factors of persistent air leak after major pulmonary resection and use of chemical pleurodesis. Ann Thorac Surg 2010; 89:891-7; discussion 897-8. PubMed
  • Merritt RE, Mathisen DJ, Wain JC, Gaissert HA, Donahue D, Lanuti M, Allan JS, Morse CR, Wright CD. Long-term results of sleeve lobectomy in the management of non-small cell lung carcinoma and low-grade neoplasms. Ann Thorac Surg 2009; 88:1574-81; discussion 1581-2. PubMed
  • Honings J, Gaissert HA, Ruangchira-Urai R, Wain JC, Wright CD, Mathisen DJ, Mark EJ. Pathologic characteristics of resected squamous cell carcinoma of the trachea: prognostic factors based on an analysis of 59 cases. Virchows Arch 2010; 455:423-9. PubMed
  • Bradbury PA, Kulke MH, Heist RS, Zhou W, Ma C, Xu W, Marshall AL, Zhai R, Hooshmand SM, Asomaning K, Su L, Shepherd FA, Lynch TJ, Wain JC, Christiani DC, Liu G. Cisplatin pharmacogenetics, DNA repair polymorphisms, and esophageal cancer outcomes. Pharmacogenet Genomics 2009; 19:613-25. PubMed
  • Gaissert HA, Keum DY, Wright CD, Ancukiewicz M, Monroe E, Donahue DM, Wain JC, Lanuti M, Allan JS, Choi NC, Mathisen DJ. POINT: Operative risk of pneumonectomy--influence of preoperative induction therapy. J Thorac Cardiovasc Surg 2009; 138:289-94. PubMed
  • Lanuti M, De Delva PE, Gaissert HA, Wright CD, Wain JC, Allan JS, Donahue DM, Mathisen DJ. Review of superior vena cava resection in the management of benign disease and pulmonary or mediastinal malignancies. Ann Thorac Surg 2009; 88:392-7. PubMed
  • Bradbury PA, Zhai R, Ma C, Xu W, Hopkins J, Kulke MJ, Asomaning K, Wang Z, Su L, Heist RS, Lynch TJ, Wain JC, Christiani D, Liu G. Vascular endothelial growth factor polymorphisms and esophageal cancer prognosis. Clin Cancer Res 2009; 15:4680-5. PubMed
  • Cescon DW,Bradbury PA,Asomaning K,Hopkins J,Zhai R,Zhou W,Wang Z,Kulke M,Su L,Ma C,Xu W,Marshall AL,Heist RS,Wain JC,Lynch TJ Jr,Christiani DC,Liu G. p53 Arg72Pro and MDM2 T309G polymorphisms, histology, and esophageal cancer prognosis. Clin Cancer Res 2009; 15:3103-9. PubMed
  • Orezzoli JP,Wain JC,Fuller AF Jr. Surgical management of the subdiaphragmatic mass: a sequential combined approach with laparoscopy followed by posterior thoracotomy. Int J Gynecol Cancer 2009; 19:294-9. PubMed
  • Wain JC. Postintubation tracheal stenosis. Semin Thorac Cardiovasc Surg 2009; 21:284-9. PubMed
  • Lanuti M,Sharma A,Digumarthy SR,Wright CD,Donahue DM,Wain JC,Mathisen DJ,Shepard JA. Radiofrequency ablation for treatment of medically inoperable stage I non-small cell lung cancer. J Thorac Cardiovasc Surg 2009; 137:160-6. PubMed
  • Meltzer AJ,Weiss MJ,Veillette GR,Sahara H,Ng CY,Cochrane ME,Houser SL,Sachs DH,Rosengard BR,Madsen JC,Wain JC,Allan JS. Repetitive gastric aspiration leads to augmented indirect allorecognition after lung transplantation in miniature swine. Transplantation 2008; 86:1824-9. PubMed
  • Tse D,Zhai R,Zhou W,Heist RS,Asomaning K,Su L,Lynch TJ,Wain JC,Christiani DC,Liu G. Polymorphisms of the NER pathway genes, ERCC1 and XPD are associated with esophageal adenocarcinoma risk. Cancer Causes Control 2008; 19:1077-83. PubMed
  • Zhai R,Liu G,Asomaning K,Su L,Kulke MH,Heist RS,Nishioka NS,Lynch TJ,Wain JC,Lin X,Christiani DC. Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk. Carcinogenesis 2008; 29:2330-4. PubMed
