Jonathan L. Hecht, MD, PhD

Beth Israel Deaconess Medical Center

Beth Israel Deaconess Medical Center
Phone: (617) 667-4344


jlhecht@bidmc.harvard.edu

Jonathan L. Hecht, MD, PhD

Beth Israel Deaconess Medical Center

EDUCATIONAL TITLES

  • Associate Professor, Pathology, Harvard Medical School
  • Associate Professor, Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School
  • Associate Professor, Pathology, Beth Israel Deaconess Medical Center

DF/HCC PROGRAM AFFILIATION

Research Abstract

I am the pathologist for the ovarian cancer section of the "Nurses' Health Study," an epidemiology based investigation of risk factors for disease in women sponsored by NIH. In that capacity, I have helped to collect tissue and evaluate the histology of several hundred cases of ovarian cancer. We are studying genetic polymorphisms, patterns of gene promoter methylation, and protein expression to correlate molecular markers in tumors to dietary and environmental cancer risk factors. I have evaluated the relevance of specific morphometric (histologic) criterion for pre-cancerous lesions of the endometrium called "endometrial intraepithelial neoplasia" (EIN). We have correlated our subjective diagnoses with mutations in the PTEN gene and risk of subsequent evolution to invasive cancer.

Publications

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  • Johnson MB, Wang PP, Atabay KD, Murphy EA, Doan RN, Hecht JL, Walsh CA. Single-cell analysis reveals transcriptional heterogeneity of neural progenitors in human cortex. Nat Neurosci 2015. PubMed
  • Hecht JL, Konstantinopoulos PA, Awtrey CS, Soslow RA. Immunohistochemical Loss of BRCA1 Protein in Uterine Serous Carcinoma. Int J Gynecol Pathol 2014; 33:282-7. PubMed
  • Fadare O, Desouki MM, Gwin K, Hanley KZ, Jarboe EA, Liang SX, Quick CM, Zheng W, Parkash V, Hecht JL. Frequent expression of napsin A in clear cell carcinoma of the endometrium: potential diagnostic utility. Am J Surg Pathol 2014; 38:189-96. PubMed
  • Hu J, Lu J, Lian G, Zhang J, Hecht JL, Sheen VL. Filamin B regulates chondrocyte proliferation and differentiation through Cdk1 signaling. PLoS ONE 2014; 9:e89352. PubMed
  • Fadare O, Parkash V, Gwin K, Hanley KZ, Jarboe EA, Liang SX, Quick CM, Zheng W, Rawish KR, Hecht JL, Desouki MM. Utility of 留-methylacyl-coenzyme-A racemase (p504s) immunohistochemistry in distinguishing endometrial clear cell carcinomas from serous and endometrioid carcinomas. Hum Pathol 2013; 44:2814-21. PubMed
  • Schmolze D, Awtrey CS, Hecht JL. Value of additional level sections in the evaluation of lymph nodes for endometrial carcinoma staging. Am J Clin Pathol 2013; 140:516-8. PubMed
  • Howitt BE, Herfs M, Brister K, Oliva E, Longtine J, Hecht JL, Nucci MR. Intestinal-type Endocervical Adenocarcinoma In Situ: An Immunophenotypically Distinct Subset of AIS Affecting Older Women. Am J Surg Pathol 2013; 37:625-33. PubMed
  • Fadare O, Gwin K, Desouki MM, Crispens MA, Jones HW, Khabele D, Liang SX, Zheng W, Mohammed K, Hecht JL, Parkash V. The clinicopathologic significance of p53 and BAF-250a (ARID1A) expression in clear cell carcinoma of the endometrium. Mod Pathol 2013. PubMed
