Photo of John G. Flanagan,  PhD

John G. Flanagan, PhD

Harvard Medical School

Harvard Medical School
Phone: (617) 432-4096
Fax: (617) 432-1144


flanagan@hms.harvard.edu

John G. Flanagan, PhD

Harvard Medical School

EDUCATIONAL TITLES

  • Professor, Cell Biology, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Research Abstract

We are interested in the basic biology of cell-cell signaling mechanisms, particularly in the context of cell and axon migration. Derangements of these mechanisms in general, including the specific molecules we study, play crucial roles in metastasis and other aspects of cancer.

Publications

Powered by Harvard Catalyst
  • Preitner N, Quan J, Nowakowski DW, Hancock ML, Shi J, Tcherkezian J, Young-Pearse TL, Flanagan JG. APC is an RNA-binding protein, and its interactome provides a link to neural development and microtubule assembly. Cell 2014; 158:368-82. PubMed
  • Hancock ML, Preitner N, Quan J, Flanagan JG. MicroRNA-132 is enriched in developing axons, locally regulates Rasa1 mRNA, and promotes axon extension. J Neurosci 2014; 34:66-78. PubMed
  • Preitner N, Quan J, Flanagan JG. This message will self-destruct: NMD regulates axon guidance. Cell 2013; 153:1185-7. PubMed
  • Preitner N, Flanagan JG. Axonal mRNA translation: an unexpected link to axon survival and the mitochondrion. Neuron 2012; 73:629-31. PubMed
  • Hancock ML, Nowakowski DW, Role LW, Talmage DA, Flanagan JG. Type III neuregulin 1 regulates pathfinding of sensory axons in the developing spinal cord and periphery. Development 2011; 138:4887-98. PubMed
  • Coles CH, Shen Y, Tenney AP, Siebold C, Sutton GC, Lu W, Gallagher JT, Jones EY, Flanagan JG, Aricescu AR. Proteoglycan-Specific Molecular Switch for RPTP{sigma} Clustering and Neuronal Extension. Science 2011. PubMed
  • Tcherkezian J, Brittis PA, Thomas F, Roux PP, Flanagan JG. Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Cell 2010; 141:632-44. PubMed
  • Shen Y, Tenney AP, Busch SA, Horn KP, Cuascut FX, Liu K, He Z, Silver J, Flanagan JG. PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration. Science 2009; 326:592-6. PubMed
  • Chen Y, Mohammadi M, Flanagan JG. Graded levels of FGF protein span the midbrain and can instruct graded induction and repression of neural mapping labels. Neuron 2009; 62:773-80. PubMed
  • Baba A,Akagi K,Takayanagi M,Flanagan JG,Kobayashi T,Hattori M. Fyn tyrosine kinase regulates the surface expression of glycosylphosphatidylinositol-linked ephrin via the modulation of sphingomyelin metabolism. J Biol Chem 2009; 284:9206-14. PubMed
  • Qiu R,Wang X,Davy A,Wu C,Murai K,Zhang H,Flanagan JG,Soriano P,Lu Q. Regulation of neural progenitor cell state by ephrin-B. J Cell Biol 2008; 181:973-83. PubMed
  • Osterfield M, Egelund R, Young LM, Flanagan JG. Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system. Development 2008; 135:1189-99. PubMed
  • Chen Y, Flanagan JG. Follow your nose: axon pathfinding in olfactory map formation. Cell 2006; 127:881-4. PubMed
  • Johnson KG, Tenney AP, Ghose A, Duckworth AM, Higashi ME, Parfitt K, Marcu O, Heslip TR, Marsh JL, Schwarz TL, Flanagan JG, Van Vactor D. The HSPGs Syndecan and Dallylike bind the receptor phosphatase LAR and exert distinct effects on synaptic development. Neuron 2006; 49:517-31. PubMed
  • Flanagan JG. Neural map specification by gradients. Curr Opin Neurobiol 2006; 16:59-66. PubMed
Hide