Photo of John V. Frangioni,  MD, PhD

John V. Frangioni, MD, PhD

Beth Israel Deaconess Medical Center

Beth Israel Deaconess Medical Center
Phone: (617) 667-0692
Fax: (617) 667-0981


jfrangio@bidmc.harvard.edu

John V. Frangioni, MD, PhD

Beth Israel Deaconess Medical Center

EDUCATIONAL TITLES

  • Professor, Medicine, Harvard Medical School
  • Professor, Radiology, Harvard Medical School
  • Attending Physician, Hematology/Oncology, Beth Israel Deaconess Medical Center

DF/HCC PROGRAM AFFILIATION

Research Abstract

My primary research focus is in vivo cancer detection. My laboratory is organized into three sections: 1) low-molecular weight ligand discovery, 2) contrast agent development and 3) imaging technology development. Working together, these sections form an integrated and organized effort to identify a clinical problem that can be solved by imaging, then to solve the problem by developing the appropriate contrast agents and detection technology. The long-term goal of this research is to detect the smallest possible number of malignant cells to guide cancer diagnosis, prognosis and therapy.

Publications

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  • Boonstra MC, van Driel PB, van Willigen DM, Stammes MA, Prevoo HA, Tummers QR, Mazar AP, Beekman FJ, Kuppen PJ, van de Velde CJ, Löwik CW, Frangioni JV, van Leeuwen FW, Sier CF, Vahrmeijer AL. uPAR-targeted multimodal tracer for pre- and intraoperative imaging in cancer surgery. 2015; 6:14260-73. PubMed
  • Wada H, Hyun H, Vargas C, Genega EM, Gravier J, Gioux S, Frangioni JV, Choi HS. Sentinel Lymph Node Mapping of Liver. Ann Surg Oncol 2015. PubMed
  • Handgraaf HJ, Boogerd LS, Verbeek FP, Tummers QR, Hardwick JC, Baeten CI, Frangioni JV, van de Velde CJ, Vahrmeijer AL. Intraoperative fluorescence imaging to localize tumors and sentinel lymph nodes in rectal cancer. Minim Invasive Ther Allied Technol 2015. PubMed
  • Tummers QR, Schepers A, Hamming JF, Kievit J, Frangioni JV, van de Velde CJ, Vahrmeijer AL. Intraoperative guidance in parathyroid surgery using near-infrared fluorescence imaging and low-dose Methylene Blue. Surgery 2015. PubMed
  • Boonstra MC, Tolner B, Schaafsma BE, Boogerd LS, Prevoo HA, Bhavsar G, Kuppen PJ, Sier CF, Bonsing BA, Frangioni JV, van de Velde CJ, Chester KA, Vahrmeijer AL. Preclinical evaluation of a novel CEA-targeting near-infrared fluorescent tracer delineating colorectal and pancreatic tumors. Int J Cancer 2015. PubMed
  • Verbeek FP, Tummers QR, Rietbergen DD, Peters AA, Schaafsma BE, van de Velde CJ, Frangioni JV, van Leeuwen FW, Gaarenstroom KN, Vahrmeijer AL. Sentinel Lymph Node Biopsy in Vulvar Cancer Using Combined Radioactive and Fluorescence Guidance. Int J Gynecol Cancer 2015. PubMed
  • Gibbs SL, Genega E, Salemi J, Kianzad V, Goodwill HL, Xie Y, Oketokoun R, Khurd P, Kamen A, Frangioni JV. Near-infrared fluorescent digital pathology for the automation of disease diagnosis and biomarker assessment. 2015; 14:1-9. PubMed
  • Hyun H, Park MH, Owens EA, Wada H, Henary M, Handgraaf HJ, Vahrmeijer AL, Frangioni JV, Choi HS. Structure-inherent targeting of near-infrared fluorophores for parathyroid and thyroid gland imaging. Nat Med 2015; 21:192-7. PubMed