  • Fadare O, Liang SX, Crispens MA, Jones HW, Khabele D, Gwin K, Zheng W, Mohammed K, Parkash V, Hecht JL, Desouki MM. Expression of the oncofetal protein IGF2BP3 in endometrial clear cell carcinoma: assessment of frequency and significance. Hum Pathol 2013. PubMed
  • Kotsopoulos J, Terry KL, Poole EM, Rosner B, Murphy MA, Hecht JL, Crum CP, Missmer SA, Cramer DW, Tworoger SS. Ovarian cancer risk factors by tumor dominance, a surrogate for cell of origin. Int J Cancer 2013. PubMed
  • Fadare O, Zheng W, Crispens MA, Jones HW, Khabele D, Gwin K, Liang SX, Mohammed K, Desouki MM, Parkash V, Hecht JL. Morphologic and other clinicopathologic features of endometrial clear cell carcinoma: a comprehensive analysis of 50 rigorously classified cases. Am J Cancer Res 2013; 3:70-95. PubMed
  • Fadare O, Parkash V, Dupont WD, Acs G, Atkins KA, Irving JA, Pirog EC, Quade BJ, Quddus MR, Rabban JT, Vang R, Hecht JL. The diagnosis of endometrial carcinomas with clear cells by gynecologic pathologists: an assessment of interobserver variability and associated morphologic features. Am J Surg Pathol 2012; 36:1107-18. PubMed
  • Hecht JL. To count and how to count, that is the question. Am J Clin Pathol 2011; 135:480. PubMed
  • Levine D, Brown DL, Andreotti RF, Benacerraf B, Benson CB, Brewster WR, Coleman B, Depriest P, Doubilet PM, Goldstein SR, Hamper UM, Hecht JL, Horrow M, Hur HC, Marnach M, Patel MD, Platt LD, Puscheck E, Smith-Bindman R. Management of Asymptomatic Ovarian and Other Adnexal Cysts Imaged at US: Society of Radiologists in Ultrasound Consensus Conference Statement. Radiology 2010; 256:943-54. PubMed
  • Levine D, Brown DL, Andreotti RF, Benacerraf B, Benson CB, Brewster WR, Coleman B, DePriest P, Doubilet PM, Goldstein SR, Hamper UM, Hecht JL, Horrow M, Hur HC, Marnach M, Patel MD, Platt LD, Puscheck E, Smith-Bindman R. Management of asymptomatic ovarian and other adnexal cysts imaged at US: Society of Radiologists in Ultrasound consensus conference statement. Ultrasound Q 2010; 26:121-31. PubMed
  • Kotsopoulos J, Hecht JL, Marotti JD, Kelemen LE, Tworoger SS. Relationship between dietary and supplemental intake of folate, methionine, vitamin B6 and folate receptor alpha expression in ovarian tumors. Int J Cancer 2010; 126:2191-8. PubMed
  • Gates MA, Rosner BA, Hecht JL, Tworoger SS. Risk factors for epithelial ovarian cancer by histologic subtype. Am J Epidemiol 2009; 171:45-53. PubMed
  • Asch E,Levine D,Pedrosa I,Hecht JL,Kruskal J. Patterns of Misinterpretation of Adnexal Masses on CT and MR in an Academic Radiology Department(1). Acad Radiol 2009; 16:969-80. PubMed
  • McElrath TF, Hecht JL. Invited commentary: Intrauterine epidemiology. Am J Epidemiol 2009; 170:159-61; discussion 162-3. PubMed
  • Hecht JL,Kotsopoulos J,Hankinson SE,Tworoger SS. Relationship between epidemiologic risk factors and hormone receptor expression in ovarian cancer: results from the Nurses' Health Study. Cancer Epidemiol Biomarkers Prev 2009; 18:1624-30. PubMed
  • Hecht JL, Dolinski BM, Gardner HA, Violette SM, Weinreb PH. Overexpression of the alphavbeta6 integrin in endometrial cancer. Appl Immunohistochem Mol Morphol 2008; 16:543-7. PubMed
  • Hecht JL, Kotsopoulos J, Gates MA, Hankinson SE, Tworoger SS. Validation of tissue microarray technology in ovarian cancer: results from the Nurses' Health Study. Cancer Epidemiol Biomarkers Prev 2008; 17:3043-50. PubMed
