Jordan A. Kreidberg, MD, PhD

Boston Children's Hospital

Boston Children's Hospital


Jordan.kreidberg@tch.harvard.edu

Jordan A. Kreidberg, MD, PhD

Boston Children's Hospital

EDUCATIONAL TITLES

  • Associate Professor, Pediatrics, Harvard Medical School
  • Assistant Professor, Pediatrics, Boston Children's Hospital

Research Abstract

Our work focuses on two areas related to cancer. The first focus is on the Wilms' tumor suppressor gene, which encodes a transcription factor required in organogenesis. We are using Wt1 transgenic and knockout mice to evaluate the function of Wt1 in development and cancer. The second focus is on the function of integrins, which are cell adhesion receptors. Our interest is on understanding the mechanism by which alpha3 beta1 integrin regulates cadherin mediated adhesion, and how this may affect tumor invasiveness.

Publications

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  • Kann M, Bae E, Lenz MO, Li L, Trannguyen B, Schumacher VA, Taglienti ME, Bordeianou L, Hartwig S, Rinschen MM, Schermer B, Benzing T, Fan CM, Kreidberg JA. WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals. Development 2015; 142:1254-66. PubMed
  • Kann M, Ettou S, Jung YL, Lenz MO, Taglienti ME, Park PJ, Schermer B, Benzing T, Kreidberg JA. Genome-Wide Analysis of Wilms' Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms. J Am Soc Nephrol 2015. PubMed
  • Zhang AF, Wu SL, Jung Y, Qin S, Hancock WS, Kreidberg JA. Identification of Novel Glycans with Disialylated Structures in 留3 Integrin from Mouse Kidney Cells with the Phenotype of Polycystic Kidney Disease. J Proteome Res 2014. PubMed
  • Chu JY, Sims-Lucas S, Bushnell DS, Bodnar AJ, Kreidberg JA, Ho J. Dicer function is required in the metanephric mesenchyme for early kidney development. Am J Physiol Renal Physiol 2014; 306:F764-72. PubMed
  • McMahon GM, Datta D, Bruneau S, Kann M, Khalid M, Ho J, Seto T, Kreidberg JA, Stillman IE, Briscoe DM. Constitutive activation of the mTOR signaling pathway within the normal glomerulus. Biochem Biophys Res Commun 2012; 425:244-9. PubMed
  • Qin S, Taglienti M, Nauli SM, Contrino L, Takakura A, Zhou J, Kreidberg JA. Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease. J Clin Invest 2010; 120:3617-28. PubMed
  • da Silva RG, Tavora B, Robinson SD, Reynolds LE, Szekeres C, Lamar J, Batista S, Kostourou V, Germain MA, Reynolds AR, Jones DT, Watson AR, Jones JL, Harris A, Hart IR, Iruela-Arispe ML, Dipersio CM, Kreidberg JA, Hodivala-Dilke KM. Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF. Am J Pathol 2010; 177:1534-48. PubMed
  • Kreidberg JA. siRNA Therapy for Glomerulonephritis. J Am Soc Nephrol 2010; 21:549-51. PubMed
  • Hartwig S, Ho J, Pandey P, Macisaac K, Taglienti M, Xiang M, Alterovitz G, Ramoni M, Fraenkel E, Kreidberg JA. Genomic characterization of Wilms' tumor suppressor 1 targets in nephron progenitor cells during kidney development. Development 2010; 137:1189-203. PubMed
  • Kong T, Xu D, Yu W, Takakura A, Boucher I, Tran M, Kreidberg JA, Shah J, Zhou J, Denker BM. G alpha 12 inhibits alpha2 beta1 integrin-mediated Madin-Darby canine kidney cell attachment and migration on collagen-I and blocks tubulogenesis. Mol Biol Cell 2009; 20:4596-610. PubMed
  • Ho J,Ng KH,Rosen S,Dostal A,Gregory RI,Kreidberg JA. Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. J Am Soc Nephrol 2008; 19:2069-75. PubMed
  • Kreidberg JA. Integrins and matrix in the glomerulus: old mysteries and new insights. J Am Soc Nephrol 2008; 19:650-1. PubMed