  • Tummers QR, Boonstra MC, Frangioni JV, van de Velde CJ, Vahrmeijer AL, Bonsing BA. Intraoperative near-infrared fluorescence imaging of a paraganglioma using methylene blue: A case report. Int J Surg Case Rep 2015; 6C:150-3. PubMed
  • Wada H, Hyun H, Vargas C, Gravier J, Park G, Gioux S, Frangioni JV, Henary M, Choi HS. Pancreas-targeted NIR fluorophores for dual-channel image-guided abdominal surgery. Theranostics 2015; 5:1-11. PubMed
  • Tummers QR, Hoogstins CE, Peters AA, de Kroon CD, Trimbos JB, van de Velde CJ, Frangioni JV, Vahrmeijer AL, Gaarenstroom KN. The Value of Intraoperative Near-Infrared Fluorescence Imaging Based on Enhanced Permeability and Retention of Indocyanine Green: Feasibility and False-Positives in Ovarian Cancer. PLoS ONE 2015; 10:e0129766. PubMed
  • Inoue K, Gibbs SL, Liu F, Lee JH, Xie Y, Ashitate Y, Fujii H, Frangioni JV, Choi HS. Microscopic Validation of Macroscopic In Vivo Images Enabled by Same-Slide Optical and Nuclear Fusion. J Nucl Med 2014. PubMed
  • Hyun H, Wada H, Bao K, Gravier J, Yadav Y, Laramie M, Henary M, Frangioni JV, Choi HS. Phosphonated near-infrared fluorophores for biomedical imaging of bone. Angew Chem Int Ed Engl 2014; 53:10668-72. PubMed
  • Tummers QR, Verbeek FP, Prevoo HA, Braat AE, Baeten CI, Frangioni JV, van de Velde CJ, Vahrmeijer AL. First Experience on Laparoscopic Near-Infrared Fluorescence Imaging of Hepatic Uveal Melanoma Metastases Using Indocyanine Green. Surg Innov 2014. PubMed
  • Verbeek FP, van der Vorst JR, Tummers QR, Boonstra MC, de Rooij KE, Löwik CW, Valentijn AR, van de Velde CJ, Choi HS, Frangioni JV, Vahrmeijer AL. Near-Infrared Fluorescence Imaging of Both Colorectal Cancer and Ureters Using a Low-Dose Integrin Targeted Probe. Ann Surg Oncol 2014. PubMed
  • Ashitate Y, Hyun H, Kim SH, Lee JH, Henary M, Frangioni JV, Choi HS. Simultaneous mapping of pan and sentinel lymph nodes for real-time image-guided surgery. Theranostics 2014; 4:693-700. PubMed
  • Park MH, Hyun H, Ashitate Y, Wada H, Park G, Lee JH, Njiojob C, Henary M, Frangioni JV, Choi HS. Prototype nerve-specific near-infrared fluorophores. Theranostics 2014; 4:823-33. PubMed
  • Verbeek FP, Troyan SL, Mieog JS, Liefers GJ, Moffitt LA, Rosenberg M, Hirshfield-Bartek J, Gioux S, van de Velde CJ, Vahrmeijer AL, Frangioni JV. Near-infrared fluorescence sentinel lymph node mapping in breast cancer: a multicenter experience. Breast Cancer Res Treat 2014; 143:333-42. PubMed
  • van der Vorst JR, Schaafsma BE, Hutteman M, Verbeek FP, Liefers GJ, Hartgrink HH, Smit VT, Löwik CW, van de Velde CJ, Frangioni JV, Vahrmeijer AL. Near-infrared fluorescence-guided resection of colorectal liver metastases. Cancer 2013; 119:3411-8. PubMed
  • Gilmore DM, Khullar OV, Jaklitsch MT, Chirieac LR, Frangioni JV, Colson YL. Identification of metastatic nodal disease in a phase 1 dose-escalation trial of intraoperative sentinel lymph node mapping in non-small cell lung cancer using near-infrared imaging. J Thorac Cardiovasc Surg 2013; 146:562-70; discussion 569-70. PubMed
  • van der Vorst JR, Schaafsma BE, Verbeek FP, Swijnenburg RJ, Tummers QR, Hutteman M, Hamming JF, Kievit J, Frangioni JV, van de Velde CJ, Vahrmeijer AL. Intraoperative near-infrared fluorescence imaging of parathyroid adenomas with use of low-dose methylene blue. Head Neck 2013. PubMed