  • Heist RS,Zhou W,Wang Z,Liu G,Neuberg D,Su L,Asomaning K,Hollis BW,Lynch TJ,Wain JC,Giovannucci E,Christiani DC. Circulating 25-hydroxyvitamin D, VDR polymorphisms, and survival in advanced non-small-cell lung cancer. J Clin Oncol 2008; 26:5596-602. PubMed
  • Ter-Minassian M,Zhai R,Asomaning K,Su L,Zhou W,Liu G,Heist RS,Lynch TJ,Wain JC,Lin X,De Vivo I,Christiani DC. Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer. Carcinogenesis 2008; 29:2147-52. PubMed
  • de Delva PE,Morse CR,Austen WG Jr,Gaissert HA,Lanuti M,Wain JC,Wright CD,Mathisen DJ. Surgical management of failed colon interposition. Eur J Cardiothorac Surg 2008; 34:432-7; discussion 437. PubMed
  • Asomaning K, Miller DP, Liu G, Wain JC, Lynch TJ, Su L, Christiani DC. Second hand smoke, age of exposure and lung cancer risk. Lung Cancer 2008; 61:13-20. PubMed
  • Shen KR,Wain JC,Wright CD,Grillo HC,Mathisen DJ. Postpneumonectomy syndrome: surgical management and long-term results. J Thorac Cardiovasc Surg 2008; 135:1210-6; discussion 1216-9. PubMed
  • Ison MG, Sharma A, Shepard JA, Wain JC, Ginns LC. Outcome of influenza infection managed with oseltamivir in lung transplant recipients. J Heart Lung Transplant 2008; 27:282-8. PubMed
  • Heist RS, Zhai R, Liu G, Zhou W, Lin X, Su L, Asomaning K, Lynch TJ, Wain JC, Christiani DC. VEGF polymorphisms and survival in early-stage non-small-cell lung cancer. J Clin Oncol 2008; 26:856-62. PubMed
  • Liu G, Wheatley-Price P, Zhou W, Park S, Heist RS, Asomaning K, Wain JC, Lynch TJ, Su L, Christiani DC. Genetic polymorphisms of MDM2, cumulative cigarette smoking and nonsmall cell lung cancer risk. Int J Cancer 2007; 122:915-8. PubMed
  • Wright CD, Choi NC, Wain JC, Mathisen DJ, Lynch TJ, Fidias P. Induction chemoradiotherapy followed by resection for locally advanced Masaoka stage III and IVA thymic tumors. Ann Thorac Surg 2008; 85:385-9. PubMed
  • Zhai R, Liu G, Zhou W, Su L, Heist RS, Lynch TJ, Wain JC, Asomaning K, Lin X, Christiani DC. Vascular endothelial growth factor genotypes, haplotypes, gender, and the risk of non-small cell lung cancer. Clin Cancer Res 2008; 14:612-7. PubMed
  • Bradbury PA, Heist RS, Kulke MH, Zhou W, Marshall AL, Miller DP, Su L, Park S, Temel J, Fidias P, Sequist L, Lynch TJ, Wain JC, Shepherd FA, Christiani DC, Liu G. A rapid outcomes ascertainment system improves the quality of prognostic and pharmacogenetic outcomes from observational studies. Cancer Epidemiol Biomarkers Prev 2008; 17:204-11. PubMed
  • Shoji T, Sahara H, Muniappan A, Guenther DA, Wain JC, Houser SL, Bravard MA, Pujara AC, Hasse RS, Sachs DH, Madsen JC, Allan JS. Operational Tolerance to Class I Disparate Lungs Can Be Induced Despite Pretransplant Immunization With Class I Allopeptides. Transplantation 2007; 84:1467-1473. PubMed
  • Liu G, Zhou W, Yeap BY, Su L, Wain JC, Poneros JM, Nishioka NS, Lynch TJ, Christiani DC. XRCC1 and XPD Polymorphisms and Esophageal Adenocarcinoma Risk. Carcinogenesis 2007; 28:1254-8. PubMed
  • Heist RS, Zhou W, Chirieac LR, Cogan-Drew T, Liu G, Su L, Neuberg D, Lynch TJ, Wain JC, Christiani DC. MDM2 polymorphism, survival, and histology in early-stage non-small-cell lung cancer. J Clin Oncol 2007; 25:2243-7. PubMed