  • McElrath TF, Hecht JL, Dammann O, Boggess K, Onderdonk A, Markenson G, Harper M, Delpapa E, Allred EN, Leviton A,. Pregnancy disorders that lead to delivery before the 28th week of gestation: an epidemiologic approach to classification. Am J Epidemiol 2008; 168:980-9. PubMed
  • Fadare O, Orejudos MP, Jain R, Mariappan MR, Hecht JL, Renshaw IL, Hileeto D, Wang SA, Ghofrani M, Liang SX. A comparative analysis of lymphatic vessel density in ovarian serous tumors of low malignant potential (borderline tumors) with and without lymph node involvement. Int J Gynecol Pathol 2008; 27:483-90. PubMed
  • Onderdonk AB, Hecht JL, McElrath TF, Delaney ML, Allred EN, Leviton A,. Colonization of second-trimester placenta parenchyma. Am J Obstet Gynecol 2008; 199:52.e1-52.e10. PubMed
  • Hecht JL, Allred EN, Kliman HJ, Zambrano E, Doss BJ, Husain A, Pflueger SM, Chang CH, Livasy CA, Roberts D, Bhan I, Ross DW, Senagore PK, Leviton A,. Histological characteristics of singleton placentas delivered before the 28th week of gestation. Pathology 2008; 40:372-6. PubMed
  • Levine D, Asch E, Mehta TS, Broder J, O'Donnell C, Hecht JL. Assessment of factors that affect the quality of performance and interpretation of sonography of adnexal masses. J Ultrasound Med 2008; 27:721-8. PubMed
  • Tworoger SS, Gertig DM, Gates MA, Hecht JL, Hankinson SE. Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancer. Cancer 2008; 112:1169-77. PubMed
  • Asch E, Levine D, Kim Y, Hecht JL. Histologic, surgical, and imaging correlations of adnexal masses. J Ultrasound Med 2008; 27:327-42. PubMed
  • Hecht JL, Onderdonk A, Delaney M, Allred EN, Kliman HJ, Zambrano E, Pflueger SM, Livasy CA, Bhan I, Leviton A,. Characterization of chorioamnionitis in 2nd-trimester C-section placentas and correlation with microorganism recovery from subamniotic tissues. Pediatr Dev Pathol 2008; 11:15-22. PubMed
  • Gates MA, Tworoger SS, Hecht JL, De Vivo I, Rosner B, Hankinson SE. A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer. Int J Cancer 2007; 121:2225-32. PubMed
  • Hecht JL, Kliman HJ, Allred EN, Pflueger SM, Chang CH, Doss BJ, Roberts D, Livasy CA, Bhan I, Zambrano E, Ross DW, Senagore P, Husain AN, Leviton A. Reference weights for placentas delivered before the 28th week of gestation. Placenta 2007; 28:987-90. PubMed
  • Danforth KN, Tworoger SS, Hecht JL, Rosner BA, Colditz GA, Hankinson SE. Breastfeeding and risk of ovarian cancer in two prospective cohorts. Cancer Causes Control 2007; 18:517-523. PubMed
  • Gilmore H, Fleischhacker D, Hecht JL. Diagnosis of chronic endometritis in biopsies with stromal breakdown. Hum Pathol 2006; 38:581-4. PubMed
  • Danforth KN, Tworoger SS, Hecht JL, Rosner BA, Colditz GA, Hankinson SE. A prospective study of postmenopausal hormone use and ovarian cancer risk. Br J Cancer 2006; 96:151-6. PubMed
  • Galan M, Kim YB, Hecht JL. Does physiologic breakdown mask significant pathology in endometrial biopsies? A retrospective case-control study. Arch Pathol Lab Med 2006; 130:1847-9. PubMed
  • Hecht JL, Mutter GL. Molecular and pathologic aspects of endometrial carcinogenesis. J Clin Oncol 2006; 24:4783-91. PubMed
  • Tworoger SS, Hecht JL, Giovannucci E, Hankinson SE. Intake of folate and related nutrients in relation to risk of epithelial ovarian cancer. Am J Epidemiol 2006; 163:1101-11. PubMed