  • Schaafsma B, Verbeek F, Peters A, van der Vorst J, de Kroon C, van Poelgeest M, Trimbos J, van de Velde C, Frangioni J, Vahrmeijer A, Gaarenstroom K. Near-infrared fluorescence sentinel lymph node biopsy in vulvar cancer: a randomised comparison of lymphatic tracers. BJOG 2013; 120:758-764. PubMed
  • Verbeek FP, van der Vorst JR, Schaafsma BE, Swijnenburg RJ, Gaarenstroom KN, Elzevier HW, van de Velde CJ, Frangioni JV, Vahrmeijer AL. Intraoperative Near-Infrared Fluorescence-Guided Identification of the Ureters using Low-Dose Methylene Blue: A First-in-Human Experience. J Urol 2013. PubMed
  • Gilmore DM, Khullar OV, Gioux S, Stockdale A, Frangioni JV, Colson YL, Russell SE. Effective Low-dose Escalation of Indocyanine Green for Near-infrared Fluorescent Sentinel Lymph Node Mapping in Melanoma. Ann Surg Oncol 2013. PubMed
  • Schaafsma BE, Verbeek FP, van der Vorst JR, Hutteman M, Kuppen PJ, Frangioni JV, van de Velde CJ, Vahrmeijer AL. Ex vivo sentinel node mapping in colon cancer combining blue dye staining and fluorescence imaging. J Surg Res 2013. PubMed
  • Choi HS, Gibbs SL, Lee JH, Kim SH, Ashitate Y, Liu F, Hyun H, Park G, Xie Y, Bae S, Henary M, Frangioni JV. Targeted zwitterionic near-infrared fluorophores for improved optical imaging. Nat Biotechnol 2013; 31:148-53. PubMed
  • Nguyen JT, Ashitate Y, Buchanan IA, Ibrahim AM, Gioux S, Patel PP, Frangioni JV, Lee BT. Bone flap perfusion assessment using near-infrared fluorescence imaging. J Surg Res 2012; 178:e43-50. PubMed
  • Frangioni JV. Nonprofit foundations for open-source biomedical technology development. Nat Biotechnol 2012; 30:928-32. PubMed
  • Schaafsma BE, van der Vorst JR, Gaarenstroom KN, Peters AA, Verbeek FP, de Kroon CD, Trimbos JB, van Poelgeest MI, Frangioni JV, van de Velde CJ, Vahrmeijer AL. Randomized comparison of near-infrared fluorescence lymphatic tracers for sentinel lymph node mapping of cervical cancer. Gynecol Oncol 2012; 127:126-30. PubMed
  • van der Vorst JR, Schaafsma BE, Verbeek FP, Keereweer S, Jansen JC, van der Velden LA, Langeveld AP, Hutteman M, Löwik CW, van de Velde CJ, Frangioni JV, Vahrmeijer AL. Near-infrared fluorescence sentinel lymph node mapping of the oral cavity in head and neck cancer patients. Oral Oncol 2012. PubMed
  • van der Vorst JR, Vahrmeijer AL, Hutteman M, Bosse T, Smit VT, van de Velde CJ, Frangioni JV, Bonsing BA. Near-infrared fluorescence imaging of a solitary fibrous tumor of the pancreas using methylene blue. World J Gastrointest Surg 2012; 4:180-4. PubMed
  • van der Vorst JR, Schaafsma BE, Verbeek FP, Hutteman M, Mieog JS, Lowik CW, Liefers GJ, Frangioni JV, van de Velde CJ, Vahrmeijer AL. Randomized Comparison of Near-infrared Fluorescence Imaging Using Indocyanine Green and 99(m) Technetium With or Without Patent Blue for the Sentinel Lymph Node Procedure in Breast Cancer Patients. Ann Surg Oncol 2012. PubMed
  • Bhatia S, Frangioni JV, Hoffman RM, Iafrate AJ, Polyak K. The challenges posed by cancer heterogeneity. Nat Biotechnol 2012; 30:604-10. PubMed
