Jonathan S. Duke-Cohan, Ph.D.

Dana-Farber Cancer Institute

Dana-Farber Cancer Institute
Phone: (617) 632-3816
Fax: (617) 632-3160


Jonathan_Duke-Cohan@dfci.harvard.edu

Jonathan S. Duke-Cohan, Ph.D.

Dana-Farber Cancer Institute

EDUCATIONAL TITLES

  • Principal Associate in Medicine, Medicine, Harvard Medical School
  • Principal Associate in Medicine, Hematologic Neoplasia/Medical Oncology, Dana-Farber Cancer Institute

DF/HCC PROGRAM AFFILIATION

Research Abstract

Our research focuses on two areas. First, defining the immune response at the molecular, biochemical and cellular level in response to orthopox vaccination. Identification of the temporal processing of vaccinia proteins, immunogenic peptides, specific antibody responses detected using protein arrays and analysis of the kinetics of the host immune response transcriptome will all provide critical handles for design of efficient vaccines, maximizing the potential host immune response. Second, we are actively involved in defining the molecular events mediated by the plexin/semaphorin axis in thymocyte maturation, with particular focus upon plexin/sema regulation of chemokine-directed thymocyte migration.

Publications

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  • Mallis RJ, Bai K, Arthanari H, Hussey RE, Handley M, Li Z, Chingozha L, Duke-Cohan JS, Lu H, Wang JH, Zhu C, Wagner G, Reinherz EL. Pre-TCR ligand binding impacts thymocyte development before αβTCR expression. Proc Natl Acad Sci U S A 2015; 112:8373-8. PubMed
  • Xiao Y, Yu S, Zhu B, Bedoret D, Bu X, Francisco LM, Hua P, Duke-Cohan JS, Umetsu DT, Sharpe AH, DeKruyff RH, Freeman GJ. RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance. J Exp Med 2014. PubMed
  • Choi YI, Duke-Cohan JS, Chen W, Liu B, Rossy J, Tabarin T, Ju L, Gui J, Gaus K, Zhu C, Reinherz EL. Dynamic control of β1 integrin adhesion by the plexinD1-sema3E axis. Proc Natl Acad Sci U S A 2014; 111:379-84. PubMed
  • Naito M, Hainz U, Burkhardt UE, Fu B, Ahove D, Stevenson KE, Rajasagi M, Zhu B, Alonso A, Witten E, Matsuoka K, Neuberg D, Duke-Cohan JS, Wu CJ, Freeman GJ. CD40L-Tri, a novel formulation of recombinant human CD40L that effectively activates B cells. Cancer Immunol Immunother 2013. PubMed
  • Choi YI, Duke-Cohan JS, Tan J, Gui J, Singh MK, Epstein JA, Reinherz EL. Plxnd1 expression in thymocytes regulates their intrathymic migration while that in thymic endothelium impacts medullary topology. 2013; 4:392. PubMed
  • Marina O, Duke-Cohan JS, Wu CJ. A coprecipitation-based validation methodology for interactions identified using protein microarrays. Methods Mol Biol 2011; 723:239-54. PubMed
  • Marina O, Hainz U, Biernacki MA, Zhang W, Cai A, Duke-Cohan JS, Liu F, Brusic V, Neuberg D, Kutok JL, Alyea EP, Canning CM, Soiffer RJ, Ritz J, Wu CJ. Serologic markers of effective tumor immunity against chronic lymphocytic leukemia include nonmutated B-cell antigens. Cancer Res 2010; 70:1344-55. PubMed
  • Rabinovsky R, Pochanard P, McNear C, Brachmann SM, Duke-Cohan JS, Garraway LA, Sellers WR. p85 Associates with unphosphorylated PTEN and the PTEN-associated complex. Mol Cell Biol 2009; 29:5377-88. PubMed
  • Krishnaswamy S, Kanteti R, Duke-Cohan JS, Loganathan S, Liu W, Ma PC, Sattler M, Singleton PA, Ramnath N, Innocenti F, Nicolae DL, Ouyang Z, Liang J, Minna J, Kozloff MF, Ferguson MK, Natarajan V, Wang YC, Garcia JG, Vokes EE, Salgia R. Ethnic differences and functional analysis of MET mutations in lung cancer. Clin Cancer Res 2009; 15:5714-23. PubMed
  • Grandpre LE,Duke-Cohan JS,Ewald BA,Devoy C,Barouch DH,Letvin NL,Reinherz EL,Baden LR,Dolin R,Seaman MS. Immunogenicity of recombinant Modified Vaccinia Ankara following a single or multi-dose vaccine regimen in rhesus monkeys. Vaccine 2009; 27:1549-56. PubMed
  • Duke-Cohan JS,Wollenick K,Witten EA,Seaman MS,Baden LR,Dolin R,Reinherz EL. The heterogeneity of human antibody responses to vaccinia virus revealed through use of focused protein arrays. Vaccine 2009; 27:1154-65. PubMed
  • Choi YI,Duke-Cohan JS,Ahmed WB,Handley MA,Mann F,Epstein JA,Clayton LK,Reinherz EL. PlexinD1 glycoprotein controls migration of positively selected thymocytes into the medulla. Immunity 2008; 29:888-98. PubMed
  • Azouz A, Gunn TM, Duke-Cohan JS. Juvenile-onset loss of lipid-raft domains in attractin-deficient mice. Exp Cell Res 2007; 313:761-71. PubMed
  • Romero V, Larsen CE, Duke-Cohan JS, Fox EA, Romero T, Clavijo OP, Fici DA, Husain Z, Almeciga I, Alford DR, Awdeh ZL, Zuñiga J, El-Dahdah L, Alper CA, Yunis EJ. Genetic fixity in the human major histocompatibility complex and block size diversity in the class I region including HLA-E. BMC Genet 2007; 8:14. PubMed
  • Khwaja FW, Duke-Cohan JS, Brat DJ, Van Meir EG. Attractin is elevated in the cerebrospinal fluid of patients with malignant astrocytoma and mediates glioma cell migration. Clin Cancer Res 2006; 12:6331-6. PubMed
  • Gudi R, Barkinge J, Hawkins S, Chu F, Manicassamy S, Sun Z, Duke-Cohan JS, Prasad KV. Siva-1 negatively regulates NF-kappaB activity: effect on T-cell receptor-mediated activation-induced cell death (AICD). Oncogene 2006; 25:3458-62. PubMed
  • Duke-Cohan JS, Kang H, Liu H, Rudd CE. Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein. J Biol Chem 2006; 281:13743-50. PubMed
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