There are five areas of research focus in our laboratory. First is identification of novel therapeutic targets amongst the tyrosine kinase family of proteins. These efforts focus on sarcomas, mesothelioma, and other solid tumors. Second is discovery of oncogenic mechanisms and therapeutic targets in leiomyosarcoma, gastrointestinal stromal tumor, and mesothelioma. Third is use of molecular cytogenetic methods to identify novel oncogenes in solid tumors. Fourth is development of novel approaches to administering targeted therapies in cancer. Fifth is characterization of response and resistance mechanisms to targeted therapies in cancer.