  • Ashitate Y, Kim SH, Tanaka E, Henary M, Choi HS, Frangioni JV, Flaumenhaft R. Two-wavelength near-infrared fluorescence for the quantitation of drug antiplatelet effects in large animal model systems. J. Vasc. Surg. 2012; 56:171-80. PubMed
  • Orcutt KD, Rhoden JJ, Ruiz-Yi B, Frangioni JV, Wittrup KD. Effect of small-molecule-binding affinity on tumor uptake in vivo: a systematic study using a pretargeted bispecific antibody. Mol Cancer Ther 2012; 11:1365-72. PubMed
  • Liu F, Lunsford EP, Tong J, Ashitate Y, Gibbs SL, Yu J, Choi HS, Henske EP, Frangioni JV. Real-time monitoring of tumorigenesis, dissemination, & drug response in a preclinical model of lymphangioleiomyomatosis/tuberous sclerosis complex. PLoS ONE 2012; 7:e38589. PubMed
  • Hutteman M, Choi HS, Mieog JS, van der Vorst JR, Ashitate Y, Kuppen PJ, van Groningen MC, Löwik CW, Smit VT, van de Velde CJ, Frangioni JV, Vahrmeijer AL. Clinical translation of ex vivo sentinel lymph node mapping for colorectal cancer using invisible near-infrared fluorescence light. Ann Surg Oncol 2011; 18:1006-14. PubMed
  • Frangioni JV. The myth of multimodality diagnostic agents. Mol Imaging 2011; 10:79-80. PubMed
  • Hutteman M, Mieog JS, van der Vorst JR, Liefers GJ, Putter H, Löwik CW, Frangioni JV, van de Velde CJ, Vahrmeijer AL. Randomized, double-blind comparison of indocyanine green with or without albumin premixing for near-infrared fluorescence imaging of sentinel lymph nodes in breast cancer patients. Breast Cancer Res Treat 2011. PubMed
  • Mieog JS, Troyan SL, Hutteman M, Donohoe KJ, van der Vorst JR, Stockdale A, Liefers GJ, Choi HS, Gibbs-Strauss SL, Putter H, Gioux S, Kuppen PJ, Ashitate Y, Löwik CW, Smit VT, Oketokoun R, Ngo LH, van de Velde CJ, Frangioni JV, Vahrmeijer AL. Toward Optimization of Imaging System and Lymphatic Tracer for Near-Infrared Fluorescent Sentinel Lymph Node Mapping in Breast Cancer. Ann Surg Oncol 2011. PubMed
  • van der Vorst JR, Hutteman M, Mieog JS, de Rooij KE, Kaijzel EL, Löwik CW, Putter H, Kuppen PJ, Frangioni JV, van de Velde CJ, Vahrmeijer AL. Near-Infrared Fluorescence Imaging of Liver Metastases in Rats using Indocyanine Green. J Surg Res 2011. PubMed
  • Orcutt KD, Slusarczyk AL, Cieslewicz M, Ruiz-Yi B, Bhushan KR, Frangioni JV, Wittrup KD. Engineering an antibody with picomolar affinity to DOTA chelates of multiple radionuclides for pretargeted radioimmunotherapy and imaging. Nucl Med Biol 2011; 38:223-33. PubMed
  • Choi HS, Ashitate Y, Lee JH, Kim SH, Matsui A, Insin N, Bawendi MG, Semmler-Behnke M, Frangioni JV, Tsuda A. Rapid translocation of nanoparticles from the lung airspaces to the body. Nat Biotechnol 2010; 28:1300-3. PubMed
  • Choi HS, Frangioni JV. Nanoparticles for biomedical imaging: fundamentals of clinical translation. Mol Imaging 2010; 9:291-310. PubMed
  • Lee BT, Hutteman M, Gioux S, Stockdale A, Lin SJ, Ngo LH, Frangioni JV. The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in perforator flap breast reconstruction. Plast Reconstr Surg 2010; 126:1472-81. PubMed
  • Matsui A, Lee BT, Winer JH, Laurence RG, Frangioni JV. Predictive capability of near-infrared fluorescence angiography in submental perforator flap survival. Plast Reconstr Surg 2010; 126:1518-27. PubMed
  • Gioux S, Choi HS, Frangioni JV. Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation. Mol Imaging 2010; 9:237-55. PubMed