  • Quaggin SE, Kreidberg JA. Development of the renal glomerulus: good neighbors and good fences. Development 2008; 135:609-20. PubMed
  • Natoli TA, Liu J, Eremina V, Hodgens K, Li C, Hamano Y, Mundel P, Kalluri R, Miner JH, Quaggin SE, Kreidberg JA. A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary development. J Am Soc Nephrol 2002; 13:2058-67. PubMed
  • Zent R, Bush KT, Pohl ML, Quaranta V, Koshikawa N, Wang Z, Kreidberg JA, Sakurai H, Stuart RO, Nig. Involvement of laminin binding integrins and laminin-5 in branching morphogenesis of the ureteric bud during kidney development. Dev Biol 2002; 238:289-302. PubMed
  • Wei Y, Eble JA, Wang Z, Kreidberg JA, Chapman HA. Urokinase receptors promote beta1 integrin function through interactions with integrin alpha3beta1. Mol Biol Cell 2001; 12:2975-86. PubMed
  • Lin Y, Liu A, Zhang S, Ruusunen T, Kreidberg JA, Peltoketo H, Drummond I, Vainio S. Induction of ureter branching as a response to Wnt-2b signaling during early kidney organogenesis. Dev Dyn 2001; 222:26-39. PubMed
  • Klinowska TC, Alexander CM, Georges-Labouesse E, Van der Neut R, Kreidberg JA, Jones CJ, Sonnenberg A, Streuli CH. Epithelial development and differentiation in the mammary gland is not dependent on alpha 3 or alpha 6 integrin subunits. Dev Biol 2001; 233:449-67. PubMed
  • Menko AS, Kreidberg JA, Ryan TT, Van Bockstaele E, Kukuruzinska MA. Loss of alpha3beta1 integrin function results in an altered differentiation program in the mouse submandibular gland. Dev Dyn 2001; 220:337-49. PubMed
  • Kreidberg JA. Functions of alpha3beta1 integrin. Curr Opin Cell Biol 2000; 12:548-53. PubMed
  • DiPersio CM, van der Neut R, Georges-Labouesse E, Kreidberg JA, Sonnenberg A, Hynes RO. alpha3beta1 and alpha6beta4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development. J Cell Sci 2000; 113 ( Pt 17):3051-62. PubMed
  • Kreidberg JA, Symons JM. Integrins in kidney development, function, and disease. Am J Physiol Renal Physiol 2000; 279:F233-42. PubMed
  • Wang Z, Symons JM, Goldstein SL, McDonald A, Miner JH, Kreidberg JA. (Alpha)3(beta)1 integrin regulates epithelial cytoskeletal organization. J Cell Sci 1999; 112 ( Pt 17):2925-35. PubMed
  • Kreidberg JA, Natoli TA, McGinnis L, Donovan M, Biggers JD, Amstutz A. Coordinate action of Wt1 and a modifier gene supports embryonic survival in the oviduct. Mol Reprod Dev 1999; 52:366-75. PubMed
  • Anton ES, Kreidberg JA, Rakic P. Distinct functions of alpha3 and alpha(v) integrin receptors in neuronal migration and laminar organization of the cerebral cortex. Neuron 1999; 22:277-89. PubMed
  • Donovan MJ, Natoli TA, Sainio K, Amstutz A, Jaenisch R, Sariola H, Kreidberg JA. Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud. Dev Genet 1999; 24:252-62. PubMed
  • Ivins JK, Colognato H, Kreidberg JA, Yurchenco PD, Lander AD. Neuronal receptors mediating responses to antibodyactivated laminin-1. J Neurosci 1998; 18:9703-15. PubMed
  • Kreidberg JA, Donovan MJ, Goldstein SL, Rennke H, Shepherd K, Jones RC, Jaenisch R. Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis. Development 1996; 122:3537-47. PubMed
  • Kreidberg JA, Sariola H, Loring JM, Maeda M, Pelletier J, Housman D, Jaenisch R. WT-1 is required for early kidney development. Cell 1993; 74:679-91. PubMed
  • Kreidberg JA, Kelly TJ. Genetic analysis of the human thymidine kinase gene promoter. Mol Cell Biol 1986; 6:2903-9. PubMed
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