  • Hecht JL, Pinkus JL, Pinkus GS. Monoclonal antibody MOC-31 reactivity as a marker for adenocarcinoma in cytologic preparations. Cancer 2005; 108:56-9. PubMed
  • Drapkin R, von Horsten HH, Lin Y, Mok SC, Crum CP, Welch WR, Hecht JL. Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas. Cancer Res 2005; 65:2162-9. PubMed
  • Hecht JL, Ince TA, Baak JP, Baker HE, Ogden MW, Mutter GL. Prediction of endometrial carcinoma by subjective endometrial intraepithelial neoplasia diagnosis. Mod Pathol 2004; 18:324-30. PubMed
  • Witkiewicz AK, Hecht JL, Cviko A, McKeon FD, Ince TA, Crum CP. Microglandular hyperplasia: a model for the de novo emergence and evolution of endocervical reserve cells. Hum Pathol 2005; 36:154-61. PubMed
  • Drapkin R, Crum CP, Hecht JL. Expression of candidate tumor markers in ovarian carcinoma and benign ovary: evidence for a link between epithelial phenotype and neoplasia. Hum Pathol 2004; 35:1014-21. PubMed
  • Nascimento AF, Granter SR, Cviko A, Yuan L, Hecht JL, Crum CP. Vulvar acanthosis with altered differentiation: a precursor to verrucous carcinoma? Am J Surg Pathol 2004; 28:638-43. PubMed
  • Hecht JL, Pinkus JL, Pinkus GS. Enhanced detection of atypical hyperplasia in endometrial polyps by PTEN expression. Appl Immunohistochem Mol Morphol 2004; 12:36-9. PubMed
  • Qian X, Hecht JL. Pancreatic fine needle aspiration. A comparison of computed tomographic and endoscopic ultrasonographic guidance. Acta Cytol 2003; 47:723-6. PubMed
  • Hecht JL, Cibas ES, Kutok JL. Fine-needle aspiration cytology of lymphoproliferative disorders in the immunosuppressed patient: the diagnostic utility of in situ hybridization for Epstein-Barr virus. Diagn Cytopathol 2002; 26:360-5. PubMed
  • Lee BH, Hecht JL, Pinkus JL, Pinkus GS. WT1, estrogen receptor, and progesterone receptor as markers for breast or ovarian primary sites in metastatic adenocarcinoma to body fluids. Am J Clin Pathol 2002; 117:745-50. PubMed
  • Hecht JL, Lee BH, Pinkus JL, Pinkus GS. The value of Wilms tumor susceptibility gene 1 in cytologic preparations as a marker for malignant mesothelioma. Cancer 2002; 96:105-9. PubMed
  • Hecht JL, Sheets EE, Lee KR. Atypical glandular cells of undetermined significance in conventional cervical/vaginal smears and thin-layer preparations. Cancer 2002; 96:1-4. PubMed
  • Domchek SM, Hecht JL, Fleming MD, Pinkus GS, Canellos GP. Lymphomas of the breast: primary and secondary involvement. Cancer 2002; 94:6-13. PubMed
  • Hecht JL, Pinkus JL, Weinstein LJ, Pinkus GS. The value of thyroid transcription factor-1 in cytologic preparations as a marker for metastatic adenocarcinoma of lung origin. Am J Clin Pathol 2001; 116:483-8. PubMed
  • Thorner AR, Travis AC, Hecht JL, Conrow DS, Fisher DC. Unusual presentations of malignancy. Case 3. Mantle-cell lymphoma of soft tissue. J Clin Oncol 2001; 19:3291-3. PubMed
  • Hecht JL, Aster JC. Molecular biology of Burkitt's lymphoma. J Clin Oncol 2000; 18:3707-21. PubMed
  • Velasquez MM, Hecht J, Quinn VP, Emmons KM, DiClemente CC, Dolan-Mullen P. Application of motivational interviewing to prenatal smoking cessation: training and implementation issues. Tob Control 2000; 9 Suppl 3:III36-40. PubMed
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