  • Zubris KA, Khullar OV, Griset AP, Gibbs-Strauss S, Frangioni JV, Colson YL, Grinstaff MW. Ease of synthesis, controllable sizes, and in vivo large-animal-lymph migration of polymeric nanoparticles. ChemMedChem 2010; 5:1435-8. PubMed
  • Liu F, Misra P, Lunsford EP, Vannah JT, Liu Y, Lenkinski RE, Frangioni JV. A dose- and time-controllable syngeneic animal model of breast cancer microcalcification. Breast Cancer Res Treat 2010; 122:87-94. PubMed
  • Matsui A, Tanaka E, Choi HS, Kianzad V, Gioux S, Lomnes SJ, Frangioni JV. Real-time, near-infrared, fluorescence-guided identification of the ureters using methylene blue. Surgery 2010; 148:78-86. PubMed
  • Orcutt KD, Nasr KA, Whitehead DG, Frangioni JV, Wittrup KD. Biodistribution and Clearance of Small Molecule Hapten Chelates for Pretargeted Radioimmunotherapy. Mol Imaging Biol 2010. PubMed
  • Schulz MD, Khullar O, Frangioni JV, Grinstaff MW, Colson YL. Nanotechnology in thoracic surgery. Ann Thorac Surg 2010; 89:S2188-90. PubMed
  • Winer JH, Choi HS, Gibbs-Strauss SL, Ashitate Y, Colson YL, Frangioni JV. Intraoperative localization of insulinoma and normal pancreas using invisible near-infrared fluorescent light. Ann Surg Oncol 2010; 17:1094-100. PubMed
  • Orcutt KD, Ackerman ME, Cieslewicz M, Quiroz E, Slusarczyk AL, Frangioni JV, Wittrup KD. A modular IgG-scFv bispecific antibody topology. Protein Eng. Des. Sel. 2010; 23:221-8. PubMed
  • Kesavan K, Ratliff J, Johnson EW, Dahlberg W, Asara JM, Misra P, Frangioni JV, Jacoby DB. Annexin A2 is a molecular target for TM601, a peptide with tumor-targeting and anti-angiogenic effects. J Biol Chem 2010; 285:4366-74. PubMed
  • Lee BT, Matsui A, Hutteman M, Lin SJ, Winer JH, Laurence RG, Frangioni JV. Intraoperative near-infrared fluorescence imaging in perforator flap reconstruction: current research and early clinical experience. J Reconstr Microsurg 2010; 26:59-65. PubMed
  • Choi HS, Liu W, Liu F, Nasr K, Misra P, Bawendi MG, Frangioni JV. Design considerations for tumour-targeted nanoparticles. Nat Nanotechnol 2009; 5:42-7. PubMed
  • Frangioni JV. The problem is background, not signal. Mol Imaging 2009; 8:303-4. PubMed
  • Matsui A, Lee BT, Winer JH, Laurence RG, Frangioni JV. Submental perforator flap design with a near-infrared fluorescence imaging system: the relationship among number of perforators, flap perfusion, and venous drainage. Plast Reconstr Surg 2009; 124:1098-104. PubMed
  • Troyan SL, Kianzad V, Gibbs-Strauss SL, Gioux S, Matsui A, Oketokoun R, Ngo L, Khamene A, Azar F, Frangioni JV. The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in breast cancer sentinel lymph node mapping. Ann Surg Oncol 2009; 16:2943-52. PubMed
  • Matsui A, Lee BT, Winer JH, Kianzad V, Frangioni JV. Image-guided perforator flap design using invisible near-infrared light and validation with x-ray angiography. Ann Plast Surg 2009; 63:327-30. PubMed
  • Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP, Spiegelman BM. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature 2009; 460:1154-8. PubMed
