Photo of Jorge E. Chavarro,

Jorge E. Chavarro

Brigham And Women's Hospital

Brigham And Women's Hospital


jchavarr@hsph.harvard.edu

Jorge E. Chavarro

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Medicine, Harvard Medical School
  • Associate Epidemiologist, Medicine, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My research focuses on investigating the role of diet and the interaction between dietary and genetic factors in the pathogenesis of diseases affecting reproductive and hormone sensitive organs, particularly malignancies of reproductive organs. This broad interest is currently focused in two areas. First, I am investigating the role of fatty acids and their metabolism in the development and progression of prostate cancer. Using data from ongoing cohort studies, I study the relationships of dietary fatty acid intakes and biomarkers of fatty acid intake and their metabolism, including de novo lipogenesis, with prostate cancer risk and survival. Also, because prostate cancer treatment often has adverse cardiovascular and metabolic consequences, I am investigating the role of modifiable lifestyle factors on non-cancer mortally, particularly cardiovascular disease, among men with prostate cancer.

In addition to my prostate cancer work, I am currently investigating how different

dietary and lifestyle factors are related to male and female fertility and infertility treatment outcomes with the goal of identifying strategies for fertility preservation in cancer survivors and in the general population.

Publications

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  • Tee MC, Cao Y, Warnock GL, Hu FB, Chavarro JE. Effect of bariatric surgery on oncologic outcomes: a systematic review and meta-analysis. Surg Endosc 2013; 27:4449-56. PubMed
  • Chavarro JE, Kenfield SA, Stampfer MJ, Loda M, Campos H, Sesso HD, Ma J. Blood levels of saturated and monounsaturated fatty acids as markers of de novo lipogenesis and risk of prostate cancer. Am J Epidemiol 2013; 178:1246-55. PubMed
  • Richman EL, Kenfield SA, Chavarro JE, Stampfer MJ, Giovannucci EL, Willett WC, Chan JM. Fat intake after diagnosis and risk of lethal prostate cancer and all-cause mortality. JAMA Intern Med 2013; 173:1318-26. PubMed
  • Patterson RE, Colditz GA, Hu FB, Schmitz KH, Ahima RS, Brownson RC, Carson KR, Chavarro JE, Chodosh LA, Gehlert S, Gill J, Glanz K, Haire-Joshu D, Herbst KL, Hoehner CM, Hovmand PS, Irwin ML, Jacobs LA, James AS, Jones LW, Kerr J, Kibel AS, King IB, Ligibel JA, Meyerhardt JA, Natarajan L, Neuhouser ML, Olefsky JM, Proctor EK, Redline S, Rock CL, Rosner B, Sarwer DB, Schwartz JS, Sears DD, Sesso HD, Stampfer MJ, Subramanian SV, Taveras EM, Tchou J, Thompson B, Troxel AB, Wessling-Resnick M, Wolin KY, Thornquist MD. The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) initiative: rationale and design. Cancer Causes Control 2013; 24:695-704. PubMed
  • Song Y, Chavarro JE, Cao Y, Qiu W, Mucci L, Sesso HD, Stampfer MJ, Giovannucci E, Pollak M, Liu S, Ma J. Whole milk intake is associated with prostate cancer-specific mortality among U.S. male physicians. J Nutr 2013; 143:189-96. PubMed
  • Nguyen PL, Ma J, Chavarro JE, Freedman ML, Lis R, Fedele G, Fiore C, Qiu W, Fiorentino M, Finn S, Penney KL, Eisenstein A, Schumacher FR, Mucci LA, Stampfer MJ, Giovannucci E, Loda M. Fatty Acid Synthase Polymorphisms, Tumor Expression, Body Mass Index, Prostate Cancer Risk, and Survival. J Clin Oncol 2010; 28:3958-64. PubMed
  • Chavarro JE,Stampfer MJ,Hall MN,Sesso HD,Ma J. A 22-y prospective study of fish intake in relation to prostate cancer incidence and mortality. Am J Clin Nutr 2008; 88:1297-303. PubMed
  • Hall MN,Chavarro JE,Lee IM,Willett WC,Ma J. A 22-year prospective study of fish, n-3 fatty acid intake, and colorectal cancer risk in men. Cancer Epidemiol Biomarkers Prev 2008; 17:1136-43. PubMed
  • Chavarro JE, Stampfer MJ, Campos H, Kurth T, Willett WC, Ma J. A prospective study of trans-fatty acid levels in blood and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 2008; 17:95-101. PubMed
  • Chavarro JE, Stampfer MJ, Li H, Campos H, Kurth T, Ma J. A prospective study of polyunsaturated fatty acid levels in blood and prostate cancer risk. Cancer Epidemiol Biomarkers Prev 2007; 16:1364-70. PubMed
  • Chavarro JE, Peterson KE, Sobol AM, Wiecha JL, Gortmaker SL. Effects of a school-based obesity-prevention intervention on menarche (United States). Cancer Causes Control 2005; 16:1245-52. PubMed