Photo of Joren C. Madsen,  MD, PhD

Joren C. Madsen, MD, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-6506
Fax: (617) 724-9892


jcmadsen@mgh.harvard.edu

Joren C. Madsen, MD, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Surgery, Harvard Medical School
  • Director, MGH Transplant Center, Department of Surgery, Massachusetts General Hospital
  • Co-Director, Transplantation Biology Research Center, Surgery, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

The risk of cancer in immunosuppressed transplant recipients is significantly elevated. Suppression of the immune system leads to decreased resistance to viral infection and associated increased risk of certain cancers, mainly those with a viral aetiology. In our laboratory, we are investigating ways to induce immune tolerance and allow allograft acceptance in patients in need of a transplant without the need for chronic immunosuppression. The goal of our investigations is to achieve a state of tolerance to the donor organ which will also assure that immune competence is maintained so that the risk of cancer is similar to that of the general public.

Publications

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  • Madariaga ML, Michel SG, La Muraglia GM, Sihag S, Leonard DA, Farkash EA, Colvin RB, Cetrulo CL, Huang CA, Sachs DH, Madsen JC, Allan JS. Recipient-Matching of Passenger Leukocytes Prolongs Survival of Donor Lung Allografts in Miniature Swine. Transplantation 2015. PubMed
  • Peraino JS, Zhang H, Rajasekera PV, Wei M, Madsen JC, Sachs DH, Huang CA, Wang Z. Diphtheria toxin-based bivalent human IL-2 fusion toxin with improved efficacy for targeting human CD25(+) cells. J Immunol Methods 2014; 405:57-66. PubMed
  • Yamada Y, Aoyama A, Tocco G, Boskovic S, Nadazdin O, Alessandrini A, Madsen JC, Cosimi AB, Benichou G, Kawai T. Differential effects of denileukin diftitox IL-2 immunotoxin on NK and regulatory T cells in nonhuman primates. J Immunol 2012; 188:6063-70. PubMed
  • Nadazdin O, Boskovic S, Murakami T, Tocco G, Smith RN, Colvin RB, Sachs DH, Allan J, Madsen JC, Kawai T, Cosimi AB, Benichou G. Host alloreactive memory T cells influence tolerance to kidney allografts in nonhuman primates. Sci Transl Med 2011; 3:86ra51. PubMed