  • Matsui A, Lee BT, Winer JH, Laurence RG, Frangioni JV. Quantitative assessment of perfusion and vascular compromise in perforator flaps using a near-infrared fluorescence-guided imaging system. Plast Reconstr Surg 2009; 124:451-60. PubMed
  • Tanaka E, Chen FY, Flaumenhaft R, Graham GJ, Laurence RG, Frangioni JV. Real-time assessment of cardiac perfusion, coronary angiography, and acute intravascular thrombi using dual-channel near-infrared fluorescence imaging. J Thorac Cardiovasc Surg 2009; 138:133-40. PubMed
  • Choi HS,Ipe BI,Misra P,Lee JH,Bawendi MG,Frangioni JV. Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots. Nano Lett 2009; 9:2354-9. PubMed
  • Ciocan R,Lenkinski RE,Bernstein J,Bancu M,Marquis R,Ivanishev A,Kourtelidis F,Matsui A,Borenstein J,Frangioni JV. MRI contrast using solid-state, B1-distorting, microelectromechanical systems (MEMS) microresonant devices (MRDs). Magn Reson Med 2009; 61:860-6. PubMed
  • Matsui A,Lee BT,Winer JH,Vooght CS,Laurence RG,Frangioni JV. Real-time intraoperative near-infrared fluorescence angiography for perforator identification and flap design. Plast Reconstr Surg 2009; 123:125e-7e. PubMed
  • Matsui A,Lomnes SJ,Frangioni JV. Optical clearing of the skin for near-infrared fluorescence image-guided surgery. J Biomed Opt 2009; 14:024019. PubMed
  • Humblet V,Misra P,Bhushan KR,Nasr K,Ko YS,Tsukamoto T,Pannier N,Frangioni JV,Maison W. Multivalent scaffolds for affinity maturation of small molecule cell surface binders and their application to prostate tumor targeting. J Med Chem 2008; 52:544-50. PubMed
  • Pannier N,Humblet V,Misra P,Frangioni JV,Maison W. Multivalent peptidomimetics for tumor targeting. Adv Exp Med Biol 2009; 611:403-4. PubMed
  • Bhushan KR,Misra P,Liu F,Mathur S,Lenkinski RE,Frangioni JV. Detection of breast cancer microcalcifications using a dual-modality SPECT/NIR fluorescent probe. J Am Chem Soc 2008; 130:17648-9. PubMed
  • Lenkinski RE,Bloch BN,Liu F,Frangioni JV,Perner S,Rubin MA,Genega EM,Rofsky NM,Gaston SM. An illustration of the potential for mapping MRI/MRS parameters with genetic over-expression profiles in human prostate cancer. MAGMA 2008; 21:411-21. PubMed
  • Frangioni JV. New technologies for human cancer imaging. J Clin Oncol 2008; 26:4012-21. PubMed
  • Yuan TL,Choi HS,Matsui A,Benes C,Lifshits E,Luo J,Frangioni JV,Cantley LC. Class 1A PI3K regulates vessel integrity during development and tumorigenesis. Proc Natl Acad Sci U S A 2008; 105:9739-44. PubMed
  • Frangioni JV. The impact of greed on academic medicine and patient care. Nat Biotechnol 2008; 26:503-7. PubMed
  • Knapp DW, Adams LG, Degrand AM, Niles JD, Ramos-Vara JA, Weil AB, O'Donnell MA, Lucroy MD, Frangioni JV. Sentinel lymph node mapping of invasive urinary bladder cancer in animal models using invisible light. Eur Urol 2007; 52:1700-8. PubMed
  • Misra P, Humblet V, Pannier N, Maison W, Frangioni JV. Production of multimeric prostate-specific membrane antigen small-molecule radiotracers using a solid-phase 99mTc preloading strategy. J Nucl Med 2007; 48:1379-89. PubMed
  • Parungo CP, Soybel DI, Colson YL, Kim SW, Ohnishi S, DeGrand AM, Laurence RG, Soltesz EG, Chen FY, Cohn LH, Bawendi MG, Frangioni JV. Lymphatic drainage of the peritoneal space: a pattern dependent on bowel lymphatics. Ann Surg Oncol 2006; 14:286-98. PubMed