  • Gaissert HA, Honings J, Grillo HC, Donahue DM, Wain JC, Wright CD, Mathisen DJ. Segmental laryngotracheal and tracheal resection for invasive thyroid carcinoma. Ann Thorac Surg 2007; 83:1952-9. PubMed
  • Zhou W, Heist RS, Liu G, Asomaning K, Neuberg DS, Hollis BW, Wain JC, Lynch TJ, Giovannucci E, Su L, Christiani DC. Circulating 25-hydroxyvitamin D levels predict survival in early-stage non-small-cell lung cancer patients. J Clin Oncol 2007; 25:479-85. PubMed
  • Lanuti M, de Delva PE, Wright CD, Gaissert HA, Wain JC, Donahue DM, Allan JS, Mathisen DJ. Post-esophagectomy gastric outlet obstruction: role of pyloromyotomy and management with endoscopic pyloric dilatation. Eur J Cardiothorac Surg 2006; 31:149-53. PubMed
  • Zhou W, Heist RS, Liu G, Asomaning K, Miller DP, Neuberg DS, Wain JC, Lynch TJ, Christiani DC. Second hand smoke exposure and survival in early-stage non-small-cell lung cancer patients. Clin Cancer Res 2006; 12:7187-93. PubMed
  • Lanuti M, de Delva PE, Maher A, Wright CD, Gaissert HA, Wain JC, Donahue DM, Mathisen DJ. Feasibility and outcomes of an early extubation policy after esophagectomy. Ann Thorac Surg 2006; 82:2037-41. PubMed
  • Zhou W, Heist RS, Liu G, Neuberg DS, Asomaning K, Su L, Wain JC, Lynch TJ, Giovannucci E, Christiani DC. Polymorphisms of vitamin d receptor and survival in early-stage non-small cell lung cancer patients. Cancer Epidemiol Biomarkers Prev 2006; 15:2239-45. PubMed
  • Miller DP, Asomaning K, Liu G, Wain JC, Lynch TJ, Neuberg D, Su L, Christiani DC. An association between glutathione S-transferase P1 gene polymorphism and younger age at onset of lung carcinoma. Cancer 2006; 107:1570-7. PubMed
  • Heist RS, Marshall AL, Liu G, Zhou W, Su L, Neuberg D, Lynch TJ, Wain J, Christiani DC. Matrix metalloproteinase polymorphisms and survival in stage I non-small cell lung cancer. Clin Cancer Res 2006; 12:5448-53. PubMed
  • Zhou W, Heist RS, Liu G, Park S, Neuberg DS, Asomaning K, Wain JC, Lynch TJ, Christiani DC. Smoking cessation before diagnosis and survival in early stage non-small cell lung cancer patients. Lung Cancer 2006; 53:375-80. PubMed
  • Cho MH, Malhotra A, Donahue DM, Wain JC, Harris RS, Karmpaliotis D, Patel SR. Mechanical ventilation and air leaks after lung biopsy for acute respiratory distress syndrome. Ann Thorac Surg 2006; 82:261-6. PubMed
  • Gaissert HA, Grillo HC, Shadmehr MB, Wright CD, Gokhale M, Wain JC, Mathisen DJ. Uncommon primary tracheal tumors. Ann Thorac Surg 2006; 82:268-72; discussion 272-3. PubMed
  • Bendell JC, Lauwers GY, Willett C, Clark JW, Warshaw AL, Wain JC, Ryan DP. Pancreatoblastoma in a teenage patient. Clin Adv Hematol Oncol 2006; 4:150-3; discussion 154. PubMed
  • Choi NC, Fischman AJ, Niemierko A, Ryu JS, Lynch T, Wain J, Wright C, Fidias P, Mathisen D. Dose-response relationship between probability of pathologic tumor control and glucose metabolic rate measured with FDG PET after preoperative chemoradiotherapy in locally advanced non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 2002; 54:1024-35. PubMed
  • Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science 2002; 296:1883-6. PubMed
  • Wright CD, Menard MT, Wain JC, Donahue DM, Grillo HC, Lynch TJ, Choi NC, Mathisen DJ. Induction chemoradiation compared with induction radiation for lung cancer involving the superior sulcus. Ann Thorac Surg 2002; 73:1541-4. PubMed
Hide