  • Humblet V, Misra P, Frangioni JV. An HPLC/mass spectrometry platform for the development of multimodality contrast agents and targeted therapeutics: prostate-specific membrane antigen small molecule derivatives. Contrast Media Mol Imaging 2006; 1:196-211. PubMed
  • Humblet V, Lapidus R, Williams LR, Tsukamoto T, Rojas C, Majer P, Hin B, Ohnishi S, De Grand AM, Zaheer A, Renze JT, Nakayama A, Slusher BS, Frangioni JV. High-affinity near-infrared fluorescent small-molecule contrast agents for in vivo imaging of prostate-specific membrane antigen. Mol Imaging 2005; 4:448-62. PubMed
  • Parungo CP, Colson YL, Kim SW, Kim S, Cohn LH, Bawendi MG, Frangioni JV. Sentinel lymph node mapping of the pleural space. Chest 2005; 127:1799-804. PubMed
  • Parungo CP, Ohnishi S, Kim SW, Kim S, Laurence RG, Soltesz EG, Chen FY, Colson YL, Cohn LH, Bawendi MG, Frangioni JV. Intraoperative identification of esophageal sentinel lymph nodes with near-infrared fluorescence imaging. J Thorac Cardiovasc Surg 2005; 129:844-50. PubMed
  • Romeo G, Frangioni JV, Kazlauskas A. Profilin acts downstream of LDL to mediate diabetic endothelial cell dysfunction. FASEB J 2004; 18:725-7. PubMed
  • Cowley SM, Kang RS, Frangioni JV, Yada JJ, DeGrand AM, Radhakrishnan I, Eisenman RN. Functional Analysis of the Mad1-mSin3A Repressor-Corepressor Interaction Reveals Determinants of Specificity, Affinity, and Transcriptional Response. Mol Cell Biol 2004; 24:2698-2709. PubMed
  • Kim S, Lim YT, Soltesz EG, De Grand AM, Lee J, Nakayama A, Parker JA, Mihaljevic T, Laurence RG, Dor DM, Cohn LH, Bawendi MG, Frangioni JV. Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat Biotechnol 2003; 22:93-7. PubMed
  • Alves FC, Donato P, Sherry AD, Zaheer A, Zhang S, Lubag AJ, Merritt ME, Lenkinski RE, Frangioni JV, Neves M, Prata MI, Santos AC, de Lima JJ, Geraldes CF. Silencing of phosphonate-gadolinium magnetic resonance imaging contrast by hydroxyapatite binding. Invest Radiol 2003; 38:750-60. PubMed
  • De Grand AM, Frangioni JV. An operational near-infrared fluorescence imaging system prototype for large animal surgery. Technol Cancer Res Treat 2003; 2:553-62. PubMed
  • Maison W, Frangioni JV. Improved chemical strategies for the targeted therapy of cancer. Angew Chem Int Ed Engl 2003; 42:4726-8. PubMed
  • Lenkinski RE, Ahmed M, Zaheer A, Frangioni JV, Goldberg SN. Near-infrared fluorescence imaging of microcalcification in an animal model of breast cancer. Acad Radiol 2003; 10:1159-64. PubMed
  • Frangioni JV. In vivo near-infrared fluorescence imaging. Curr Opin Chem Biol 2003; 7:626-34. PubMed
  • Lim YT, Kim S, Nakayama A, Stott NE, Bawendi MG, Frangioni JV. Selection of quantum dot wavelengths for biomedical assays and imaging. Mol Imaging 2003; 2:50-64. PubMed
  • Nakayama A, Bianco AC, Zhang CY, Lowell BB, Frangioni JV. Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging. Mol Imaging 2003; 2:37-49. PubMed
  • English JR, Accorsi R, Idoine JD, Parker JA, Renze JT, Lanza RC, Frangioni JV. Sub-millimeter technetium-99m calibration sources. Mol Imaging Biol 2003; 4:380-4. PubMed
  • Zaheer A, Wheat TE, Frangioni JV. IRDye78 conjugates for near-infrared fluorescence imaging. Mol Imaging 2003; 1:354-64. PubMed
  • Nakayama A, del Monte F, Hajjar RJ, Frangioni JV. Functional near-infrared fluorescence imaging for cardiac surgery and targeted gene therapy. Mol Imaging 2003; 1:365-77. PubMed
  • Voss SD, DeGrand AM, Romeo GR, Cantley LC, Frangioni JV. An integrated vector system for cellular studies of phage display-derived peptides. Anal Biochem 2002; 308:364-72. PubMed
  • Brunet A, Kanai F, Stehn J, Xu J, Sarbassova D, Frangioni JV, Dalal SN, DeCaprio JA, Greenberg ME, Yaffe MB. 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J Cell Biol 2002; 156:817-28. PubMed
  • Zaheer A, Lenkinski RE, Mahmood A, Jones AG, Cantley LC, Frangioni JV. In vivo near-infrared fluorescence imaging of osteoblastic activity. Nat Biotechnol 2001; 19:1148-54. PubMed
  • Frangioni JV, LaRiccia LM, Cantley LC, Montminy MR. Minimal activators that bind to the KIX domain of p300/CBP identified by phage display screening. Nat Biotechnol 2000; 18:1080-5. PubMed
  • Ashitate Y, Vooght CS, Hutteman M, Oketokoun R, Choi HS, Frangioni JV. Simultaneous assessment of luminal integrity and vascular perfusion of the gastrointestinal tract using dual-channel near-infrared fluorescence. 2012; 11:301-8. PubMed
  • Mazhar A, Dell S, Cuccia DJ, Gioux S, Durkin AJ, Frangioni JV, Tromberg BJ. Wavelength optimization for rapid chromophore mapping using spatial frequency domain imaging. J Biomed Opt 2011; 15:061716. PubMed
  • Mazhar A, Cuccia DJ, Gioux S, Durkin AJ, Frangioni JV, Tromberg BJ. Structured illumination enhances resolution and contrast in thick tissue fluorescence imaging. J Biomed Opt 2010; 15:010506. PubMed
  • Hyun H, Bordo MW, Nasr K, Feith D, Lee JH, Kim SH, Ashitate Y, Moffitt LA, Rosenberg M, Henary M, Choi HS, Frangioni JV. cGMP-Compatible preparative scale synthesis of near-infrared fluorophores. Contrast Media Mol Imaging 2012; 7:516-24. PubMed
  • Gioux S, Ashitate Y, Hutteman M, Frangioni JV. Motion-gated acquisition for in vivo optical imaging. J Biomed Opt 2010; 14:064038. PubMed
  • Hausdorff SF, Frangioni JV, Birnbaum MJ. Role of p21ras in insulin-stimulated glucose transport in 3T3-L1 adipocytes. J Biol Chem 1994; 269:21391-4. PubMed
  • Frangioni JV, Moghal N, Stuart-Tilley A, Neel BG, Alper SL. The DNA binding domain of retinoic acid receptor beta is required for ligand-dependent suppression of proliferation. Application of general purpose mammalian coexpression vectors. J Cell Sci 1994; 107 ( Pt 4):827-38. PubMed
  • Frangioni JV, Oda A, Smith M, Salzman EW, Neel BG. Calpain-catalyzed cleavage and subcellular relocation of protein phosphotyrosine phosphatase 1B (PTP-1B) in human platelets. EMBO J 1993; 12:4843-56. PubMed
  • Frangioni JV, Neel BG. Use of a general purpose mammalian expression vector for studying intracellular protein targeting: identification of critical residues in the nuclear lamin A/C nuclear localization signal. J Cell Sci 1993; 105 ( Pt 2):481-8. PubMed
  • Frangioni JV, Neel BG. Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins. Anal Biochem 1993; 210:179-87. PubMed
  • Frangioni JV, Beahm PH, Shifrin V, Jost CA, Neel BG. The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence. Cell 1992; 68:545-60. PubMed
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